{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T08:41:58Z","timestamp":1789202518251,"version":"build-2803163510"},"reference-count":186,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.canlet.2019.06.001","type":"journal-article","created":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T06:20:16Z","timestamp":1559802016000},"page":"72-85","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"special_numbering":"C","title":["Modulation of regulatory T cells by natural products in cancer"],"prefix":"10.1016","volume":"459","author":[{"given":"Afsane","family":"Bahrami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Fereidouni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Pirro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Bianconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2019.06.001_bib1","doi-asserted-by":"crossref","first-page":"18538","DOI":"10.1073\/pnas.0509182102","article-title":"Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+\/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer","volume":"102","author":"Sato","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.canlet.2019.06.001_bib2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1023\/A:1022951824806","article-title":"Reversal of tumor-induced immunosuppression by TGF-\u03b2 inhibitors","volume":"21","author":"Wojtowicz-Praga","year":"2003","journal-title":"Investig. New Drugs"},{"key":"10.1016\/j.canlet.2019.06.001_bib3","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.immuni.2011.08.012","article-title":"An essential role of the transcription factor GATA-3 for the function of regulatory T cells","volume":"35","author":"Wang","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.canlet.2019.06.001_bib4","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1365-2249.2011.04496.x","article-title":"Cytokine profile and induction of T helper type 17 and regulatory T cells by human peripheral mononuclear cells after microbial exposure","volume":"167","author":"Donkor","year":"2012","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.canlet.2019.06.001_bib5","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.pharmthera.2018.12.004","article-title":"Targeting indoleamine-2,3-dioxygenase in cancer: scientific rationale and clinical evidence","volume":"196","author":"Ricciuti","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.canlet.2019.06.001_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetimm.2016.06.006","article-title":"Intratumoral FoxP3 expression is associated with angiogenesis and prognosis in malignant canine mammary tumors","volume":"178","author":"Carvalho","year":"2016","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.canlet.2019.06.001_bib7","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.semcancer.2017.11.005","article-title":"Enzymes involved in tumor-driven angiogenesis: a valuable target for anticancer therapy","volume":"56","author":"Ricciuti","year":"2019","journal-title":"Semin. Canc. Biol."},{"key":"10.1016\/j.canlet.2019.06.001_bib8","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nrc3239","article-title":"The blockade of immune checkpoints in cancer immunotherapy","volume":"12","author":"Pardoll","year":"2012","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.canlet.2019.06.001_bib9","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1055\/s-0030-1249859","article-title":"Anti-inflammatory plant natural products for cancer therapy","volume":"76","author":"Aravindaram","year":"2010","journal-title":"Planta Med."},{"key":"10.1016\/j.canlet.2019.06.001_bib10","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nri1806","article-title":"Regulatory T cells, tumour immunity and immunotherapy","volume":"6","author":"Zou","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.canlet.2019.06.001_bib11","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1093\/intimm\/dxh165","article-title":"Crucial role of FOXP3 in the development and function of human CD25+ CD4+ regulatory T cells","volume":"16","author":"Yagi","year":"2004","journal-title":"Int. Immunol."},{"key":"10.1016\/j.canlet.2019.06.001_bib12","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.immuni.2011.03.029","article-title":"A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity","volume":"35","author":"Haribhai","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.canlet.2019.06.001_bib13","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1093\/intimm\/10.12.1969","article-title":"Immunologic self-tolerance maintained by CD25+ CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic\/suppressive state","volume":"10","author":"Takahashi","year":"1998","journal-title":"Int. Immunol."},{"key":"10.1016\/j.canlet.2019.06.001_bib14","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1084\/jem.192.2.303","article-title":"Immunologic self-tolerance maintained by CD25+ CD4+ regulatory T cells constitutively expressing cytotoxic T lymphocyte\u2013associated antigen 4","volume":"192","author":"Takahashi","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.canlet.2019.06.001_bib15","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1182\/blood-2004-07-2959","article-title":"Triggering of OX40 (CD134) on CD4+ CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR","volume":"105","author":"Valzasina","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.canlet.2019.06.001_bib16","doi-asserted-by":"crossref","first-page":"3580","DOI":"10.4049\/jimmunol.172.6.3580","article-title":"Distinct roles for the OX40-OX40 ligand interaction in regulatory and nonregulatory T cells","volume":"172","author":"Takeda","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.canlet.2019.06.001_bib17","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.immuni.2009.05.002","article-title":"Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor?","volume":"30","author":"de Lafaille","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.canlet.2019.06.001_bib18","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.2741\/2775","article-title":"Factors regulating apoptosis and homeostasis of CD4+ CD25 (high) FOXP3+ regulatory T cells are new therapeutic targets","volume":"13","author":"Yang","year":"2008","journal-title":"Front. Biosci.: J. Vis. Lit."},{"key":"10.1016\/j.canlet.2019.06.001_bib19","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/ni1455","article-title":"Foxp3 in control of the regulatory T cell lineage","volume":"8","author":"Zheng","year":"2007","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.canlet.2019.06.001_bib20","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.intimp.2010.11.024","article-title":"Plasticity of Treg cells: is reprogramming of Treg cells possible in the presence of FOXP3?","volume":"11","author":"Beyer","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.canlet.2019.06.001_bib21","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1215\/15228517-2007-010","article-title":"Inhibiting TGF-\u03b2 signaling restores immune surveillance in the SMA-560 glioma model","volume":"9","author":"Tran","year":"2007","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.canlet.2019.06.001_bib22","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/MOH.0000000000000389","article-title":"The regulation and importance of monocyte chemoattractant protein-1","volume":"25","author":"Bianconi","year":"2018","journal-title":"Curr. Opin. Hematol."