{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:51:59Z","timestamp":1792785119830,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"UIC Multi-Disciplinary Chancellor"},{"name":"UIC Dean Scholar"},{"name":"Ann and Sol Schreiber Ovarian Cancer Research Fund Alliance Postdoctoral Award","award":["543296"],"award-info":[{"award-number":["543296"]}],"id":[{"id":"https:\/\/ror.org\/05hg41718","id-type":"ROR","asserted-by":"crossref"}]},{"name":"NIH NIEHS","award":["UG3 ES029073"],"award-info":[{"award-number":["UG3 ES029073"]}]},{"name":"Tell Every Amazing Lady TEALWALK"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","cancerletters.info","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.canlet.2018.07.003","type":"journal-article","created":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T14:15:20Z","timestamp":1530800120000},"page":"221-231","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Prolactin signaling drives tumorigenesis in human high grade serous ovarian cancer cells and in a spontaneous fallopian tube derived model"],"prefix":"10.1016","volume":"433","author":[{"given":"Subbulakshmi","family":"Karthikeyan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Dean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel D.","family":"Lantvit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Endsley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna E.","family":"Burdette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2018.07.003_bib1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/01.pgp.0000101080.35393.16","article-title":"The histologic type and stage distribution of ovarian carcinomas of surface epithelial origin","volume":"23","author":"Seidman","year":"2004","journal-title":"Int. J. Gynecol. Pathol. Official J. Int. Soc. Gynecol. Pathol."},{"key":"10.1016\/j.canlet.2018.07.003_bib2","doi-asserted-by":"crossref","first-page":"709","DOI":"10.2741\/S401","article-title":"The origin of ovarian cancers\u2013hypotheses and controversies","volume":"5","author":"Auersperg","year":"2013","journal-title":"Front Biosci (Schol Ed)"},{"key":"10.1016\/j.canlet.2018.07.003_bib3","doi-asserted-by":"crossref","first-page":"6116","DOI":"10.1158\/1078-0432.CCR-04-2509","article-title":"Patterns of gene expression in different histotypes of epithelial ovarian cancer correlate with those in normal fallopian tube, endometrium, and colon","volume":"11","author":"Marquez","year":"2005","journal-title":"Clin. Canc. Res. Official J. Am. Assoc. Canc. Res."},{"key":"10.1016\/j.canlet.2018.07.003_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0080314","article-title":"Gene expression signature of normal cell-of-origin predicts ovarian tumor outcomes","volume":"8","author":"Merritt","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.canlet.2018.07.003_bib5","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.ccr.2013.10.013","article-title":"Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in Brca;Tp53;Pten models","volume":"24","author":"Perets","year":"2013","journal-title":"Canc. Cell"},{"key":"10.1016\/j.canlet.2018.07.003_bib6","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/IGC.0b013e3181a41613","article-title":"Histopathology of ovarian tumors in laying hens: a preclinical model of human ovarian cancer","volume":"19","author":"Barua","year":"2009","journal-title":"Int. J. Gynecol. Canc."},{"key":"10.1016\/j.canlet.2018.07.003_bib7","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/nrc3535","article-title":"The hen as a model of ovarian cancer","volume":"13","author":"Johnson","year":"2013","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.canlet.2018.07.003_bib8","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.mce.2005.03.019","article-title":"Models of ovarian cancer\u2013are we there yet?","volume":"239","author":"Garson","year":"2005","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.canlet.2018.07.003_bib9","first-page":"2778","article-title":"Spontaneous transformation of rat ovarian surface epithelial cells results in well to poorly differentiated tumors with a parallel range of cytogenetic complexity","volume":"54","author":"Testa","year":"1994","journal-title":"Canc. Res."},{"key":"10.1016\/j.canlet.2018.07.003_bib10","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1093\/carcin\/21.4.585","article-title":"Development of a syngeneic mouse model for events related to ovarian cancer","volume":"21","author":"Roby","year":"2000","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.canlet.2018.07.003_bib11","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3389\/fonc.2014.00053","article-title":"A new spontaneously transformed syngeneic model of high-grade serous ovarian cancer with a tumor-initiating cell population","volume":"4","author":"McCloskey","year":"2014","journal-title":"Front Oncol."},{"key":"10.1016\/j.canlet.2018.07.003_bib12","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3389\/fonc.2015.00154","article-title":"Spontaneous transformation of murine oviductal epithelial cells: a model system to investigate the onset of fallopian-derived tumors","volume":"5","author":"Endsley","year":"2015","journal-title":"Front Oncol."