{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:58:24Z","timestamp":1773215904017,"version":"3.50.1"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.canlet.2020.02.001","type":"journal-article","created":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T17:06:15Z","timestamp":1581527175000},"page":"75-86","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Next-generation sequencing in thymic epithelial tumors uncovered novel genomic aberration sites and strong correlation between TMB and MSH6 single nucleotide variations"],"prefix":"10.1016","volume":"476","author":[{"given":"Kai","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaming","family":"Che","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianfei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runsen","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dingpei","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7303-3116","authenticated-orcid":false,"given":"Yonghua","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziying","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daoyun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hecheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10 Suppl 4","key":"10.1016\/j.canlet.2020.02.001_bib1","doi-asserted-by":"crossref","first-page":"S260","DOI":"10.1097\/JTO.0b013e3181f1f62d","article-title":"Epidemiology of thymoma and associated malignancies","volume":"5","author":"Engels","year":"2010","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.canlet.2020.02.001_bib2","series-title":"Proceedings of the First International Conference on Thymic Malignancies. August 20-21, 2009","first-page":"S259","year":"2010"},{"issue":"4","key":"10.1016\/j.canlet.2020.02.001_bib3","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1093\/ejcts\/ezv288","article-title":"Surgical treatment of thymoma: an 11-year experience with 761 patients","volume":"49","author":"Zhao","year":"2016","journal-title":"Eur. J. Cardio. Thorac. Surg."},{"issue":"10 Suppl 4","key":"10.1016\/j.canlet.2020.02.001_bib4","doi-asserted-by":"crossref","first-page":"S304","DOI":"10.1097\/JTO.0b013e3181f20c05","article-title":"Staging system of thymoma","volume":"5","author":"Masaoka","year":"2010","journal-title":"J. Thorac. Oncol."},{"issue":"11","key":"10.1016\/j.canlet.2020.02.001_bib5","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1016\/j.jtho.2018.08.005","article-title":"Systemic therapy in advanced thymic epithelial tumors: insights from the RYTHMIC prospective cohort","volume":"13","author":"Merveilleux du Vignaux","year":"2018","journal-title":"J. Thorac. Oncol."},{"issue":"12","key":"10.1016\/j.canlet.2020.02.001_bib6","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1097\/JTO.0000000000000363","article-title":"Clinical characteristics and outcomes for patients with thymic carcinoma: evaluation of Masaoka staging","volume":"9","author":"Litvak","year":"2014","journal-title":"J. Thorac. Oncol."},{"issue":"3","key":"10.1016\/j.canlet.2020.02.001_bib7","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/S0003-4975(03)00555-1","article-title":"Therapy for thymic epithelial tumors: a clinical study of 1,320 patients from Japan","volume":"76","author":"Kondo","year":"2003","journal-title":"Ann. Thorac. Surg."},{"issue":"3","key":"10.1016\/j.canlet.2020.02.001_bib8","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.ijrobp.2003.11.021","article-title":"Thymic carcinoma: state of the art review","volume":"59","author":"Eng","year":"2004","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"10","key":"10.1016\/j.canlet.2020.02.001_bib9","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1097\/JTO.0000000000000654","article-title":"The 2015 world Health organization classification of tumors of the thymus: continuity and changes","volume":"10","author":"Marx","year":"2015","journal-title":"J. Thorac. Oncol."},{"issue":"2","key":"10.1016\/j.canlet.2020.02.001_bib10","first-page":"173","article-title":"Thymic neoplasm: a rare disease with a complex clinical presentation","volume":"5","author":"Rashid","year":"2013","journal-title":"J. Thorac. Dis."