},{"key":"10.1016\/j.canlet.2019.06.001_bib23","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1016\/j.febslet.2006.04.033","article-title":"The logic of TGF\u03b2 signaling","volume":"580","author":"Massagu\u00e9","year":"2006","journal-title":"FEBS Lett."},{"key":"10.1016\/j.canlet.2019.06.001_bib24","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1196\/annals.1375.031","article-title":"Upregulation of Foxp3 expression in mouse and human Treg is IL\u20102\/STAT5 dependent","volume":"1079","author":"Murawski","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.canlet.2019.06.001_bib25","doi-asserted-by":"crossref","first-page":"5373","DOI":"10.1200\/JCO.2006.05.9584","article-title":"Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse","volume":"24","author":"Bates","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.canlet.2019.06.001_bib26","first-page":"2017","article-title":"Expression and clinical significance of cancer stem cell markers CD24, CD44, and CD133 in pancreatic ductal adenocarcinoma and chronic pancreatitis","author":"Durko","year":"2017","journal-title":"Dis. Markers"},{"key":"10.1016\/j.canlet.2019.06.001_bib27","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/hed.24595","article-title":"Inflammation\u2010induced myeloid\u2010derived suppressor cells associated with squamous cell carcinoma of the head and neck","volume":"39","author":"Chen","year":"2017","journal-title":"Head Neck"},{"key":"10.1016\/j.canlet.2019.06.001_bib28","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1080\/08820139.2016.1194428","article-title":"Role of tregs in cancer dormancy or recurrence","volume":"45","author":"Manjili","year":"2016","journal-title":"Immunol. Investig."},{"key":"10.1016\/j.canlet.2019.06.001_bib29","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.4049\/jimmunol.169.5.2756","article-title":"Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma","volume":"169","author":"Liyanage","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.canlet.2019.06.001_bib30","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1182\/blood-2006-02-002774","article-title":"Regulatory T cells in cancer","volume":"108","author":"Beyer","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.canlet.2019.06.001_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/nrc3245","article-title":"The immune contexture in human tumours: impact on clinical outcome","volume":"12","author":"Fridman","year":"2012","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.canlet.2019.06.001_bib32","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/cr.2016.151","article-title":"Regulatory T cells in cancer immunotherapy","volume":"27","author":"Tanaka","year":"2017","journal-title":"Cell Res."},{"key":"10.1016\/j.canlet.2019.06.001_bib33","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/ajcn\/79.5.727","article-title":"Polyphenols: food sources and bioavailability","volume":"79","author":"Manach","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.canlet.2019.06.001_bib34","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1039\/b802662a","article-title":"Dietary phenolics: chemistry, bioavailability and effects on health","volume":"26","author":"Crozier","year":"2009","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.canlet.2019.06.001_bib35","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ejphar.2006.06.025","article-title":"Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: a review of their intracellular targets","volume":"545","author":"Ramassamy","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.canlet.2019.06.001_bib36","doi-asserted-by":"crossref","first-page":"9236","DOI":"10.3390\/ijms16059236","article-title":"In vitro and in vivo antitumoral effects of combinations of polyphenols, or polyphenols and anticancer drugs: perspectives on cancer treatment","volume":"16","author":"Fantini","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.canlet.2019.06.001_bib37","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3390\/nu8080515","article-title":"Natural polyphenols for prevention and treatment of cancer","volume":"8","author":"Zhou","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.canlet.2019.06.001_bib38","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/nrc1189","article-title":"Cancer chemoprevention with dietary phytochemicals","volume":"3","author":"Surh","year":"2003","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.canlet.2019.06.001_bib39","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1177\/039463201302600111","article-title":"Regulatory T-cell modulation by green tea in chronic lymphocytic leukemia","volume":"26","author":"D'arena","year":"2013","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.canlet.2019.06.001_bib40","series-title":"Therapeutic Potential of Curcumin in Diabetic Complications","author":"Parsamanesh","year":"2018"},{"key":"10.1016\/j.canlet.2019.06.001_bib41","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1097\/CEJ.0b013e32832c389e","article-title":"Cancer chemopreventive activity of the prenylated coumarin, umbelliprenin, in vivo","volume":"18","author":"Iranshahi","year":"2009","journal-title":"Eur. J. Cancer Prev."},{"key":"10.1016\/j.canlet.2019.06.001_bib42","doi-asserted-by":"crossref","first-page":"4386","DOI":"10.2174\/1381612822666160527113501","article-title":"Difluorinated curcumin: a promising curcumin analogue with improved anti-tumor activity and pharmacokinetic profile","volume":"22","author":"Momtazi","year":"2016","journal-title":"Curr. Pharmaceut. Des."},{"key":"10.1016\/j.canlet.2019.06.001_bib43","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s10787-016-0301-4","article-title":"Antioxidant effects of curcuminoids in patients with type 2 diabetes mellitus: a randomized controlled trial","volume":"25","author":"Panahi","year":"2017","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.canlet.2019.06.001_bib44","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.jff.2015.01.005","article-title":"Effect of curcuminoids on oxidative stress: a systematic review and meta-analysis of randomized controlled trials","volume":"18","author":"Sahebkar","year":"2015","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.canlet.2019.06.001_bib45","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.3390\/molecules20022728","article-title":"The multifaceted role of curcumin in cancer prevention and treatment","volume":"20","author":"Shanmugam","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.canlet.2019.06.001_bib46","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1258\/acb.2012.012040","article-title":"A randomized controlled trial on the anti-inflammatory effects of curcumin in patients with chronic sulphur mustard-induced cutaneous complications","volume":"49","author":"Panahi","year":"2012","journal-title":"Ann. Clin. Biochem."