{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:31:46Z","timestamp":1792024306400,"version":"4.4.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NSC94-2320-B-320-021"],"award-info":[{"award-number":["NSC94-2320-B-320-021"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NSC96-2320-B-320-016"],"award-info":[{"award-number":["NSC96-2320-B-320-016"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NSC101-2320-B-320-007"],"award-info":[{"award-number":["NSC101-2320-B-320-007"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST103-2320-B-320-009"],"award-info":[{"award-number":["MOST103-2320-B-320-009"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","cancerletters.info","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.canlet.2016.08.021","type":"journal-article","created":{"date-parts":[[2016,8,29]],"date-time":"2016-08-29T15:42:13Z","timestamp":1472485333000},"page":"21-31","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"title":["Positive regulation of HIF-1A expression by EBV oncoprotein LMP1 in nasopharyngeal carcinoma cells"],"prefix":"10.1016","volume":"382","author":[{"given":"Wei-Wen","family":"Sung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chih","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peir-Rong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Hui","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeng-Woei","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2016.08.021_bib0010","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nrc1452","article-title":"Epstein-Barr virus: 40 years on","volume":"4","author":"Young","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.canlet.2016.08.021_bib0015","first-page":"1355","article-title":"Undifferentiated, nonkeratinizing, and squamous cell carcinoma of the nasopharynx. Variants of Epstein-Barr virus-infected neoplasia","volume":"146","author":"Pathmanathan","year":"1995","journal-title":"Am. J. Pathol"},{"key":"10.1016\/j.canlet.2016.08.021_bib0020","first-page":"5365","article-title":"High frequency of chromosome 3p deletion in histologically normal nasopharyngeal epithelia from southern Chinese","volume":"60","author":"Chan","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.canlet.2016.08.021_bib0025","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/ijc.10689","article-title":"Frequent chromosome 9p losses in histologically normal nasopharyngeal epithelia from southern Chinese","volume":"102","author":"Chan","year":"2002","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.canlet.2016.08.021_bib0030","doi-asserted-by":"crossref","first-page":"e131","DOI":"10.1038\/emm.2014.84","article-title":"Epstein-Barr virus latent genes","volume":"47","author":"Kang","year":"2015","journal-title":"Exp. Mol. Med"},{"key":"10.1016\/j.canlet.2016.08.021_bib0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2013.05.018","article-title":"Pathogenic role of Epstein-Barr virus latent membrane protein-1 in the development of nasopharyngeal carcinoma","volume":"337","author":"Yoshizaki","year":"2013","journal-title":"Cancer Lett"},{"key":"10.1016\/j.canlet.2016.08.021_bib0040","doi-asserted-by":"crossref","first-page":"20370","DOI":"10.1073\/pnas.1014194107","article-title":"Human tumor virus utilizes exosomes for intercellular communication","volume":"107","author":"Meckes","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.canlet.2016.08.021_bib0045","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2016.08.021_bib0050","doi-asserted-by":"crossref","first-page":"5223","DOI":"10.1128\/MCB.24.12.5223-5234.2004","article-title":"Epstein-Barr virus latent membrane protein 1 induces synthesis of hypoxia-inducible factor 1\u03b1","volume":"24","author":"Wakisaka","year":"2004","journal-title":"Mol. Cell. Biol"},{"key":"10.1016\/j.canlet.2016.08.021_bib0055","doi-asserted-by":"crossref","first-page":"9870","DOI":"10.1158\/0008-5472.CAN-06-1679","article-title":"EBV latent membrane protein 1 up-regulates hypoxia-inducible factor 1alpha through Siah1-mediated down-regulation of prolyl hydroxylases 1 and 3 in nasopharyngeal epithelial cells","volume":"66","author":"Kondo","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.canlet.2016.08.021_bib0060","first-page":"2595","article-title":"Coexpression of hypoxia-inducible factors 1 alpha and 2 alpha, carbonic anhydrase IX, and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to survival","volume":"8","author":"Hui","year":"2002","journal-title":"Clin. Cancer Res"},{"key":"10.1016\/j.canlet.2016.08.021_bib0065","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/s12105-009-0148-8","article-title":"Epstein-Barr virus latent membrane protein 1 is not associated with vessel density nor with hypoxia inducible factor 1 alpha expression in nasopharyngeal carcinoma tissue","volume":"3","author":"Benders","year":"2009","journal-title":"Head Neck Pathol"},{"key":"10.1016\/j.canlet.2016.08.021_bib0070","doi-asserted-by":"crossref","first-page":"4304","DOI":"10.1073\/pnas.90.9.4304","article-title":"General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia","volume":"90","author":"Wang","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.canlet.2016.08.021_bib0075","doi-asserted-by":"crossref","first-page":"21513","DOI":"10.1016\/S0021-9258(20)80571-7","article-title":"Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia","volume":"268","author":"Wang","year":"1993","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.canlet.2016.08.021_bib0080","doi-asserted-by":"crossref","first-page":"5510","DOI":"10.1073\/pnas.92.12.5510","article-title":"Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension","volume":"92","author":"Wang","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.canlet.2016.08.021_bib0085","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1126\/science.1059796","article-title":"Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation","volume":"292","author":"Jaakkola","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.canlet.2016.08.021_bib0090","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/35017054","article-title":"Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein","volume":"2","author":"Ohh","year":"2000","journal-title":"Nat. Cell