},{"issue":"1","key":"10.1016\/j.canlet.2020.02.001_bib11","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.thorsurg.2010.08.001","article-title":"Management of stage I and II thymoma","volume":"21","author":"Detterbeck","year":"2011","journal-title":"Thorac. Surg. Clin."},{"issue":"11","key":"10.1016\/j.canlet.2020.02.001_bib12","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.3760\/cma.j.issn.0366-6999.20130177","article-title":"Thymoma: current diagnosis and treatment","volume":"126","author":"Detterbeck","year":"2013","journal-title":"Chin. Med. J. (Engl.)"},{"issue":"5","key":"10.1016\/j.canlet.2020.02.001_bib13","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1056\/NEJMoa1102873","article-title":"Reduced lung-cancer mortality with low-dose computed tomographic screening","volume":"365","author":"National Lung Screening Trial Research","year":"2011","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.canlet.2020.02.001_bib14","doi-asserted-by":"crossref","first-page":"671","DOI":"10.3348\/kjr.2018.0400","article-title":"Distinguishing between thymic epithelial tumors and benign cysts via computed tomography","volume":"20","author":"Lee","year":"2019","journal-title":"Korean J. Radiol."},{"issue":"1","key":"10.1016\/j.canlet.2020.02.001_bib15","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.thorsurg.2010.08.010","article-title":"Thymic carcinoma: is it a separate entity? From molecular to clinical evidence","volume":"21","author":"Marx","year":"2011","journal-title":"Thorac. Surg. Clin."},{"issue":"2","key":"10.1016\/j.canlet.2020.02.001_bib16","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00432-014-1800-6","article-title":"Key components of chemotherapy for thymic malignancies: a systematic review and pooled analysis for anthracycline-, carboplatin- or cisplatin-based chemotherapy","volume":"141","author":"Okuma","year":"2015","journal-title":"J. Canc. Res. Clin. Oncol."},{"issue":"3","key":"10.1016\/j.canlet.2020.02.001_bib17","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.lungcan.2008.03.013","article-title":"Mutational status of EGFR and KIT in thymoma and thymic carcinoma","volume":"62","author":"Yoh","year":"2008","journal-title":"Lung Canc."},{"issue":"8","key":"10.1016\/j.canlet.2020.02.001_bib18","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/ng.3016","article-title":"A specific missense mutation in GTF2I occurs at high frequency in thymic epithelial tumors","volume":"46","author":"Petrini","year":"2014","journal-title":"Nat. Genet."},{"key":"10.1016\/j.canlet.2020.02.001_bib19","doi-asserted-by":"crossref","first-page":"7336","DOI":"10.1038\/srep07336","article-title":"Mutations of epigenetic regulatory genes are common in thymic carcinomas","volume":"4","author":"Wang","year":"2014","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.canlet.2020.02.001_bib20","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1097\/JTO.0000000000000397","article-title":"Massively parallel sequencing identifies recurrent mutations in TP53 in thymic carcinoma associated with poor prognosis","volume":"10","author":"Moreira","year":"2015","journal-title":"J. Thorac. Oncol."},{"issue":"2","key":"10.1016\/j.canlet.2020.02.001_bib21","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.lungcan.2014.08.020","article-title":"Genetic profiling of thymic carcinoma using targeted next-generation sequencing","volume":"86","author":"Shitara","year":"2014","journal-title":"Lung Canc."},{"key":"10.1016\/j.canlet.2020.02.001_bib22","doi-asserted-by":"crossref","DOI":"10.21037\/med.2019.03.03","article-title":"WT1 as an immunotherapy target for thymic epithelial tumors: a novel method to activate anti-tumor immunity","volume":"3","author":"Takahashi","year":"2019","journal-title":"Mediastinum"},{"key":"10.1016\/j.canlet.2020.02.001_bib23","doi-asserted-by":"crossref","DOI":"10.21037\/med.2017.11.03","article-title":"GTF2I gene mutation\u2014a driver of thymoma pathogenesis","volume":"1","author":"M\u00fcllauer","year":"2017","journal-title":"Mediastinum"},{"issue":"2","key":"10.1016\/j.canlet.2020.02.001_bib24","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.ccell.2018.01.003","article-title":"The integrated genomic landscape of thymic epithelial tumors","volume":"33","author":"Radovich","year":"2018","journal-title":"Canc. Cell"},{"issue":"3","key":"10.1016\/j.canlet.2020.02.001_bib25","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s12253-016-0144-8","article-title":"Molecular profiling of thymoma and thymic carcinoma: genetic differences and potential novel therapeutic targets","volume":"23","author":"Enkner","year":"2017","journal-title":"Pathol. Oncol. Res."