{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T16:09:40Z","timestamp":1777738180771,"version":"3.51.4"},"reference-count":67,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81202901"],"award-info":[{"award-number":["81202901"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Changjiang Scholars and Innovative Research Team in University","award":["PCSIRT-IRT1193"],"award-info":[{"award-number":["PCSIRT-IRT1193"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","cancerletters.info","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.canlet.2015.05.032","type":"journal-article","created":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T09:48:36Z","timestamp":1435225716000},"page":"19-31","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Icariside II-induced mitochondrion and lysosome mediated apoptosis is counterbalanced by an autophagic salvage response in hepatoblastoma"],"prefix":"10.1016","volume":"366","author":[{"given":"Ya-di","family":"Geng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-min","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-zheng","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4791-8615","authenticated-orcid":false,"given":"Ling-yi","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2015.05.032_bib0010","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1053\/j.gastro.2004.09.011","article-title":"Primary liver cancer: worldwide incidence and trends","volume":"127","author":"Bosch","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.canlet.2015.05.032_bib0015","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/(SICI)1096-911X(199803)30:3<141::AID-MPO1>3.0.CO;2-H","article-title":"Hepatoblastoma incidence in the United States from 1973 to 1992","volume":"30","author":"Ross","year":"1998","journal-title":"Med. Pediatr. Oncol"},{"key":"10.1016\/j.canlet.2015.05.032_bib0020","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/cncr.10632","article-title":"Pretreatment prognostic factors and treatment results in children with hepatoblastoma \u2013 a report from the German Cooperative Pediatric Liver Tumor Study HB 94","volume":"95","author":"Fuchs","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.canlet.2015.05.032_bib0025","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jpedsurg.2003.10.012","article-title":"Improved survival outcome for hepatoblastoma based on an optimal chemotherapeutic regimen \u2013 a report from the study group for pediatric solid malignant tumors in the Kyushu area","volume":"39","author":"Suita","year":"2004","journal-title":"J. Pediatr. Surg"},{"key":"10.1016\/j.canlet.2015.05.032_bib0030","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1007\/BF00299776","article-title":"Conversion of unresectable to resectable hepatoblastoma and long-term follow-up study","volume":"19","author":"Reynolds","year":"1995","journal-title":"World J. Surg"},{"key":"10.1016\/j.canlet.2015.05.032_bib0035","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nchembio.1712","article-title":"Targeting mitochondria metabolism for cancer therapy","volume":"11","author":"Weinberg","year":"2015","journal-title":"Nat. Chem. Biol"},{"key":"10.1016\/j.canlet.2015.05.032_bib0040","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nrm2308","article-title":"The BCL-2 protein family: opposing activities that mediate cell death","volume":"9","author":"Youle","year":"2008","journal-title":"Nat. Rev. Mol.Cell Biol"},{"key":"10.1016\/j.canlet.2015.05.032_bib0045","doi-asserted-by":"crossref","first-page":"3927","DOI":"10.1038\/sj.onc.1206622","article-title":"Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine","volume":"22","author":"Boya","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2015.05.032_bib0050","doi-asserted-by":"crossref","first-page":"E255","DOI":"10.1038\/ncb1101-e255","article-title":"Organelle-specific initiation of cell death pathways","volume":"3","author":"Ferri","year":"2001","journal-title":"Nat. Cell Biol"},{"key":"10.1016\/j.canlet.2015.05.032_bib0055","doi-asserted-by":"crossref","first-page":"19140","DOI":"10.1074\/jbc.M802513200","article-title":"Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues","volume":"283","author":"Droga-Mazovec","year":"2008","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.canlet.2015.05.032_bib0060","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0167-4838(99)00263-0","article-title":"Lysosomal cysteine proteases: more than scavengers","volume":"1477","author":"Turk","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.canlet.2015.05.032_bib0065","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/nrc1949","article-title":"Cysteine cathepsins: multifunctional enzymes in cancer","volume":"6","author":"Mohamed","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.canlet.2015.05.032_bib0070","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.mito.2014.06.006","article-title":"Lysosomal membrane permeabilization in cell death: concepts and challenges","volume":"19","author":"Repnik","year":"2014","journal-title":"Mitochondrion"},{"key":"10.1016\/j.canlet.2015.05.032_bib0075","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/nrc1738","article-title":"Lysosomes and autophagy in cell death control","volume":"5","author":"Kroemer","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.canlet.2015.05.032_bib0080","doi-asserted-by":"crossref","first-page":"G436","DOI":"10.1152\/ajpgi.00019.2004","article-title":"TNF-\u03b1-mediated