Biol"},{"key":"10.1016\/j.canlet.2016.08.021_bib0095","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/cdd.2008.12","article-title":"Biology of HIF-1\u03b1","volume":"15","author":"Weidemann","year":"2008","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.canlet.2016.08.021_bib0100","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.tibs.2008.08.002","article-title":"HIF-1 regulation: not so easy come, easy go","volume":"33","author":"Yee Koh","year":"2008","journal-title":"Trends Biochem. Sci"},{"key":"10.1016\/j.canlet.2016.08.021_bib0105","doi-asserted-by":"crossref","first-page":"3853","DOI":"10.2174\/138161209789649376","article-title":"Factors interacting with HIF-1\u03b1 mRNA: novel therapeutic targets","volume":"15","author":"Galb\u00e1n","year":"2009","journal-title":"Curr. Pharm. Des"},{"key":"10.1016\/j.canlet.2016.08.021_bib0110","doi-asserted-by":"crossref","first-page":"3844","DOI":"10.2174\/138161209789649420","article-title":"Regulation of HIF-1\u03b1 at the transcription level","volume":"15","author":"G\u00f6rlach","year":"2009","journal-title":"Curr. Pharm. Des"},{"key":"10.1016\/j.canlet.2016.08.021_bib0115","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.1091\/mbc.E10-07-0617","article-title":"Hypoxia-inducible factor-1\u03b1 mRNA: a new target for destabilization by tristetraprolin in endothelial cells","volume":"22","author":"Chamboredon","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.canlet.2016.08.021_bib0120","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1006\/bbrc.1999.0995","article-title":"HIF1A gene transcription is dependent on a core promoter sequence encompassing activating and inhibiting sequences located upstream from the transcription initiation site and cis elements located within the 5\u2032UTR","volume":"261","author":"Minet","year":"1999","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1016\/j.canlet.2016.08.021_bib0125","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.1074\/jbc.M808491200","article-title":"SWI\/SNF regulates the cellular response to hypoxia","volume":"284","author":"Kenneth","year":"2009","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.canlet.2016.08.021_bib0130","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1038\/onc.2010.481","article-title":"Tumor-associated CpG demethylation augments hypoxia-induced effects by positive autoregulation of HIF-1\u03b1","volume":"30","author":"Koslowski","year":"2011","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2016.08.021_bib0135","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1039\/C4MB00351A","article-title":"HIF-1 promotes the expression of its \u03b1-subunit via an epigenetically regulated transactivation loop","volume":"10","author":"Asby","year":"2014","journal-title":"Mol. Biosyst"},{"key":"10.1016\/j.canlet.2016.08.021_bib0140","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/onc.2009.441","article-title":"Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics","volume":"29","author":"Semenza","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2016.08.021_bib0145","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.canlet.2009.01.037","article-title":"EBV LMP-1 negatively regulates expression and pro-apoptotic activity of Par-4 in nasopharyngeal carcinoma cells","volume":"279","author":"Lee","year":"2009","journal-title":"Cancer Lett"},{"key":"10.1016\/j.canlet.2016.08.021_bib0150","doi-asserted-by":"crossref","first-page":"8857","DOI":"10.1128\/JVI.73.10.8857-8866.1999","article-title":"Requirement for cell-to-cell contact in Epstein\u2013Barr virus infection of nasopharyngeal carcinoma cells and keratinocytes","volume":"73","author":"Chang","year":"1999","journal-title":"J. Virol"},{"key":"10.1016\/j.canlet.2016.08.021_bib0155","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1038\/sj.onc.1208319","article-title":"Epstein-Barr virus latent membrane protein 1 represses p53-mediated DNA repair and transcriptional activity","volume":"24","author":"Liu","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2016.08.021_bib0160","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1128\/MCB.00973-07","article-title":"RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1 alpha","volume":"28","author":"Galb\u00e1n","year":"2008","journal-title":"Mol. Cell. Biol"},{"key":"10.1016\/j.canlet.2016.08.021_bib0165","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.bbrc.2004.07.173","article-title":"Androgens regulate the binding of endogenous HuR to the AU-rich 3\u2032UTRs of HIF-1alpha and EGF mRNA","volume":"322","author":"Sheflin","year":"2004","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1016\/j.canlet.2016.08.021_bib0170","doi-asserted-by":"crossref","first-page":"4129","DOI":"10.1091\/mbc.E11-11-0949","article-title":"Multilevel regulation of HIF-1 signaling by TTP","volume":"23","author":"F\u00e4hling","year":"2012","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.canlet.2016.08.021_bib0175","doi-asserted-by":"crossref","first-page":"D301","DOI":"10.1093\/nar\/gkq1069","article-title":"RBPDB: a database of RNA-binding