{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:48:27Z","timestamp":1790365707952,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Faculty of Medicine"},{"DOI":"10.13039\/501100004375","name":"Tel Aviv University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004375","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.canlet.2020.11.011","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T17:28:53Z","timestamp":1605806933000},"page":"224-233","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["DIO3, the thyroid hormone inactivating enzyme, promotes tumorigenesis and metabolic reprogramming in high grade serous ovarian cancer"],"prefix":"10.1016","volume":"501","author":[{"given":"Dotan","family":"Moskovich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adi","family":"Alfandari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Finkelshtein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avivit","family":"Weisz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aviva","family":"Katzav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debora","family":"Kidron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeny","family":"Edelstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Veroslavski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Perets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nissim","family":"Arbib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yfat","family":"Kadan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3527-6344","authenticated-orcid":false,"given":"Ami","family":"Fishman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9914-632X","authenticated-orcid":false,"given":"Bernard","family":"Lerer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8624-3182","authenticated-orcid":false,"given":"Osnat","family":"Ashur-Fabian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2020.11.011_bib1","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/S0140-6736(13)62146-7","article-title":"Ovarian cancer","volume":"384","author":"Jayson","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.canlet.2020.11.011_bib2","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/s41467-017-00962-1","article-title":"High grade serous ovarian carcinomas originate in the fallopian tube","volume":"8","author":"Labidi-Galy","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2020.11.011_bib3","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1158\/0008-5472.CAN-15-1382","article-title":"It's totally tubular riding the new wave of ovarian cancer research","volume":"76","author":"Perets","year":"2016","journal-title":"Canc. Res."},{"key":"10.1016\/j.canlet.2020.11.011_bib4","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","article-title":"Understanding the Warburg effect: the metabolic requirements of cell proliferation","volume":"324","author":"Vander Heiden","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.canlet.2020.11.011_bib5","doi-asserted-by":"crossref","first-page":"R367","DOI":"10.1530\/ERC-17-0192","article-title":"Role of thyroid hormones in the neoplastic process: an overview","volume":"24","author":"Goemann","year":"2017","journal-title":"Endocr. Relat. Canc."},{"key":"10.1016\/j.canlet.2020.11.011_bib6","first-page":"315","article-title":"Deiodination in cancer growth: the role of type III deiodinase","volume":"37","author":"Sibilio","year":"2012","journal-title":"Minerva Endocrinol."},{"key":"10.1016\/j.canlet.2020.11.011_bib7","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/s41574-019-0218-2","article-title":"Deiodinases and their intricate role in thyroid hormone homeostasis","volume":"15","author":"Luongo","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.canlet.2020.11.011_bib8","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3389\/fendo.2014.00215","article-title":"Type 3 deiodinase: role in cancer growth, stemness, and metabolism","volume":"5","author":"Ciavardelli","year":"2014","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.canlet.2020.11.011_bib9","doi-asserted-by":"crossref","first-page":"R625","DOI":"10.1530\/ERC-18-0097","article-title":"Current concepts and challenges to unravel the role of iodothyronine deiodinases in human neoplasias","volume":"25","author":"Goemann","year":"2018","journal-title":"Endocr. Relat. Canc."},{"key":"10.1016\/j.canlet.2020.11.011_bib10","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1172\/JCI84465","article-title":"Reciprocal interplay between thyroid hormone and microRNA-21 regulates hedgehog pathway\u2013driven skin tumorigenesis","volume":"126","author":"Di Girolamo","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.canlet.2020.11.011_bib11","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1158\/0008-5472.CAN-15-1542","article-title":"Activated thyroid hormone promotes differentiation and chemotherapeutic sensitization of colorectal cancer stem cells by regulating Wnt and BMP4 signaling","volume":"76","author":"Catalano","year":"2016","journal-title":"Canc. Res."},{"key":"10.1016\/j.canlet.2020.11.011_bib12","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1530\/ERC-15-0162","article-title":"MAPK and SHH pathways modulate type 3 deiodinase expression in papillary thyroid carcinoma","volume":"23","author":"Romitti","year":"2016","journal-title":"Endocr. Relat. Canc."