lysosomal permeabilization is FAN and caspase 8\/Bid dependent","volume":"287","author":"Werneburg","year":"2004","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol"},{"key":"10.1016\/j.canlet.2015.05.032_bib0085","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1101\/gad.17558811","article-title":"The dynamic nature of autophagy in cancer","volume":"25","author":"Kimmelman","year":"2011","journal-title":"Genes Dev"},{"key":"10.1016\/j.canlet.2015.05.032_bib0090","doi-asserted-by":"crossref","first-page":"891","DOI":"10.4161\/auto.6.7.13038","article-title":"Autophagic degradation of active caspase-8 A crosstalk mechanism between autophagy and apoptosis","volume":"6","author":"Hou","year":"2010","journal-title":"Autophagy"},{"key":"10.1016\/j.canlet.2015.05.032_bib0095","first-page":"286","article-title":"Integration of autophagy, proteasomal degradation, unfolded protein response and apoptosis","volume":"34","author":"Benbrook","year":"2012","journal-title":"Exp. Oncol"},{"key":"10.1016\/j.canlet.2015.05.032_bib0100","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1158\/1078-0432.CCR-10-2634","article-title":"Principles and current strategies for targeting autophagy for cancer treatment","volume":"17","author":"Amaravadi","year":"2011","journal-title":"Clin. Cancer Res"},{"key":"10.1016\/j.canlet.2015.05.032_bib0105","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.ccr.2011.03.012","article-title":"Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo","volume":"19","author":"Sheen","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2015.05.032_bib0110","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1172\/JCI26390","article-title":"Autophagy in cell death: an innocent convict?","volume":"115","author":"Levine","year":"2005","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.canlet.2015.05.032_bib0115","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/nrc1189","article-title":"Cancer chemoprevention with dietary phytochemicals","volume":"3","author":"Surh","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.canlet.2015.05.032_bib0120","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.canlet.2009.02.024","article-title":"Cyclooxygenase-2\/prostaglandin E-2 pathway mediates icariside II induced apoptosis in human PC-3 prostate cancer cells","volume":"280","author":"Lee","year":"2009","journal-title":"Cancer Lett"},{"key":"10.1016\/j.canlet.2015.05.032_bib0125","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1016\/j.fct.2012.06.027","article-title":"Icariside II potentiates paclitaxel-induced apoptosis in human melanoma A375 cells by inhibiting TLR4 signaling pathway","volume":"50","author":"Wu","year":"2012","journal-title":"Food Chem. Toxicol"},{"key":"10.1016\/j.canlet.2015.05.032_bib0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0028706","article-title":"Icariside II induces apoptosis in U937 acute myeloid leukemia cells: role of inactivation of STAT3-related signaling","volume":"7","author":"Kang","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.canlet.2015.05.032_bib0135","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.canlet.2009.02.024","article-title":"Cyclooxygenase-2\/prostaglandin E2 pathway mediates icariside II induced apoptosis in human PC-3 prostate cancer cells","volume":"280","author":"Lee","year":"2009","journal-title":"Cancer Lett"},{"key":"10.1016\/j.canlet.2015.05.032_bib0140","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1271\/bbb.120077","article-title":"Induction of apoptosis by Icariside II through extrinsic and intrinsic signaling pathways in human breast cancer MCF7 cells","volume":"76","author":"Huang","year":"2012","journal-title":"Biosci. Biotechnol. Biochem"},{"key":"10.1016\/j.canlet.2015.05.032_bib0145","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cbi.2012.05.005","article-title":"Reactive oxygen species-mediated mitochondrial pathway is involved in Baohuoside I-induced apoptosis in human non-small cell lung cancer","volume":"199","author":"Song","year":"2012","journal-title":"Chem. Biol. Interact"},{"key":"10.1016\/j.canlet.2015.05.032_bib0150","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1128\/AAC.00914-09","article-title":"Mitochondrial DNA depletion and respiratory chain activity in primary human subcutaneous adipocytes treated with nucleoside analogue reverse transcriptase inhibitors","volume":"54","author":"Stankov","year":"2010","journal-title":"Antimicrob. Agents Chemother"},{"key":"10.1016\/j.canlet.2015.05.032_bib0155","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.canlet.2013.06.021","article-title":"Calyxin Y induces hydrogen peroxide-dependent autophagy and apoptosis via JNK activation in human non-small cell lung cancer NCI-H460 cells","volume":"340","author":"Zhang","year":"2013","journal-title":"Cancer Lett"},{"key":"10.1016\/j.canlet.2015.05.032_bib0160","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1128\/MCB.00159-12","article-title":"The stress response mediator ATF3 represses androgen signaling by binding the androgen receptor","volume":"32","author":"Wang","year":"2012","journal-title":"Mol. Cell. Biol"},{"key":"10.1016\/j.canlet.2015.05.032_bib0165","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1089\/ars.2008.2270","article-title":"Regulation of autophagy by reactive oxygen