{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:05:55Z","timestamp":1790075155992,"version":"4.0.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","cancerletters.info","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.canlet.2015.11.022","type":"journal-article","created":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T16:59:47Z","timestamp":1448297987000},"page":"38-47","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Autophagy-deficiency in hepatic progenitor cells leads to the defects of stemness and enhances susceptibility to neoplastic transformation"],"prefix":"10.1016","volume":"371","author":[{"given":"Feng","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiliang","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2015.11.022_bib0010","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0092-8674(00)81692-X","article-title":"Stem cells: units of development, units of regeneration, and units in evolution","volume":"100","author":"Weissman","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2015.11.022_bib0015","doi-asserted-by":"crossref","first-page":"4553","DOI":"10.1158\/0008-5472.CAN-05-3986","article-title":"Normal stem cells and cancer stem cells: the niche matters","volume":"66","author":"Li","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.canlet.2015.11.022_bib0020","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1002\/ijc.23041","article-title":"Adult stem cells in progression and therapy of hepatocellular carcinoma","volume":"121","author":"Herr","year":"2007","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.canlet.2015.11.022_bib0025","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/emmm.201201999","article-title":"Autophagic control of cell \u2018stemness\u2019","volume":"5","author":"Pan","year":"2013","journal-title":"EMBO Mol. Med"},{"key":"10.1016\/j.canlet.2015.11.022_bib0030","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.cell.2014.11.006","article-title":"Metabolic control of autophagy","volume":"159","author":"Galluzzi","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2015.11.022_bib0035","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1056\/NEJMra1205406","article-title":"Autophagy in human health and disease","volume":"368","author":"Choi","year":"2013","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.canlet.2015.11.022_bib0040","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1084\/jem.20101145","article-title":"The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance","volume":"208","author":"Mortensen","year":"2011","journal-title":"J. Exp. Med"},{"key":"10.1016\/j.canlet.2015.11.022_bib0045","doi-asserted-by":"crossref","first-page":"4806","DOI":"10.1182\/blood-2010-06-288589","article-title":"FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells","volume":"116","author":"Liu","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.canlet.2015.11.022_bib0050","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/nn.3365","article-title":"FIP200 is required for maintenance and differentiation of postnatal neural stem cells","volume":"16","author":"Wang","year":"2013","journal-title":"Nat. Neurosci"},{"key":"10.1016\/j.canlet.2015.11.022_bib0055","doi-asserted-by":"crossref","first-page":"830","DOI":"10.4161\/auto.24132","article-title":"Autophagy in stem cells","volume":"9","author":"Guan","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.canlet.2015.11.022_bib0060","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1159\/000430287","article-title":"Autophagy is required for the maintenance of liver progenitor cell functionality","volume":"36","author":"Cheng","year":"2015","journal-title":"Cell. Physiol. Biochem"},{"key":"10.1016\/j.canlet.2015.11.022_bib0065","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.gde.2010.12.008","article-title":"Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night","volume":"21","author":"Mathew","year":"2011","journal-title":"Curr. Opin. Genet. Dev"},{"key":"10.1016\/j.canlet.2015.11.022_bib0070","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/2045-3701-3-35","article-title":"Paradoxical roles of autophagy in different stages of tumorigenesis: protector for normal or cancer cells","volume":"3","author":"Sun","year":"2013","journal-title":"Cell Biosci"},{"key":"10.1016\/j.canlet.2015.11.022_bib0075","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.cell.2008.01.038","article-title":"Stem cells and niches: mechanisms that promote stem cell maintenance throughout life","volume":"132","author":"Morrison","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2015.11.022_bib0080","doi-asserted-by":"crossref","first-page":"11755","DOI":"10.1074\/jbc.R800071200","article-title":"PTEN, stem cells, and cancer stem cells","volume":"284","author":"Hill","year":"2009","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.canlet.2015.11.022_bib0085","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.cellsig.2013.02.013","article-title":"The multiple roles for Sox2 in stem cell maintenance and tumorigenesis","volume":"25","author":"Liu","year":"2013","journal-title":"Cell. Signal"},{"key":"10.1016\/j.canlet.2015.11.022_bib0090","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1002\/hep.22860","article-title":"Inhibition of c-Jun NH2-terminal kinase switches Smad3 signaling from oncogenesis to tumor-suppression in rat hepatocellular carcinoma","volume":"49","author":"Nagata","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.canlet.2015.11.022_bib0095","doi-asserted-by":"crossref","first-page":"e501","DOI":"10.1038\/cddis.2013.35","article-title":"Paradoxical role of autophagy in the dysplastic and tumor-forming stages of hepatocarcinoma development in rats","volume":"4","author":"Sun","year":"2013","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.canlet.2015.11.022_bib0100","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/hep.22047","article-title":"Identification of adult hepatic progenitor cells capable of repopulating injured rat liver","volume":"47","author":"Yovchev","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.canlet.2015.11.022_bib0105","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/hep.21448","article-title":"Novel