},{"key":"10.1016\/j.canlet.2018.07.003_bib13","first-page":"2615","article-title":"Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue","volume":"54","author":"Huguet","year":"1994","journal-title":"Canc. Res."},{"key":"10.1016\/j.canlet.2018.07.003_bib14","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1158\/1541-7786.MCR-11-0177","article-title":"WNT7A regulates tumor growth and progression in ovarian cancer through the WNT\/beta-catenin pathway","volume":"10","author":"Yoshioka","year":"2012","journal-title":"Mol. Canc. Res. MCR"},{"key":"10.1016\/j.canlet.2018.07.003_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0304-3835(92)90014-M","article-title":"Induction of proliferin gene expression by diverse chemical agents that promote morphological transformation in C3H\/10T1\/2 cultures","volume":"64","author":"Parfett","year":"1992","journal-title":"Canc. Lett."},{"key":"10.1016\/j.canlet.2018.07.003_bib16","doi-asserted-by":"crossref","DOI":"10.1136\/thoraxjnl-2016-209333.13","article-title":"Mouse lung adenocarcinoma cell lines reveal Prl2c2 as a novel lung tumour promoter","volume":"71","author":"Kanellakis","year":"2016","journal-title":"Thorax"},{"key":"10.1016\/j.canlet.2018.07.003_bib17","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1038\/jid.2014.166","article-title":"Regulation of fibulin-2 gene expression by integrin alpha3beta1 contributes to the invasive phenotype of transformed keratinocytes","volume":"134","author":"Missan","year":"2014","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.canlet.2018.07.003_bib18","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/nrendo.2015.36","article-title":"New insights in prolactin: pathological implications","volume":"11","author":"Bernard","year":"2015","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.canlet.2018.07.003_bib19","doi-asserted-by":"crossref","first-page":"5226","DOI":"10.1158\/0008-5472.CAN-08-4652","article-title":"Biological significance of prolactin in gynecologic cancers","volume":"69","author":"Levina","year":"2009","journal-title":"Canc. Res."},{"key":"10.1016\/j.canlet.2018.07.003_bib20","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/471428a","article-title":"Cancer: missing the mark","volume":"471","author":"Buchen","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2018.07.003_bib21","doi-asserted-by":"crossref","first-page":"7547","DOI":"10.1073\/pnas.1017300108","article-title":"Modeling high-grade serous ovarian carcinogenesis from the fallopian tube","volume":"108","author":"Karst","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.canlet.2018.07.003_bib22","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.ygyno.2015.05.040","article-title":"In vivo tumor growth of high-grade serous ovarian cancer cell lines","volume":"138","author":"Mitra","year":"2015","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.canlet.2018.07.003_bib23","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.diff.2012.06.004","article-title":"A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities","volume":"84","author":"Najdi","year":"2012","journal-title":"Differentiation"},{"key":"10.1016\/j.canlet.2018.07.003_bib24","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s13059-016-1012-2","article-title":"Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR","volume":"17","author":"Haeussler","year":"2016","journal-title":"Genome Biol."},{"key":"10.1016\/j.canlet.2018.07.003_bib25","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1126\/science.1231143","article-title":"Multiplex genome engineering using CRISPR\/Cas systems","volume":"339","author":"Cong","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.canlet.2018.07.003_bib26","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1101\/gad.10.8.1008","article-title":"Germ-line passage is required for establishment of methylation and expression patterns of imprinted but not of nonimprinted genes","volume":"10","author":"Tucker","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/j.canlet.2018.07.003_bib27","doi-asserted-by":"crossref","first-page":"69871","DOI":"10.18632\/oncotarget.11499","article-title":"Cadherin-6 type 2, K-cadherin (CDH6) is regulated by mutant p53 in the fallopian tube but is not expressed in the ovarian surface","volume":"7","author":"Karthikeyan","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.canlet.2018.07.003_bib28","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.canlet.2017.01.011","article-title":"Activin A stimulates migration of the fallopian tube epithelium, an origin of high-grade serous ovarian cancer, through non-canonical signaling","volume":"391","author":"Dean","year":"2017","journal-title":"Canc. Lett."