},{"key":"10.1016\/j.canlet.2019.06.001_bib47","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.clnu.2014.12.019","article-title":"Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: a randomized controlled trial and an updated meta-analysis","volume":"34","author":"Panahi","year":"2015","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.canlet.2019.06.001_bib48","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/ptr.5211","article-title":"Investigation of the efficacy of adjunctive therapy with bioavailability\u2010boosted curcuminoids in major depressive disorder","volume":"29","author":"Panahi","year":"2015","journal-title":"Phytother Res."},{"key":"10.1016\/j.canlet.2019.06.001_bib49","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.phrs.2016.11.017","article-title":"Curcumin use in pulmonary diseases: state of the art and future perspectives","volume":"115","author":"Lelli","year":"2017","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.canlet.2019.06.001_bib50","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.26538","article-title":"Phytosomal curcumin inhibits tumor growth in colitis\u2010associated colorectal cancer","author":"Marjaneh","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.canlet.2019.06.001_bib51","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.cytogfr.2016.10.001","article-title":"Curcumin as a natural regulator of monocyte chemoattractant protein-1","volume":"33","author":"Karimian","year":"2017","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.canlet.2019.06.001_bib52","first-page":"1","article-title":"Curcumin as a MicroRNA regulator in cancer: a review, reviews of physiology","author":"Momtazi","year":"2016","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.canlet.2019.06.001_bib53","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.phrs.2016.03.026","article-title":"Curcumin downregulates human tumor necrosis factor-\u03b1 levels: a systematic review and meta-analysis of randomized controlled trials","volume":"107","author":"Sahebkar","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.canlet.2019.06.001_bib54","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.autrev.2017.11.016","article-title":"Curcumin: a natural modulator of immune cells in systemic lupus erythematosus","volume":"17","author":"Momtazi-Borojeni","year":"2018","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.canlet.2019.06.001_bib55","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1002\/jcp.25778","article-title":"Therapeutic effects of curcumin in inflammatory and immune-mediated diseases: a nature-made jack-of-all-trades?","volume":"233","author":"Abdollahi","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.canlet.2019.06.001_bib56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jnutbio.2018.12.005","article-title":"Macrophage plasticity, polarization and function in response to curcumin, a diet-derived polyphenol, as an immunomodulatory agent","volume":"66","author":"Mohammadi","year":"2019","journal-title":"JNB (J. Nutr. Biochem.)"},{"key":"10.1016\/j.canlet.2019.06.001_bib57","first-page":"20","article-title":"Clinical utility of curcumin extract","volume":"19","author":"Asher","year":"2013","journal-title":"Altern. Ther. Health Med."},{"key":"10.1016\/j.canlet.2019.06.001_bib58","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1472-6882-6-10","article-title":"Dose escalation of a curcuminoid formulation","volume":"6","author":"Lao","year":"2006","journal-title":"BMC Complement Altern. Med."},{"key":"10.1016\/j.canlet.2019.06.001_bib59","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.intimp.2012.06.016","article-title":"Curcumin inhibits suppressive capacity of naturally occurring CD4+ CD25+ regulatory T cells in mice in vitro","volume":"14","author":"Zhao","year":"2012","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.canlet.2019.06.001_bib60","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.archoralbio.2018.04.015","article-title":"Curcumin enhances anti-tumor immune response in tongue squamous cell carcinoma","volume":"92","author":"Liao","year":"2018","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.canlet.2019.06.001_bib61","first-page":"1866","article-title":"Curcumin up regulates T helper 1 cells in patients with colon cancer","volume":"9","author":"Xu","year":"2017","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.canlet.2019.06.001_bib62","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1002\/jcb.26302","article-title":"Curcumin converts Foxp3+ regulatory T cells to T helper 1 cells in patients with lung cancer","volume":"119","author":"Zou","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.canlet.2019.06.001_bib63","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/cmi.2010.11","article-title":"Curcumin reverses T cell-mediated adaptive immune dysfunctions in tumor-bearing hosts","volume":"7","author":"Bhattacharyya","year":"2010","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.canlet.2019.06.001_bib64","doi-asserted-by":"crossref","first-page":"856","DOI":"10.15252\/embj.201490784","article-title":"Autophagy in malignant transformation and cancer progression","volume":"34","author":"Galluzzi","year":"2015","journal-title":"EMBO J."},{"key":"10.1016\/j.canlet.2019.06.001_bib65","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2017.1356151","article-title":"Chloroquine supplementation increases the cytotoxic effect of curcumin against Her2\/neu overexpressing breast cancer cells in vitro and in vivo in nude mice while counteracts it in immune competent mice","volume":"6","author":"Masuelli","year":"2017","journal-title":"OncoImmunology"},{"key":"10.1016\/j.canlet.2019.06.001_bib66","doi-asserted-by":"crossref","first-page":"3636","DOI":"10.1021\/nn500216y","article-title":"Nanoparticle-delivered transforming growth factor-\u03b2 siRNA enhances vaccination against advanced melanoma by modifying tumor microenvironment","volume":"8","author":"Xu","year":"2014","journal-title":"ACS Nano"},{"key":"10.1016\/j.canlet.2019.06.001_bib67","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/mt.2015.165","article-title":"Curcumin micelles remodel tumor microenvironment and enhance vaccine activity in an advanced melanoma model","volume":"24","author":"Lu","year":"2016","journal-title":"Mol. Ther."