{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T11:37:09Z","timestamp":1784029029579,"version":"3.55.0"},"reference-count":60,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Sciences","doi-asserted-by":"crossref","award":["#24790529"],"award-info":[{"award-number":["#24790529"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1016\/j.canlet.2013.07.015","type":"journal-article","created":{"date-parts":[[2013,7,20]],"date-time":"2013-07-20T12:01:02Z","timestamp":1374321662000},"page":"116-127","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Synergistic effect of combined treatment with gamma-tocotrienol and statin on human malignant mesothelioma cells"],"prefix":"10.1016","volume":"339","author":[{"given":"Guligena","family":"Tuerdi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saki","family":"Ichinomiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana","family":"Siddig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eriko","family":"Suwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Yano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2013.07.015_b0005","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0140-6736(05)67025-0","article-title":"Malignant mesothelioma","author":"Robinson","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.canlet.2013.07.015_b0010","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/sj.bjc.6690105","article-title":"The European mesothelioma epidemic","volume":"79","author":"Peto","year":"1999","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.canlet.2013.07.015_b0015","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0140-6736(95)90462-X","article-title":"Continuing increase in mesothelioma mortality in Britain","volume":"345","author":"Peto","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.canlet.2013.07.015_b0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ajim.20246","article-title":"Estimation of future mortality from pleural malignant mesothelioma in Japan based on an age-cohort model","volume":"49","author":"Murayama","year":"2006","journal-title":"Am. J. Ind. Med."},{"issue":"2011","key":"10.1016\/j.canlet.2013.07.015_b0025","first-page":"716","article-title":"Global mesothelioma deaths reported to the World Health Organization between 1994 and","volume":"89","author":"Delgermaa","year":"2008","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.canlet.2013.07.015_b0030","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.annepidem.2011.05.010","article-title":"Mesothelioma from chrysotile asbestos: update","volume":"21","author":"Kanarek","year":"2011","journal-title":"Ann. Epidemiol."},{"key":"10.1016\/j.canlet.2013.07.015_b0035","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1165\/rcmb.2006-0011OC","article-title":"Asbestos induces nitric oxide synthesis in mesothelioma cells via Rho signaling inhibition","volume":"36","author":"Riganti","year":"2007","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.canlet.2013.07.015_b0040","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1042\/bj1000138","article-title":"The isolation and properties of delta-tocotrienol from Hevea latex","volume":"100","author":"Whittle","year":"1966","journal-title":"Biochem. J."},{"key":"10.1016\/j.canlet.2013.07.015_b0045","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1753-4887.2012.00512.x","article-title":"Tocotrienol research: past into present","volume":"70","author":"Wong","year":"2012","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.canlet.2013.07.015_b0050","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1007\/s10495-009-0406-y","article-title":"Endoplasmic reticulum stress mediates gamma-tocotrienol-induced apoptosis in mammary tumor cells","volume":"14","author":"Wali","year":"2009","journal-title":"Apoptosis"},{"key":"10.1016\/j.canlet.2013.07.015_b0055","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1007\/s11745-007-3102-0","article-title":"Synergistic antiproliferative effects of gamma-tocotrienol and statin treatment on mammary tumor cells","volume":"42","author":"Wali","year":"2007","journal-title":"Lipids"},{"key":"10.1016\/j.canlet.2013.07.015_b0060","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1667\/RR1632.1","article-title":"Gamma-Tocotrienol ameliorates intestinal radiation injury and reduces vascular oxidative stress after total-body irradiation by an HMG-CoA reductase-dependent mechanism","volume":"171","author":"Berb\u00e9ea","year":"2009","journal-title":"Radiat. Res."