{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T11:52:29Z","timestamp":1787140349747,"version":"build-2736575974"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Italian Association for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"name":"AIRCS","award":["IG15232"],"award-info":[{"award-number":["IG15232"]}]},{"name":"AIRCS","award":["IG21408"],"award-info":[{"award-number":["IG21408"]}]},{"DOI":"10.13039\/501100003407","name":"Italian Ministry of University and Research","doi-asserted-by":"publisher","award":["RBFR12SOQ1"],"award-info":[{"award-number":["RBFR12SOQ1"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Italian Ministry of University and Research","doi-asserted-by":"publisher","award":["FARB2017"],"award-info":[{"award-number":["FARB2017"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Italian Ministry for University and Research (MIUR)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Torino"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.canlet.2019.04.029","type":"journal-article","created":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T20:27:13Z","timestamp":1556569633000},"page":"29-39","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"special_numbering":"C","title":["Hyaluronated liposomes containing H2S-releasing doxorubicin are effective against P-glycoprotein-positive\/doxorubicin-resistant osteosarcoma cells and xenografts"],"prefix":"10.1016","volume":"456","author":[{"given":"Elena","family":"Gazzano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Buondonno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Marengo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Rolando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Chegaev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Kopecka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Saponara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Sorge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9316-5095","authenticated-orcid":false,"given":"Claudia Maria","family":"Hattinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Gasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Fruttero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Brancaccio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Serra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Stella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3194-961X","authenticated-orcid":false,"given":"Elias","family":"Fattal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4754-6591","authenticated-orcid":false,"given":"Silvia","family":"Arpicco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9787-4836","authenticated-orcid":false,"given":"Chiara","family":"Riganti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2019.04.029_bib1","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1517\/14656566.2015.1102226","article-title":"An update on chemotherapy for osteosarcoma","volume":"16","author":"Ferrari","year":"2015","journal-title":"Expert Opin. Pharmacother."},{"key":"10.1016\/j.canlet.2019.04.029_bib2","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1517\/14728214.2015.1051965","article-title":"Advances in emerging drugs for osteosarcoma","volume":"20","author":"Hattinger","year":"2015","journal-title":"Expert Opin. Emerg. Drugs"},{"key":"10.1016\/j.canlet.2019.04.029_bib3","doi-asserted-by":"crossref","first-page":"673","DOI":"10.2217\/fon-2016-0519","article-title":"Doxorubicin-resistant osteosarcoma: novel therapeutic approaches in sight?","volume":"13","author":"Hattinger","year":"2017","journal-title":"Future Oncol."},{"key":"10.1016\/j.canlet.2019.04.029_bib4","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nrc706","article-title":"Multidrug resistance in cancer: role of ATP-dependent transporters","volume":"2","author":"Gottesman","year":"2002","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.canlet.2019.04.029_bib5","doi-asserted-by":"crossref","first-page":"261","DOI":"10.2174\/1568009616666151106120434","article-title":"Targeting ABCB1 and ABCC1 with their Specific Inhibitor CBT-1\u00ae can overcome drug resistance in osteosarcoma","volume":"16","author":"Fanelli","year":"2016","journal-title":"Curr. Cancer Drug Targets"},{"key":"10.1016\/j.canlet.2019.04.029_bib6","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1056\/NEJM199511233332103","article-title":"Expression of P-glycoprotein in high-grade osteosarcomas in relation to clinical outcome","volume":"23","author":"Baldini","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.canlet.2019.04.029_bib7","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1093\/jnci\/89.22.1706","article-title":"P-glycoprotein expression: critical