{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:41:11Z","timestamp":1787668871502,"version":"build-2736575974"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["1R01CA167967-01A1"],"award-info":[{"award-number":["1R01CA167967-01A1"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Adelson Medical Research Foundation"},{"DOI":"10.13039\/501100001809","name":"China National Natural Science Foundation","doi-asserted-by":"publisher","award":["81573454"],"award-info":[{"award-number":["81573454"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"crossref","award":["7172142"],"award-info":[{"award-number":["7172142"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"crossref"}]},{"name":"CAMS Innovation Fund for Medical Sciences (CIFMS)","award":["2016-I2M-3-007"],"award-info":[{"award-number":["2016-I2M-3-007"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","cancerletters.info","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.canlet.2017.08.001","type":"journal-article","created":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T15:16:00Z","timestamp":1502378160000},"page":"66-75","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["P-REX1 amplification promotes progression of cutaneous melanoma via the PAK1\/P38\/MMP-2 pathway"],"prefix":"10.1016","volume":"407","author":[{"given":"Jinhua","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Hirose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanhua","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Chong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Kiyohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac P.","family":"Witz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1915-3683","authenticated-orcid":false,"given":"Dave S.B.","family":"Hoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.canlet.2017.08.001_bib1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/BF03256334","article-title":"Melanoma biomarkers: current status and utility in diagnosis, prognosis, and response to therapy","volume":"13","author":"Haass","year":"2009","journal-title":"Mol. Diagn. Ther."},{"issue":"5","key":"10.1016\/j.canlet.2017.08.001_bib2","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/DAD.0b013e31828a2ec5","article-title":"Cutaneous malignant melanoma: update on diagnostic and prognostic biomarkers","volume":"36","author":"Abbas","year":"2014","journal-title":"Am. J. Dermatopathol."},{"issue":"10","key":"10.1016\/j.canlet.2017.08.001_bib3","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1093\/jnci\/86.10.761","article-title":"Clinical and histopathologic predictors of survival in patients with malignant melanoma: a population-based study in Sweden","volume":"86","author":"Thorn","year":"1994","journal-title":"J.\u00a0Natl. Cancer Inst."},{"issue":"4","key":"10.1016\/j.canlet.2017.08.001_bib4","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s002590050529","article-title":"Cutaneous malignant melanoma: clinical aspects, imaging modalities and treatment","volume":"27","author":"Ak","year":"2000","journal-title":"Eur. J. Nucl. Med."},{"issue":"6","key":"10.1016\/j.canlet.2017.08.001_bib5","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s10585-010-9307-2","article-title":"Gene signature of the metastatic potential of cutaneous melanoma: too much for too little?","volume":"27","author":"Timar","year":"2010","journal-title":"Clin. Exp. Metastasis"},{"issue":"6","key":"10.1016\/j.canlet.2017.08.001_bib6","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.ccr.2010.11.023","article-title":"Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R\/PI3K","volume":"18","author":"Villanueva","year":"2010","journal-title":"Cancer Cell"},{"issue":"2","key":"10.1016\/j.canlet.2017.08.001_bib7","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.cell.2012.06.024","article-title":"A\u00a0landscape of driver mutations in melanoma","volume":"150","author":"Hodis","year":"2012","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.canlet.2017.08.001_bib8","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1093\/nar\/gku1393","article-title":"Patient-specific driver gene prediction and risk assessment through integrated network analysis of cancer omics profiles","volume":"43","author":"Bertrand","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"7","key":"10.1016\/j.canlet.2017.08.001_bib9","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/j.cell.2015.05.044","article-title":"Genomic classification of cutaneous melanoma","volume":"161","author":"Cancer Genome Atlas N","year":"2015","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.canlet.2017.08.001_bib10","doi-asserted-by":"crossref","first-page":"e1005895","DOI":"10.1371\/journal.pgen.1005895","article-title":"Genomic landscape survey identifies SRSF1 as a key oncodriver in small cell lung cancer","volume":"12","author":"Jiang","year":"2016","journal-title":"PLoS Genet."