{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T04:05:41Z","timestamp":1740110741960,"version":"3.37.3"},"reference-count":27,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T00:00:00Z","timestamp":1478649600000},"content-version":"am","delay-in-days":344,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation of China","doi-asserted-by":"publisher","award":["81070421"],"award-info":[{"award-number":["81070421"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004374","name":"Chongqing Medical University","doi-asserted-by":"publisher","award":["2012"],"award-info":[{"award-number":["2012"]}],"id":[{"id":"10.13039\/501100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.canlet.2015.08.017","type":"journal-article","created":{"date-parts":[[2015,8,28]],"date-time":"2015-08-28T20:35:24Z","timestamp":1440794124000},"page":"222-228","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["ABL SH3 mutant inhibits BCR-ABL activity and increases imatinib sensitivity by targeting RIN1 protein in CML cell"],"prefix":"10.1016","volume":"369","author":[{"given":"Xin","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yajuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangxue","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weixi","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenglan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenli","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2015.08.017_bib0010","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nrm1280","article-title":"Regulation of the c-Abl and Bcr-Abl tyrosine kinases","volume":"5","author":"Hantschel","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"10.1016\/j.canlet.2015.08.017_bib0015","doi-asserted-by":"crossref","first-page":"3278","DOI":"10.1182\/blood-2008-10-183665","article-title":"BCR-ABL SH3-SH2 domain mutations in chronic myeloid leukemia patients on imatinib","volume":"116","author":"Sherbenou","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.canlet.2015.08.017_bib0020","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/S0092-8674(03)00194-6","article-title":"Structural basis for the autoinhibition of c-Abl tyrosine kinase","volume":"112","author":"Nagar","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2015.08.017_bib0025","doi-asserted-by":"crossref","first-page":"5443","DOI":"10.1074\/jbc.R112.438382","article-title":"Structure and dynamic regulation of Abl kinases","volume":"288","author":"Panjarian","year":"2013","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.canlet.2015.08.017_bib0030","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.molcel.2006.01.035","article-title":"Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase","volume":"21","author":"Nagar","year":"2006","journal-title":"Mol. Cell"},{"key":"10.1016\/j.canlet.2015.08.017_bib0035","doi-asserted-by":"crossref","first-page":"7744","DOI":"10.1038\/sj.onc.1204978","article-title":"Mutational analysis of the regulatory function of the c-Abl Src homology 3 domain","volume":"20","author":"Brasher","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2015.08.017_bib0040","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1074\/mcp.M800450-MCP200","article-title":"Characterization of domain-peptide interaction interface: a generic structure-based model to decipher the binding specificity of SH3 domains","volume":"8","author":"Hou","year":"2008","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.canlet.2015.08.017_bib0045","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S1534-5807(01)00008-9","article-title":"Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1","volume":"1","author":"Tall","year":"2001","journal-title":"Dev. Cell"},{"key":"10.1016\/j.canlet.2015.08.017_bib0050","doi-asserted-by":"crossref","first-page":"4954","DOI":"10.1073\/pnas.94.10.4954","article-title":"Protein binding and signaling properties of RIN1 suggest a unique effector function","volume":"94","author":"Han","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.canlet.2015.08.017_bib0055","doi-asserted-by":"crossref","first-page":"31401","DOI":"10.1074\/jbc.M804002200","article-title":"Enhancement of ABL kinase catalytic efficiency by a direct binding regulator is independent of other regulatory mechanisms","volume":"283","author":"Cao","year":"2008","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.canlet.2015.08.017_bib0060","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S1074-7613(00)80452-5","article-title":"Regulation of the oncogenic activity of BCR-ABL by a tightly bound substrate protein RIN1","volume":"6","author":"Afar","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/j.canlet.2015.08.017_bib0065","doi-asserted-by":"crossref","first-page":"W423","DOI":"10.1093\/nar\/gks398","article-title":"PepSite: prediction of peptide-binding sites from protein surfaces","volume":"40","author":"Trabuco","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.canlet.2015.08.017_bib0070","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1002\/jcc.20289","article-title":"Scalable molecular dynamics with