{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:40:40Z","timestamp":1790793640380,"version":"4.1.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31670913"],"award-info":[{"award-number":["31670913"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872353"],"award-info":[{"award-number":["81872353"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.canlet.2019.08.018","type":"journal-article","created":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T02:12:54Z","timestamp":1567476774000},"page":"24-35","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Progranulin promotes melanoma progression by inhibiting natural killer cell recruitment to the tumor microenvironment"],"prefix":"10.1016","volume":"465","author":[{"given":"Ramouna","family":"Voshtani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojdeh S.","family":"Tavallaie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3043-1840","authenticated-orcid":false,"given":"Xiaojing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2019.08.018_bib1","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1007\/s00109-003-0474-3","article-title":"Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis","volume":"81","author":"He","year":"2003","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.canlet.2019.08.018_bib2","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.4049\/jimmunol.1600862","article-title":"Progranulin controls sepsis via C\/EBP\u03b1-regulated Il10 transcription and ubiquitin ligase\/proteasome-mediated protein degradation","volume":"197","author":"Yan","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.canlet.2019.08.018_bib3","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S0092-8674(02)01141-8","article-title":"Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair","volume":"111","author":"Zhu","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2019.08.018_bib4","first-page":"2438","article-title":"Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin","volume":"118","author":"Kessenbrock","year":"2008","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.canlet.2019.08.018_bib5","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1074\/mcp.M800095-MCP200","article-title":"Novel MMP-9 substrates in cancer cells revealed by a label-free quantitative proteomics approach","volume":"7","author":"Xu","year":"2008","journal-title":"Mol. Cell. Proteom."},{"key":"10.1016\/j.canlet.2019.08.018_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035115","article-title":"Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12)","volume":"7","author":"Suh","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.canlet.2019.08.018_bib7","doi-asserted-by":"crossref","first-page":"4896","DOI":"10.1128\/MCB.01775-07","article-title":"Pharmacoproteomics of a metalloproteinase hydroxamate inhibitor in breast cancer cells: dynamics of membrane type 1 matrix metalloproteinase-mediated membrane protein shedding","volume":"28","author":"Butler","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.canlet.2019.08.018_bib8","doi-asserted-by":"crossref","first-page":"4201","DOI":"10.1128\/MCB.00056-09","article-title":"ADAMTS-7, a direct target of PTHrP, adversely regulates endochondral bone growth by associating with and inactivating GEP growth factor","volume":"29","author":"Bai","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.canlet.2019.08.018_bib9","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1189\/jlb.0812429","article-title":"Insights into the role of progranulin in immunity, infection, and inflammation","volume":"93","author":"Jian","year":"2013","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.canlet.2019.08.018_bib10","doi-asserted-by":"crossref","first-page":"58381","DOI":"10.18632\/oncotarget.11126","article-title":"Growth factor progranulin promotes tumorigenesis of cervical cancer via PI3K\/Akt\/mTOR signaling pathway","volume":"7","author":"Feng","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.canlet.2019.08.018_bib11","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1007\/s00109-003-0474-3","article-title":"Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis","volume":"81","author":"He","year":"2003","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.canlet.2019.08.018_bib12","first-page":"3222","article-title":"Progranulin gene expression regulates epithelial cell growth and promotes tumor growth in vivo","volume":"59","author":"He","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2019.08.018_bib13","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/onc.2016.226","article-title":"Progranulin and granulin-like protein as novel VEGF-independent angiogenic factors derived from human mesothelioma cells","volume":"36","author":"Eguchi","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2019.08.018_bib14","first-page":"3085","article-title":"Progranulin promotes colorectal cancer proliferation and angiogenesis through TNFR2\/Akt and ERK signaling pathways","volume":"5","author":"Yang","year":"2015","journal-title":"Am. J. Canc. Res."},{"key":"10.1016\/j.canlet.2019.08.018_bib15","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1097\/00029330-200805020-00004","article-title":"Expression of PC cell-derived growth factor and vascular endothelial growth factor in esophageal squamous cell carcinoma and their clinicopathologic significance","volume":"121","author":"Chen","year":"2008","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.canlet.2019.08.018_bib16","first-page":"2045","article-title":"Clinicopathologic and prognostic implications of progranulin in breast carcinoma","volume":"124","author":"Li","year":"2011","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.canlet.2019.08.018_bib17","first-page":"5331","article-title":"Biological activities and signaling pathways of the granulin\/epithelin precursor","volume":"59","author":"Zanocco-Marani","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2019.08.018_bib18","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1073\/pnas.98.1.142","article-title":"Mediation of estrogen mitogenic effect in human breast cancer MCF-7 cells by PC-cell-derived growth factor (PCDGF\/granulin precursor)","volume":"98","author":"Lu","year":"2001","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.canlet.2019.08.018_bib19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.yexmp.2015.11.021","article-title":"PGRN promotes migration and invasion of epithelial ovarian cancer cells through an epithelial mesenchymal transition program and the activation of cancer associated fibroblasts","volume":"100","author":"Dong","year":"2016","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.canlet.2019.08.018_bib20","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1471-2407-7-22","article-title":"Inhibition of PC cell-derived growth factor (PCDGF)\/granulin-epithelin precursor (GEP) decreased cell proliferation and invasion through downregulation of cyclin D and CDK 4 and inactivation of MMP-2","volume":"7","author":"Liu","year":"2007","journal-title":"BMC Canc."