},{"key":"10.1016\/j.canlet.2019.06.001_bib68","series-title":"Resveratrol for Breast Cancer Prevention and Therapy: Preclinical Evidence and Molecular Mechanisms, Seminars in Cancer Biology","first-page":"209","author":"Sinha","year":"2016"},{"key":"10.1016\/j.canlet.2019.06.001_bib69","series-title":"Resveratrol as an Anti-cancer Agent: A Review, Critical Reviews in Food Science and Nutrition","author":"Muhammad","year":"2018"},{"key":"10.1016\/j.canlet.2019.06.001_bib70","doi-asserted-by":"crossref","first-page":"304","DOI":"10.3390\/molecules21030304","article-title":"Anti-oxidant, anti-inflammatory and anti-angiogenic properties of resveratrol in ocular diseases","volume":"21","author":"Lan\u00e7on","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.canlet.2019.06.001_bib71","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1007\/s12603-015-0611-z","article-title":"Resveratrol requires red wine polyphenols for optimum antioxidant activity","volume":"20","author":"Cavallini","year":"2016","journal-title":"J. Nutr. Health Aging"},{"key":"10.1016\/j.canlet.2019.06.001_bib72","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ijcard.2015.04.008","article-title":"Lack of efficacy of resveratrol on C-reactive protein and selected cardiovascular risk factors\u2014results from a systematic review and meta-analysis of randomized controlled trials","volume":"189","author":"Sahebkar","year":"2015","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.canlet.2019.06.001_bib73","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.bbadis.2014.10.016","article-title":"Preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular diseases","volume":"1852","author":"Zordoky","year":"2015","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.canlet.2019.06.001_bib74","first-page":"984","article-title":"Synergistic cytotoxic effects of resveratrol in combination with ceramide metabolizing enzymes in Ph+ acute lymphoblastic leukemia","volume":"1","author":"O\u011fuz","year":"2017"},{"key":"10.1016\/j.canlet.2019.06.001_bib75","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/cdd.2008.51","article-title":"Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells","volume":"15","author":"Scarlatti","year":"2008","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.canlet.2019.06.001_bib76","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0051655","article-title":"Resveratrol reduces prostate cancer growth and metastasis by inhibiting the Akt\/MicroRNA-21 pathway","volume":"7","author":"Sheth","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.canlet.2019.06.001_bib77","doi-asserted-by":"crossref","first-page":"8723","DOI":"10.1002\/jcb.27202","article-title":"Stem cell- and gene-based therapies as potential candidates in Alzheimer's therapy","volume":"119","author":"Hosseini","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.canlet.2019.06.001_bib78","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1002\/cncr.29793","article-title":"Resveratrol inhibits ovarian tumor growth in an in vivo mouse model","volume":"122","author":"Tan","year":"2016","journal-title":"Cancer"},{"key":"10.1016\/j.canlet.2019.06.001_bib79","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.3390\/nu9111231","article-title":"Effects of resveratrol against lung cancer: in vitro and in vivo studies","volume":"9","author":"Yousef","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.canlet.2019.06.001_bib80","series-title":"Anticancer Activities of Resveratrol in Colorectal Cancer","author":"Schaafsma","year":"2016"},{"key":"10.1016\/j.canlet.2019.06.001_bib81","doi-asserted-by":"crossref","first-page":"472","DOI":"10.3892\/or.2015.4384","article-title":"Resveratrol induces cell cycle arrest in human gastric cancer MGC803 cells via the PTEN-regulated PI3K\/Akt signaling pathway","volume":"35","author":"Jing","year":"2016","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.canlet.2019.06.001_bib82","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1749-6632.2010.05873.x","article-title":"Chemoprevention in experimental animals","volume":"1215","author":"Namasivayam","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.canlet.2019.06.001_bib83","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1749-6632.2010.05852.x","article-title":"Chemosensitization of tumors by resveratrol","volume":"1215","author":"Gupta","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.canlet.2019.06.001_bib84","first-page":"893","article-title":"Low dose of resveratrol enhanced immune response of mice","volume":"23","author":"Feng","year":"2002","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.canlet.2019.06.001_bib85","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.intimp.2007.12.006","article-title":"Resveratrol induces the suppression of tumor-derived CD4+ CD25+ regulatory T cells","volume":"8","author":"Yang","year":"2008","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.canlet.2019.06.001_bib86","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s12013-015-0513-z","article-title":"Modification of antitumor immunity and tumor microenvironment by resveratrol in mouse renal tumor model","volume":"72","author":"Chen","year":"2015","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.canlet.2019.06.001_bib87","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035650","article-title":"Resveratrol prevents endothelial cells injury in high-dose interleukin-2 therapy against melanoma","volume":"7","author":"Guan","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.canlet.2019.06.001_bib88","series-title":"Tumor-evoked Regulatory B Cells Promote Breast Cancer Metastasis by Converting Resting CD4+ T Cells to T-Regulatory Cells","author":"Olkhanud","year":"2011"},{"key":"10.1016\/j.canlet.2019.06.001_bib89","series-title":"Anti-CD20 Antibody Promotes Cancer Escape via Enrichment of Tumor-Evoked Regulatory B Cells Expressing Low Levels of CD20 and CD137L","first-page":"2012","author":"Bodogai","year":"2013"},{"key":"10.1016\/j.canlet.2019.06.001_bib90","doi-asserted-by":"crossref","first-page":"5996","DOI":"10.1158\/0008-5472.CAN-08-4619","article-title":"Breast cancer lung metastasis requires expression of chemokine receptor CCR4 and regulatory T cells","volume":"69","author":"Olkhanud","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2019.06.001_bib91","first-page":"1300606","article-title":"Inhibition of breast cancer metastasis by resveratrol-mediated inactivation of tumor-evoked regulatory B cells","author":"Lee-Chang","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.canlet.2019.06.001_bib92","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s10059-012-0081-7","article-title":"An analogue of resveratrol HS-1793 exhibits anticancer activity against MCF-7 cells via inhibition of mitochondrial biogenesis gene expression","volume":"34","author":"Jeong","year":"2012","journal-title":"Mol. Cells"},{"key":"10.1016\/j.canlet.2019.06.001_bib93","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.intimp.2012.07.018","article-title":"Resveratrol analog, HS-1793 enhance anti-tumor immunity by reducing the CD4+ CD25+ regulatory T cells in FM3A tumor bearing mice","volume":"14","author":"Jeong","year":"2012","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.canlet.2019.06.001_bib94","doi-asserted-by":"crossref","first-page":"592","DOI":"10.3892\/etm.2012.472","article-title":"Resveratrol analogue HS-1793 induces the modulation of tumor-derived T cells","volume":"3","author":"Choi","year":"2012","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.canlet.2019.06.001_bib95","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/ptr.2283","article-title":"Cancer phytotherapeutics: role for flavonoids at the cellular level","volume":"22","author":"Kale","year":"2008","journal-title":"Phytother Res.: Int. J. Devoted Pharmacol. Toxicol. Eval. Nat. Prod. Deriv."