},{"issue":"5","key":"10.1016\/j.canlet.2017.08.001_bib11","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.3892\/ol.2015.3686","article-title":"Overexpression and lack of copy number variation in the BMI-1 gene in human glioma","volume":"10","author":"Madathan Kandy","year":"2015","journal-title":"Oncol. Lett."},{"issue":"4","key":"10.1016\/j.canlet.2017.08.001_bib12","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/(SICI)1098-2264(199708)19:4<278::AID-GCC11>3.0.CO;2-C","article-title":"Increased chromosome 20 copy number detected by fluorescence in situ hybridization (FISH) in malignant melanoma","volume":"19","author":"Barks","year":"1997","journal-title":"Genes Chromosom. Cancer"},{"issue":"2","key":"10.1016\/j.canlet.2017.08.001_bib13","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/pcmr.12436","article-title":"The extent of whole-genome copy number alterations predicts aggressive features in primary melanomas","volume":"29","author":"Gandolfi","year":"2016","journal-title":"Pigment Cell Melanoma Res."},{"issue":"3","key":"10.1016\/j.canlet.2017.08.001_bib14","first-page":"233","article-title":"Amplification of N-myc oncogene in human melanoma cells","volume":"37","author":"Bauer","year":"1990","journal-title":"Neoplasma"},{"issue":"5","key":"10.1016\/j.canlet.2017.08.001_bib15","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.humpath.2006.01.003","article-title":"BRAF and c-kit gene copy number in mutation-positive malignant melanoma","volume":"37","author":"Willmore-Payne","year":"2006","journal-title":"Hum. Pathol."},{"issue":"13","key":"10.1016\/j.canlet.2017.08.001_bib16","doi-asserted-by":"crossref","first-page":"4288","DOI":"10.1158\/1078-0432.CCR-09-0280","article-title":"GAB2 amplifications refine molecular classification of melanoma","volume":"15","author":"Chernoff","year":"2009","journal-title":"Clin. Cancer Res.Off. J. Am. Assoc. Cancer Res."},{"issue":"2","key":"10.1016\/j.canlet.2017.08.001_bib17","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1158\/1078-0432.CCR-15-1162","article-title":"Copy number changes are associated with response to treatment with carboplatin, paclitaxel, and sorafenib in melanoma","volume":"22","author":"Wilson","year":"2016","journal-title":"Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res."},{"issue":"4","key":"10.1016\/j.canlet.2017.08.001_bib18","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/pcmr.12249","article-title":"In melanoma, Hippo signaling is affected by copy number alterations and YAP1 overexpression impairs patient survival","volume":"27","author":"Menzel","year":"2014","journal-title":"Pigment Cell Melanoma Res."},{"issue":"9","key":"10.1016\/j.canlet.2017.08.001_bib19","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1002\/ijc.29970","article-title":"MAP kinase pathway gene copy alterations in NRAS\/BRAF wild-type advanced melanoma","volume":"138","author":"Orouji","year":"2016","journal-title":"Int. J. Cancer"},{"issue":"6","key":"10.1016\/j.canlet.2017.08.001_bib20","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.molcel.2010.11.029","article-title":"Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer","volume":"40","author":"Sosa","year":"2010","journal-title":"Mol. Cell"},{"issue":"29","key":"10.1016\/j.canlet.2017.08.001_bib21","doi-asserted-by":"crossref","first-page":"25813","DOI":"10.1074\/jbc.M110.211292","article-title":"Epigenetic regulation of phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 gene expression in prostate cancer cells","volume":"286","author":"Wong","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"issue":"30","key":"10.1016\/j.canlet.2017.08.001_bib22","doi-asserted-by":"crossref","first-page":"3968","DOI":"10.1038\/onc.2014.328","article-title":"P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K\/AKT and MEK\/ERK signaling in breast cancer","volume":"34","author":"Dillon","year":"2015","journal-title":"Oncogene"},{"issue":"32","key":"10.1016\/j.canlet.2017.08.001_bib23","doi-asserted-by":"crossref","first-page":"23708","DOI":"10.1074\/jbc.M703771200","article-title":"P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration","volume":"282","author":"Hernandez-Negrete","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"issue":"1","key":"10.1016\/j.canlet.2017.08.001_bib24","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/jid.2014.323","article-title":"A\u00a0Rac1-independent role for P-Rex1 in melanoblasts","volume":"135","author":"Lindsay","year":"2015","journal-title":"J.