{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:11:43Z","timestamp":1790565103382,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.canlet.2021.01.024","type":"journal-article","created":{"date-parts":[[2021,1,30]],"date-time":"2021-01-30T08:05:52Z","timestamp":1611993952000},"page":"163-173","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["In vivo selection of highly metastatic human ovarian cancer sublines reveals role for AMIGO2 in intra-peritoneal metastatic regulation"],"prefix":"10.1016","volume":"503","author":[{"given":"Yueying","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zonggao","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1926-9686","authenticated-orcid":false,"given":"Xuejuan","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catlin","family":"O'Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8128-5295","authenticated-orcid":false,"given":"Connor","family":"Ott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Grisoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3659-1020","authenticated-orcid":false,"given":"Eric","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Volk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan","family":"Conroy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Franz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamarie","family":"Bryant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2155-6652","authenticated-orcid":false,"given":"Leigh","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Crowley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Grisoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9089-6354","authenticated-orcid":false,"given":"Aris T.","family":"Alexandrou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth I.","family":"Harper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa","family":"Asem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0473-2869","authenticated-orcid":false,"given":"Jeff","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie","family":"Leonard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Santanello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2076-6620","authenticated-orcid":false,"given":"Tyvette S.","family":"Hilliard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Sharon","family":"Stack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2021.01.024_bib1","series-title":"The World Ovarian Cancer Coalition Every Woman Study: identifying challenges and opportunities to improve survival and quality of life","author":"Reid","year":"2020"},{"key":"10.1016\/j.canlet.2021.01.024_bib2","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","article-title":"Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012","volume":"136","author":"Ferlay","year":"2015","journal-title":"Int. J. Canc."},{"key":"10.1016\/j.canlet.2021.01.024_bib3","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/S0140-6736(14)61396-9","article-title":"40-year trends in an index of survival for all cancers combined and survival adjusted for age and sex for each cancer in England and Wales, 1971-2011: a population-based study","volume":"385","author":"Quaresma","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.canlet.2021.01.024_bib4","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.ygyno.2015.12.021","article-title":"Ovarian cancer outcomes: predictors of early death","volume":"140","author":"Urban","year":"2016","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.canlet.2021.01.024_bib5","series-title":"SEER Cancer Statistics Review","year":"1975"},{"key":"10.1016\/j.canlet.2021.01.024_bib6","first-page":"25","article-title":"Current approaches and challenges in managing and monitoring treatment response in ovarian cancer","volume":"5","author":"Marcus","year":"2014","journal-title":"J. Canc."},{"key":"10.1016\/j.canlet.2021.01.024_bib7","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.2353\/ajpath.2010.100105","article-title":"Ovarian cancer development and metastasis","volume":"177","author":"Lengyel","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.canlet.2021.01.024_bib8","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1038\/onc.2013.321","article-title":"Epithelial ovarian cancer experimental models","volume":"33","author":"Lengyel","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2021.01.024_bib9","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.trsl.2016.03.016","article-title":"New models of hematogenous ovarian cancer metastasis demonstrate preferential spread to the ovary and a requirement for the ovary for abdominal dissemination","volume":"175","author":"Coffman","year":"2016","journal-title":"Transl. Res."},{"key":"10.1016\/j.canlet.2021.01.024_bib10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ccr.2014.05.002","article-title":"Hematogenous metastasis of ovarian cancer: rethinking mode of spread","volume":"26","author":"Pradeep","year":"2014","journal-title":"Canc. Cell"},{"key":"10.1016\/j.canlet.2021.01.024_bib11","first-page":"9","article-title":"Complex determinants of epithelial: mesenchymal phenotypic plasticity in ovarian cancer","author":"Klymenko","year":"2017","journal-title":"Cancers"},{"key":"10.1016\/j.canlet.2021.01.024_bib12","doi-asserted-by":"crossref","first-page":"5127","DOI":"10.1038\/s41388-018-0317-x","article-title":"Multicellular detachment generates metastatic spheroids during intra-abdominal dissemination in epithelial ovarian cancer","volume":"37","author":"Al Habyan","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2021.01.024_bib13","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/nrc1143","article-title":"The