{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T02:13:10Z","timestamp":1784599990165,"version":"3.55.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100010909","name":"Young Scientists Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010909","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772684"],"award-info":[{"award-number":["81772684"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21401072"],"award-info":[{"award-number":["21401072"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.canlet.2018.07.040","type":"journal-article","created":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T22:54:43Z","timestamp":1533336883000},"page":"66-79","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["\u03b2-catenin contributes to cordycepin-induced MGMT inhibition and reduction of temozolomide resistance in glioma cells by increasing intracellular reactive oxygen species"],"prefix":"10.1016","volume":"435","author":[{"given":"Yiming","family":"Bi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dazhuang","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaochu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2018.07.040_bib1","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.171","article-title":"Biological activity of tumor-treating fields in preclinical glioma models","volume":"8","author":"Silginer","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.canlet.2018.07.040_bib2","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa043330","article-title":"Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma","volume":"352","author":"Stupp","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.canlet.2018.07.040_bib3","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1142\/S0192415X08006387","article-title":"Cordycepin is an immunoregulatory active ingredient of Cordyceps sinensis","volume":"36","author":"Zhou","year":"2008","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.canlet.2018.07.040_bib4","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.intimp.2010.09.011","article-title":"Anti-inflammatory effects of cordycepin via suppression of inflammatory mediators in BV2 microglial cells","volume":"10","author":"Jeong","year":"2010","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.canlet.2018.07.040_bib5","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1074\/jbc.M109.071159","article-title":"Cordycepin inhibits protein synthesis and cell adhesion through effects on signal transduction","volume":"285","author":"Wong","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2018.07.040_bib6","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ejphar.2006.11.073","article-title":"Cordycepin (3'-deoxyadenosine) inhibits human platelet aggregation in a cyclic AMP- and cyclic GMP-dependent manner","volume":"558","author":"Cho","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.canlet.2018.07.040_bib7","doi-asserted-by":"crossref","first-page":"4905","DOI":"10.1021\/jf205091b","article-title":"Cordycepin stimulated steroidogenesis in MA-10 mouse Leydig tumor cells through the protein kinase C Pathway","volume":"60","author":"Pao","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.canlet.2018.07.040_bib8","doi-asserted-by":"crossref","first-page":"309","DOI":"10.4014\/jmb.1507.07090","article-title":"Apoptotic effects of cordycepin through the extrinsic pathway and p38 MAPK activation in human glioblastoma U87MG cells","volume":"26","author":"Baik","year":"2016","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1016\/j.canlet.2018.07.040_bib9","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cbi.2014.03.010","article-title":"Cordycepin induces apoptosis of C6 glioma cells through the adenosine 2A receptor-p53-caspase-7-PARP pathway","volume":"216","author":"Chen","year":"2014","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.canlet.2018.07.040_bib10","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.taap.2011.08.030","article-title":"Cordycepin-induced apoptosis and autophagy in breast cancer cells are independent of the estrogen receptor","volume":"257","author":"Choi","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.canlet.2018.07.040_bib11","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1080\/15384101.2014.1000097","article-title":"Cordycepin induces cell cycle arrest and apoptosis by inducing DNA damage and up-regulation of p53 in Leukemia cells","volume":"14","author":"Liao","year":"2015","journal-title":"Cell Cycle"},{"key":"10.1016\/j.canlet.2018.07.040_bib12","doi-asserted-by":"crossref","first-page":"11350","DOI":"10.3390\/molecules190811350","article-title":"Cordycepin induces S phase arrest and apoptosis in human gallbladder cancer cells","volume":"19","author":"Wang","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.canlet.2018.07.040_bib13","first-page":"115","article-title":"Enhanced MGMT expression contributes to temozolomide resistance in glioma stem-like cells","volume":"33","author":"Qiu","year":"2014","journal-title":"Chin. J. Canc."},{"key":"10.1016\/j.canlet.2018.07.040_bib14","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1111\/j.1471-4159.2005.03583.x","article-title":"O6-methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells","volume":"96","author":"Hermisson","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.canlet.2018.07.040_bib15","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1093\/neuonc\/noq032","article-title":"Sensitivity to temozolomide in brain tumor initiating cells","volume":"12","author":"Blough","year":"2010","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.canlet.2018.07.040_bib16","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/neuonc\/nop003","article-title":"O6-Methylguanine DNA methyltransferase protein expression in tumor cells predicts outcome of temozolomide therapy in glioblastoma patients","volume":"12","author":"Spiegl-Kreinecker","year":"2010","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.canlet.2018.07.040_bib17","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1056\/NEJMoa043331","article-title":"MGMT gene silencing and benefit from temozolomide in glioblastoma","volume":"352","author":"Hegi","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.canlet.2018.07.040_bib18","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrc3419","article-title":"WNT signalling pathways as therapeutic targets in cancer","volume":"13","author":"Anastas","year":"2013","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.canlet.2018.07.040_bib19","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1038\/emboj.2012.124","article-title":"Mitotic and mitogenic Wnt signalling","volume":"31","author":"Niehrs","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.canlet.2018.07.040_bib20","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/nature04185","article-title":"A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation","volume":"438","author":"Zeng","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2018.07.040_bib21","doi-asserted-by":"crossref","first-page":"8904","DOI":"10.1038\/ncomms9904","article-title":"Wnt\/beta-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance","volume":"6","author":"Wickstrom","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2018.07.040_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0076320","article-title":"Cordycepin regulates GSK-3beta\/beta-catenin signaling in human leukemia cells","volume":"8","author":"Ko","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.canlet.2018.07.040_bib23","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1158\/0008-5472.CAN-09-1947","article-title":"Drug combination studies and their synergy quantification using the Chou-Talalay method","volume":"70","author":"Chou","year":"2010","journal-title":"Canc. Res."