\u00a0Investig. Dermatol."},{"key":"10.1016\/j.canlet.2017.08.001_bib25","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/ncomms1560","article-title":"P-Rex1 is required for efficient melanoblast migration and melanoma metastasis","volume":"2","author":"Lindsay","year":"2011","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.canlet.2017.08.001_bib26","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1093\/hmg\/ddt420","article-title":"Epigenome-wide DNA methylation landscape of melanoma progression to brain metastasis reveals aberrations on homeobox D cluster associated with prognosis","volume":"23","author":"Marzese","year":"2014","journal-title":"Hum. Mol. Genet."},{"issue":"36","key":"10.1016\/j.canlet.2017.08.001_bib27","doi-asserted-by":"crossref","first-page":"4789","DOI":"10.1200\/JCO.2011.36.7706","article-title":"Genetic activation of the MET pathway and prognosis of patients with high-risk, radically resected gastric cancer","volume":"29","author":"Graziano","year":"2011","journal-title":"J.\u00a0Clin. Oncol."},{"issue":"3","key":"10.1016\/j.canlet.2017.08.001_bib28","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/gepi.21887","article-title":"A\u00a0genome-wide association study of early spontaneous preterm delivery","volume":"39","author":"Zhang","year":"2015","journal-title":"Genet. Epidemiol."},{"issue":"6","key":"10.1016\/j.canlet.2017.08.001_bib29","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1111\/acer.12429","article-title":"Exon microarray analysis of human dorsolateral prefrontal cortex in alcoholism","volume":"38","author":"Manzardo","year":"2014","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.canlet.2017.08.001_bib30","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.gdata.2014.12.004","article-title":"Discovery of gene regulation pattern in lung cancer by gene expression profiling using human tissues","volume":"3","author":"Fu","year":"2015","journal-title":"Genomics Data"},{"issue":"8","key":"10.1016\/j.canlet.2017.08.001_bib31","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1038\/jid.2013.114","article-title":"B7-H3 associated with tumor progression and epigenetic regulatory activity in cutaneous melanoma","volume":"133","author":"Wang","year":"2013","journal-title":"J.\u00a0Investig. Dermatol."},{"issue":"10","key":"10.1016\/j.canlet.2017.08.001_bib32","doi-asserted-by":"crossref","first-page":"3870","DOI":"10.1158\/0008-5472.CAN-09-4120","article-title":"FOXC1 is a potential prognostic biomarker with functional significance in basal-like breast cancer","volume":"70","author":"Ray","year":"2010","journal-title":"Cancer Res."},{"issue":"30","key":"10.1016\/j.canlet.2017.08.001_bib33","doi-asserted-by":"crossref","first-page":"30165","DOI":"10.18632\/oncotarget.5030","article-title":"RASSF8 regulates progression of cutaneous melanoma through nuclear factor-kappab","volume":"6","author":"Wang","year":"2015","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.canlet.2017.08.001_bib34","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/jid.2014.418","article-title":"Epigenetic changes of EGFR have an important role in BRAF inhibitor-resistant cutaneous melanomas","volume":"135","author":"Wang","year":"2015","journal-title":"J.\u00a0Investig. Dermatol."},{"issue":"5","key":"10.1016\/j.canlet.2017.08.001_bib35","first-page":"2276","article-title":"Regulation of MMP-1 and MMP-2 production through CD147\/extracellular matrix metalloproteinase inducer interactions","volume":"61","author":"Sun","year":"2001","journal-title":"Cancer Res."},{"issue":"6","key":"10.1016\/j.canlet.2017.08.001_bib36","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1373\/clinchem.2013.213611","article-title":"Genome-wide characterization of circulating tumor cells identifies novel prognostic genomic alterations in systemic melanoma metastasis","volume":"60","author":"Chiu","year":"2014","journal-title":"Clin. Chem."