},{"key":"10.1016\/j.canlet.2013.07.015_b0065","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1074\/jbc.M610028200","article-title":"Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis","volume":"282","author":"Ahn","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2013.07.015_b0070","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1002\/ijc.26054","article-title":"Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by increasing intracellular dihydrosphingosine and dihydroceramide","volume":"130","author":"Jiang","year":"2012","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.canlet.2013.07.015_b0075","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1002\/ijc.25546","article-title":"Gamma-tocotrienol as an effective agent in targeting prostate cancer stem cell-like population","volume":"128","author":"Luk","year":"2011","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.canlet.2013.07.015_b0080","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.canlet.2012.10.003","article-title":"Eliminating drug resistant breast cancer stem-like cells with combination of simvastatin and gamma-tocotrienol","volume":"328","author":"Gopalan","year":"2013","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2013.07.015_b0085","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1002\/ijc.24766","article-title":"Synergistic actions of atorvastatin with gamma-tocotrienol and celecoxib against human colon cancer HT29 and HCT116 cells","volume":"126","author":"Yang","year":"2010","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.canlet.2013.07.015_b0090","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.jnutbio.2005.11.001","article-title":"Apoptosis induction by gamma-tocotrienol in human hepatoma Hep3B cells","volume":"17","author":"Sakai","year":"2006","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.canlet.2013.07.015_b0095","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.bbrc.2011.12.091","article-title":"Statins inhibit expression of thioredoxin reductase 1 in rat and human liver and reduce tumour development","volume":"417","author":"Skogastierna","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.canlet.2013.07.015_b0100","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1001\/archinte.164.13.1427","article-title":"Effectiveness of statin therapy in adults with coronary heart disease","volume":"164","author":"Wilt","year":"2004","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.canlet.2013.07.015_b0105","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.cgh.2012.08.037","article-title":"Statins and colorectal cancer","volume":"11","author":"Lochhead","year":"2013","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.canlet.2013.07.015_b0110","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/sj.leu.2402476","article-title":"HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosis","volume":"16","author":"Wong","year":"2002","journal-title":"Leukemia"},{"key":"10.1016\/j.canlet.2013.07.015_b0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2012.04.011","article-title":"Statins and cancer: current and future prospects","volume":"324","author":"Osmak","year":"2012","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2013.07.015_b0120","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.jacc.2012.07.007","article-title":"The controversies of statin therapy: weighing the evidence","volume":"60","author":"Jukema","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.canlet.2013.07.015_b0125","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s10549-012-2154-x","article-title":"Statin use and risk of breast cancer: a meta-analysis of observational studies","volume":"135","author":"Undela","year":"2012","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.canlet.2013.07.015_b0130","first-page":"1099","article-title":"Statin use and risk of pancreatic cancer: a meta-analysis","volume":"23","author":"Cui","year":"2012","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.canlet.2013.07.015_b0135","first-page":"483","article-title":"Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer","volume":"2","author":"Thibault","year":"1996","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2013.07.015_b0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-3835(01)00412-8","article-title":"Rho signals to cell growth and apoptosis","volume":"165","author":"Aznar","year":"2001","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2013.07.015_b0145","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s12263-011-0225-y","article-title":"Synergistic anticancer effects of combined gamma-tocotrienol with statin or receptor tyrosine kinase inhibitor treatment","volume":"7","author":"Sylvester","year":"2012","journal-title":"Genes Nutr."},{"key":"10.1016\/j.canlet.2013.07.015_b0150","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s11745-009-3344-0","article-title":"Suppression in mevalonate synthesis mediates antitumor effects of combined statin and gamma-tocotrienol treatment","volume":"44","author":"Wali","year":"2009","journal-title":"Lipids"},{"key":"10.1016\/j.canlet.2013.07.015_b0155","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1177\/153537020422900701","article-title":"Studies of the isoprenoid-mediated inhibition of mevalonate synthesis applied to cancer chemotherapy and chemoprevention","volume":"229","author":"Mo","year":"2004","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.canlet.2013.07.015_b0160","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3389\/fgene.2012.00104","article-title":"Enhanced genotoxicity of silver nanoparticles in DNA repair deficient Mammalian cells","volume":"3","author":"Lim","year":"2012","journal-title":"Front. Genet."