{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T21:24:55Z","timestamp":1777325095019,"version":"3.51.4"},"reference-count":37,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["YA-24659157"],"award-info":[{"award-number":["YA-24659157"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.canlet.2015.03.026","type":"journal-article","created":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T08:54:19Z","timestamp":1428310459000},"page":"17-27","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":146,"title":["MicroRNA-124 inhibits cancer cell growth through PTB1\/PKM1\/PKM2 feedback cascade in colorectal cancer"],"prefix":"10.1016","volume":"363","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0648-1370","authenticated-orcid":false,"given":"Kohei","family":"Taniguchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiko","family":"Sugito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minami","family":"Kumazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruka","family":"Shinohara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nami","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihito","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Otsuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bunji","family":"Uno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhisa","family":"Uchiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Akao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2015.03.026_bib0010","first-page":"10","article-title":"Cancer statistics, 2012","volume":"62","author":"Siegel","year":"2012","journal-title":"CA Cancer J. Clin"},{"key":"10.1016\/j.canlet.2015.03.026_bib0015","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1146\/annurev.pathol.4.110807.092222","article-title":"MicroRNAs in cancer","volume":"4","author":"Lee","year":"2009","journal-title":"Annu. Rev. Pathol"},{"key":"10.1016\/j.canlet.2015.03.026_bib0020","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1053\/j.gastro.2012.09.032","article-title":"Epigenetics of colorectal cancer","volume":"143","author":"Goel","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.canlet.2015.03.026_bib0025","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.ejso.2011.05.005","article-title":"MicroRNAs in colorectal cancer: function, dysregulation and potential as novel biomarkers","volume":"37","author":"Nugent","year":"2011","journal-title":"Eur. J. Surg. Oncol"},{"key":"10.1016\/j.canlet.2015.03.026_bib0030","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.molcel.2007.07.015","article-title":"The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing","volume":"27","author":"Makeyev","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1016\/j.canlet.2015.03.026_bib0035","doi-asserted-by":"crossref","first-page":"528","DOI":"10.4161\/rna.7.5.12262","article-title":"The pro-differentiating role of miR-124: indicating the road to become a neuron","volume":"7","author":"Maiorano","year":"2010","journal-title":"RNA Biol"},{"key":"10.1016\/j.canlet.2015.03.026_bib0040","doi-asserted-by":"crossref","first-page":"9962","DOI":"10.1074\/jbc.M111.332627","article-title":"Loss of brain-enriched miR-124 microRNA enhances stem-like traits and invasiveness of glioma cells","volume":"287","author":"Xia","year":"2012","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.canlet.2015.03.026_bib0045","article-title":"MiR-124 suppresses growth of human colorectal cancer by inhibiting STAT3","volume":"8","author":"Zhang","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.canlet.2015.03.026_bib0050","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1093\/carcin\/bgp250","article-title":"miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma","volume":"31","author":"Furuta","year":"2010","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.canlet.2015.03.026_bib0055","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/path.4030","article-title":"miR-124 inhibits cell proliferation in gastric cancer through down-regulation of SPHK1","volume":"227","author":"Xia","year":"2012","journal-title":"J. Pathol"},{"key":"10.1016\/j.canlet.2015.03.026_bib0060","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.febslet.2010.11.038","article-title":"MicroRNA-124 suppresses oral squamous cell carcinoma motility by targeting ITGB1","volume":"585","author":"Hunt","year":"2011","journal-title":"FEBS Lett"},{"key":"10.1016\/j.canlet.2015.03.026_bib0065","first-page":"41","article-title":"box\/RNA unwindase rck\/p54 contributes to maintenance of cell growth by affecting cell cycle in cultured cells","volume":"29","author":"Akao","year":"2006","journal-title":"Int. J. Oncol"},{"key":"10.1016\/j.canlet.2015.03.026_bib0070","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1093\/carcin\/22.12.1965","article-title":"Co-overexpression of DEAD box protein rck\/p54 and c-myc protein in human colorectal adenomas and the relevance of their expression in cultured cell lines","volume":"22","author":"Hashimoto","year":"2001","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.canlet.2015.03.026_bib0075","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1126\/science.123.3191.309","article-title":"On the origin of cancer cells","volume":"123","author":"Warburg","year":"1956","journal-title":"Science"},{"key":"10.1016\/j.canlet.2015.03.026_bib0080","doi-asserted-by":"crossref","first-page":"8977","DOI":"10.1158\/0008-5472.CAN-10-2513","article-title":"Turning on a fuel switch of cancer: hnRNP proteins regulate alternative splicing of pyruvate kinase mRNA","volume":"70","author":"Chen","year":"2010","journal-title":"Cancer Res"},{"key":"10.1016\/j.canlet.2015.03.026_bib0085","doi-asserted-by":"crossref","first-page":"13807","DOI":"10.1016\/S0021-9258(18)67091-7","article-title":"The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing","volume":"261","author":"Noguchi","year":"1986","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.canlet.2015.03.026_bib0090","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nature06734","article-title":"The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth","volume":"452","author":"Christofk","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2015.03.026_bib0095","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1084\/jem.20111487","article-title":"Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression","volume":"209","author":"Goldberg","year":"2012","journal-title":"J. Exp. Med"},{"key":"10.1016\/j.canlet.2015.03.026_bib0100","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/nature08697","article-title":"HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer","volume":"463","author":"David","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2015.03.026_bib0105","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1073\/pnas.0914845107","article-title":"The