},{"key":"10.1016\/j.canlet.2018.07.003_bib29","doi-asserted-by":"crossref","first-page":"43843","DOI":"10.18632\/oncotarget.5983","article-title":"CSIOVDB: a microarray gene expression database of epithelial ovarian cancer subtype","volume":"6","author":"Tan","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.canlet.2018.07.003_bib30","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1002\/emmm.201201823","article-title":"Functional genomics identifies five distinct molecular subtypes with clinical relevance and pathways for growth control in epithelial ovarian cancer","volume":"5","author":"Tan","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.canlet.2018.07.003_bib31","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.15252\/emmm.201404208","article-title":"Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients","volume":"6","author":"Tan","year":"2014","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.canlet.2018.07.003_bib32","doi-asserted-by":"crossref","first-page":"l1","DOI":"10.1126\/scisignal.2004088","article-title":"Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal","volume":"6","author":"Gao","year":"2013","journal-title":"Sci. Signal."},{"key":"10.1016\/j.canlet.2018.07.003_bib33","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data","volume":"2","author":"Cerami","year":"2012","journal-title":"Canc. Discov."},{"key":"10.1016\/j.canlet.2018.07.003_bib34","first-page":"1941","article-title":"PRL-induced ERalpha gene expression is mediated by Janus kinase 2 (Jak2) while signal transducer and activator of transcription 5b (Stat5b) phosphorylation involves Jak2 and a second tyrosine kinase","volume":"15","author":"Frasor","year":"2001","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.canlet.2018.07.003_bib35","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1210\/en.2003-0420","article-title":"Prostaglandin F(2alpha) (PGF(2alpha)) and prolactin signaling: PGF(2alpha)-mediated inhibition of prolactin receptor expression in the Corpus luteum","volume":"144","author":"Stocco","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.canlet.2018.07.003_bib36","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.pharmthera.2017.05.009","article-title":"Prolactin receptor targeting in breast and prostate cancers: new insights into an old challenge","volume":"179","author":"Goffin","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.canlet.2018.07.003_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0189641","article-title":"Diagnostic markers for the detection of ovarian cancer in BRCA1 mutation carriers","volume":"12","author":"Gschwantler-Kaulich","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.canlet.2018.07.003_bib38","doi-asserted-by":"crossref","first-page":"12645","DOI":"10.1038\/ncomms12645","article-title":"Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status","volume":"7","author":"Coscia","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2018.07.003_bib39","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1158\/0008-5472.CAN-16-1454","article-title":"Prolactin receptor-mediated internalization of imaging agents detects epithelial ovarian cancer with enhanced sensitivity and specificity","volume":"77","author":"Sundaram","year":"2017","journal-title":"Canc. Res."},{"key":"10.1016\/j.canlet.2018.07.003_bib40","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.canlet.2016.03.007","article-title":"Prolactin inhibits a major tumor-suppressive function of wild type BRCA1","volume":"375","author":"Chen","year":"2016","journal-title":"Canc. Lett."},{"key":"10.1016\/j.canlet.2018.07.003_bib41","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.stemcr.2017.08.011","article-title":"Prolactin alters the mammary epithelial hierarchy, increasing progenitors and facilitating ovarian steroid action","volume":"9","author":"O'Leary","year":"2017","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.canlet.2018.07.003_bib42","doi-asserted-by":"crossref","first-page":"53015","DOI":"10.1074\/jbc.M410233200","article-title":"Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis","volume":"279","author":"Thompson","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2018.07.003_bib43","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1210\/en.2017-00184","article-title":"Prolactin: the bright and the dark side","volume":"158","author":"Lopez Vicchi","year":"2017","journal-title":"Endocrinology"},{"key":"10.1016\/j.canlet.2018.07.003_bib44","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.cell.2017.05.016","article-title":"Wnt\/beta-Catenin signaling, disease, and emerging therapeutic modalities","volume":"169","author":"Nusse","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2018.07.003_bib45","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.ygyno.2013.09.034","article-title":"The Wnt\/beta-catenin pathway in ovarian cancer: a review","volume":"131","author":"Arend","year":"2013","journal-title":"Gynecol. Oncol."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383518304518?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383518304518?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T06:27:35Z","timestamp":1532500055000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383518304518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":45,"alternative-id":["S0304383518304518"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2018.07.003","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prolactin signaling drives tumorigenesis in human high grade serous ovarian cancer cells and in a spontaneous fallopian tube derived model","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2018.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}