},{"key":"10.1016\/j.canlet.2020.11.011_bib13","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1053\/j.gastro.2012.06.042","article-title":"beta-Catenin regulates deiodinase levels and thyroid hormone signaling in colon cancer cells","volume":"143","author":"Dentice","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.canlet.2020.11.011_bib14","doi-asserted-by":"crossref","first-page":"14466","DOI":"10.1073\/pnas.0706754104","article-title":"Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes","volume":"104","author":"Dentice","year":"2007","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.canlet.2020.11.011_bib15","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.ccr.2013.10.013","article-title":"Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in Brca; Tp53; Pten models","volume":"24","author":"Perets","year":"2013","journal-title":"Canc. Cell"},{"key":"10.1016\/j.canlet.2020.11.011_bib16","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1038\/onc.2015.262","article-title":"The thyroid hormone-alphavbeta3 integrin axis in ovarian cancer: regulation of gene transcription and MAPK-dependent proliferation","volume":"35","author":"Shinderman-Maman","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2020.11.011_bib17","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1158\/1541-7786.MCR-11-0187","article-title":"Thyroid hormone is a MAPK-dependent growth factor for human myeloma cells acting via alphavbeta3 integrin","volume":"9","author":"Cohen","year":"2011","journal-title":"Mol. Canc. Res."},{"key":"10.1016\/j.canlet.2020.11.011_bib18","doi-asserted-by":"crossref","first-page":"W566","DOI":"10.1093\/nar\/gkv468","article-title":"ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap","volume":"43","author":"Metsalu","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.canlet.2020.11.011_bib19","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/s41596-019-0128-8","article-title":"Protocol Update for large-scale genome and gene function analysis with the PANTHER classification system (v. 14.0)","volume":"14","author":"Mi","year":"2019","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.canlet.2020.11.011_bib20","article-title":"The STRING database in 2017: quality-controlled protein\u2013protein association networks, made broadly accessible","author":"Szklarczyk","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.canlet.2020.11.011_bib21","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1038\/ncomms3126","article-title":"Evaluating cell lines as tumour models by comparison of genomic profiles","volume":"4","author":"Domcke","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2020.11.011_bib22","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1038\/nprot.2012.097","article-title":"Primary culture and immortalization of human fallopian tube secretory epithelial cells","volume":"7","author":"Karst","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.canlet.2020.11.011_bib23","doi-asserted-by":"crossref","first-page":"10526","DOI":"10.1073\/pnas.1323873111","article-title":"Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism","volume":"111","author":"Schweizer","year":"2014","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.canlet.2020.11.011_bib24","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1210\/me.2007-0490","article-title":"The thyroid hormone-inactivating deiodinase functions as a homodimer","volume":"22","author":"Sagar","year":"2008","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.canlet.2020.11.011_bib25","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1210\/en.2002-220960","article-title":"In vivo dimerization of types 1, 2, and 3 iodothyronine selenodeiodinases","volume":"144","author":"Curcio-Morelli","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.canlet.2020.11.011_bib26","first-page":"1366","article-title":"Evidence that the human placental 5-monodeiodinase is a phospholipid-requiring enzyme","volume":"74","author":"Santini","year":"1992","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.canlet.2020.11.011_bib27","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1097\/PAS.0b013e31822f58bc","article-title":"Diagnosis of serous tubal intraepithelial carcinoma based on morphologic and immunohistochemical features: a reproducibility study","volume":"35","author":"Visvanathan","year":"2011","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.canlet.2020.11.011_bib28","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1507\/endocrj.EJ13-0418","article-title":"Cytosolic T3-binding protein modulates dynamic alteration of T3-mediated gene expression in cells","volume":"61","author":"Takeshige","year":"2014","journal-title":"Endocr. J."},{"key":"10.1016\/j.canlet.2020.11.011_bib29","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1096\/fj.15-280933","article-title":"\u03bc-Crystallin controls muscle function through thyroid hormone action","volume":"30","author":"Seko","year":"2016","journal-title":"Faseb. J."},{"key":"10.1016\/j.canlet.2020.11.011_bib30","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1471-4159.2011.07220.x","article-title":"Mammalian forebrain ketimine reductase identified as \u03bc\u2010crystallin; potential regulation by thyroid hormones","volume":"118","author":"Hallen","year":"2011","journal-title":"J. Neurochem."