},{"key":"10.1016\/j.canlet.2013.07.015_b0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1349-7006.2009.01336.x","article-title":"Genomic abnormalities and signal transduction dysregulation in malignant mesothelioma cells","volume":"101","author":"Sekido","year":"2010","journal-title":"Cancer Sci."},{"key":"10.1016\/j.canlet.2013.07.015_b0170","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/sj.bjc.6600673","article-title":"Chemotherapy for malignant pleural mesothelioma: past results and recent developments","volume":"88","author":"Tomek","year":"2003","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.canlet.2013.07.015_b0175","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1158\/1078-0432.CCR-08-1579","article-title":"Valproate, in combination with pemetrexed and cisplatin, provides additional efficacy to the treatment of malignant mesothelioma","volume":"15","author":"Vandermeers","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2013.07.015_b0180","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/ptr.3107","article-title":"The tocotrienol-rich fraction from rice bran enhances cisplatin-induced cytotoxicity in human mesothelioma H28 cells","volume":"24","author":"Nakashima","year":"2010","journal-title":"Phytother. Res."},{"key":"10.1016\/j.canlet.2013.07.015_b0185","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s10549-010-0786-2","article-title":"Tocotrienols induce apoptosis in breast cancer cell lines via an endoplasmic reticulum stress-dependent increase in extrinsic death receptor signaling","volume":"124","author":"Park","year":"2010","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.canlet.2013.07.015_b0190","doi-asserted-by":"crossref","first-page":"639","DOI":"10.3181\/0810-RM-300","article-title":"Combined treatment of gamma-tocotrienol with statins induce mammary tumor cell cycle arrest in G1","volume":"234","author":"Wali","year":"2009","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.canlet.2013.07.015_b0195","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jnutbio.2008.03.003","article-title":"Gamma-Tocotrienol induces mitochondria-mediated apoptosis in human gastric adenocarcinoma SGC-7901 cells","volume":"20","author":"Sun","year":"2009","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.canlet.2013.07.015_b0200","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.atherosclerosis.2007.09.034","article-title":"Effects of ezetimibe and\/or simvastatin on LDL receptor protein expression and on LDL receptor and HMG-CoA reductase gene expression: a randomized trial in healthy men","volume":"198","author":"Berthold","year":"2008","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.canlet.2013.07.015_b0205","doi-asserted-by":"crossref","first-page":"4307","DOI":"10.1210\/jc.2002-012041","article-title":"Regulation of hepatic low-density lipoprotein receptor, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and cholesterol 7alpha-hydroxylase mRNAs in human liver","volume":"87","author":"Rudling","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.canlet.2013.07.015_b0210","doi-asserted-by":"crossref","first-page":"25054","DOI":"10.1074\/jbc.M605575200","article-title":"Insig-dependent ubiquitination and degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase stimulated by delta- and gamma-tocotrienols","volume":"281","author":"Song","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2013.07.015_b0215","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.fertnstert.2011.08.010","article-title":"Resveratrol inhibits the mevalonate pathway and potentiates the antiproliferative effects of simvastatin in rat theca-interstitial cells","volume":"96","author":"Wong","year":"2011","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.canlet.2013.07.015_b0220","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1021\/jm201657x","article-title":"Design and synthesis of active site inhibitors of the human farnesyl pyrophosphate synthase: apoptosis and inhibition of ERK phosphorylation in multiple myeloma cells","volume":"55","author":"Lin","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.canlet.2013.07.015_b0225","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1161\/hc0602.103393","article-title":"Statins have biphasic effects on angiogenesis","volume":"105","author":"Weis","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.canlet.2013.07.015_b0230","first-page":"6015","article-title":"Alendronate inhibits lysophosphatidic acid-induced migration of human ovarian cancer cells by attenuating the activation of rho","volume":"62","author":"Sawada","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2013.07.015_b0235","doi-asserted-by":"crossref","first-page":"6080","DOI":"10.1038\/sj.onc.1208744","article-title":"Human