{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:53:57Z","timestamp":1791302037764,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001513","name":"Cancer Society of New Zealand","doi-asserted-by":"publisher","award":["E1807"],"award-info":[{"award-number":["E1807"]}],"id":[{"id":"10.13039\/501100001513","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001528","name":"Wellington Medical Research Foundation","doi-asserted-by":"publisher","award":["E1707"],"award-info":[{"award-number":["E1707"]}],"id":[{"id":"10.13039\/501100001528","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001538","name":"Victoria University of Wellington","doi-asserted-by":"publisher","award":["204067"],"award-info":[{"award-number":["204067"]}],"id":[{"id":"10.13039\/501100001538","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","cancerletters.info","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.canlet.2015.06.001","type":"journal-article","created":{"date-parts":[[2015,6,6]],"date-time":"2015-06-06T15:06:20Z","timestamp":1433603180000},"page":"251-260","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["\u03b2I-tubulin mutations in the laulimalide\/peloruside binding site mediate drug sensitivity by altering drug\u2013tubulin interactions and microtubule stability"],"prefix":"10.1016","volume":"365","author":[{"given":"Arun","family":"Kanakkanthara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Rowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica J.","family":"Field","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter T.","family":"Northcote","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul H.","family":"Teesdale-Spittle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2015.06.001_bib0010","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1083\/jcb.201407095","article-title":"The contribution of \u03b1\u03b2-tubulin curvature to microtubule dynamics","volume":"207","author":"Brouhard","year":"2014","journal-title":"J. Cell Biol"},{"key":"10.1016\/j.canlet.2015.06.001_bib0015","doi-asserted-by":"crossref","first-page":"5050","DOI":"10.1016\/j.bmc.2014.02.035","article-title":"Microtubule-targeting agents are clinically successful due to both mitotic and interphase impairment of microtubule function","volume":"22","author":"Field","year":"2014","journal-title":"Bioorg. Med. Chem"},{"key":"10.1016\/j.canlet.2015.06.001_bib0020","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nrd3253","article-title":"Microtubule-binding agents: a dynamic field of cancer therapeutics","volume":"9","author":"Dumontet","year":"2010","journal-title":"Nat. Rev. Drug Discov"},{"key":"10.1016\/j.canlet.2015.06.001_bib0025","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1021\/jo991296y","article-title":"Peloruside A: a potent cytotoxic macrolide isolated from the New Zealand marine sponge Mycale sp","volume":"65","author":"West","year":"2000","journal-title":"J. Org. Chem"},{"key":"10.1016\/j.canlet.2015.06.001_bib0030","first-page":"3356","article-title":"Peloruside A, a novel antimitotic agent with paclitaxel-like microtubule stabilizing activity","volume":"62","author":"Hood","year":"2002","journal-title":"Cancer Res"},{"key":"10.1016\/j.canlet.2015.06.001_bib0035","doi-asserted-by":"crossref","first-page":"3644","DOI":"10.1021\/jo00250a053","article-title":"Laulimalides: new potent cytotoxic macrolides from a marine sponge and a nudibranch predator","volume":"53","author":"Corley","year":"1988","journal-title":"J. Org. Chem"},{"key":"10.1016\/j.canlet.2015.06.001_bib0040","first-page":"653","article-title":"Laulimalide and isolaulimalide, new paclitaxel-like microtubule stabilizing agents","volume":"59","author":"Mooberry","year":"1999","journal-title":"Cancer Res"},{"key":"10.1016\/j.canlet.2015.06.001_bib0045","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.3390\/md8041059","article-title":"Microtubule-stabilizing drugs from marine sponges: focus on peloruside A and zampanolide","volume":"8","author":"Miller","year":"2010","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.canlet.2015.06.001_bib0050","doi-asserted-by":"crossref","first-page":"5063","DOI":"10.1158\/0008-5472.CAN-04-0771","article-title":"Peloruside A does not bind to the taxoid site on \u03b2-tubulin and retains its activity in multidrug-resistant cell lines","volume":"64","author":"Gaitanos","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.canlet.2015.06.001_bib0055","doi-asserted-by":"crossref","first-page":"9109","DOI":"10.1021\/bi020211b","article-title":"The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity","volume":"41","author":"Pryor","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.canlet.2015.06.001_bib0060","doi-asserted-by":"crossref","DOI":"10.1158\/1535-7163.MCT-15-0167","article-title":"Peloruside A inhibits growth of human lung and breast tumor xenografts in an athymic nu\/nu mouse model","author":"Meyer","year":"2015","journal-title":"Mol. Cancer