},{"key":"10.1016\/j.canlet.2019.06.001_bib96","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s00011-009-0037-3","article-title":"Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease","volume":"58","author":"Garc\u00eda-Lafuente","year":"2009","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.canlet.2019.06.001_bib97","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0304-3835(97)00183-3","article-title":"Effect of antiproliferative flavonoids on ascorbic acid accumulation in human colon adenocarcinoma cells","volume":"116","author":"Kuo","year":"1997","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2019.06.001_bib98","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11060-010-0221-x","article-title":"Delayed growth of glioma by Scutellaria flavonoids involve inhibition of Akt, GSK-3 and NF-\u03baB signaling","volume":"101","author":"Parajuli","year":"2011","journal-title":"J. Neuro Oncol."},{"key":"10.1016\/j.canlet.2019.06.001_bib99","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1055\/s-0028-1088364","article-title":"In vitro antitumor mechanisms of various Scutellaria extracts and constituent flavonoids","volume":"75","author":"Parajuli","year":"2009","journal-title":"Planta Med."},{"key":"10.1016\/j.canlet.2019.06.001_bib100","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10549-006-9430-6","article-title":"Phase I trial and antitumor effects of BZL101 for patients with advanced breast cancer","volume":"105","author":"Rugo","year":"2007","journal-title":"Breast Canc. Res. Treat."},{"key":"10.1016\/j.canlet.2019.06.001_bib101","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s10549-009-0678-5","article-title":"A phase 1B dose escalation trial of Scutellaria barbata (BZL101) for patients with metastatic breast cancer","volume":"120","author":"Perez","year":"2010","journal-title":"Breast Canc. Res. Treat."},{"key":"10.1016\/j.canlet.2019.06.001_bib102","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1023\/A:1021638411150","article-title":"Phenolic compounds of plants of the Scutellaria L. genus. Distribution, structure, and properties","volume":"38","author":"Malikov","year":"2002","journal-title":"Chem. Nat. Compd."},{"key":"10.1016\/j.canlet.2019.06.001_bib103","series-title":"Trends in New Crops and New Uses","first-page":"580","article-title":"Skullcap: potential medicinal crop, reprinted from","author":"Joshee","year":"2002"},{"key":"10.1016\/j.canlet.2019.06.001_bib104","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1142\/S0192415X02000077","article-title":"Effects of Kampo herbal medicine on plasma melatonin concentration in patients","volume":"30","author":"Watanabe","year":"2002","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.canlet.2019.06.001_bib105","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00299-004-0862-3","article-title":"A metabolomic analysis of medicinal diversity in Huang-qin (Scutellaria baicalensis Georgi) genotypes: discovery of novel compounds","volume":"23","author":"Murch","year":"2004","journal-title":"Plant Cell Rep."},{"key":"10.1016\/j.canlet.2019.06.001_bib106","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/0006-291X(82)91081-6","article-title":"Selective inhibition of platelet lipoxygenase by baicalein","volume":"105","author":"Sekiya","year":"1982","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.canlet.2019.06.001_bib107","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1080\/15216549600201221","article-title":"Inhibition of microsomal lipid peroxidation by baicalein: a possible formation of an iron\u2010baicalein complex","volume":"39","author":"Gao","year":"1996","journal-title":"IUBMB Life"},{"key":"10.1016\/j.canlet.2019.06.001_bib108","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1078\/0944-7113-00374","article-title":"Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): a medicinal plant with anxiolytic properties","volume":"10","author":"Awad","year":"2003","journal-title":"Phytomedicine"},{"key":"10.1016\/j.canlet.2019.06.001_bib109","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.etap.2005.07.015","article-title":"Pharmacological activity in growth inhibition and apoptosis of cultured human leiomyomal cells of tropical plant Scutellaria barbata D. Don (Lamiaceae)","volume":"21","author":"Lee","year":"2006","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.canlet.2019.06.001_bib110","series-title":"Neoclerodane Diterpenoids from Scutellaria Barbata with Cytotoxic Activities","first-page":"1","author":"Wang","year":"2018"},{"key":"10.1016\/j.canlet.2019.06.001_bib111","series-title":"Cytotoxic Neoclerodane Diterpenoids from Scutellaria Barbata D. Don","author":"Wang","year":"2018"},{"key":"10.1016\/j.canlet.2019.06.001_bib112","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12906-016-1551-9","article-title":"Scutellaria barbata D. Don extract inhibits the tumor growth through down-regulating of Treg cells and manipulating Th1\/Th17 immune response in hepatoma H22-bearing mice","volume":"17","author":"Kan","year":"2017","journal-title":"BMC Complement Altern. Med."},{"key":"10.1016\/j.canlet.2019.06.001_bib113","first-page":"2935","article-title":"Advances of wogonin, an extract from Scutellaria baicalensis, for the treatment of multiple tumors","volume":"9","author":"Wu","year":"2016","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.canlet.2019.06.001_bib114","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s00262-011-1130-3","article-title":"Scutellaria extract and wogonin inhibit tumor-mediated induction of T reg cells via inhibition of TGF-\u03b21 activity, Cancer Immunology","volume":"61","author":"Dandawate","year":"2012","journal-title":"Immunotherapy"},{"key":"10.1016\/j.canlet.2019.06.001_bib115","doi-asserted-by":"crossref","first-page":"11365","DOI":"10.1007\/s13277-016-5013-2","article-title":"Naringenin inhibits proliferation, migration, and invasion as well as induces apoptosis of gastric cancer SGC7901 cell line by downregulation of AKT pathway","volume":"37","author":"Bao","year":"2016","journal-title":"Tumor Biol."},{"key":"10.1016\/j.canlet.2019.06.001_bib116","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1158\/0008-5472.CAN-08-3393","article-title":"Naringenin: a potential immunomodulator for inhibiting lung fibrosis and metastasis","volume":"69","author":"Du","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2019.06.001_bib117","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s13238-011-1056-8","article-title":"Naringenin reduces lung metastasis in a breast cancer resection model","volume":"2","author":"Qin","year":"2011","journal-title":"Protein & cell"},{"key":"10.1016\/j.canlet.2019.06.001_bib118","doi-asserted-by":"crossref","first-page":"5440","DOI":"10.1039\/c1cc10778j","article-title":"A single-molecule study of the inhibition effect of Naringenin on transforming growth factor-\u03b2 ligand\u2013receptor binding","volume":"47","author":"Yang","year":"2011","journal-title":"Chem. Commun."