},{"key":"10.1016\/j.canlet.2020.11.011_bib31","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cels.2018.06.003","article-title":"Four key steps control glycolytic flux in mammalian cells","volume":"7","author":"Tanner","year":"2018","journal-title":"Cell systems"},{"key":"10.1016\/j.canlet.2020.11.011_bib32","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s10545-011-9382-9","article-title":"Mitochondrial ATP synthase: architecture, function and pathology","volume":"35","author":"Jonckheere","year":"2012","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.canlet.2020.11.011_bib33","doi-asserted-by":"crossref","first-page":"4443","DOI":"10.1073\/pnas.96.8.4443","article-title":"Thyroid hormone, T3-dependent phosphorylation and translocation of Trip230 from the Golgi complex to the nucleus","volume":"96","author":"Chen","year":"1999","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.canlet.2020.11.011_bib34","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.1093\/emboj\/17.12.3398","article-title":"Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators","volume":"17","author":"Huang","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.canlet.2020.11.011_bib35","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1172\/JCI15990","article-title":"Thyroid functions of mouse cathepsins B, K, and L","volume":"111","author":"Friedrichs","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.canlet.2020.11.011_bib36","doi-asserted-by":"crossref","first-page":"468","DOI":"10.3892\/mmr.2014.2706","article-title":"Cathepsin L is involved in proliferation and invasion of ovarian cancer cells","volume":"11","author":"Zhang","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.canlet.2020.11.011_bib37","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.3892\/or.2015.3742","volume":"33","author":"Tang","year":"2015","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.canlet.2020.11.011_bib38","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1073\/pnas.1013746108","article-title":"Microenvironmental control of malignancy exerted by RNASET2, a widely conserved extracellular RNase","volume":"108","author":"Acquati","year":"2011","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.canlet.2020.11.011_bib39","doi-asserted-by":"crossref","first-page":"27356","DOI":"10.1074\/jbc.M513452200","article-title":"The histidine triad protein Hint1 triggers apoptosis independent of its enzymatic activity","volume":"281","author":"Weiske","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2020.11.011_bib40","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1111\/febs.13253","article-title":"Lysosomal proteins in cell death and autophagy","volume":"282","author":"Mrschtik","year":"2015","journal-title":"FEBS J."},{"key":"10.1016\/j.canlet.2020.11.011_bib41","doi-asserted-by":"crossref","first-page":"32785","DOI":"10.18632\/oncotarget.9051","article-title":"Loss of PAX8 in high-grade serous ovarian cancer reduces cell survival despite unique modes of action in the fallopian tube and ovarian surface epithelium","volume":"7","author":"Rodgers","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.canlet.2020.11.011_bib42","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1210\/en.2013-2108","article-title":"The sonic hedgehog-induced type 3 deiodinase facilitates tumorigenesis of basal cell carcinoma by reducing Gli2 inactivation","volume":"155","author":"Luongo","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.canlet.2020.11.011_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0020861","article-title":"3, 3\u2032 5 triiodo L thyronine induces apoptosis in human breast cancer MCF-7cells, repressing SMP30 expression through negative thyroid response elements","volume":"6","author":"Sar","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.canlet.2020.11.011_bib44","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1089\/thy.2000.10.1023","article-title":"Thyroid hormone regulation of apoptosis induced by retinoic acid in promyeloleukemic HL-60 cells: studies with retinoic acid receptor-specific and retinoid\u00d7 receptor-specific ligands","volume":"10","author":"Hara","year":"2000","journal-title":"Thyroid"},{"key":"10.1016\/j.canlet.2020.11.011_bib45","first-page":"1","article-title":"PAX8 activates a p53-p21-dependent pro-proliferative effect in high grade serous ovarian carcinoma","author":"Ghannam-Shahbari","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2020.11.011_bib46","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.3892\/or.2015.4408","article-title":"MARCKSL1 exhibits anti-angiogenic effects through suppression of VEGFR-2-dependent Akt\/PDK-1\/mTOR phosphorylation","volume":"35","author":"Kim","year":"2016","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.canlet.2020.11.011_bib47","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.ccr.2012.02.014","article-title":"Metabolic reprogramming: a cancer hallmark even warburg did not anticipate","volume":"21","author":"Ward","year":"2012","journal-title":"Canc. Cell"},{"key":"10.1016\/j.canlet.2020.11.011_bib48","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1210\/er.2009-0007","article-title":"Molecular aspects of thyroid hormone actions","volume":"31","author":"Cheng","year":"2010","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.canlet.2020.11.011_bib49","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.3390\/jcm9061679","article-title":"Thyroid hormones and functional ovarian reserve: systemic vs. Peripheral dysfunctions","volume":"9","author":"Colella","year":"2020","journal-title":"J. Clin. Med."}],"updated-by":[{"DOI":"10.1016\/j.canlet.2023.216196","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000}}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383520306030?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383520306030?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T15:56:39Z","timestamp":1759593399000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383520306030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":49,"alternative-id":["S0304383520306030"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2020.11.011","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DIO3, the thyroid hormone inactivating enzyme, promotes tumorigenesis and metabolic reprogramming in high grade serous ovarian cancer","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2020.11.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}