{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T06:21:29Z","timestamp":1781936489850,"version":"3.54.5"},"reference-count":53,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,10,6]],"date-time":"2015-10-06T00:00:00Z","timestamp":1444089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"NCI","doi-asserted-by":"publisher","award":["U54CA143803"],"award-info":[{"award-number":["U54CA143803"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"NCI","doi-asserted-by":"publisher","award":["CA163124"],"award-info":[{"award-number":["CA163124"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"NCI","doi-asserted-by":"publisher","award":["CA093900"],"award-info":[{"award-number":["CA093900"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"NCI","doi-asserted-by":"publisher","award":["CA143055"],"award-info":[{"award-number":["CA143055"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007880","name":"Johns Hopkins University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007880","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.canlet.2015.10.005","type":"journal-article","created":{"date-parts":[[2015,10,21]],"date-time":"2015-10-21T07:54:13Z","timestamp":1445414053000},"page":"237-242","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["Ecological paradigms to understand the dynamics of metastasis"],"prefix":"10.1016","volume":"380","author":[{"given":"Sarah R.","family":"Amend","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sounak","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel S.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth J.","family":"Pienta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2015.10.005_bib0010","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1742-4682-8-36","article-title":"Modeling invasion of metastasizing cancer cells to bone marrow utilizing ecological principles","volume":"8","author":"Chen","year":"2011","journal-title":"Theor. Biol. Med. Model"},{"key":"10.1016\/j.canlet.2015.10.005_bib0015","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2015.10.005_bib0020","doi-asserted-by":"crossref","first-page":"5849","DOI":"10.1158\/1078-0432.CCR-13-2158","article-title":"The cancer diaspora: metastasis beyond the seed and soil hypothesis","volume":"19","author":"Pienta","year":"2013","journal-title":"Clin. Cancer Res"},{"key":"10.1016\/j.canlet.2015.10.005_bib0025","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1002\/jcb.24813","article-title":"Niche inheritance: a cooperative pathway to enhance cancer cell fitness though ecosystem engineering","volume":"115","author":"Yang","year":"2014","journal-title":"J. Cell. Biochem"},{"issue":"2014","key":"10.1016\/j.canlet.2015.10.005_bib0030","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3322\/caac.21235","article-title":"Cancer treatment and survivorship statistics","volume":"64","author":"DeSantis","year":"2014","journal-title":"CA Cancer J. Clin"},{"key":"10.1016\/j.canlet.2015.10.005_bib0035","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/nrc3606","article-title":"Life history trade-offs in cancer evolution","volume":"13","author":"Aktipis","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.canlet.2015.10.005_bib0040","doi-asserted-by":"crossref","first-page":"20130016","DOI":"10.1098\/rsfs.2013.0016","article-title":"Evolution of intratumoral phenotypic heterogeneity: the role of trait inheritance","volume":"3","author":"Gallaher","year":"2013","journal-title":"Interface focus"},{"key":"10.1016\/j.canlet.2015.10.005_bib0045","doi-asserted-by":"crossref","first-page":"e51844","DOI":"10.1371\/journal.pone.0051844","article-title":"Biological stoichiometry in tumor micro-environments","volume":"8","author":"Kareva","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.canlet.2015.10.005_bib0050","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/ncb3015","article-title":"The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis","volume":"16","author":"McAllister","year":"2014","journal-title":"Nat. Cell Biol"},{"key":"10.1016\/j.canlet.2015.10.005_bib0055","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/nrc2013","article-title":"Cancer as an evolutionary and ecological process","volume":"6","author":"Merlo","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.canlet.2015.10.005_bib0060","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3934\/mbe.2005.2.381","article-title":"The ecology and evolutionary biology of cancer: a review of mathematical models of necrosis and tumor cell diversity, mathematical biosciences and engineering","volume":"2","author":"Nagy","year":"2005","journal-title":"Math. Biosci. Eng"},{"key":"10.1016\/j.canlet.2015.10.005_bib0065","doi-asserted-by":"crossref","first-page":"9669","DOI":"10.18632\/oncotarget.3430","article-title":"Ecology meets cancer biology: the cancer swamp promotes the lethal cancer phenotype","volume":"6","author":"Amend","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.canlet.2015.10.005_bib0070","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1158\/1078-0432.CCR-12-0366","article-title":"Disrupting the networks of cancer","volume":"18","author":"Camacho","year":"2012","journal-title":"Clin. Cancer Res"},{"key":"10.1016\/j.canlet.2015.10.005_bib0075","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/nrc3298","article-title":"Evolutionary dynamics of carcinogenesis and why targeted therapy does not work","volume":"12","author":"Gillies","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.canlet.2015.10.005_bib0080","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nature10762","article-title":"Clonal evolution in cancer","volume":"481","author":"Greaves","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2015.10.005_bib0085","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1593\/tlo.08178","article-title":"Ecological