hepatic progenitor cell surface markers in the adult rat liver","volume":"45","author":"Yovchev","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.canlet.2015.11.022_bib0110","first-page":"353","article-title":"Evaluation of the differentiation potential of WB-F344 rat liver epithelial stem-like cells in vivo. Differentiation to hepatocytes after transplantation into dipeptidylpeptidase-IV-deficient rat liver","volume":"151","author":"Coleman","year":"1997","journal-title":"Am. J. Pathol"},{"key":"10.1016\/j.canlet.2015.11.022_bib0115","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0002-9440(10)65574-5","article-title":"Long-term, near-total liver replacement by transplantation of isolated hepatocytes in rats treated with retrorsine","volume":"153","author":"Laconi","year":"1998","journal-title":"Am. J. Pathol"},{"key":"10.1016\/j.canlet.2015.11.022_bib0120","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrm3028","article-title":"Mechanisms of mitophagy","volume":"12","author":"Youle","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"10.1016\/j.canlet.2015.11.022_bib0125","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1073\/pnas.1409563112","article-title":"Loss of autophagy causes a synthetic lethal deficiency in DNA repair","volume":"112","author":"Liu","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.canlet.2015.11.022_bib0130","doi-asserted-by":"crossref","first-page":"12362","DOI":"10.1038\/srep12362","article-title":"Autophagy confers DNA damage repair pathways to protect the hematopoietic system from nuclear radiation injury","volume":"5","author":"Lin","year":"2015","journal-title":"Sci. Rep"},{"key":"10.1016\/j.canlet.2015.11.022_bib0135","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1146\/annurev.biochem.73.011303.073723","article-title":"Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints","volume":"73","author":"Sancar","year":"2004","journal-title":"Annu. Rev. Biochem"},{"key":"10.1016\/j.canlet.2015.11.022_bib0140","doi-asserted-by":"crossref","first-page":"7663","DOI":"10.1038\/sj.onc.1209816","article-title":"Epigenetics and the plasticity of differentiation in normal and cancer stem cells","volume":"25","author":"Lotem","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2015.11.022_bib0145","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nrm3420","article-title":"DNA damage checkpoints in stem cells, ageing and cancer","volume":"13","author":"Sperka","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"10.1016\/j.canlet.2015.11.022_bib0150","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1172\/JCI66026","article-title":"Differentiation of progenitors in the liver: a matter of local choice","volume":"123","author":"Boulter","year":"2013","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.canlet.2015.11.022_bib0155","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1002\/hep.25713","article-title":"Structural analysis of oval-cell-mediated liver regeneration in rats","volume":"56","author":"Dezso","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.canlet.2015.11.022_bib0160","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.redox.2014.12.003","article-title":"Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy","volume":"4","author":"Poillet-Perez","year":"2015","journal-title":"Redox Biol"},{"key":"10.1016\/j.canlet.2015.11.022_bib0165","doi-asserted-by":"crossref","first-page":"5276","DOI":"10.1038\/ncomms6276","article-title":"Autophagy supports genomic stability by degrading retrotransposon RNA","volume":"5","author":"Guo","year":"2014","journal-title":"Nat. Commun"},{"key":"10.1016\/j.canlet.2015.11.022_bib0170","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1101\/gad.1545107","article-title":"Autophagy suppresses tumor progression by limiting chromosomal instability","volume":"21","author":"Mathew","year":"2007","journal-title":"Genes Dev"},{"key":"10.1016\/j.canlet.2015.11.022_bib0175","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1101\/gad.1565707","article-title":"Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis","volume":"21","author":"Karantza-Wadsworth","year":"2007","journal-title":"Genes Dev"},{"key":"10.1016\/j.canlet.2015.11.022_bib0180","doi-asserted-by":"crossref","first-page":"7537","DOI":"10.1158\/0008-5472.CAN-11-2170","article-title":"Autophagy enhanced by microtubule- and mitochondrion-associated MAP1S suppresses genome instability and hepatocarcinogenesis","volume":"71","author":"Xie","year":"2011","journal-title":"Cancer Res"},{"key":"10.1016\/j.canlet.2015.11.022_bib0185","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1172\/JCI73941","article-title":"The role for autophagy in cancer","volume":"125","author":"White","year":"2015","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.canlet.2015.11.022_bib0190","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nrc1170","article-title":"Genomic instability \u2013 the engine of tumorigenesis?","volume":"3","author":"Sieber","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.canlet.2015.11.022_bib0195","doi-asserted-by":"crossref","first-page":"842","DOI":"10.3892\/ijmm.2012.1060","article-title":"Parallel induction of cell proliferation and inhibition of cell differentiation in hepatic progenitor cells by hepatitis B virus X gene","volume":"30","author":"Huang","year":"2012","journal-title":"Int. J. Mol. Med"}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383515006989?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383515006989?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T16:47:35Z","timestamp":1567356455000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383515006989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S0304383515006989"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2015.11.022","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Autophagy-deficiency in hepatic progenitor cells leads to the defects of stemness and enhances susceptibility to neoplastic transformation","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2015.11.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}