determinant in the response to osteosarcoma chemotherapy","volume":"19","author":"Chan","year":"1997","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.canlet.2019.04.029_bib8","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/cncr.11546","article-title":"The association of P-glycoprotein with response to chemotherapy and clinical outcome in patients with osteosarcoma. A meta-analysis","volume":"98","author":"Pakos","year":"2003","journal-title":"Cancer"},{"key":"10.1016\/j.canlet.2019.04.029_bib9","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1200\/JCO.2003.03.144","article-title":"Value of P-glycoprotein and clinicopathologic factors as the basis for new treatment strategies in high-grade osteosarcoma of the extremities","volume":"21","author":"Serra","year":"2003","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.canlet.2019.04.029_bib10","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/HCO.0000000000000034","article-title":"Anthracycline-related cardiotoxicity in childhood cancer survivors","volume":"29","author":"Lipshultz","year":"2014","journal-title":"Curr. Opin. Cardiol."},{"key":"10.1016\/j.canlet.2019.04.029_bib11","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1081\/CNV-120016412","article-title":"Phase II trial of pegylated-liposomal doxorubicin (Doxil) in sarcoma","volume":"21","author":"Skubitz","year":"2003","journal-title":"Canc. Invest."},{"key":"10.1016\/j.canlet.2019.04.029_bib12","first-page":"543","article-title":"Non-pegylated liposomal doxorubicin plus ifosfamide in metastatic soft tissue sarcoma: results from a phase-II trial","volume":"35","author":"De Sanctis","year":"2015","journal-title":"Anticancer Res."},{"key":"10.1016\/j.canlet.2019.04.029_bib13","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.drup.2016.10.003","article-title":"New insights and evolving role of Pegylated liposomal doxorubicin in cancer therapy","volume":"29","author":"Gabizon","year":"2016","journal-title":"Drug Resist. Updates"},{"key":"10.1016\/j.canlet.2019.04.029_bib14","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jconrel.2017.11.042","article-title":"Folate-targeted liposomal nitrooxy-doxorubicin: an effective tool against P-glycoprotein-positive and folate receptor-positive tumors","volume":"270","author":"Gazzano","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.canlet.2019.04.029_bib15","doi-asserted-by":"crossref","first-page":"4881","DOI":"10.1021\/acs.jmedchem.6b00184","article-title":"H2S-donating doxorubicins may overcome cardiotoxicity and multidrug resistance","volume":"59","author":"Chegaev","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.canlet.2019.04.029_bib16","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s00018-018-2967-9","article-title":"Endoplasmic reticulum-targeting doxorubicin: a new tool effective against doxorubicin-resistant osteosarcoma","volume":"76","author":"Buondonno","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.canlet.2019.04.029_bib17","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s10637-018-0590-0","article-title":"New NO- and H2S-releasing doxorubicins as targeted therapy against chemoresistance in castration-resistant prostate cancer: in vitro and in vivo evaluations","volume":"36","author":"Bigagli","year":"2018","journal-title":"Investig. New Drugs"},{"key":"10.1016\/j.canlet.2019.04.029_bib18","doi-asserted-by":"crossref","first-page":"e213","DOI":"10.1097\/MPH.0b013e3181e5e247","article-title":"Immunoexpression of Ezrin and CD44 in patients with osteosarcoma","volume":"32","author":"Boldrini","year":"2010","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"10.1016\/j.canlet.2019.04.029_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0060329","article-title":"Silencing of CD44 gene expression in human 143-B osteosarcoma cells promotes metastasis of intratibial tumors in SCID mice","volume":"8","author":"Gvozdenovic","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.canlet.2019.04.029_bib20","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1002\/jbmr.1817","article-title":"CD44 enhances tumor formation and lung metastasis in experimental osteosarcoma and is an additional predictor for poor patient outcome","volume":"28","author":"Gvozdenovic","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.canlet.2019.04.029_bib21","article-title":"CD44 is a direct target of miR-199a-3p and contributes to aggressive progression in osteosarcoma","volume":"5","author":"Gao","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.canlet.2019.04.029_bib22","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1159\/000489072","article-title":"CRISPR-Cas9-mediated silencing of CD44 in human highly