{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T13:47:16Z","timestamp":1768571236452,"version":"3.49.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,2,23]],"date-time":"2020-02-23T00:00:00Z","timestamp":1582416000000},"content-version":"am","delay-in-days":298,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000005","name":"DOD","doi-asserted-by":"publisher","award":["W81XWH-14-1-0551"],"award-info":[{"award-number":["W81XWH-14-1-0551"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"P01","doi-asserted-by":"publisher","award":["P01 CA128814-08"],"award-info":[{"award-number":["P01 CA128814-08"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.canlet.2019.02.012","type":"journal-article","created":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T23:24:43Z","timestamp":1550100283000},"page":"145-162","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Identification and characterization of small molecule inhibitors of the ubiquitin ligases Siah1\/2 in melanoma and prostate cancer cells"],"prefix":"10.1016","volume":"449","author":[{"given":"Yongmei","family":"Feng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. Hampton","family":"Sessions","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuqiang","family":"Ban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Placencio-Hickok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen-Ting","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu-Yue","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Pass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David B.","family":"Terry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Cadwell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurie A.","family":"Bankston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert C.","family":"Liddington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas D.Y.","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony B.","family":"Pinkerton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduard","family":"Sergienko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Gleave","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil A.","family":"Bhowmick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artem","family":"Cherkasov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3859-0400","authenticated-orcid":false,"given":"Ze'ev A.","family":"Ronai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2019.02.012_bib1","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.cell.2004.06.001","article-title":"Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia","volume":"117","author":"Nakayama","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2019.02.012_bib2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s12013-013-9636-2","article-title":"Regulators and effectors of Siah ubiquitin ligases","volume":"67","author":"Qi","year":"2013","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.canlet.2019.02.012_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004348","article-title":"Fine tuning of the UPR by the ubiquitin ligases Siah1\/2","volume":"10","author":"Scortegagna","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.canlet.2019.02.012_bib4","doi-asserted-by":"crossref","first-page":"16713","DOI":"10.1073\/pnas.0804063105","article-title":"The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways","volume":"105","author":"Qi","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.canlet.2019.02.012_bib5","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ccr.2010.05.024","article-title":"Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors","volume":"18","author":"Qi","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2019.02.012_bib6","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.ccr.2013.02.016","article-title":"The E3 ubiquitin ligase Siah2 contributes to castration-resistant prostate cancer by regulation of androgen receptor transcriptional activity","volume":"23","author":"Qi","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2019.02.012_bib7","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1038\/onc.2013.149","article-title":"Siah2 regulates tight junction integrity and cell polarity through control of ASPP2 stability","volume":"33","author":"Kim","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2019.02.012_bib8","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/j.1755-148X.2009.00628.x","article-title":"Inhibition of Siah2 ubiquitin ligase by vitamin K3 (menadione) attenuates hypoxia and MAPK signaling and blocks melanoma tumorigenesis","volume":"22","author":"Shah","year":"2009","journal-title":"Pigment Cell Melanoma Res."},{"key":"10.1016\/j.canlet.2019.02.012_bib9","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.chembiol.2013.06.008","article-title":"Structure-based design of covalent Siah inhibitors","volume":"20","author":"Stebbins","year":"2013","journal-title":"Chem. Biol."},{"key":"10.1016\/j.canlet.2019.02.012_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003210","article-title":"A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity","volume":"9","author":"Cloutier","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.canlet.2019.02.012_bib11","doi-asserted-by":"crossref","first-page":"34278","DOI":"10.1074\/jbc.M506707200","article-title":"Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex","volume":"280","author":"Santelli","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2019.02.012_bib12","doi-asserted-by":"crossref","first-page":"8563","DOI":"10.1021\/jm201098n","article-title":"Targeting the binding function 3 (BF3) site of the human androgen receptor through virtual screening","volume":"54","author":"Lack","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.canlet.2019.02.012_bib13","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1021\/acs.jcim.7b00137","article-title":"Best practices of computer-aided drug discovery: lessons learned from the development of a preclinical candidate for prostate cancer with a new mechanism of action","volume":"57","author":"Ban","year":"2017","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.canlet.2019.02.012_bib14","series-title":"Molecular Operating Environment (MOE), Chemical Computing Group ULC","author":"MolecularOperatingEnvironment","year":"2017"},{"key":"10.1016\/j.canlet.2019.02.012_bib15","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1021\/jm030644s","article-title":"Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening","volume":"47","author":"Halgren","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.canlet.2019.02.012_bib16","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.jmgm.2006.06.002","article-title":"eHiTS: a new fast, exhaustive flexible ligand docking system","volume":"26","author":"Zsoldos","year":"2007","journal-title":"J. Mol. Graph. Model."