Ther"},{"key":"10.1016\/j.canlet.2015.06.001_bib0065","first-page":"1509","article-title":"In vitro and in vivo anticancer activities of synthetic (\u2212)-laulimalide, a marine natural product microtubule stabilizing agent","volume":"27","author":"Liu","year":"2007","journal-title":"Anticancer Res"},{"key":"10.1016\/j.canlet.2015.06.001_bib0070","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1021\/jm070410z","article-title":"Sponge-derived fijianolide polyketide class: further evaluation of their structural and cytotoxicity properties","volume":"50","author":"Johnson","year":"2007","journal-title":"J. Med. Chem"},{"key":"10.1016\/j.canlet.2015.06.001_bib0075","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1021\/mp800043n","article-title":"Function-oriented synthesis: biological evaluation of laulimalide analogues derived from a last step cross metathesis diversification strategy","volume":"5","author":"Mooberry","year":"2008","journal-title":"Mol. Pharm"},{"key":"10.1016\/j.canlet.2015.06.001_bib0080","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.chembiol.2013.01.014","article-title":"The binding sites of microtubule-stabilizing agents","volume":"20","author":"Field","year":"2013","journal-title":"Chem. Biol"},{"key":"10.1016\/j.canlet.2015.06.001_bib0085","doi-asserted-by":"crossref","first-page":"147","DOI":"10.2174\/187152013804487263","article-title":"Cytoskeletal alterations that confer resistance to anti-tubulin chemotherapeutics","volume":"13","author":"Kanakkanthara","year":"2013","journal-title":"Anticancer Agents Med. Chem"},{"key":"10.1016\/j.canlet.2015.06.001_bib0090","doi-asserted-by":"crossref","first-page":"17118","DOI":"10.1074\/jbc.272.27.17118","article-title":"Paclitaxel-resistant human ovarian cancer cells have mutant \u03b2-tubulins that exhibit impaired paclitaxel-driven polymerization","volume":"272","author":"Giannakakou","year":"1997","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.canlet.2015.06.001_bib0095","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.1073\/pnas.040546297","article-title":"A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells","volume":"97","author":"Giannakakou","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.canlet.2015.06.001_bib0100","doi-asserted-by":"crossref","first-page":"11765","DOI":"10.1074\/jbc.M110.162214","article-title":"Hallmarks of molecular action of microtubule stabilizing agents: effects of epothilone B, ixabepilone, peloruside A, and laulimalide on microtubule conformation","volume":"286","author":"Khrapunovich-Baine","year":"2011","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.canlet.2015.06.001_bib0105","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.chembiol.2010.05.019","article-title":"Discovery and characterization of the laulimalide-microtubule binding mode by mass shift perturbation mapping","volume":"17","author":"Bennet","year":"2010","journal-title":"Chem. Biol"},{"key":"10.1016\/j.canlet.2015.06.001_bib0110","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1021\/ci1002894","article-title":"The assembly-inducing laulimalide\/peloruside A binding site on tubulin: molecular modeling and biochemical studies with [3H]peloruside A","volume":"50","author":"Nguyen","year":"2010","journal-title":"J. Chem. Inf. Model"},{"key":"10.1016\/j.canlet.2015.06.001_bib0115","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1177\/117693510700300028","article-title":"The roles of \u03b2-tubulin mutations and isotype expression in acquired drug resistance","volume":"3","author":"Huzil","year":"2007","journal-title":"Cancer Inform"},{"key":"10.1016\/j.canlet.2015.06.001_bib0120","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1002\/anie.201307749","article-title":"Structural basis of microtubule stabilization by laulimalide and peloruside A","volume":"53","author":"Prota","year":"2014","journal-title":"Angew. Chem. Int. Ed Engl"},{"key":"10.1016\/j.canlet.2015.06.001_bib0125","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1002\/cbic.201000294","article-title":"Molecular recognition of peloruside A by microtubules. The C24 primary alcohol is essential for biological activity","volume":"11","author":"Pera","year":"2010","journal-title":"Chembiochem"},{"key":"10.1016\/j.canlet.2015.06.001_bib0130","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1126\/science.1230582","article-title":"Molecular mechanism of action of microtubule-stabilizing agents","volume":"339","author":"Prota","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.canlet.2015.06.001_bib0135","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1021\/mp060016h","article-title":"Laulimalide and synthetic laulimalide analogues are synergistic with paclitaxel and 2-methoxyestradiol","volume":"3","author":"Clark","year":"2006","journal-title":"Mol. Pharm"},{"key":"10.1016\/j.canlet.2015.06.001_bib0140","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s00280-010-1461-3","article-title":"Synergistic