},{"key":"10.1016\/j.canlet.2018.07.040_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1001275","article-title":"Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1","volume":"7","author":"Saha","year":"2011","journal-title":"PLoS Pathogens"},{"key":"10.1016\/j.canlet.2018.07.040_bib25","first-page":"249217","article-title":"Cordyceps militaris grown on germinated soybean induces G2\/M cell cycle arrest through downregulation of cyclin B1 and Cdc25c in human colon cancer HT-29 cells","volume":"2012","author":"Mollah","year":"2012","journal-title":"Evid. base Compl. Alternative Med.: ECAM"},{"key":"10.1016\/j.canlet.2018.07.040_bib26","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1158\/1535-7163.MCT-14-0113","article-title":"Evaluation of novel imidazotetrazine analogues designed to overcome temozolomide resistance and glioblastoma regrowth","volume":"14","author":"Ramirez","year":"2015","journal-title":"Mol. Canc. Therapeut."},{"key":"10.1016\/j.canlet.2018.07.040_bib27","doi-asserted-by":"crossref","first-page":"911","DOI":"10.3892\/ijo.2017.3862","article-title":"Cordycepin induces apoptosis in SGC7901 cells through mitochondrial extrinsic phosphorylation of PI3K\/Akt by generating ROS","volume":"50","author":"Nasser","year":"2017","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.canlet.2018.07.040_bib28","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1158\/1078-0432.CCR-09-3106","article-title":"Survival of patients with newly diagnosed glioblastoma treated with radiation and temozolomide in research studies in the United States","volume":"16","author":"Grossman","year":"2010","journal-title":"Clin. Canc. Res."},{"key":"10.1016\/j.canlet.2018.07.040_bib29","doi-asserted-by":"crossref","first-page":"559","DOI":"10.3892\/ijo.2015.3271","article-title":"Sulforaphane reverses chemo-resistance to temozolomide in glioblastoma cells by NF-kappaB-dependent pathway downregulating MGMT expression","volume":"48","author":"Lan","year":"2016","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.canlet.2018.07.040_bib30","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1158\/1535-7163.MCT-11-0801","article-title":"STAT3 inhibition overcomes temozolomide resistance in glioblastoma by downregulating MGMT expression","volume":"11","author":"Kohsaka","year":"2012","journal-title":"Mol. Canc. Therapeut."},{"key":"10.1016\/j.canlet.2018.07.040_bib31","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/s41419-017-0251-9","article-title":"Fasudil increases temozolomide sensitivity and suppresses temozolomide-resistant glioma growth via inhibiting ROCK2\/ABCG2","volume":"9","author":"Zhang","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.canlet.2018.07.040_bib32","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.canlet.2015.07.007","article-title":"NVP-BEZ235, a novel dual PI3K-mTOR inhibitor displays anti-glioma activity and reduces chemoresistance to temozolomide in human glioma cells","volume":"367","author":"Yu","year":"2015","journal-title":"Canc. Lett."},{"key":"10.1016\/j.canlet.2018.07.040_bib33","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.canlet.2015.02.003","article-title":"miR-603 promotes glioma cell growth via Wnt\/beta-catenin pathway by inhibiting WIF1 and CTNNBIP1","volume":"360","author":"Guo","year":"2015","journal-title":"Canc. Lett."},{"key":"10.1016\/j.canlet.2018.07.040_bib34","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/neuonc\/not194","article-title":"TCTP promotes glioma cell proliferation in vitro and in vivo via enhanced beta-catenin\/TCF-4 transcription","volume":"16","author":"Gu","year":"2014","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.canlet.2018.07.040_bib35","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.388","article-title":"O6-methylguanine DNA methyltransferase as a promising target for the treatment of temozolomide-resistant gliomas","volume":"4","author":"Fan","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.canlet.2018.07.040_bib36","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jns.2016.05.054","article-title":"Akt and beta-catenin contribute to TMZ resistance and EMT of MGMT negative malignant glioma cell line","volume":"367","author":"Yi","year":"2016","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.canlet.2018.07.040_bib37","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1111\/jnc.13174","article-title":"Sulforaphane enhances temozolomide-induced apoptosis because of down-regulation of miR-21 via Wnt\/beta-catenin signaling in glioblastoma","volume":"134","author":"Lan","year":"2015","journal-title":"J. Neurochem."},{"key":"10.1016\/j.canlet.2018.07.040_bib38","doi-asserted-by":"crossref","first-page":"13372","DOI":"10.1038\/srep13372","article-title":"Cordycepin induced MA-10 mouse Leydig tumor cell apoptosis by regulating p38 MAPKs and PI3K\/AKT signaling pathways","volume":"5","author":"Pan","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.canlet.2018.07.040_bib39","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.3892\/ijo.2013.1762","article-title":"Apoptosis induction of human prostate carcinoma cells by cordycepin through reactive oxygen speciesmediated mitochondrial death pathway","volume":"42","author":"Lee","year":"2013","journal-title":"Int. J. Oncol."}],"updated-by":[{"DOI":"10.1016\/j.canlet.2019.06.006","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000}}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383518305044?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383518305044?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T15:41:18Z","timestamp":1759592478000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383518305044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":39,"alternative-id":["S0304383518305044"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2018.07.040","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u03b2-catenin contributes to cordycepin-induced MGMT inhibition and reduction of temozolomide resistance in glioma cells by increasing intracellular reactive oxygen species","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2018.07.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}