},{"issue":"10 Suppl 4","key":"10.1016\/j.canlet.2020.02.001_bib26","doi-asserted-by":"crossref","first-page":"S286","DOI":"10.1097\/JTO.0b013e3181f209a8","article-title":"Thymoma and thymic carcinoma: molecular pathology and targeted therapy","volume":"5","author":"Strobel","year":"2010","journal-title":"J. Thorac. Oncol."},{"issue":"16","key":"10.1016\/j.canlet.2020.02.001_bib27","doi-asserted-by":"crossref","first-page":"4855","DOI":"10.1158\/1078-0432.CCR-17-0066","article-title":"Genomic analysis of thymic epithelial tumors identifies novel subtypes associated with distinct clinical features","volume":"23","author":"Lee","year":"2017","journal-title":"Clin. Canc. Res."},{"issue":"2","key":"10.1016\/j.canlet.2020.02.001_bib28","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/crj.12569","article-title":"Mutation analysis of the EGFR gene and its downstream signaling pathway in thymic carcinoma patients from a Chinese Han population","volume":"12","author":"Zhan","year":"2018","journal-title":"Clin. Res. J"},{"issue":"1","key":"10.1016\/j.canlet.2020.02.001_bib29","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13148-019-0619-z","article-title":"Discovery and validation of DNA methylation markers for overall survival prognosis in patients with thymic epithelial tumors","volume":"11","author":"Li","year":"2019","journal-title":"Clin. Epigenet."},{"issue":"11","key":"10.1016\/j.canlet.2020.02.001_bib30","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1093\/carcin\/bgx094","article-title":"The genomic and epigenomic landscape in thymic carcinoma","volume":"38","author":"Saito","year":"2017","journal-title":"Carcinogenesis"},{"issue":"4","key":"10.1016\/j.canlet.2020.02.001_bib31","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/bjc.2015.425","article-title":"A large microRNA cluster on chromosome 19 is a transcriptional hallmark of WHO type A and AB thymomas","volume":"114","author":"Radovich","year":"2016","journal-title":"Br. J. Canc."},{"issue":"1","key":"10.1016\/j.canlet.2020.02.001_bib32","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13073-017-0424-2","article-title":"Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden","volume":"9","author":"Chalmers","year":"2017","journal-title":"Genome Med."},{"issue":"5","key":"10.1016\/j.canlet.2020.02.001_bib33","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1001\/jamaoncol.2018.7098","article-title":"Assessment of blood tumor mutational burden as a potential biomarker for immunotherapy in patients with non-small cell lung cancer with use of a next-generation sequencing cancer gene panel","volume":"5","author":"Wang","year":"2019","journal-title":"JAMA Oncol."},{"issue":"7","key":"10.1016\/j.canlet.2020.02.001_bib34","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1093\/bioinformatics\/btt755","article-title":"MSIsensor: microsatellite instability detection using paired tumor-normal sequence data","volume":"30","author":"Niu","year":"2014","journal-title":"Bioinformatics"},{"issue":"6127","key":"10.1016\/j.canlet.2020.02.001_bib35","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1126\/science.1235122","article-title":"Cancer genome landscapes","volume":"339","author":"Vogelstein","year":"2013","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.canlet.2020.02.001_bib36","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/modpathol.2009.160","article-title":"Upregulation of vimentin and aberrant expression of E-cadherin\/beta-catenin complex in oral squamous cell carcinomas: correlation with the clinicopathological features and patient outcome","volume":"23","author":"Liu","year":"2010","journal-title":"Mod. Pathol."},{"issue":"9","key":"10.1016\/j.canlet.2020.02.001_bib37","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1093\/annonc\/mdr626","article-title":"Activating c-KIT mutations in a subset of thymic carcinoma and response to different c-KIT inhibitors","volume":"23","author":"Schirosi","year":"2012","journal-title":"Ann. Oncol."