{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:26:47Z","timestamp":1791084407378,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["cancerletters.info","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1016\/j.canlet.2013.06.023","type":"journal-article","created":{"date-parts":[[2013,6,26]],"date-time":"2013-06-26T12:01:44Z","timestamp":1372248104000},"page":"30-42","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Polyphenol tri-vanillic ester 13c inhibits P-JAK2V617F and Bcr\u2013Abl oncokinase expression in correlation with STAT3\/STAT5 inactivation and apoptosis induction in human leukemia cells"],"prefix":"10.1016","volume":"340","author":[{"given":"Anne","family":"Tr\u00e9cul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Morceau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthoula","family":"Gaigneaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Orsini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Chateauvieux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Grandjenette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Dicato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Diederich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2013.06.023_b0005","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1179\/1476830512Y.0000000006","article-title":"Role of polyphenols in cell death control","volume":"15","author":"Giovannini","year":"2012","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.canlet.2013.06.023_b0010","doi-asserted-by":"crossref","first-page":"5308","DOI":"10.1002\/anie.201107724","article-title":"Curcumin \u2013 from molecule to biological function","volume":"51","author":"Esatbeyoglu","year":"2012","journal-title":"Angew. Chem."},{"key":"10.1016\/j.canlet.2013.06.023_b0015","article-title":"Trivanillic polyphenols with anticancer cytostatic effects through the targeting of multiple kinases and intracellular Ca(2+) release","author":"Lamoral-Theys","year":"2011","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.canlet.2013.06.023_b0020","doi-asserted-by":"crossref","first-page":"31704","DOI":"10.1074\/jbc.271.49.31704","article-title":"P210 and P190(BCR\/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members","volume":"271","author":"Ilaria","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2013.06.023_b0025","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.leukres.2007.11.032","article-title":"Src family kinases promote AML cell survival through activation of signal transducers and activators of transcription (STAT)","volume":"32","author":"Ozawa","year":"2008","journal-title":"Leuk. Res."},{"key":"10.1016\/j.canlet.2013.06.023_b0030","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1172\/JCI9940","article-title":"Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression","volume":"107","author":"Epling-Burnette","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.canlet.2013.06.023_b0035","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s12263-012-0281-y","article-title":"Dietary compounds as potent inhibitors of the signal transducers and activators of transcription (STAT) 3 regulatory network","volume":"7","author":"Trecul","year":"2012","journal-title":"Genes Nutr."},{"key":"10.1016\/j.canlet.2013.06.023_b0040","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(05)74230-6","article-title":"Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders","volume":"365","author":"Baxter","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.canlet.2013.06.023_b0045","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.molmed.2005.10.003","article-title":"A JAK2 mutation in myeloproliferative disorders: pathogenesis and therapeutic and scientific prospects","volume":"11","author":"James","year":"2005","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.canlet.2013.06.023_b0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.blre.2004.02.002","article-title":"Molecular pathogenesis of Philadelphia chromosome negative myeloproliferative disorders","volume":"19","author":"Kralovics","year":"2005","journal-title":"Blood Rev."},{"key":"10.1016\/j.canlet.2013.06.023_b0055","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1182\/blood-2005-05-1898","article-title":"The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia","volume":"106","author":"Levine","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.canlet.2013.06.023_b0060","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.ajpath.2011.09.030","article-title":"Notch-induced hIL-6 production facilitates the maintenance of self-renewal of hCD34+ cord blood cells through the activation of Jak-PI3K-STAT3 pathway","volume":"180","author":"Choi","year":"2012","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.canlet.2013.06.023_b0065","doi-asserted-by":"crossref","first-page":"3922","DOI":"10.3748\/wjg.v17.i34.3922","article-title":"Sorafenib inhibits growth and metastasis of hepatocellular carcinoma by blocking STAT3","volume":"17","author":"Gu","year":"2011","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.canlet.2013.06.023_b0070","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1034\/j.1600-0609.2001.t01-1-00385.x","article-title":"Constitutive activation of STAT transcription factors in acute myelogenous leukemia","volume":"67","author":"Spiekermann","year":"2001","journal-title":"Eur. J. Haematol."