},{"key":"10.1016\/j.canlet.2019.06.001_bib119","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13058-016-0698-0","article-title":"Naringenin prevents TGF-\u03b21 secretion from breast cancer and suppresses pulmonary metastasis by inhibiting PKC activation","volume":"18","author":"Zhang","year":"2016","journal-title":"Breast Canc. Res."},{"key":"10.1016\/j.canlet.2019.06.001_bib120","article-title":"Antimutagenic effects of tannic acid on somatic and germ cells of rats","volume":"40","author":"HASSAN","year":"2016","journal-title":"Egypt. J. Genet. Cytol."},{"key":"10.1016\/j.canlet.2019.06.001_bib121","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.jep.2005.01.062","article-title":"Antibacterial screening of some Peruvian medicinal plants used in Calleria District","volume":"99","author":"Kloucek","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.canlet.2019.06.001_bib122","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1142\/S0192415X16500956","article-title":"Standardized extract from Caesalpinia spinosa is cytotoxic over cancer stem cells and enhance anticancer activity of doxorubicin","volume":"44","author":"Sandoval","year":"2016","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.canlet.2019.06.001_bib123","doi-asserted-by":"crossref","first-page":"e2243","DOI":"10.1038\/cddis.2016.134","article-title":"Immune-system-dependent anti-tumor activity of a plant-derived polyphenol rich fraction in a melanoma mouse model","volume":"7","author":"Gomez-Cadena","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.canlet.2019.06.001_bib124","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1472-6882-12-38","article-title":"A gallotannin-rich fraction from Caesalpinia spinosa (Molina) Kuntze displays cytotoxic activity and raises sensitivity to doxorubicin in a leukemia cell line","volume":"12","author":"Casta\u00f1eda","year":"2012","journal-title":"BMC Complement Altern. Med."},{"key":"10.1016\/j.canlet.2019.06.001_bib125","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1472-6882-13-74","article-title":"Gallotannin-rich Caesalpinia spinosa fraction decreases the primary tumor and factors associated with poor prognosis in a murine breast cancer model","volume":"13","author":"Urue\u00f1a","year":"2013","journal-title":"BMC Complement Altern. Med."},{"key":"10.1016\/j.canlet.2019.06.001_bib126","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1177\/1534735415596425","article-title":"Multifunctional T lymphocytes generated after therapy with an antitumor gallotanin-rich normalized fraction are related to primary tumor size reduction in a breast cancer model","volume":"14","author":"Urue\u00f1a","year":"2015","journal-title":"Integr. Cancer Ther."},{"key":"10.1016\/j.canlet.2019.06.001_bib127","doi-asserted-by":"crossref","first-page":"356","DOI":"10.3389\/fonc.2018.00356","article-title":"Prophylactic versus therapeutic treatment with P2Et polyphenol-rich extract has opposite effects on tumor growth","volume":"8","author":"Lasso","year":"2018","journal-title":"Front. Oncol."},{"key":"10.1016\/j.canlet.2019.06.001_bib128","series-title":"Soybean Isoflavone Extract Suppresses Early but Not Later Promotion of Hepatocarcinogenesis by Phenobarbital in Female Rat Liver","author":"Lee","year":"1995"},{"key":"10.1016\/j.canlet.2019.06.001_bib129","series-title":"Effect of Soya Bean Saponins on Azoxymethane\u2010induced Preneoplastic Lesions in the Colon of Mice","author":"Koratkar","year":"1997"},{"key":"10.1016\/j.canlet.2019.06.001_bib130","doi-asserted-by":"crossref","first-page":"439s","DOI":"10.1093\/ajcn\/70.3.439s","article-title":"Legumes and soybeans: overview of their nutritional profiles and health effects","volume":"70","author":"Messina","year":"1999","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.canlet.2019.06.001_bib131","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/00017285-199711000-00003","article-title":"Phytoestrogens and human function","volume":"32","author":"Anderson","year":"1997","journal-title":"Nutr. Today"},{"key":"10.1016\/j.canlet.2019.06.001_bib132","doi-asserted-by":"crossref","first-page":"566S","DOI":"10.1093\/jn\/132.3.566S","article-title":"Soy, soy phytoestrogens and cardiovascular disease","volume":"132","author":"Clarkson","year":"2002","journal-title":"J. Nutr."},{"key":"10.1016\/j.canlet.2019.06.001_bib133","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1158\/1940-6207.CAPR-14-0464","article-title":"Consumption of soy isoflavone enriched bread in men with prostate cancer is associated with reduced proinflammatory cytokines and immunosuppressive cells","volume":"8","author":"Lesinski","year":"2015","journal-title":"Cancer Prev. Res."},{"key":"10.1016\/j.canlet.2019.06.001_bib134","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/0891-5849(95)02227-9","article-title":"Structure-antioxidant activity relationships of flavonoids and phenolic acids","volume":"20","author":"Rice-Evans","year":"1996","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.canlet.2019.06.001_bib135","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0300-483X(00)00210-9","article-title":"Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention","volume":"148","author":"Bagchi","year":"2000","journal-title":"Toxicology"},{"key":"10.1016\/j.canlet.2019.06.001_bib136","doi-asserted-by":"crossref","first-page":"49625","DOI":"10.18632\/oncotarget.17867","article-title":"Dietary grape seed proanthocyanidins inactivate regulatory T cells by promoting NER-dependent DNA repair in dendritic cells in UVB-exposed skin","volume":"8","author":"Vaid","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.canlet.2019.06.001_bib137","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.intimp.2010.11.035","article-title":"Immunomodulatory effects of eicosapentaenoic acid through induction of regulatory T cells","volume":"11","author":"Iwami","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.canlet.2019.06.001_bib138","series-title":"Dietary Fish Oil Alters T Lymphocyte Cell Populations and Exacerbates Disease in a Mouse Model of Inflammatory Colitis","first-page":"2010","author":"Woodworth","year":"2010"},{"key":"10.1016\/j.canlet.2019.06.001_bib139","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1038\/jid.2014.488","article-title":"Docosahexaenoic acid alleviates atopic dermatitis by generating Tregs and IL-10\/TGF-\u03b2-modified macrophages via a TGF-\u03b2-dependent mechanism","volume":"135","author":"Han","year":"2015","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.canlet.2019.06.001_bib140","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1194\/jlr.M900101-JLR200","article-title":"Docosahexaenoic acid reduces suppressive and migratory functions of CD4CD25 regulatory T-cells","volume":"50","author":"Yessoufou","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.canlet.2019.06.001_bib141","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1080\/01635581.2016.1212245","article-title":"Involvement of regulatory T cells and their cytokines repertoire in chemopreventive action of fish oil in experimental colon cancer","volume":"68","author":"Renuka","year":"2016","journal-title":"Nutr. Canc."