},{"issue":"6","key":"10.1016\/j.canlet.2020.02.001_bib38","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/nrc3929","article-title":"Hijacked in cancer: the KMT2 (MLL) family of methyltransferases","volume":"15","author":"Rao","year":"2015","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.canlet.2020.02.001_bib39","doi-asserted-by":"crossref","first-page":"8554","DOI":"10.1038\/ncomms9554","article-title":"Systematic analysis of somatic mutations impacting gene expression in 12 tumour types","volume":"6","author":"Ding","year":"2015","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.canlet.2020.02.001_bib40","first-page":"413","article-title":"Impacts of somatic mutations on gene expression: an association perspective","volume":"18","author":"Jia","year":"2017","journal-title":"Briefings Bioinf."},{"key":"10.1016\/j.canlet.2020.02.001_bib41","series-title":"Thymus Transcriptome of TGF-\u03b2 Superfamily","first-page":"247","author":"Jurberg","year":"2019"},{"issue":"23","key":"10.1016\/j.canlet.2020.02.001_bib42","doi-asserted-by":"crossref","first-page":"13255","DOI":"10.1073\/pnas.231326898","article-title":"Frameshift-mutation-derived peptides as tumor-specific antigens in inherited and spontaneous colorectal cancer","volume":"98","author":"Saeterdal","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"10.1016\/j.canlet.2020.02.001_bib43","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s002620100222","article-title":"A TGF betaRII frameshift-mutation-derived CTL epitope recognised by HLA-A2-restricted CD8+ T cells","volume":"50","author":"Saeterdal","year":"2001","journal-title":"Cancer Immunol. Immunother."},{"issue":"1","key":"10.1016\/j.canlet.2020.02.001_bib44","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/ijc.1298","article-title":"Frameshift peptide-derived T-cell epitopes: a source of novel tumor-specific antigens","volume":"93","author":"Linnebacher","year":"2001","journal-title":"Int. J. Canc."},{"issue":"8","key":"10.1016\/j.canlet.2020.02.001_bib45","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S1470-2045(17)30516-8","article-title":"Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis","volume":"18","author":"Turajlic","year":"2017","journal-title":"Lancet Oncol."},{"issue":"8","key":"10.1016\/j.canlet.2020.02.001_bib46","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1001\/jama.2019.9177","article-title":"PD-L1 status and survival in patients with lung cancer","volume":"322","author":"Yang","year":"2019","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.canlet.2020.02.001_bib47","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.lungcan.2018.11.021","article-title":"High PD-L1 expression correlates with primary resistance to EGFR-TKIs in treatment naive advanced EGFR-mutant lung adenocarcinoma patients","volume":"127","author":"Hsu","year":"2019","journal-title":"Lung Canc."},{"issue":"9","key":"10.1016\/j.canlet.2020.02.001_bib48","first-page":"1689","article-title":"Multimodal detection of PD-L1: reasonable biomarkers for immune checkpoint inhibitor","volume":"8","author":"Yang","year":"2018","journal-title":"Am. J. Cancer Res."},{"issue":"8","key":"10.1016\/j.canlet.2020.02.001_bib49","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.jtho.2018.04.013","article-title":"Expression patterns, prognostic value, and intratumoral heterogeneity of PD-L1 and PD-1 in thymoma and thymic carcinoma","volume":"13","author":"Owen","year":"2018","journal-title":"J. Thorac. Oncol."},{"issue":"11","key":"10.1016\/j.canlet.2020.02.001_bib50","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1111\/1759-7714.12826","article-title":"Impact of PD-L1, transforming growth factor-beta expression and tumor-infiltrating CD8(+) T cells on clinical outcome of patients with advanced thymic epithelial tumors","volume":"9","author":"Duan","year":"2018","journal-title":"Thorac. Cancer"},{"issue":"3","key":"10.1016\/j.canlet.2020.02.001_bib51","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1097\/JTO.0000000000000429","article-title":"Diffuse high intensity PD-L1 staining in thymic epithelial tumors","volume":"10","author":"Padda","year":"2015","journal-title":"J. Thorac. Oncol."