{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:43:53Z","timestamp":1792687433603,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81172476"],"award-info":[{"award-number":["81172476"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81272885"],"award-info":[{"award-number":["81272885"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81472427"],"award-info":[{"award-number":["81472427"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People&apos;s Republic of China","doi-asserted-by":"publisher","award":["20120073110090"],"award-info":[{"award-number":["20120073110090"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["13JC1404501"],"award-info":[{"award-number":["13JC1404501"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.canlet.2016.03.036","type":"journal-article","created":{"date-parts":[[2016,3,24]],"date-time":"2016-03-24T11:17:55Z","timestamp":1458818275000},"page":"127-136","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":67,"title":["Tumor-associated macrophage-derived CXCL8 could induce ER\u03b1 suppression via HOXB13 in endometrial cancer"],"prefix":"10.1016","volume":"376","author":[{"given":"Huan","family":"Tong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie-Qi","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei-Zhou","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Yuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ran","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ping","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2016.03.036_bib0010","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21332","article-title":"Cancer statistics, 2016","volume":"66","author":"Siegel","year":"2016","journal-title":"CA Cancer J. Clin"},{"key":"10.1016\/j.canlet.2016.03.036_bib0015","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3322\/caac.21338","article-title":"Cancer statistics in China, 2015","volume":"66","author":"Chen","year":"2016","journal-title":"CA Cancer J. Clin"},{"key":"10.1016\/j.canlet.2016.03.036_bib0020","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1038\/onc.2014.193","article-title":"Loss of Cdh1 and Trp53 in the uterus induces chronic inflammation with modification of tumor microenvironment","volume":"34","author":"Stodden","year":"2015","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2016.03.036_bib0025","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nrclinonc.2010.216","article-title":"Emerging therapeutic targets in endometrial cancer","volume":"8","author":"Dedes","year":"2011","journal-title":"Nat. Rev. Clin. Oncol"},{"key":"10.1016\/j.canlet.2016.03.036_bib0030","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/nrc3622","article-title":"Links between oestrogen receptor activation and proteolysis: relevance to hormone-regulated cancer therapy","volume":"14","author":"Zhou","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.canlet.2016.03.036_bib0035","doi-asserted-by":"crossref","first-page":"4038","DOI":"10.1200\/JCO.2009.27.4290","article-title":"Influence of sex hormones on cancer progression","volume":"28","author":"Folkerd","year":"2010","journal-title":"J. Clin. Oncol"},{"key":"10.1016\/j.canlet.2016.03.036_bib0040","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1007\/s00204-012-0868-5","article-title":"Estrogen receptors and human disease: an update","volume":"86","author":"Burns","year":"2012","journal-title":"Arch. Toxicol"},{"key":"10.1016\/j.canlet.2016.03.036_bib0045","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1158\/1078-0432.CCR-12-3039","article-title":"Lack of estrogen receptor-alpha is associated with epithelial-mesenchymal transition and PI3K alterations in endometrial carcinoma","volume":"19","author":"Wik","year":"2013","journal-title":"Clin. Cancer Res"},{"key":"10.1016\/j.canlet.2016.03.036_bib0050","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S0140-6736(11)60993-8","article-title":"Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials","volume":"378","author":"Davies","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.canlet.2016.03.036_bib0055","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature07205","article-title":"Cancer-related inflammation","volume":"454","author":"Mantovani","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2016.03.036_bib0060","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nri2448","article-title":"Exploring the full spectrum of macrophage activation","volume":"8","author":"Mosser","year":"2008","journal-title":"Nat. Rev. Immunol"},{"key":"10.1016\/j.canlet.2016.03.036_bib0065","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ygyno.2014.10.012","article-title":"Tumor-associated macrophages: co-conspirators and orchestrators of immune suppression in endometrial adenocarcinoma","volume":"135","author":"Zsiros","year":"2014","journal-title":"Gynecol. Oncol"},{"key":"10.1016\/j.canlet.2016.03.036_bib0070","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S1471-4906(02)02302-5","article-title":"Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes","volume":"23","author":"Mantovani","year":"2002","journal-title":"Trends