},{"key":"10.1016\/j.canlet.2019.06.001_bib142","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s10753-009-9136-0","article-title":"Fish oil-supplemented parenteral nutrition in severe acute pancreatitis patients and effects on immune function and infectious risk: a randomized controlled trial","volume":"32","author":"Wang","year":"2009","journal-title":"Inflammation"},{"key":"10.1016\/j.canlet.2019.06.001_bib143","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1200\/JCO.2004.10.041","article-title":"Tolerance and cancer: mechanisms of tumor evasion and strategies for breaking tolerance","volume":"22","author":"Mapara","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.canlet.2019.06.001_bib144","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1182\/blood-2003-06-1850","article-title":"Interleukin-10 gene promoter polymorphisms influence the clinical outcome of diffuse large B-cell lymphoma","volume":"103","author":"Lech-Maranda","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.canlet.2019.06.001_bib145","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1081\/CNV-100102550","article-title":"Comparison of serum interleukin-10 (IL-10) levels between normal volunteers and patients with advanced melanoma","volume":"19","author":"Nemunaitis","year":"2001","journal-title":"Canc. Invest."},{"key":"10.1016\/j.canlet.2019.06.001_bib146","article-title":"Reduction of splenic immunosuppressive cells and enhancement of anti-tumor immunity by synergy of fish oil and selenium yeast","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.canlet.2019.06.001_bib147","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.bbagen.2010.03.016","article-title":"Agaritine purified from Agaricus blazei Murrill exerts anti-tumor activity against leukemic cells","volume":"1800","author":"Endo","year":"2010","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.canlet.2019.06.001_bib148","series-title":"Phase I Clinical Study of the Dietary Supplement, Agaricus Blazei Murill, in Cancer Patients in Remission, Evidence-Based Complementary and Alternative Medicine","first-page":"2011","author":"Ohno","year":"2011"},{"key":"10.1016\/j.canlet.2019.06.001_bib149","first-page":"2011","article-title":"The mushroom Agaricus blazei Murill elicits medicinal effects on tumor, infection, allergy, and inflammation through its modulation of innate immunity and amelioration of Th1\/Th2 imbalance and inflammation","author":"Hetland","year":"2011","journal-title":"Adv. Pharmacol. Sci."},{"key":"10.1016\/j.canlet.2019.06.001_bib150","first-page":"2015","article-title":"Immunomodulatory effects of the Agaricus blazei Murrill-based mushroom extract AndoSan in patients with multiple myeloma undergoing high dose chemotherapy and autologous stem cell transplantation: a randomized, double blinded clinical study","author":"Tangen","year":"2015","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.canlet.2019.06.001_bib151","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0304-3835(85)90002-3","article-title":"Anticarcinogenic action of an alcohol-insoluble fraction (LAP1) from culture medium of Lentinus edodes mycelia","volume":"27","author":"Sugano","year":"1985","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2019.06.001_bib152","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1080\/00021369.1990.10869950","article-title":"Structural characterization of the immunoactive and antiviral water-solubilized lignin in an extract of the culture medium of Lentinus edodes mycelia (LEM)","volume":"54","author":"Suzuki","year":"1990","journal-title":"Agric. Biol. Chem."},{"key":"10.1016\/j.canlet.2019.06.001_bib153","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/j.1349-7006.2010.01841.x","article-title":"Oral ingestion of Lentinula edodes mycelia extract inhibits B16 melanoma growth via mitigation of regulatory T cell\u2010mediated immunosuppression","volume":"102","author":"Tanaka","year":"2011","journal-title":"Cancer Sci."},{"key":"10.1016\/j.canlet.2019.06.001_bib154","series-title":"Growing Gourmet and Medicinal Mushrooms","first-page":"267","author":"Stamets","year":"2000"},{"key":"10.1016\/j.canlet.2019.06.001_bib155","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.phymed.2004.07.009","article-title":"Zingiberis rhizoma: a comprehensive review on the ginger effect and efficacy profiles","volume":"12","author":"Chrubasik","year":"2005","journal-title":"Phytomedicine"},{"key":"10.1016\/j.canlet.2019.06.001_bib156","doi-asserted-by":"crossref","first-page":"30787","DOI":"10.18632\/oncotarget.25704","article-title":"Autophagy-dependent apoptosis is triggered by a semi-synthetic [6]-gingerol analogue in triple negative breast cancer cells","volume":"9","author":"Luna-Dulcey","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.canlet.2019.06.001_bib157","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1023\/A:1021254725842","article-title":"Botanicals in cancer chemoprevention","volume":"21","author":"Park","year":"2002","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.canlet.2019.06.001_bib158","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1002\/ijc.26316","article-title":"Administration of 6\u2010gingerol greatly enhances the number of tumor\u2010infiltrating lymphocytes in murine tumors","volume":"130","author":"Ju","year":"2012","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.canlet.2019.06.001_bib159","series-title":"Devil's Club (Oplopanax Horridus): an Ethnobotanical Review","author":"Lantz","year":"2004"},{"key":"10.1016\/j.canlet.2019.06.001_bib160","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s10068-017-0029-y","article-title":"Anti-oxidative and anti-inflammatory activities of devil's club (Oplopanax horridus) leaves","volume":"26","author":"Jang","year":"2017","journal-title":"Food Sci. Biotechnol."},{"key":"10.1016\/j.canlet.2019.06.001_bib161","series-title":"Oplopanax Horridus: Phytochemistry and Pharmacological Diversity and Structure-Activity Relationship on Anticancer Effects, Evidence-Based Complementary and Alternative Medicine","first-page":"2018","author":"Wu","year":"2018"},{"key":"10.1016\/j.canlet.2019.06.001_bib162","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1002\/ptr.5129","article-title":"Extracts of Devil's club (Oplopanax horridus) exert therapeutic efficacy in experimental models of acute myeloid leukemia","volume":"28","author":"McGill","year":"2014","journal-title":"Phytother Res."