},{"key":"10.1016\/j.canlet.2013.06.023_b0075","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1002\/1097-0142(19950115)75:2<464::AID-CNCR2820750209>3.0.CO;2-E","article-title":"Philadelphia chromosome-negative chronic myelogenous leukemia with rearrangement of the breakpoint cluster region. Long-term follow-up results","volume":"75","author":"Cortes","year":"1995","journal-title":"Cancer"},{"key":"10.1016\/j.canlet.2013.06.023_b0080","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1046\/j.1365-2257.2002.00413.x","article-title":"BCR\/ABL p210, p190 and p230 fusion genes in 250 Mexican patients with chronic myeloid leukaemia (CML)","volume":"24","author":"Arana-Trejo","year":"2002","journal-title":"Clin. Lab. Haematol."},{"key":"10.1016\/j.canlet.2013.06.023_b0085","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/S0092-8674(03)00191-0","article-title":"A myristoyl\/phosphotyrosine switch regulates c-Abl","volume":"112","author":"Hantschel","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2013.06.023_b0090","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1182\/blood.V96.10.3343","article-title":"The molecular biology of chronic myeloid leukemia","volume":"96","author":"Deininger","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.canlet.2013.06.023_b0095","article-title":"Src family kinases mediate cytoplasmic retention of activated STAT5 in BCR-ABL-positive cells","author":"Chatain","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2013.06.023_b0100","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/emmm.201000062","article-title":"Stat5 is indispensable for the maintenance of bcr\/abl-positive leukaemia","volume":"2","author":"Hoelbl","year":"2010","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.canlet.2013.06.023_b0105","doi-asserted-by":"crossref","first-page":"3550","DOI":"10.1182\/blood-2011-12-397554","article-title":"Essential role for Stat5a\/b in myeloproliferative neoplasms induced by BCR-ABL1 and JAK2(V617F) in mice","volume":"119","author":"Walz","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.canlet.2013.06.023_b0110","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1128\/MCB.17.6.3295","article-title":"Abrogation of interleukin-3 dependence of myeloid cells by the v-src oncogene requires SH2 and SH3 domains which specify activation of STATs","volume":"17","author":"Chaturvedi","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.canlet.2013.06.023_b0115","doi-asserted-by":"crossref","first-page":"3823","DOI":"10.1016\/j.bmc.2010.04.047","article-title":"Simple di- and trivanillates exhibit cytostatic properties toward cancer cells resistant to pro-apoptotic stimuli","volume":"18","author":"Lamoral-Theys","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.canlet.2013.06.023_b0120","doi-asserted-by":"crossref","first-page":"6419","DOI":"10.1093\/nar\/17.15.6419","article-title":"Rapid detection of octamer binding proteins with \u2018mini-extracts\u2019, prepared from a small number of cells","volume":"17","author":"Schreiber","year":"1989","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.canlet.2013.06.023_b0125","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/bioinformatics\/btn501","article-title":"Integrating and annotating the interactome using the MiMI plugin for cytoscape","volume":"25","author":"Gao","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.canlet.2013.06.023_b0130","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.canlet.2013.06.023_b0135","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/j.bcp.2006.07.029","article-title":"Curcumin regulates signal transducer and activator of transcription (STAT) expression in K562 cells","volume":"72","author":"Blasius","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.canlet.2013.06.023_b0140","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/S0006-2952(03)00501-X","article-title":"Induction of apoptosis by curcumin: mediation by glutathione S-transferase P1\u20131 inhibition","volume":"66","author":"Duvoix","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.canlet.2013.06.023_b0145","doi-asserted-by":"crossref","DOI":"10.2174\/138161281939131127115940","article-title":"The STAT3 inhibitor Stattic Impairs cardiomyocyte mitochondrial function through increased reactive oxygen species formation","author":"Boengler","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.canlet.2013.06.023_b0150","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/CAD.0b013e32833f44fd","article-title":"Sorafenib induces apoptosis in HL60 cells by inhibiting Src kinase-mediated STAT3 phosphorylation","volume":"22","author":"Zhao","year":"2011","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.canlet.2013.06.023_b0155","doi-asserted-by":"crossref","first-page":"4955","DOI":"10.1128\/MCB.24.11.4955-4967.2004","article-title":"Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity","volume":"24","author":"Argetsinger","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.canlet.2013.06.023_b0160","doi-asserted-by":"crossref","first-page":"35631","DOI":"10.1074\/jbc.M005401200","article-title":"C-Abl