species (ROS): implications for cancer progression and treatment","volume":"11","author":"Azad","year":"2009","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.canlet.2015.05.032_bib0170","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/mc.20599","article-title":"Lysosomal destabilization and cathepsin B contributes for cytochrome c release and caspase activation in embelin-induced apoptosis","volume":"49","author":"Joy","year":"2010","journal-title":"Mol. Carcinog"},{"key":"10.1016\/j.canlet.2015.05.032_bib0175","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.mam.2006.08.005","article-title":"Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy","volume":"27","author":"Eskelinen","year":"2006","journal-title":"Mol. Aspects Med"},{"key":"10.1016\/j.canlet.2015.05.032_bib0180","doi-asserted-by":"crossref","first-page":"6434","DOI":"10.1038\/onc.2008.310","article-title":"Lysosomal membrane permeabilization in cell death","volume":"27","author":"Boya","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2015.05.032_bib0185","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1007\/s10495-007-0052-1","article-title":"Lysosomal and mitochondrial pathways in miltefosine-induced apoptosis in U937 cells","volume":"12","author":"Paris","year":"2007","journal-title":"Apoptosis"},{"key":"10.1016\/j.canlet.2015.05.032_bib0190","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/sj.cdd.4400696","article-title":"Life and death decisions: regulation of apoptosis by proteolysis of signaling molecules","volume":"7","author":"Utz","year":"2000","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.canlet.2015.05.032_bib0195","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.ceb.2003.10.009","article-title":"Mechanisms of caspase activation","volume":"15","author":"Boatright","year":"2003","journal-title":"Curr. Opin. Cell Biol"},{"key":"10.1016\/j.canlet.2015.05.032_bib0200","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1172\/JCI9914","article-title":"Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c","volume":"106","author":"Guicciardi","year":"2000","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.canlet.2015.05.032_bib0205","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1084\/jem.20072152","article-title":"Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation","volume":"205","author":"Conus","year":"2008","journal-title":"J. Exp. Med"},{"key":"10.1016\/j.canlet.2015.05.032_bib0210","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s10495-006-0475-0","article-title":"Caspase-8 dependent trail-induced apoptosis in cancer cell lines is inhibited by vitamin C and catalase","volume":"12","author":"Perez-Cruz","year":"2007","journal-title":"Apoptosis"},{"key":"10.1016\/j.canlet.2015.05.032_bib0215","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.taap.2009.05.020","article-title":"N,N-dimethyl phytosphingosine induces caspase-8-dependent cytochrome c release and apoptosis through ROS generation in human leukemia cells","volume":"239","author":"Kim","year":"2009","journal-title":"Toxicol. Appl. Pharmacol"},{"key":"10.1016\/j.canlet.2015.05.032_bib0220","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.fct.2014.08.002","article-title":"Blockade of epidermal growth factor receptor\/mammalian target of rapamycin pathway by Icariside II results in reduced cell proliferation of osteosarcoma cells","volume":"73","author":"Yang","year":"2014","journal-title":"Food Chem. Toxicol"},{"key":"10.1016\/j.canlet.2015.05.032_bib0225","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1242\/jcs.114.20.3619","article-title":"A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation","volume":"114","author":"Munafo","year":"2001","journal-title":"J. Cell Sci"},{"key":"10.1016\/j.canlet.2015.05.032_bib0230","doi-asserted-by":"crossref","first-page":"542","DOI":"10.4161\/auto.4600","article-title":"How to interpret LC3 immunoblotting","volume":"3","author":"Mizushima","year":"2007","journal-title":"Autophagy"},{"key":"10.1016\/j.canlet.2015.05.032_bib0235","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1038\/ncb1192","article-title":"Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes","volume":"6","author":"Shimizu","year":"2004","journal-title":"Nat. Cell Biol"},{"key":"10.1016\/j.canlet.2015.05.032_bib0240","doi-asserted-by":"crossref","first-page":"188","DOI":"10.4161\/auto.7.2.14181","article-title":"Dissecting the dynamic turnover of GFP-LC3 in the autolysosome","volume":"7","author":"Ni","year":"2011","journal-title":"Autophagy"},{"key":"10.1016\/j.canlet.2015.05.032_bib0245","series-title":"Autophagosome and Phagosome","first-page":"77","article-title":"LC3 and autophagy","author":"Tanida","year":"2008"},{"key":"10.1016\/j.canlet.2015.05.032_bib0250","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nrm2245","article-title":"Autophagy: from phenomenology to molecular understanding in less than a decade","volume":"8","author":"Klionsky","year":"2007","journal-title":"Nat. Rev. Mol.Cell Biol"},{"key":"10.1016\/j.canlet.2015.05.032_bib0255","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nature06639","article-title":"Autophagy fights disease through cellular self-digestion","volume":"451","author":"Mizushima","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2015.05.032_bib0260","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.devcel.2008.08.012","article-title":"The