},{"key":"10.1016\/j.canlet.2019.06.001_bib163","first-page":"2016","article-title":"Reviews on mechanisms of in vitro antioxidant activity of polysaccharides","author":"Wang","year":"2016","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.canlet.2019.06.001_bib164","series-title":"Structural Analysis of Glycans, Essentials of Glycobiology","author":"Mulloy","year":"2009"},{"key":"10.1016\/j.canlet.2019.06.001_bib165","series-title":"Polysaccharide-based Anticancer Prodrugs","first-page":"163","author":"Caliceti","year":"2010"},{"key":"10.1016\/j.canlet.2019.06.001_bib166","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.3390\/md8092435","article-title":"Marine polysaccharides in pharmaceutical applications: an overview","volume":"8","author":"Laurienzo","year":"2010","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.canlet.2019.06.001_bib167","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/star.201400127","article-title":"Seaweed polysaccharides and their potential biomedical applications","volume":"67","author":"Venkatesan","year":"2015","journal-title":"Starch Staerke"},{"key":"10.1016\/j.canlet.2019.06.001_bib168","series-title":"Marine Biomaterials in Therapeutics and Diagnostic","first-page":"1247","author":"Srivastava","year":"2015"},{"key":"10.1016\/j.canlet.2019.06.001_bib169","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.carbpol.2013.12.008","article-title":"Carrageenan and its applications in drug delivery","volume":"103","author":"Li","year":"2014","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.canlet.2019.06.001_bib170","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.tibtech.2011.03.008","article-title":"Advances in bacterial exopolysaccharides: from production to biotechnological applications","volume":"29","author":"Freitas","year":"2011","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.canlet.2019.06.001_bib171","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1007\/978-3-319-16298-0_63","article-title":"Bacterial polysaccharides: production and applications in cosmetic industry","author":"Freitas","year":"2015","journal-title":"Polysaccharides: Bioactivity Biotechnol."},{"key":"10.1016\/j.canlet.2019.06.001_bib172","first-page":"279","author":"Lindberg","year":"1990"},{"key":"10.1016\/j.canlet.2019.06.001_bib173","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.copbio.2014.01.010","article-title":"Bioactive fungal polysaccharides as potential functional ingredients in food and nutraceuticals","volume":"26","author":"Giavasis","year":"2014","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.canlet.2019.06.001_bib174","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1039\/c2fo10279j","article-title":"Antitumor activity of mushroom polysaccharides: a review","volume":"3","author":"Ren","year":"2012","journal-title":"Food Funct."},{"key":"10.1016\/j.canlet.2019.06.001_bib175","doi-asserted-by":"crossref","first-page":"667","DOI":"10.2174\/1871520617666171113121246","article-title":"Ganoderma lucidum polysaccharides as an anti-cancer agent","volume":"18","author":"Sohretoglu","year":"2018","journal-title":"Anti Cancer Agents Med. Chem."},{"key":"10.1016\/j.canlet.2019.06.001_bib176","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.carbpol.2018.10.028","article-title":"Effective cancer immunotherapy by Ganoderma lucidum polysaccharide-gold nanocomposites through dendritic cell activation and memory T cell response","volume":"205","author":"Zhang","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.canlet.2019.06.001_bib177","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1142\/S0192415X98000415","article-title":"Effect of Ganoderma lucidum on postherpetic neuralgia","volume":"26","author":"Hijikata","year":"1998","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.canlet.2019.06.001_bib178","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s12967-015-0465-5","article-title":"Ganoderma lucidum polysaccharide extract inhibits hepatocellular carcinoma growth by downregulating regulatory T cells accumulation and function by inducing microRNA-125b","volume":"13","author":"Li","year":"2015","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.canlet.2019.06.001_bib179","first-page":"81","article-title":"Bitter melon: a panacea for inflammation and cancer","volume":"14","author":"Dandawate","year":"2016","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.canlet.2019.06.001_bib180","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jep.2010.12.045","article-title":"Hypoglycemic effect of bitter melon compared with metformin in newly diagnosed type 2 diabetes patients","volume":"134","author":"Fuangchan","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.canlet.2019.06.001_bib181","first-page":"363","article-title":"Evaluation of the efficacy of bitter gourd (momordica charantia) as an oral hypoglycemic agent--a randomized controlled clinical trial","volume":"47","author":"John","year":"2003","journal-title":"Indian J. Physiol. Pharmacol."},{"key":"10.1016\/j.canlet.2019.06.001_bib182","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.jclinepi.2006.07.009","article-title":"The effect of Momordica charantia capsule preparation on glycemic control in type 2 diabetes mellitus needs further studies","volume":"60","author":"Dans","year":"2007","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.canlet.2019.06.001_bib183","doi-asserted-by":"crossref","first-page":"33202","DOI":"10.18632\/oncotarget.8898","article-title":"Immunomodulatory role of bitter melon extract in inhibition of head and neck squamous cell carcinoma growth","volume":"7","author":"Bhattacharya","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.canlet.2019.06.001_bib184","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1158\/1940-6207.CAPR-17-0046","article-title":"Bitter melon enhances natural killer\u2013mediated toxicity against head and neck cancer cells","volume":"10","author":"Bhattacharya","year":"2017","journal-title":"Cancer Prev. Res."},{"key":"10.1016\/j.canlet.2019.06.001_bib185","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1158\/1940-6207.CAPR-17-0237","article-title":"Bitter melon prevents the development of 4-NQO\u2013induced oral squamous cell carcinoma in an immunocompetent mouse model by modulating immune signaling","volume":"11","author":"Sur","year":"2018","journal-title":"Cancer Prev. Res."},{"issue":"11","key":"10.1016\/j.canlet.2019.06.001_bib186","first-page":"2047","article-title":"Perspectives on new synthetic curcumin analogs and their potential anticancer properties","volume":"19","author":"Vyas","year":"2013","journal-title":"Curr Pharm Des."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383519303453?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383519303453?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T10:38:30Z","timestamp":1562841510000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383519303453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":186,"alternative-id":["S0304383519303453"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2019.06.001","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modulation of regulatory T cells by natural products in cancer","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2019.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}