},{"issue":"8","key":"10.1016\/j.canlet.2020.02.001_bib52","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0182665","article-title":"Expression of PD-L1 and other immunotherapeutic targets in thymic epithelial tumors","volume":"12","author":"Arbour","year":"2017","journal-title":"PloS One"},{"issue":"18","key":"10.1016\/j.canlet.2020.02.001_bib53","doi-asserted-by":"crossref","first-page":"4727","DOI":"10.1158\/1078-0432.CCR-16-0434","article-title":"Prognostic value of programmed death ligand 1 and programmed death 1 expression in thymic carcinoma","volume":"22","author":"Yokoyama","year":"2016","journal-title":"Clin. Canc. Res."},{"issue":"2","key":"10.1016\/j.canlet.2020.02.001_bib54","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.lungcan.2015.03.003","article-title":"Immunohistochemical status of PD-L1 in thymoma and thymic carcinoma","volume":"88","author":"Katsuya","year":"2015","journal-title":"Lung Canc."},{"issue":"6","key":"10.1016\/j.canlet.2020.02.001_bib55","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/modpathol.2017.6","article-title":"Expression of PD-1 and PD-L1 in thymic epithelial neoplasms","volume":"30","author":"Weissferdt","year":"2017","journal-title":"Mod. Pathol."},{"issue":"3","key":"10.1016\/j.canlet.2020.02.001_bib56","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S1470-2045(18)30062-7","article-title":"Pembrolizumab in patients with thymic carcinoma: a single-arm, single-centre, phase 2 study","volume":"19","author":"Giaccone","year":"2018","journal-title":"Lancet Oncol."},{"issue":"15_suppl","key":"10.1016\/j.canlet.2020.02.001_bib57","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2018.36.15_suppl.3572","article-title":"Impact of MLH1, PMS2, MSH2, and MSH6 alterations on tumor mutation burden (TMB) and PD-L1 expression in 1,057 microsatellite instability-high (MSI-H) tumors","volume":"36","author":"Salem","year":"2018","journal-title":"J. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.canlet.2020.02.001_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijrobp.2019.06.612","article-title":"Tumor mutation burden and driver mutations: further insight into the genomic landscape of pediatric brain tumors","volume":"105","author":"Patel","year":"2019","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"6","key":"10.1016\/j.canlet.2020.02.001_bib59","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1158\/1078-0432.CCR-18-1892","article-title":"Genetic, epigenetic, and immunologic profiling of MMR-deficient relapsed glioblastoma","volume":"25","author":"Indraccolo","year":"2019","journal-title":"Clin. Canc. Res."},{"issue":"8","key":"10.1016\/j.canlet.2020.02.001_bib60","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1158\/0008-5472.CAN-06-0127","article-title":"A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy","volume":"66","author":"Hunter","year":"2006","journal-title":"Canc. Res."},{"issue":"7","key":"10.1016\/j.canlet.2020.02.001_bib61","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/ng.3590","article-title":"Clonal evolution of glioblastoma under therapy","volume":"48","author":"Wang","year":"2016","journal-title":"Nat. Genet."},{"issue":"9 Suppl 2","key":"10.1016\/j.canlet.2020.02.001_bib62","doi-asserted-by":"crossref","first-page":"S131","DOI":"10.1097\/JTO.0000000000000298","article-title":"State of the art of genetic alterations in thymic epithelial tumors","volume":"9","author":"Rajan","year":"2014","journal-title":"J. Thorac. Oncol."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383520300550?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383520300550?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T15:47:09Z","timestamp":1759592829000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383520300550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":62,"alternative-id":["S0304383520300550"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2020.02.001","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Next-generation sequencing in thymic epithelial tumors uncovered novel genomic aberration sites and strong correlation between TMB and MSH6 single nucleotide variations","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2020.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}