specificities","volume":"39","author":"Cook","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.canlet.2016.08.021_bib0180","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1006\/geno.1998.5416","article-title":"The human hypoxia-inducible factor 1alpha gene: HIF1A structure and evolutionary conservation","volume":"52","author":"Iyer","year":"1998","journal-title":"Genomics"},{"key":"10.1016\/j.canlet.2016.08.021_bib0185","doi-asserted-by":"crossref","first-page":"4691","DOI":"10.1091\/mbc.E07-04-0391","article-title":"Hypoxia up-regulates hypoxia-inducible factor-1alpha transcription by involving phosphatidylinositol 3-kinase and nuclear factor kappaB in pulmonary artery smooth muscle cells","volume":"18","author":"Belaiba","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.canlet.2016.08.021_bib0190","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1042\/BJ20080476","article-title":"Regulation of hypoxia-inducible factor-1alpha by NF-kappaB","volume":"412","author":"van Uden","year":"2008","journal-title":"Biochem. J."},{"key":"10.1016\/j.canlet.2016.08.021_bib0195","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1038\/labinvest.2013.111","article-title":"Transcriptional upregulation of HIF-1\u03b1 by NF-\u03baB\/p65 and its associations with \u03b2-catenin\/p300 complexes in endometrial carcinoma cells","volume":"93","author":"Yoshida","year":"2013","journal-title":"Lab. Invest"},{"key":"10.1016\/j.canlet.2016.08.021_bib0200","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/nature06905","article-title":"NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha","volume":"453","author":"Rius","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2016.08.021_bib0205","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s10059-010-0067-2","article-title":"HIF-1 and HIF-2 transcription factors \u2013 similar but not identical","volume":"29","author":"Loboda","year":"2010","journal-title":"Mol. Cells"},{"key":"10.1016\/j.canlet.2016.08.021_bib0210","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1006\/viro.1993.1597","article-title":"Expression of the Epstein-Barr virus immediate early gene, BZLF1, in nasopharyngeal carcinoma tumor cells","volume":"197","author":"Cochet","year":"1993","journal-title":"Virology"},{"key":"10.1016\/j.canlet.2016.08.021_bib0215","doi-asserted-by":"crossref","first-page":"5168","DOI":"10.1158\/0008-5472.CAN-08-4238","article-title":"The mRNA-destabilizing protein tristetraprolin is suppressed in many cancers, altering tumorigenic phenotypes and patient prognosis","volume":"69","author":"Brennan","year":"2009","journal-title":"Cancer Res"},{"key":"10.1016\/j.canlet.2016.08.021_bib0220","doi-asserted-by":"crossref","DOI":"10.1158\/0008-5472.CAN-15-3110","article-title":"Systematic analysis of AU-rich element expression in cancer reveals common functional clusters regulated by key RNA-binding proteins","author":"Hitti","year":"2016","journal-title":"Cancer Res"},{"key":"10.1016\/j.canlet.2016.08.021_bib0225","doi-asserted-by":"crossref","first-page":"174","DOI":"10.2741\/3920","article-title":"The role of tristetraprolin in cancer and inflammation","volume":"17","author":"Sanduja","year":"2012","journal-title":"Front. Biosci. (Landmark Ed.)"},{"key":"10.1016\/j.canlet.2016.08.021_bib0230","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cell.2015.12.017","article-title":"Noncoding RNA NORAD regulates genomic stability by sequestering PUMILIO proteins","volume":"164","author":"Lee","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2016.08.021_bib0235","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/jcp.22339","article-title":"Post-transcriptional regulation of the DUSP6\/MKP-3 phosphatase by MEK\/ERK signaling and hypoxia","volume":"226","author":"Bermudez","year":"2011","journal-title":"J. Cell. Physiol"},{"key":"10.1016\/j.canlet.2016.08.021_bib0240","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.2174\/138161209789649358","article-title":"Kinases as upstream regulators of the HIF system: their emerging potential as anti-cancer drug targets","volume":"15","author":"Dimova","year":"2009","journal-title":"Curr. Pharm. Des"},{"key":"10.1016\/j.canlet.2016.08.021_bib0245","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/path.4239","article-title":"Constitutive activation of distinct NF-\u03baB signals in EBV-associated nasopharyngeal carcinoma","volume":"231","author":"Chung","year":"2013","journal-title":"J. Pathol"},{"key":"10.1016\/j.canlet.2016.08.021_bib0250","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1099\/vir.0.2008\/003392-0","article-title":"Epstein-Barr virus-encoded EBNA1 modulates the AP-1 transcription factor pathway in nasopharyngeal carcinoma cells and enhances angiogenesis in vitro","volume":"89","author":"O'Neil","year":"2008","journal-title":"J. Gen. Virol"},{"key":"10.1016\/j.canlet.2016.08.021_bib0255","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.virol.2014.02.027","article-title":"Hypoxia-inducible factor 1 and its role in viral carcinogenesis","volume":"456\u2013457","author":"Cuninghame","year":"2014","journal-title":"Virology"}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383516304967?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383516304967?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T07:18:58Z","timestamp":1657178338000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383516304967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["S0304383516304967"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2016.08.021","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Positive regulation of HIF-1A expression by EBV oncoprotein LMP1 in nasopharyngeal carcinoma cells","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2016.08.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}