},{"key":"10.1016\/j.canlet.2019.08.018_bib21","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1093\/carcin\/bgh171","article-title":"PC cell-derived growth factor (PCDGF\/GP88, progranulin) stimulates migration, invasiveness and VEGF expression in breast cancer cells","volume":"25","author":"Tangkeangsirisin","year":"2004","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.canlet.2019.08.018_bib22","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1158\/0008-5472.CAN-03-2364","article-title":"PC cell-derived growth factor mediates tamoxifen resistance and promotes tumor growth of human breast cancer cells","volume":"64","author":"Tangkeangsirisin","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2019.08.018_bib23","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1158\/1078-0432.CCR-05-0929","article-title":"PC cell\u2013derived growth factor confers resistance to dexamethasone and promotes tumorigenesis in human multiple myeloma","volume":"12","author":"Wang","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2019.08.018_bib24","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1186\/1471-2407-11-231","article-title":"GP88 (PC-Cell Derived Growth Factor, progranulin) stimulates proliferation and confers letrozole resistance to aromatase overexpressing breast cancer cells","volume":"11","author":"Abrhale","year":"2011","journal-title":"BMC Canc."},{"key":"10.1016\/j.canlet.2019.08.018_bib25","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1158\/2326-6066.CIR-14-0096","article-title":"Granulin\u2013epithelin precursor renders hepatocellular carcinoma cells resistant to natural killer cytotoxicity","volume":"2","author":"Cheung","year":"2014","journal-title":"Canc. Immunol. Res."},{"key":"10.1016\/j.canlet.2019.08.018_bib26","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/nature05661","article-title":"Melanoma biology and new targeted therapy","volume":"445","author":"Gray-Schopfer","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2019.08.018_bib27","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1084\/jem.20091568","article-title":"Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice","volume":"207","author":"Yin","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.canlet.2019.08.018_bib28","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1084\/jem.20122462","article-title":"IL-2\u2013dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells","volume":"210","author":"Gasteiger","year":"2013","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.canlet.2019.08.018_bib29","doi-asserted-by":"crossref","first-page":"7234","DOI":"10.1158\/1078-0432.CCR-05-0683","article-title":"Novel genes associated with malignant melanoma but not benign melanocytic lesions","volume":"11","author":"Talantov","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2019.08.018_bib30","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.cell.2018.02.052","article-title":"An integrated TCGA pan-cancer clinical data resource to drive high-quality survival outcome analytics","volume":"173","author":"Liu","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2019.08.018_bib31","doi-asserted-by":"crossref","first-page":"7103","DOI":"10.1158\/0008-5472.CAN-06-0633","article-title":"Proepithelin promotes migration and invasion of 5637 bladder cancer cells through the activation of ERK1\/2 and the formation of a paxillin\/FAK\/ERK complex","volume":"66","author":"Monami","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2019.08.018_bib32","doi-asserted-by":"crossref","first-page":"4899","DOI":"10.1038\/s41598-018-23099-7","article-title":"Effect of CCL5 expression in the recruitment of immune cells in triple negative breast cancer","volume":"8","author":"Araujo","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.canlet.2019.08.018_bib33","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.4049\/jimmunol.173.6.3755","article-title":"Intratumoral CC chemokine ligand 5 overexpression delays tumor growth and increases tumor cell infiltration","volume":"173","author":"Lavergne","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.canlet.2019.08.018_bib34","doi-asserted-by":"crossref","first-page":"4821","DOI":"10.4049\/jimmunol.1203129","article-title":"Efficient attenuation of NK cell-mediated liver injury through genetically manipulating multiple immunogenes by using a liver-directed vector","volume":"190","author":"Geng","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.canlet.2019.08.018_bib35","first-page":"2221","article-title":"PC cell-derived growth factor (granulin precursor) expression and action in human multiple myeloma","volume":"9","author":"Wang","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2019.08.018_bib36","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/01.cad.0000236315.96574.58","article-title":"PC cell-derived growth factor overexpression promotes proliferation and survival of laryngeal carcinoma","volume":"18","author":"Kong","year":"2007","journal-title":"Anti Canccer Drugs"},{"key":"10.1016\/j.canlet.2019.08.018_bib37","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.prp.2012.02.001","article-title":"Progranulin expression in breast cancer with different intrinsic subtypes","volume":"208","author":"Li","year":"2012","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.canlet.2019.08.018_bib38","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1158\/1055-9965.EPI-12-1368","article-title":"Utility of progranulin and serum leukocyte protease inhibitor as diagnostic and prognostic biomarkers in ovarian cancer","volume":"22","author":"Carlson","year":"2013","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.canlet.2019.08.018_bib39","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ygyno.2010.09.006","article-title":"Progranulin is a potential prognostic biomarker in advanced epithelial ovarian cancers","volume":"120","author":"Han","year":"2011","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.canlet.2019.08.018_bib40","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1158\/1078-0432.CCR-1123-03","article-title":"PC cell-derived growth factor expression in prostatic intraepithelial neoplasia and prostatic adenocarcinoma","volume":"10","author":"Pan","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2019.08.018_bib41","first-page":"3739","article-title":"Expression of progranulin and the epithelin\/granulin precursor acrogranin correlates with neoplastic state in renal epithelium","volume":"21","author":"Donald","year":"2001","journal-title":"Anticancer Res."