NAMD","volume":"26","author":"Phillips","year":"2005","journal-title":"J. Comput. Chem"},{"key":"10.1016\/j.canlet.2015.08.017_bib0075","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0263-7855(96)00018-5","article-title":"VMD: visual molecular dynamics","volume":"14","author":"Humphrey","year":"1996","journal-title":"J. Mol. Graph"},{"key":"10.1016\/j.canlet.2015.08.017_bib0080","doi-asserted-by":"crossref","first-page":"27751","DOI":"10.1074\/jbc.M111.264903","article-title":"Disruption of Bcr-Abl coiled coil oligomerization by design","volume":"286","author":"Dixon","year":"2011","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.canlet.2015.08.017_bib0085","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1021\/mp200461s","article-title":"Improved coiled-coil design enhances interaction with Bcr-Abl and induces apoptosis","volume":"9","author":"Dixon","year":"2012","journal-title":"Mol. Pharm"},{"key":"10.1016\/j.canlet.2015.08.017_bib0090","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/(SICI)1521-4141(199805)28:05<1701::AID-IMMU1701>3.0.CO;2-2","article-title":"Characterization of the CD55(DAF)-binding site on the seven-span transmembrane receptor CD97","volume":"28","author":"Hamann","year":"1998","journal-title":"Eur. J. Immunol"},{"key":"10.1016\/j.canlet.2015.08.017_bib0095","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/nprot.2007.135","article-title":"A protocol for rapid generation of recombinant adenoviruses using the AdEasy system","volume":"2","author":"Luo","year":"2007","journal-title":"Nat. Protoc"},{"key":"10.1016\/j.canlet.2015.08.017_bib0100","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1007\/s12013-014-0151-x","article-title":"Modulation, bioinformatic screening, and assessment of small molecular peptides targeting the vascular endothelial growth factor receptor","volume":"70","author":"Feng","year":"2014","journal-title":"Cell Biochem. Biophys"},{"key":"10.1016\/j.canlet.2015.08.017_bib0105","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1182\/blood-2013-02-485573","article-title":"JAK of all trades: JAK2-STAT5 as novel therapeutic targets in BCR-ABL1+ chronic myeloid leukemia","volume":"122","author":"Warsch","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.canlet.2015.08.017_bib0110","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1158\/0008-5472.CAN-04-3888","article-title":"ABL oncogenes and phosphoinositide 3-kinase: mechanism of activation and downstream effectors","volume":"65","author":"Kharas","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.canlet.2015.08.017_bib0115","doi-asserted-by":"crossref","first-page":"7045","DOI":"10.1158\/0008-5472.CAN-06-4312","article-title":"BCR-tyrosine 177 Plays an essential role in Ras and Akt activation and in human hematopoietic progenitor transformation in chronic myelogenous leukemia","volume":"67","author":"Chu","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.canlet.2015.08.017_bib0120","doi-asserted-by":"crossref","first-page":"5887","DOI":"10.1242\/jcs.113688","article-title":"RIN1 orchestrates the activation of RAB5 GTPases and ABL tyrosine kinases to determine the fate of EGFR","volume":"125","author":"Balaji","year":"2012","journal-title":"J. Cell Sci"},{"key":"10.1016\/j.canlet.2015.08.017_bib0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0121833","article-title":"Identification of small molecules that disrupt signaling between ABL and its positive regulator RIN1","volume":"10","author":"Ting","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.canlet.2015.08.017_bib0130","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1182\/blood-2009-10-248211","article-title":"High STAT5 levels mediate imatinib resistance and indicate disease progression in chronic myeloid leukemia","volume":"117","author":"Warsch","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.canlet.2015.08.017_bib0135","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1093\/emboj\/18.5.1367","article-title":"Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells","volume":"18","author":"Matsumura","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.canlet.2015.08.017_bib0140","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/0092-8674(92)90241-4","article-title":"Dominant negative MYC blocks transformation by ABL oncogenes","volume":"70","author":"Sawyers","year":"1992","journal-title":"Cell"}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383515005571?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383515005571?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,11,2]],"date-time":"2019-11-02T08:17:30Z","timestamp":1572682650000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383515005571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S0304383515005571"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2015.08.017","relation":{},"ISSN":["0304-3835"],"issn-type":[{"type":"print","value":"0304-3835"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ABL SH3 mutant inhibits BCR-ABL activity and increases imatinib sensitivity by targeting RIN1 protein in CML cell","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2015.08.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}