and mouse mesotheliomas exhibit elevated AKT\/PKB activity, which can be targeted pharmacologically to inhibit tumor cell growth","volume":"24","author":"Altomare","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2013.07.015_b0240","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.lungcan.2005.04.010","article-title":"Limited efficacy of imatinib mesylate in malignant mesothelioma: a phase II trial","volume":"50","author":"Mathy","year":"2005","journal-title":"Lung Cancer"},{"key":"10.1016\/j.canlet.2013.07.015_b0245","doi-asserted-by":"crossref","first-page":"10631","DOI":"10.1158\/0008-5472.CAN-07-1705","article-title":"Integrated endoplasmic reticulum stress responses in cancer","volume":"67","author":"Moenner","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2013.07.015_b0250","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.cellsig.2007.10.032","article-title":"HSP105 interacts with GRP78 and GSK3 and promotes ER stress-induced caspase-3 activation","volume":"20","author":"Meares","year":"2008","journal-title":"Cell. Signal."},{"key":"10.1016\/j.canlet.2013.07.015_b0255","first-page":"1","article-title":"Endoplasmic reticulum ribosome-binding protein 1 (RRBP1) overexpression is frequently found in lung cancer patients and alleviates intracellular stress-induced apoptosis through the enhancement of GRP78","author":"Tsai","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2013.07.015_b0260","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jnutbio.2010.11.012","article-title":"Gamma-tocotrienol induced apoptosis is associated with unfolded protein response in human breast cancer cells","volume":"23","author":"Patacsil","year":"2012","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.canlet.2013.07.015_b0265","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/47513","article-title":"Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta","volume":"403","author":"Nakagawa","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2013.07.015_b0270","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1016\/j.fct.2011.05.011","article-title":"Chromene induces apoptosis via caspase-3 activation in human leukemia HL-60 cells","volume":"49","author":"Heo","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.canlet.2013.07.015_b0275","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1254\/jphs.08327FP","article-title":"Enhanced effect of connexin 43 on cisplatin-induced cytotoxicity in mesothelioma cells","volume":"110","author":"Sato","year":"2009","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.canlet.2013.07.015_b0280","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.bcp.2003.07.015","article-title":"Disruption of mitochondria during tocotrienol-induced apoptosis in MDA-MB-231 human breast cancer cells","volume":"67","author":"Takahashi","year":"2004","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.canlet.2013.07.015_b0285","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1600-0463.2005.apm_160.x","article-title":"Activation and relocalization of caspase 3 during the apoptotic cascade of human mesothelioma cells","volume":"113","author":"Soini","year":"2005","journal-title":"APMIS"},{"key":"10.1016\/j.canlet.2013.07.015_b0290","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/sj.cgt.7700332","article-title":"Significant augmentation of pro-apoptotic gene therapy by pharmacologic bcl-xl down-regulation in mesothelioma","volume":"8","author":"Mohiuddin","year":"2001","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.canlet.2013.07.015_b0295","doi-asserted-by":"crossref","first-page":"246","DOI":"10.4161\/cbt.6.2.3626","article-title":"Bcl2\/bcl-xL inhibitor engenders apoptosis and increases chemosensitivity in mesothelioma","volume":"6","author":"Cao","year":"2007","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.canlet.2013.07.015_b0300","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1067\/mtc.2002.119882","article-title":"Induction of apoptosis in malignant pleuralmesothelioma cells by activation of Fas (Apo-1\/CD95) death-signal pathway","volume":"23","author":"Stewart","year":"2002","journal-title":"J. Thorac. Cardiovasc. Surg."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383513005351?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383513005351?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T15:34:24Z","timestamp":1759592064000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383513005351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S0304383513005351"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2013.07.015","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synergistic effect of combined treatment with gamma-tocotrienol and statin on human malignant mesothelioma cells","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2013.07.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}