has high intrinsic tyrosine kinase activity that is stimulated by mutation of the Src homology 3 domain and by autophosphorylation at two distinct regulatory tyrosines","volume":"275","author":"Brasher","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2013.06.023_b0165","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0092-8674(02)00623-2","article-title":"Autoinhibition of c-Abl","volume":"108","author":"Pluk","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2013.06.023_b0170","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1517\/14712598.2.1.3","article-title":"HSP90 as a new therapeutic target for cancer therapy: the story unfolds","volume":"2","author":"Maloney","year":"2002","journal-title":"Expert Opin. Biol. Ther."},{"key":"10.1016\/j.canlet.2013.06.023_b0175","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/S0092-8674(03)00194-6","article-title":"Structural basis for the autoinhibition of c-Abl tyrosine kinase","volume":"112","author":"Nagar","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2013.06.023_b0180","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/biof.5520340407","article-title":"Radicicol-mediated inhibition of Bcr-Abl in K562 cells induced p38-MAPK dependent erythroid differentiation and PU.1 down-regulation","volume":"34","author":"Morceau","year":"2008","journal-title":"Biofactors"},{"key":"10.1016\/j.canlet.2013.06.023_b0185","first-page":"1799","article-title":"Geldanamycin and its analogue 17-allylamino-17-demethoxygeldanamycin lowers Bcr-Abl levels and induces apoptosis and differentiation of Bcr-Abl-positive human leukemic blasts","volume":"61","author":"Nimmanapalli","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2013.06.023_b0190","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/0092-8674(92)90241-4","article-title":"Dominant negative MYC blocks transformation by ABL oncogenes","volume":"70","author":"Sawyers","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2013.06.023_b0195","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1038\/sj.leu.2402945","article-title":"Signal transduction mediated by the Ras\/Raf\/MEK\/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention","volume":"17","author":"Chang","year":"2003","journal-title":"Leukemia"},{"key":"10.1016\/j.canlet.2013.06.023_b0200","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cell.2007.04.044","article-title":"CIP2A inhibits PP2A in human malignancies","volume":"130","author":"Junttila","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2013.06.023_b0205","first-page":"1082","article-title":"Overexpression of phospholipase D enhances Bcl-2 expression by activating STAT3 through independent activation of ERK and p38MAPK in HeLa cells","volume":"2012","author":"Choi","year":"1823","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.canlet.2013.06.023_b0210","doi-asserted-by":"crossref","first-page":"28066","DOI":"10.1074\/jbc.M805545200","article-title":"Leptin stimulates both JAK2-dependent and JAK2-independent signaling pathways","volume":"283","author":"Jiang","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2013.06.023_b0215","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1158\/1541-7786.MCR-10-0210","article-title":"Cytokine induction of tumor necrosis factor receptor 2 is mediated by STAT3 in colon cancer cells","volume":"9","author":"Hamilton","year":"2011","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.canlet.2013.06.023_b0220","article-title":"Mechanisms of resistance to BCR-ABL and other kinase inhibitors","author":"Lamontanara","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.canlet.2013.06.023_b0225","doi-asserted-by":"crossref","DOI":"10.1517\/13543776.2013.765862","article-title":"Inhibitors of JAK2 and JAK3: an update on the patent literature 2010\u20132012","author":"Dymock","year":"2013","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.canlet.2013.06.023_b0230","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3810\/pgm.2013.01.2628","article-title":"Ruxolitinib: an oral Janus kinase 1 and Janus kinase 2 inhibitor in the management of myelofibrosis","volume":"125","author":"Verstovsek","year":"2013","journal-title":"Postgrad. Med."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383513004734?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383513004734?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T04:47:31Z","timestamp":1595998051000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383513004734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S0304383513004734"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2013.06.023","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polyphenol tri-vanillic ester 13c inhibits P-JAK2V617F and Bcr\u2013Abl oncokinase expression in correlation with STAT3\/STAT5 inactivation and apoptosis induction in human leukemia cells","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2013.06.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}