interactions between peloruside A and other microtubule-stabilizing and destabilizing agents in cultured human ovarian carcinoma cells and murine T cells","volume":"68","author":"Wilmes","year":"2011","journal-title":"Cancer Chemother. Pharmacol"},{"key":"10.1016\/j.canlet.2015.06.001_bib0145","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1158\/1535-7163.MCT-05-0190","article-title":"Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of \u03b2-tubulin (Asp26Glu) and less stable microtubules","volume":"5","author":"Hari","year":"2006","journal-title":"Mol. Cancer Ther"},{"key":"10.1016\/j.canlet.2015.06.001_bib0150","first-page":"3","article-title":"Mutations in \u03b2-tubulin map to domains involved in regulation of microtubule stability in epothilone-resistant cell lines","volume":"1","author":"He","year":"2001","journal-title":"Mol. Cancer Ther"},{"key":"10.1016\/j.canlet.2015.06.001_bib0155","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1158\/1535-7163.MCT-09-0674","article-title":"Human mutations that confer paclitaxel resistance","volume":"9","author":"Yin","year":"2010","journal-title":"Mol. Cancer Ther"},{"key":"10.1016\/j.canlet.2015.06.001_bib0160","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1021\/bi051207d","article-title":"Mutations at leucine 215 of \u03b2-tubulin affect paclitaxel sensitivity by two distinct mechanisms","volume":"45","author":"Wang","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.canlet.2015.06.001_bib0165","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.1007\/s11095-012-0794-5","article-title":"Random mutagenesis of \u03b2-tubulin defines a set of dispersed mutations that confer paclitaxel resistance","volume":"29","author":"Yin","year":"2012","journal-title":"Pharm. Res"},{"key":"10.1016\/j.canlet.2015.06.001_bib0170","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1158\/1535-7163.MCT-10-1057","article-title":"Peloruside- and laulimalide-resistant human ovarian carcinoma cells have \u03b2I-tubulin mutations and altered expression of \u03b2II- and \u03b2III-tubulin isotypes","volume":"10","author":"Kanakkanthara","year":"2011","journal-title":"Mol. Cancer Ther"},{"key":"10.1016\/j.canlet.2015.06.001_bib0175","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.4161\/cc.10.19.17706","article-title":"Mutations in the \u03b2-tubulin binding site for peloruside A confer resistance by targeting a cleft significant in side chain binding","volume":"10","author":"Begaye","year":"2011","journal-title":"Cell Cycle"},{"key":"10.1016\/j.canlet.2015.06.001_bib0180","doi-asserted-by":"crossref","first-page":"7328","DOI":"10.1021\/jm901249g","article-title":"Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis","volume":"52","author":"Field","year":"2009","journal-title":"J. Med. Chem"},{"key":"10.1016\/j.canlet.2015.06.001_bib0185","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/ijc.10575","article-title":"Mutational analysis of the class I beta-tubulin gene in human breast cancer","volume":"101","author":"Hasegawa","year":"2002","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.canlet.2015.06.001_bib0190","first-page":"6615","article-title":"Phase 1 study of ABT751, a novel microtubule inhibitor,in patients with refractory hematologic malignancies","volume":"11","author":"Yee","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.canlet.2015.06.001_bib0195","first-page":"2035","article-title":"Validation of the pharmacodynamics of BMS-247550, an analogue of epothilone B, during a phase I clinical study","volume":"8","author":"McDaid","year":"2002","journal-title":"Clin. Cancer Res"},{"key":"10.1016\/j.canlet.2015.06.001_bib0200","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1021\/bi00007a014","article-title":"Substoichiometric binding of taxol suppresses microtubule dynamics","volume":"34","author":"Derry","year":"1995","journal-title":"Biochemistry"},{"key":"10.1016\/j.canlet.2015.06.001_bib0205","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0092-8674(00)80961-7","article-title":"High-resolution model of the microtubule","volume":"96","author":"Nogales","year":"1999","journal-title":"Cell"}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030438351500381X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030438351500381X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T09:10:43Z","timestamp":1566810643000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030438351500381X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S030438351500381X"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2015.06.001","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u03b2I-tubulin mutations in the laulimalide\/peloruside binding site mediate drug sensitivity by altering drug\u2013tubulin interactions and microtubule stability","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2015.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}