},{"issue":"4","key":"10.1016\/j.canlet.2017.08.001_bib37","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1007\/s13277-013-0848-2","article-title":"Prognostic value of survivin expression in breast cancer patients: a meta-analysis","volume":"34","author":"Song","year":"2013","journal-title":"Tumour Biol."},{"issue":"7","key":"10.1016\/j.canlet.2017.08.001_bib38","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1038\/sj.bjc.6600776","article-title":"Prognostic importance of survivin in breast cancer","volume":"88","author":"Kennedy","year":"2003","journal-title":"Br. J. Cancer"},{"issue":"4","key":"10.1016\/j.canlet.2017.08.001_bib39","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/sj.bjc.6603616","article-title":"Survivin is an independent predictor of short-term survival in poor prognostic breast cancer patients","volume":"96","author":"Hinnis","year":"2007","journal-title":"Br. J. Cancer"},{"issue":"4","key":"10.1016\/j.canlet.2017.08.001_bib40","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1007\/s12282-012-0403-9","article-title":"High survivin mRNA expression is a predictor of poor prognosis in breast cancer: a comparative study at the mRNA and protein level","volume":"21","author":"Xu","year":"2014","journal-title":"Breast Cancer"},{"issue":"11","key":"10.1016\/j.canlet.2017.08.001_bib41","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1373\/clinchem.2004.039149","article-title":"Survivin is an independent prognostic marker for risk stratification of breast cancer patients","volume":"50","author":"Span","year":"2004","journal-title":"Clin. Chem."},{"issue":"9","key":"10.1016\/j.canlet.2017.08.001_bib42","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1093\/carcin\/bgt155","article-title":"Survivin promotion of melanoma metastasis requires upregulation of alpha5 integrin","volume":"34","author":"McKenzie","year":"2013","journal-title":"Carcinogenesis"},{"issue":"1","key":"10.1016\/j.canlet.2017.08.001_bib43","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1093\/carcin\/bgm219","article-title":"Survivin repression by p53, Rb and E2F2 in normal human melanocytes","volume":"29","author":"Raj","year":"2008","journal-title":"Carcinogenesis"},{"issue":"4","key":"10.1016\/j.canlet.2017.08.001_bib44","first-page":"2113","article-title":"Clinical and prognostic significance of survivin, AKT and VEGF in primary mucosal oral melanoma","volume":"35","author":"Simonetti","year":"2015","journal-title":"Anticancer Res."},{"key":"10.1016\/j.canlet.2017.08.001_bib45","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1186\/1471-2407-13-338","article-title":"Sticky siRNAs targeting survivin and cyclin B1 exert an antitumoral effect on melanoma subcutaneous xenografts and lung metastases","volume":"13","author":"Kedinger","year":"2013","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.canlet.2017.08.001_bib46","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1042\/BJ20112078","article-title":"The guanine-nucleotide-exchange factor P-Rex1 is activated by protein phosphatase 1alpha","volume":"443","author":"Barber","year":"2012","journal-title":"Biochem. J."},{"issue":"9","key":"10.1016\/j.canlet.2017.08.001_bib47","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1158\/1078-0432.CCR-14-2279","article-title":"Rac1\/Pak1\/p38\/MMP-2 Axis regulates angiogenesis in ovarian cancer","volume":"21","author":"Gonzalez-Villasana","year":"2015","journal-title":"Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res."}],"updated-by":[{"DOI":"10.1016\/j.canlet.2024.216966","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T00:00:00Z","timestamp":1722124800000}}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383517304780?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383517304780?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T03:34:28Z","timestamp":1569987268000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383517304780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":47,"alternative-id":["S0304383517304780"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2017.08.001","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.canlet.2024.216966","asserted-by":"object"}]},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"P-REX1 amplification promotes progression of cutaneous melanoma via the PAK1\/P38\/MMP-2 pathway","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2017.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}