therapy for cancer: defining tumors using an ecosystem paradigm suggests new opportunities for novel cancer treatments","volume":"1","author":"Pienta","year":"2008","journal-title":"Transl. Oncol"},{"key":"10.1016\/j.canlet.2015.10.005_bib0090","doi-asserted-by":"crossref","first-page":"19052","DOI":"10.1073\/pnas.0800375105","article-title":"A movement ecology paradigm for unifying organismal movement research","volume":"105","author":"Nathan","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.canlet.2015.10.005_bib0095","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1007\/s10980-007-9108-4","article-title":"Landscape connectivity and animal behavior: functional grain as a key determinant for dispersal","volume":"22","author":"Baguette","year":"2007","journal-title":"Landscape ecol"},{"key":"10.1016\/j.canlet.2015.10.005_bib0100","doi-asserted-by":"crossref","first-page":"228","DOI":"10.2307\/3808935","article-title":"Dispersal of juvenile cougars in fragmented habitat","volume":"59","author":"Beier","year":"1995","journal-title":"J. Wildl. Manage"},{"key":"10.1016\/j.canlet.2015.10.005_bib0105","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40169-015-0055-4","article-title":"Epithelial mesenchymal transition: a double-edged sword","volume":"4","author":"Barriere","year":"2015","journal-title":"Clin. Transl. Med"},{"key":"10.1016\/j.canlet.2015.10.005_bib0110","doi-asserted-by":"crossref","first-page":"130","DOI":"10.18632\/oncotarget.2766","article-title":"Glycolysis is the primary bioenergetic pathway for cell motility and cytoskeletal remodeling in human prostate and breast cancer cells","volume":"6","author":"Shiraishi","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.canlet.2015.10.005_bib0115","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.cell.2006.11.001","article-title":"Cancer metastasis: building a framework","volume":"127","author":"Gupta","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2015.10.005_bib0120","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1353\/pbm.1985.0049","article-title":"Toward an understanding of angiogenesis: search and discovery","volume":"29","author":"Folkman","year":"1985","journal-title":"Perspect. Biol. Med"},{"key":"10.1016\/j.canlet.2015.10.005_bib0125","series-title":"Eutrophication: Causes, Consequences and Control","first-page":"1","article-title":"Eutrophication: challenges and solutions","author":"Khan","year":"2014"},{"key":"10.1016\/j.canlet.2015.10.005_bib0130","series-title":"Eutrophication: Causes, Consequences and Control","first-page":"55","article-title":"Eutrophication of Lakes","author":"Callisto","year":"2014"},{"key":"10.1016\/j.canlet.2015.10.005_bib0135","first-page":"149","article-title":"Dysregulated pH in tumor microenvironment checkmates cancer therapy","volume":"3","author":"Barar","year":"2013","journal-title":"BioImpacts"},{"key":"10.1016\/j.canlet.2015.10.005_bib0140","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ccr.2006.04.023","article-title":"Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance","volume":"9","author":"Fantin","year":"2006","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2015.10.005_bib0145","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.addr.2012.09.011","article-title":"Delivery of molecular and cellular medicine to solid tumors","volume":"64","author":"Jain","year":"2012","journal-title":"Adv. Drug Deliv. Rev"},{"key":"10.1016\/j.canlet.2015.10.005_bib0150","doi-asserted-by":"crossref","first-page":"18632","DOI":"10.1073\/pnas.1318415110","article-title":"Combining two strategies to improve perfusion and drug delivery in solid tumors","volume":"110","author":"Stylianopoulos","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.canlet.2015.10.005_bib0155","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.3892\/ol.2012.928","article-title":"Energy metabolism of cancer: glycolysis versus oxidative phosphorylation (Review)","volume":"4","author":"Zheng","year":"2012","journal-title":"Oncol. lett"},{"key":"10.1016\/j.canlet.2015.10.005_bib0160","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/BF00052210","article-title":"The population-dynamic functions of seed dispersal","volume":"107","author":"Venable","year":"1993","journal-title":"Vegetatio"},{"key":"10.1016\/j.canlet.2015.10.005_bib0165","series-title":"Dispersal Ecology and Evolution","author":"Clobert","year":"2012"},{"key":"10.1016\/j.canlet.2015.10.005_bib0170","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1146\/annurev.ento.46.1.667","article-title":"Biological control of locusts and grasshoppers","volume":"46","author":"Lomer","year":"2001","journal-title":"Annu. Rev. Entomol"},{"key":"10.1016\/j.canlet.2015.10.005_bib0175","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1146\/annurev.ento.42.1.207","article-title":"Physiology and ecology of dispersal polymorphism in insects","volume":"42","author":"Zera","year":"1997","journal-title":"Annu. Rev. Entomol"},{"key":"10.1016\/j.canlet.2015.10.005_bib0180","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1126\/science.959840","article-title":"The clonal evolution of tumor cell populations","volume":"194","author":"Nowell","year":"1976","journal-title":"Science"},{"key":"10.1016\/j.canlet.2015.10.005_bib0185","doi-asserted-by":"crossref","first-page":"11471","DOI":"10.1158\/0008-5472.CAN-07-2496","article-title":"Clonal selection of metastasis within the life history of a tumor","volume":"67","author":"Talmadge","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.canlet.2015.10.005_bib0190","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.1158\/0008-5472.CAN-05-2670","article-title":"Regulation