},{"key":"10.1016\/j.canlet.2019.02.012_bib17","doi-asserted-by":"crossref","first-page":"4924","DOI":"10.1038\/onc.2013.431","article-title":"A reciprocal role of prostate cancer on stromal DNA damage","volume":"33","author":"Banerjee","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2019.02.012_bib18","doi-asserted-by":"crossref","first-page":"379","DOI":"10.18632\/oncotarget.171","article-title":"The Siah2-HIF-FoxA2 axis in prostate cancer - new markers and therapeutic opportunities","volume":"1","author":"Qi","year":"2010","journal-title":"Oncotarget"},{"key":"10.1016\/j.canlet.2019.02.012_bib19","series-title":"Assay Guidance Manual, Bethesda (MD)","article-title":"Screening for target engagement using the cellular thermal shift assay - CETSA","author":"Axelsson","year":"2004"},{"key":"10.1016\/j.canlet.2019.02.012_bib20","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/ijc.11410","article-title":"The synthetic retinoid adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro","volume":"107","author":"Ocker","year":"2003","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.canlet.2019.02.012_bib21","doi-asserted-by":"crossref","first-page":"6501","DOI":"10.3892\/mmr.2015.4310","article-title":"Adapalene inhibits the activity of cyclin-dependent kinase 2 in colorectal carcinoma","volume":"12","author":"Shi","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.canlet.2019.02.012_bib22","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.canlet.2003.12.026","article-title":"Potentiated anticancer effects on hepatoma cells by the retinoid adapalene","volume":"208","author":"Ocker","year":"2004","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2019.02.012_bib23","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nchembio.2082","article-title":"The antitumor toxin CD437 is a direct inhibitor of DNA polymerase alpha","volume":"12","author":"Han","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.canlet.2019.02.012_bib24","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nsb743","article-title":"Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling","volume":"9","author":"Polekhina","year":"2002","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.canlet.2019.02.012_bib25","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1016\/j.bbagen.2016.10.019","article-title":"The substrate binding domains of human SIAH E3 ubiquitin ligases are now crystal clear","volume":"1861","author":"Zhang","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.canlet.2019.02.012_bib26","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0092-8674(00)80506-1","article-title":"PHYL acts to down-regulate TTK88, a transcriptional repressor of neuronal cell fates, by a SINA-dependent mechanism","volume":"90","author":"Tang","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2019.02.012_bib27","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1101\/gad.13.8.954","article-title":"Ebi regulates epidermal growth factor receptor signaling pathways in Drosophila","volume":"13","author":"Dong","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.canlet.2019.02.012_bib28","doi-asserted-by":"crossref","first-page":"5376","DOI":"10.1093\/emboj\/19.20.5376","article-title":"A role for Ebi in neuronal cell cycle control","volume":"19","author":"Boulton","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.canlet.2019.02.012_bib29","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1073\/pnas.0534783100","article-title":"A binding motif for Siah ubiquitin ligase","volume":"100","author":"House","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.canlet.2019.02.012_bib30","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nrc3120","article-title":"RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis","volume":"11","author":"Lipkowitz","year":"2011","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.canlet.2019.02.012_bib31","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1158\/0008-5472.CAN-12-4348","article-title":"Siah: a promising anticancer target","volume":"73","author":"Wong","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2019.02.012_bib32","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1128\/MCB.05790-11","article-title":"Identification of a Src tyrosine kinase\/SIAH2 E3 ubiquitin ligase pathway that regulates C\/EBPdelta expression and contributes to transformation of breast tumor cells","volume":"32","author":"Sarkar","year":"2012","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.canlet.2019.02.012_bib33","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1158\/0008-5472.CAN-11-3310","article-title":"Vascular normalization by loss of Siah2 results in increased chemotherapeutic efficacy","volume":"72","author":"Wong","year":"2012","journal-title":"Cancer Res."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383519300849?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383519300849?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T15:42:24Z","timestamp":1759592544000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383519300849"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":33,"alternative-id":["S0304383519300849"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2019.02.012","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification and characterization of small molecule inhibitors of the ubiquitin ligases Siah1\/2 in melanoma and prostate cancer cells","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2019.02.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}