metastatic osteosarcoma cells","volume":"4","author":"Liu","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.canlet.2019.04.029_bib23","doi-asserted-by":"crossref","first-page":"114095","DOI":"10.18632\/oncotarget.23125","article-title":"CD44 drives aggressiveness and chemoresistance of a metastatic human osteosarcoma xenograft model","volume":"8","author":"Mayr","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.canlet.2019.04.029_bib24","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.ejpb.2013.06.003","article-title":"Hyaluronic acid-coated liposomes for active targeting of gemcitabine","volume":"85","author":"Arpicco","year":"2013","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.canlet.2019.04.029_bib25","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S0021-9258(18)70226-3","article-title":"Phosphorus assay in column chromatography","volume":"234","author":"Bartlett","year":"1959","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2019.04.029_bib26","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1021\/mp500257s","article-title":"Liposomal nitrooxy-doxorubicin: one step over Caelyx\u00ae in drug-resistant human cancer cells","volume":"11","author":"Pedrini","year":"2014","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.canlet.2019.04.029_bib27","first-page":"323","article-title":"Establishment and characterization of multidrug-resistant human osteosarcoma cell lines","volume":"13","author":"Serra","year":"1993","journal-title":"Anticancer Res."},{"key":"10.1016\/j.canlet.2019.04.029_bib28","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1158\/0008-5472.516.65.2","article-title":"Nitric oxide reverts the resistance to doxorubicin in human colon cancer cells by inhibiting the drug efflux","volume":"65","author":"Riganti","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2019.04.029_bib29","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1021\/mp300311b","article-title":"Mitochondrial-targeting nitrooxy-doxorubicin: a new approach to overcome drug resistance","volume":"10","author":"Riganti","year":"2013","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.canlet.2019.04.029_bib30","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1161\/01.RES.0000168028.36081.e0","article-title":"Cardiac overexpression of melusin protects from dilated cardiomyopathy due to long-standing pressure overload","volume":"27","author":"De Acetis","year":"2005","journal-title":"Circ. Res."},{"key":"10.1016\/j.canlet.2019.04.029_bib31","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.molcel.2011.10.021","article-title":"Hydrogen sulfide-linked sulfhydration of NF-\u03baB mediates its antiapoptotic actions","volume":"45","author":"Sen","year":"2012","journal-title":"Mol. Cell."},{"key":"10.1016\/j.canlet.2019.04.029_bib32","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.nano.2013.06.013","article-title":"Insights in the chemical components of liposomes responsible for P-glycoprotein inhibition","volume":"10","author":"Kopecka","year":"2014","journal-title":"Nanomedicine"},{"key":"10.1016\/j.canlet.2019.04.029_bib33","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nrm3270","article-title":"The unfolded protein response: controlling cell fate decisions under ER stress and beyond","volume":"13","author":"Hetz","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.canlet.2019.04.029_bib34","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1158\/2159-8290.CD-14-1490","article-title":"Endoplasmic reticulum stress-activated cell reprogramming in oncogenesis","volume":"5","author":"Chevet","year":"2015","journal-title":"Cancer Discov."},{"key":"10.1016\/j.canlet.2019.04.029_bib35","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.ceb.2012.07.001","article-title":"Extracellular matrix, integrins, and growth factors as tailors of the stem cell niche","volume":"24","author":"Brizzi","year":"2012","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.canlet.2019.04.029_bib36","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/126906","article-title":"Enhanced growth inhibition of osteosarcoma by cytotoxic polymerized liposomal nanoparticles targeting the alcam cell surface receptor","volume":"2012","author":"Federman","year":"2012","journal-title":"Sarcoma"},{"key":"10.1016\/j.canlet.2019.04.029_bib37","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/sj.bjc.6602626","article-title":"Hyaluronidase induces a transcapillary pressure gradient and improves the distribution and uptake of liposomal doxorubicin (Caelyx) in human osteosarcoma xenografts","volume":"93","author":"Eikenes","year":"2005","journal-title":"Br. J. Canc."