},{"key":"10.1016\/j.canlet.2019.08.018_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0072107","article-title":"Progranulin is a novel independent predictor of disease progression and overall survival in chronic lymphocytic leukemia","volume":"8","author":"Gobel","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.canlet.2019.08.018_bib43","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1016\/j.humpath.2014.05.011","article-title":"GP88 (progranulin): a novel tissue and circulating biomarker for non-small cell lung carcinoma","volume":"45","author":"Edelman","year":"2014","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.canlet.2019.08.018_bib44","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.cca.2017.07.024","article-title":"Association between increased serum GP88 (progranulin) concentrations and prognosis in patients with malignant lymphomas","volume":"473","author":"Yamamoto","year":"2017","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.canlet.2019.08.018_bib45","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/35095564","article-title":"Natural killer cells, viruses and cancer","volume":"1","author":"Cerwenka","year":"2001","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.canlet.2019.08.018_bib46","doi-asserted-by":"crossref","first-page":"E9271","DOI":"10.1073\/pnas.1703921114","article-title":"Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner","volume":"114","author":"Mgrditchian","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.canlet.2019.08.018_bib47","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/cmi.2013.10","article-title":"NK cell-based immunotherapy for malignant diseases","volume":"10","author":"Cheng","year":"2013","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.canlet.2019.08.018_bib48","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/ni1582","article-title":"Functions of natural killer cells","volume":"9","author":"Vivier","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.canlet.2019.08.018_bib49","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/cmi.2012.69","article-title":"CCL5 as a potential immunotherapeutic target in triple-negative breast cancer","volume":"10","author":"Lv","year":"2013","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.canlet.2019.08.018_bib50","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.canlet.2008.03.018","article-title":"The inflammatory chemokines CCL2 and CCL5 in breast cancer","volume":"267","author":"Soria","year":"2008","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2019.08.018_bib51","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/jcp.21783","article-title":"CCL5\/CCR5 axis promotes the motility of human oral cancer cells","volume":"220","author":"Chuang","year":"2009","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.canlet.2019.08.018_bib52","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.imlet.2003.09.013","article-title":"A dual role for tumor-derived chemokine RANTES (CCL5)","volume":"90","author":"Adler","year":"2003","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.canlet.2019.08.018_bib53","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s10549-004-5328-3","article-title":"Inhibition of metastasis by inhibition of tumor-derived CCL5","volume":"89","author":"Stormes","year":"2005","journal-title":"Breast Canc. Res. Treat."},{"key":"10.1016\/j.canlet.2019.08.018_bib54","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1517\/14712591003657128","article-title":"CCL5 as an adjuvant for cancer immunotherapy","volume":"10","author":"Lapteva","year":"2010","journal-title":"Expert Opin. Biol. Ther."},{"key":"10.1016\/j.canlet.2019.08.018_bib55","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/sj.bjc.6690164","article-title":"The chemokine RANTES is secreted by human melanoma cells and is associated with enhanced tumour formation in nude mice","volume":"79","author":"Mrowietz","year":"1999","journal-title":"Br. J. Canc."},{"key":"10.1016\/j.canlet.2019.08.018_bib56","doi-asserted-by":"crossref","first-page":"6477","DOI":"10.4049\/jimmunol.166.11.6477","article-title":"Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire","volume":"166","author":"Campbell","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.canlet.2019.08.018_bib57","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1128\/MCB.23.5.1688-1702.2003","article-title":"The growth factor granulin interacts with cyclin T1 and modulates P-TEFb-dependent transcription","volume":"23","author":"Hoque","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.canlet.2019.08.018_bib58","doi-asserted-by":"crossref","first-page":"13648","DOI":"10.1074\/jbc.M409575200","article-title":"Granulin and granulin repeats interact with the tat\u00b7 P-TEFb complex and inhibit tat transactivation","volume":"280","author":"Hoque","year":"2005","journal-title":"J. Biol. Chem."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383519304550?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383519304550?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T16:27:58Z","timestamp":1569342478000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383519304550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":58,"alternative-id":["S0304383519304550"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2019.08.018","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Progranulin promotes melanoma progression by inhibiting natural killer cell recruitment to the tumor microenvironment","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2019.08.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}