alternative splicing repressors hnRNP A1\/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism","volume":"107","author":"Clower","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.canlet.2015.03.026_bib0110","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.3892\/or.2012.1958","article-title":"miR-124, miR-137 and miR-340 regulate colorectal cancer growth via inhibition of the Warburg effect","volume":"28","author":"Sun","year":"2012","journal-title":"Oncol. Rep"},{"key":"10.1016\/j.canlet.2015.03.026_bib0115","doi-asserted-by":"crossref","first-page":"8647","DOI":"10.1038\/srep08647","article-title":"Organ-specific PTB1-associated microRNAs determine expression of pyruvate kinase isoforms","volume":"5","author":"Taniguchi","year":"2015","journal-title":"Sci. Rep"},{"key":"10.1016\/j.canlet.2015.03.026_bib0120","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1161\/CIRCRESAHA.114.301633","article-title":"MicroRNA-124 controls the proliferative, migratory, and inflammatory phenotype of pulmonary vascular fibroblasts","volume":"114","author":"Wang","year":"2014","journal-title":"Circ. Res"},{"key":"10.1016\/j.canlet.2015.03.026_bib0125","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/cgt.2009.88","article-title":"Role of anti-oncomirs miR-143 and -145 in human colorectal tumors","volume":"17","author":"Akao","year":"2010","journal-title":"Cancer Gene Ther"},{"key":"10.1016\/j.canlet.2015.03.026_bib0130","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1038\/mt.2013.70","article-title":"Chemically modified synthetic microRNA-205 inhibits the growth of melanoma cells in vitro and in vivo","volume":"21","author":"Noguchi","year":"2013","journal-title":"Mol. Ther"},{"key":"10.1016\/j.canlet.2015.03.026_bib0135","first-page":"1256","article-title":"Colorectal cancer cell-derived microvesicles containing microRNA-1246 promote angiogenesis by activating Smad 1\/5\/8 signaling elicited by PML down-regulation in endothelial cells","volume":"2014","author":"Yamada","year":"1839","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.canlet.2015.03.026_bib0140","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1158\/1535-7163.MCT-08-0885","article-title":"WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells","volume":"8","author":"Tang","year":"2009","journal-title":"Mol. Cancer Ther"},{"key":"10.1016\/j.canlet.2015.03.026_bib0145","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/sj.cdd.4402233","article-title":"Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells","volume":"15","author":"Chen","year":"2008","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.canlet.2015.03.026_bib0150","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00384-012-1550-3","article-title":"Downregulation of microRNA-124 is an independent prognostic factor in patients with colorectal cancer","volume":"28","author":"Wang","year":"2013","journal-title":"Int. J. Colorectal Dis"},{"key":"10.1016\/j.canlet.2015.03.026_bib0155","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.canlet.2013.02.060","article-title":"Tumor-suppressive microRNA-145 targets catenin delta-1 to regulate Wnt\/beta-catenin signaling in human colon cancer cells","volume":"335","author":"Yamada","year":"2013","journal-title":"Cancer Lett"},{"key":"10.1016\/j.canlet.2015.03.026_bib0160","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/ncb0910-814","article-title":"Eaten alive: a history of macroautophagy","volume":"12","author":"Yang","year":"2010","journal-title":"Nat. Cell Biol"},{"key":"10.1016\/j.canlet.2015.03.026_bib0165","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.molcel.2012.01.001","article-title":"Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase","volume":"45","author":"Gao","year":"2012","journal-title":"Mol. Cell"},{"key":"10.1016\/j.canlet.2015.03.026_bib0170","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nature10598","article-title":"Nuclear PKM2 regulates beta-catenin transactivation upon EGFR activation","volume":"480","author":"Yang","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2015.03.026_bib0175","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/jmcb\/mjr030","article-title":"Exon-centric regulation of pyruvate kinase M alternative splicing via mutually exclusive exons","volume":"4","author":"Wang","year":"2012","journal-title":"J. Mol. Cell. Biol"},{"key":"10.1016\/j.canlet.2015.03.026_bib0180","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.cell.2008.08.021","article-title":"Cancer cell metabolism: Warburg and beyond","volume":"134","author":"Hsu","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2015.03.026_bib0185","doi-asserted-by":"crossref","first-page":"551","DOI":"10.18632\/oncotarget.299","article-title":"Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells","volume":"2","author":"Luo","year":"2011","journal-title":"Oncotarget"},{"key":"10.1016\/j.canlet.2015.03.026_bib0190","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.critrevonc.2005.12.003","article-title":"Regulation of angiogenesis by hypoxia-inducible factor 1","volume":"59","author":"Hirota","year":"2006","journal-title":"Crit. Rev. Oncol. Hematol"}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383515002189?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383515002189?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T15:36:04Z","timestamp":1759592164000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383515002189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S0304383515002189"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2015.03.026","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MicroRNA-124 inhibits cancer cell growth through PTB1\/PKM1\/PKM2 feedback cascade in colorectal cancer","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2015.03.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}