},{"key":"10.1016\/j.canlet.2019.04.029_bib38","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s10544-011-9626-3","article-title":"Methylene diphosphonate-conjugated adriamycin liposomes: preparation, characteristics, and targeted therapy for osteosarcomas in vitro and in vivo","volume":"14","author":"Wu","year":"2012","journal-title":"Biomed. Microdevices"},{"key":"10.1016\/j.canlet.2019.04.029_bib39","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1007\/s11095-017-2272-6","article-title":"EphA2 Targeted doxorubicin-nanoliposomes for osteosarcoma treatment","volume":"34","author":"Haghiralsadat","year":"2017","journal-title":"Pharm. Res. (N. Y.)"},{"key":"10.1016\/j.canlet.2019.04.029_bib40","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/cbdd.12953","article-title":"New liposomal doxorubicin nanoformulation for osteosarcoma: drug release kinetic study based on thermo and pH sensitivity","volume":"90","author":"Haghiralsadat","year":"2017","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.canlet.2019.04.029_bib41","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jconrel.2017.06.027","article-title":"Redox-sensitive and hyaluronic acid functionalized liposomes for cytoplasmic drug delivery to osteosarcoma in animal models","volume":"261","author":"Chi","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.canlet.2019.04.029_bib42","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djv046","article-title":"The role of C\/EBP-\u03b2 LIP in multidrug resistance","volume":"107","author":"Riganti","year":"2015","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.canlet.2019.04.029_bib43","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.lungcan.2018.03.022","article-title":"Loss of C\/EBP-\u03b2 LIP drives cisplatin resistance in malignant pleural mesothelioma","volume":"120","author":"Kopecka","year":"2018","journal-title":"Lung Canc."},{"key":"10.1016\/j.canlet.2019.04.029_bib44","doi-asserted-by":"crossref","first-page":"7260","DOI":"10.1074\/jbc.M509868200","article-title":"Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53","volume":"281","author":"Li","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2019.04.029_bib45","doi-asserted-by":"crossref","first-page":"G236","DOI":"10.1152\/ajpgi.00091.2010","article-title":"CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosis","volume":"299","author":"Cazanave","year":"2010","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.canlet.2019.04.029_bib46","doi-asserted-by":"crossref","DOI":"10.1186\/s13046-018-0967-0","article-title":"Increasing intratumor C\/EBP-\u03b2 LIP and nitric oxide levels overcome resistance to doxorubicin in triple negative breast cancer","author":"Salaroglio","year":"2018","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2019.04.029_bib47","doi-asserted-by":"crossref","first-page":"3722","DOI":"10.1128\/MCB.01507-09","article-title":"Molecular symbiosis of chop and c\/ebp beta isoform lip contributes to endoplasmic reticulum stress-induced apoptosis","volume":"30","author":"Chiribau","year":"2010","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.canlet.2019.04.029_bib48","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1146\/annurev-pharmtox-010510-100505","article-title":"Hydrogen sulfide and cell signaling","volume":"51","author":"Li","year":"2011","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.canlet.2019.04.029_bib49","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20140062","article-title":"Directed evolution of P-glycoprotein cysteines reveals site-specific, non-conservative substitutions that preserve multidrug resistance","volume":"34","author":"Swartz","year":"2014","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.canlet.2019.04.029_bib50","article-title":"Equilibrated atomic models of outward-facing P-glycoprotein and effect of ATP binding on structural dynamics","volume":"5","author":"Pan","year":"2015","journal-title":"Sci. Rep."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383519302666?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383519302666?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T15:43:22Z","timestamp":1759592602000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383519302666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":50,"alternative-id":["S0304383519302666"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2019.04.029","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hyaluronated liposomes containing H2S-releasing doxorubicin are effective against P-glycoprotein-positive\/doxorubicin-resistant osteosarcoma cells and xenografts","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2019.04.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}