Immunol"},{"key":"10.1016\/j.canlet.2016.03.036_bib0075","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.ccr.2011.02.006","article-title":"CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3","volume":"19","author":"Chen","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2016.03.036_bib0080","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1038\/onc.2014.85","article-title":"Increased metabolites of 5-lipoxygenase from hypoxic ovarian cancer cells promote tumor-associated macrophage infiltration","volume":"34","author":"Wen","year":"2015","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2016.03.036_bib0085","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.ygyno.2014.08.028","article-title":"Prognostic significance of tumor-associated macrophages in endometrial adenocarcinoma","volume":"135","author":"Kubler","year":"2014","journal-title":"Gynecol. Oncol"},{"key":"10.1016\/j.canlet.2016.03.036_bib0090","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1158\/0008-5472.CAN-14-2819","article-title":"Novel mechanism of macrophage-mediated metastasis revealed in a zebrafish model of tumor development","volume":"75","author":"Wang","year":"2015","journal-title":"Cancer Res"},{"key":"10.1016\/j.canlet.2016.03.036_bib0095","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/nrc1256","article-title":"Tumour-educated macrophages promote tumour progression and metastasis","volume":"4","author":"Pollard","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.canlet.2016.03.036_bib0100","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1038\/onc.2011.370","article-title":"Macrophage-elicited loss of estrogen receptor-alpha in breast cancer cells via involvement of MAPK and c-Jun at the ESR1 genomic locus","volume":"31","author":"Stossi","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2016.03.036_bib0105","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1002\/ijc.28679","article-title":"Activation of a positive feedback loop involving IL-6 and aromatase promotes intratumoral 17beta-estradiol biosynthesis in endometrial carcinoma microenvironment","volume":"135","author":"Che","year":"2014","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.canlet.2016.03.036_bib0110","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1158\/0008-5472.CAN-11-3290","article-title":"Estrogen receptor alpha mediates progestin-induced mammary tumor growth by interacting with progesterone receptors at the cyclin D1\/MYC promoters","volume":"72","author":"Giulianelli","year":"2012","journal-title":"Cancer Res"},{"key":"10.1016\/j.canlet.2016.03.036_bib0115","doi-asserted-by":"crossref","first-page":"5449","DOI":"10.1158\/0008-5472.CAN-13-1178","article-title":"HOXB13 mediates tamoxifen resistance and invasiveness in human breast cancer by suppressing ERalpha and inducing IL-6 expression","volume":"73","author":"Shah","year":"2013","journal-title":"Cancer Res"},{"key":"10.1016\/j.canlet.2016.03.036_bib0120","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1677\/erc.1.01301","article-title":"CXC chemokines located in the 4q21 region are up-regulated in breast cancer","volume":"14","author":"Bieche","year":"2007","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.canlet.2016.03.036_bib0125","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1593\/neo.101340","article-title":"Epidermal growth factor and estrogen act by independent pathways to additively promote the release of the angiogenic chemokine CXCL8 by breast tumor cells","volume":"13","author":"Haim","year":"2011","journal-title":"Neoplasia"},{"key":"10.1016\/j.canlet.2016.03.036_bib0130","doi-asserted-by":"crossref","first-page":"6284","DOI":"10.4049\/jimmunol.179.9.6284","article-title":"Estradiol attenuates lipopolysaccharide-induced CXC chemokine ligand 8 production by human peripheral blood monocytes","volume":"179","author":"Pioli","year":"2007","journal-title":"J. Immunol"},{"key":"10.1016\/j.canlet.2016.03.036_bib0135","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1016\/j.bbamcr.2009.09.018","article-title":"Prostaglandin F(2alpha)-F-prostanoid receptor regulates CXCL8 expression in endometrial adenocarcinoma cells via the calcium-calcineurin-NFAT pathway","volume":"1793","author":"Sales","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.canlet.2016.03.036_bib0140","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s00109-014-1181-y","article-title":"HOX genes and their role in the development of human cancers","volume":"92","author":"Bhatlekar","year":"2014","journal-title":"J. Mol. Med"},{"key":"10.1016\/j.canlet.2016.03.036_bib0145","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s10555-012-9415-3","article-title":"Stromal cells in tumor microenvironment and breast cancer","volume":"32","author":"Mao","year":"2013","journal-title":"Cancer Metastasis Rev"},{"key":"10.1016\/j.canlet.2016.03.036_bib0150","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1186\/bcr2912","article-title":"The