of E-cadherin expression by VHL and hypoxia-inducible factor","volume":"66","author":"Esteban","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.canlet.2015.10.005_bib0195","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1158\/0008-5472.CAN-05-3719","article-title":"Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B","volume":"66","author":"Krishnamachary","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.canlet.2015.10.005_bib0200","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.tips.2012.01.005","article-title":"Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy","volume":"33","author":"Semenza","year":"2012","journal-title":"Trends Pharmacol. Sci"},{"key":"10.1016\/j.canlet.2015.10.005_bib0205","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/BF00121214","article-title":"Acidic pH enhances the invasive behavior of human melanoma cells","volume":"14","author":"Martinez-Zaguilan","year":"1996","journal-title":"Clin. Exp. Metastas"},{"key":"10.1016\/j.canlet.2015.10.005_bib0210","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s12935-014-0129-1","article-title":"Acidic extracellular pH promotes epithelial mesenchymal transition in Lewis lung carcinoma model","volume":"14","author":"Suzuki","year":"2014","journal-title":"Cancer Cell Int"},{"key":"10.1016\/j.canlet.2015.10.005_bib0215","doi-asserted-by":"crossref","first-page":"6699","DOI":"10.1158\/0008-5472.CAN-06-0983","article-title":"Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice","volume":"66","author":"Rofstad","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.canlet.2015.10.005_bib0220","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/bjc.1991.378","article-title":"Glucose starvation and acidosis: effect on experimental metastatic potential, DNA content and MTX resistance of murine tumour cells","volume":"64","author":"Schlappack","year":"1991","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.canlet.2015.10.005_bib0225","first-page":"495","article-title":"Switching strategies, population dynamics, and mechanisms of co-existence in food webs with Jekyll-and-Hyde species","volume":"13","author":"Orlando","year":"2011","journal-title":"Evol. Ecol. Res"},{"key":"10.1016\/j.canlet.2015.10.005_bib0230","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/j.1550-7408.1966.tb01934.x","article-title":"An analysis of macrostome production in tetrahymena vorax strain V2S-Type*","volume":"13","author":"Buhse","year":"1966","journal-title":"J. Protozool"},{"key":"10.1016\/j.canlet.2015.10.005_bib0235","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1172\/JCI43414","article-title":"Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow","volume":"121","author":"Shiozawa","year":"2011","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.canlet.2015.10.005_bib0240","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s10555-010-9256-x","article-title":"CXCL12\/CXCR4\/CXCR7 chemokine axis and cancer progression","volume":"29","author":"Sun","year":"2010","journal-title":"Cancer Metastasis Rev"},{"key":"10.1016\/j.canlet.2015.10.005_bib0245","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1002\/jcb.10522","article-title":"Expression of CXCR4 and CXCL12 (SDF-1) in human prostate cancers (PCa) in vivo","volume":"89","author":"Sun","year":"2003","journal-title":"J. Cell. Biochem"},{"key":"10.1016\/j.canlet.2015.10.005_bib0250","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/nri2506","article-title":"Myeloid-derived suppressor cells as regulators of the immune system","volume":"9","author":"Gabrilovich","year":"2009","journal-title":"Nat. Rev. Immunol"},{"key":"10.1016\/j.canlet.2015.10.005_bib0255","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2174\/187152908785849071","article-title":"Endothelial progenitors in vascular repair and angiogenesis: how many are needed and what to do?","volume":"8","author":"Real","year":"2008","journal-title":"Cardiovasc. Hematol. Disord. Drug Targets"},{"key":"10.1016\/j.canlet.2015.10.005_bib0260","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/beheco\/1.2.131","article-title":"Distribution patterns of hummingbird flower mites (Gamasida: ascidae) in relation to floral availability on Heliconia inflorescences","volume":"1","author":"Dobkin","year":"1990","journal-title":"Behav. Ecol"},{"key":"10.1016\/j.canlet.2015.10.005_bib0265","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1111\/j.1600-0706.2013.00503.x","article-title":"Picky hitch-hikers: vector choice leads to directed dispersal and fat-tailed kernels in a passively dispersing mite","volume":"122","author":"Fronhofer","year":"2013","journal-title":"Oikos"},{"key":"10.1016\/j.canlet.2015.10.005_bib0270","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1744-7429.2004.tb00330.x","article-title":"Flower mites of calyptrogyne ghiesbreghtiana (arecaceae): evidence for dispersal using pollinating bats1","volume":"36","author":"Tschapka","year":"2004","journal-title":"Biotropica"}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383515006229?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383515006229?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T20:12:47Z","timestamp":1653336767000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383515006229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S0304383515006229"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2015.10.005","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ecological paradigms to understand the dynamics of metastasis","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2015.10.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 The Authors. Published by Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}