role of autophagy in mammalian development: cell makeover rather than cell death","volume":"15","author":"Cecconi","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.canlet.2015.05.032_bib0265","doi-asserted-by":"crossref","first-page":"8590","DOI":"10.1038\/sj.onc.1207102","article-title":"The Bcl-2 family: roles in cell survival and oncogenesis","volume":"22","author":"Cory","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2015.05.032_bib0270","first-page":"541","article-title":"Bcl-2 and Bax modulate adenine nucleotide translocase activity","volume":"63","author":"Belzacq","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.canlet.2015.05.032_bib0275","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1158\/0008-5472.CAN-05-0476","article-title":"Lysosomes as targets for cancer therapy","volume":"65","author":"Fehrenbacher","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.canlet.2015.05.032_bib0280","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.drup.2005.06.004","article-title":"Lysosomes and endoplasmic reticulum: targets for improved, selective anticancer therapy","volume":"8","author":"Linder","year":"2005","journal-title":"Drug Resist. Updat"},{"key":"10.1016\/j.canlet.2015.05.032_bib0285","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.brainres.2009.12.038","article-title":"Lipotoxicity-mediated cell dysfunction and death involve lysosomal membrane permeabilization and cathepsin L activity","volume":"1318","author":"Almaguel","year":"2010","journal-title":"Brain Res"},{"key":"10.1016\/j.canlet.2015.05.032_bib0290","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.bbamcr.2008.09.008","article-title":"Lysosomal involvement in cell death and cancer","volume":"1793","author":"Kirkegaard","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.canlet.2015.05.032_bib0295","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1084\/jem.20021952","article-title":"Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashion","volume":"197","author":"Boya","year":"2003","journal-title":"J. Exp. Med"},{"key":"10.1016\/j.canlet.2015.05.032_bib0300","doi-asserted-by":"crossref","first-page":"7883","DOI":"10.1073\/pnas.112632299","article-title":"Neuronal loss and brain atrophy in mice lacking cathepsins B and L","volume":"99","author":"Felbor","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.canlet.2015.05.032_bib0305","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1247\/csf.23.33","article-title":"Bafilomycin A(1) prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells","volume":"23","author":"Yamamoto","year":"1998","journal-title":"Cell Struct. Funct"},{"key":"10.1016\/j.canlet.2015.05.032_bib0310","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.molcel.2010.09.023","article-title":"Autophagy and the integrated stress response","volume":"40","author":"Kroemer","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.canlet.2015.05.032_bib0315","doi-asserted-by":"crossref","first-page":"736","DOI":"10.4161\/auto.28034","article-title":"The natural compound oblongifolin C inhibits autophagic flux and enhances antitumor efficacy of nutrient deprivation","volume":"10","author":"Lao","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.canlet.2015.05.032_bib0320","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.mito.2010.07.008","article-title":"Lysosomal\u2013mitochondrial cross-talk during cell death","volume":"10","author":"Repnik","year":"2010","journal-title":"Mitochondrion"},{"key":"10.1016\/j.canlet.2015.05.032_bib0325","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/ncb2012","article-title":"PINK1\/Parkin-mediated mitophagy is dependent on VDAC1 and p62\/SQSTM1","volume":"12","author":"Geisler","year":"2010","journal-title":"Nat. Cell Biol"},{"key":"10.1016\/j.canlet.2015.05.032_bib0330","doi-asserted-by":"crossref","first-page":"487","DOI":"10.4161\/auto.5774","article-title":"Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation","volume":"4","author":"Ostenfeld","year":"2008","journal-title":"Autophagy"},{"key":"10.1016\/j.canlet.2015.05.032_bib0335","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/embor.2009.172","article-title":"To aggregate or not to aggregate? A new role for p62","volume":"10","author":"Moscat","year":"2009","journal-title":"EMBO Rep"},{"key":"10.1016\/j.canlet.2015.05.032_bib0340","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.cell.2009.05.023","article-title":"p62 at the crossroads of autophagy, apoptosis, and cancer","volume":"137","author":"Moscat","year":"2009","journal-title":"Cell"}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383515004061?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383515004061?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,15]],"date-time":"2022-05-15T09:03:45Z","timestamp":1652605425000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383515004061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":67,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S0304383515004061"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2015.05.032","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Icariside II-induced mitochondrion and lysosome mediated apoptosis is counterbalanced by an autophagic salvage response in hepatoblastoma","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2015.05.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}