microenvironment in breast cancer progression: biology and implications for treatment","volume":"13","author":"Place","year":"2011","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.canlet.2016.03.036_bib0155","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1530\/ERC-15-0319","article-title":"Comprehensive genetic assessment of the ESR1 locus identifies a risk region for endometrial cancer","volume":"22","author":"O'Mara","year":"2015","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.canlet.2016.03.036_bib0160","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1158\/0008-5472.CAN-05-4005","article-title":"Distinct role of macrophages in different tumor microenvironments","volume":"66","author":"Lewis","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.canlet.2016.03.036_bib0165","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/1471-2407-10-112","article-title":"The M1 form of tumor-associated macrophages in non-small cell lung cancer is positively associated with survival time","volume":"10","author":"Ma","year":"2010","journal-title":"BMC Cancer"},{"key":"10.1016\/j.canlet.2016.03.036_bib0170","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1111\/j.1447-0756.2012.02036.x","article-title":"Tumor-associated macrophages correlate with progesterone receptor loss in endometrial endometrioid adenocarcinoma","volume":"39","author":"Jiang","year":"2013","journal-title":"J. Obstet. Gynaecol. Res"},{"key":"10.1016\/j.canlet.2016.03.036_bib0175","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.cell.2005.12.032","article-title":"Macrophage\/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway","volume":"124","author":"Zhu","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2016.03.036_bib0180","doi-asserted-by":"crossref","first-page":"636","DOI":"10.4049\/jimmunol.174.2.636","article-title":"Reduction of myeloid-derived suppressor cells and induction of M1 macrophages facilitate the rejection of established metastatic disease","volume":"174","author":"Sinha","year":"2005","journal-title":"J. Immunol"},{"issue":"8","key":"10.1016\/j.canlet.2016.03.036_bib0185","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1177\/1933719115570912","article-title":"Type 2 endometrial cancer is associated with a high density of tumor-associated macrophages in the stromal compartment","volume":"22","author":"Kelly","year":"2015","journal-title":"Reprod. Sci"},{"key":"10.1016\/j.canlet.2016.03.036_bib0190","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1215\/S1152851704001061","article-title":"The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis","volume":"7","author":"Brat","year":"2005","journal-title":"Neuro Oncol"},{"issue":"2","key":"10.1016\/j.canlet.2016.03.036_bib0195","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.canlet.2015.05.009","article-title":"Interleukin-8 upregulates integrin beta3 expression and promotes estrogen receptor-negative breast cancer cell invasion by activating the PI3K\/Akt\/NF-kappaB pathway","volume":"364","author":"Shao","year":"2015","journal-title":"Cancer Lett"},{"key":"10.1016\/j.canlet.2016.03.036_bib0200","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1056\/NEJMc1205138","article-title":"Association of a HOXB13 variant with breast cancer","volume":"367","author":"Alanee","year":"2012","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.canlet.2016.03.036_bib0205","first-page":"721","article-title":"Regulation of tumor invasion by HOXB13 gene overexpressed in human endometrial cancer","volume":"13","author":"Zhao","year":"2005","journal-title":"Oncol. Rep"},{"key":"10.1016\/j.canlet.2016.03.036_bib0210","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrc3093","article-title":"The different roles of ER subtypes in cancer biology and therapy","volume":"11","author":"Thomas","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.canlet.2016.03.036_bib0215","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.humpath.2012.09.007","article-title":"The expression ratios of estrogen receptor alpha (ERalpha) to estrogen receptor beta1 (ERbeta1) and ERalpha to ERbeta2 identify poor clinical outcome in endometrioid endometrial cancer","volume":"44","author":"Zannoni","year":"2013","journal-title":"Hum. Pathol"}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383516301963?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383516301963?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T18:17:42Z","timestamp":1656353862000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383516301963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["S0304383516301963"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2016.03.036","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tumor-associated macrophage-derived CXCL8 could induce ER\u03b1 suppression via HOXB13 in endometrial cancer","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2016.03.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}