emerging role of lysophosphatidic acid in cancer","volume":"3","author":"Mills","year":"2003","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.canlet.2021.01.024_bib14","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3389\/fonc.2013.00256","article-title":"Getting to know ovarian cancer ascites: opportunities for targeted therapy-based translational research","volume":"3","author":"Ahmed","year":"2013","journal-title":"Front Oncol"},{"key":"10.1016\/j.canlet.2021.01.024_bib15","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nrc3432","article-title":"Meeting the challenge of ascites in ovarian cancer: new avenues for therapy and research","volume":"13","author":"Kipps","year":"2013","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.canlet.2021.01.024_bib16","first-page":"891","article-title":"Enhanced c-erbB-2\/neu expression in human ovarian cancer cells correlates with more severe malignancy that can be suppressed by E1A","volume":"53","author":"Yu","year":"1993","journal-title":"Canc. Res."},{"key":"10.1016\/j.canlet.2021.01.024_bib17","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1038\/ncomms3126","article-title":"Evaluating cell lines as tumour models by comparison of genomic profiles","volume":"4","author":"Domcke","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2021.01.024_bib18","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nature10166","article-title":"Integrated genomic analyses of ovarian carcinoma","volume":"474","author":"Cancer Genome Atlas Research","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2021.01.024_bib19","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.ygyno.2015.05.040","article-title":"In vivo tumor growth of high-grade serous ovarian cancer cell lines","volume":"138","author":"Mitra","year":"2015","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.canlet.2021.01.024_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0197404","article-title":"Changes in mRNA\/protein expression and signaling pathways in in vivo passaged mouse ovarian cancer cells","volume":"13","author":"Cai","year":"2018","journal-title":"PloS One"},{"key":"10.1016\/j.canlet.2021.01.024_bib21","doi-asserted-by":"crossref","first-page":"6118","DOI":"10.1158\/0008-5472.CAN-16-1272","article-title":"CRISPR\/Cas9-Mediated Trp53 and Brca2 knockout to generate improved murine models of ovarian high-grade serous carcinoma","volume":"76","author":"Walton","year":"2016","journal-title":"Canc. Res."},{"key":"10.1016\/j.canlet.2021.01.024_bib22","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nature11003","article-title":"The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity","volume":"483","author":"Barretina","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2021.01.024_bib23","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1093\/carcin\/23.12.2011","article-title":"Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database","volume":"23","author":"Bykov","year":"2002","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.canlet.2021.01.024_bib24","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1158\/0008-5472.CAN-19-1601","article-title":"Host Wnt5a potentiates microenvironmental regulation of ovarian cancer metastasis","volume":"80","author":"Asem","year":"2020","journal-title":"Canc. Res."},{"key":"10.1016\/j.canlet.2021.01.024_bib25","doi-asserted-by":"crossref","first-page":"3817","DOI":"10.1038\/s41467-019-11729-1","article-title":"Single-cell profiling guided combinatorial immunotherapy for fast-evolving CDK4\/6 inhibitor-resistant HER2-positive breast cancer","volume":"10","author":"Wang","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2021.01.024_bib26","first-page":"1998","article-title":"Modulation of murine B16F10 melanoma plasminogen activator production by a synthetic peptide derived from the laminin A chain","volume":"53","author":"Stack","year":"1993","journal-title":"Canc. Res."},{"key":"10.1016\/j.canlet.2021.01.024_bib27","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/nbt.3290","article-title":"Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells","volume":"33","author":"Hendel","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.canlet.2021.01.024_bib28","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/nmeth.4284","article-title":"Mapping the genomic landscape of CRISPR-Cas9 cleavage","volume":"14","author":"Cameron","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.canlet.2021.01.024_bib29","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jbiotec.2015.04.024","article-title":"Rapid and highly efficient mammalian cell engineering via Cas9 protein transfection","volume":"208","author":"Liang","year":"2015","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.canlet.2021.01.024_bib30","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1101\/gr.171322.113","article-title":"Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins","volume":"24","author":"Kim","year":"2014","journal-title":"Genome Res."},{"key":"10.1016\/j.canlet.2021.01.024_bib31","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1089\/nat.2019.0790","article-title":"Evaluation and reduction of CRISPR off-target cleavage events","volume":"29","author":"Vakulskas","year":"2019","journal-title":"Nucleic Acid Therapeut."},{"key":"10.1016\/j.canlet.2021.01.024_bib32","article-title":"Ovarian cancer spheroid cells with stem cell-like properties contribute to tumor generation, metastasis and chemotherapy resistance through hypoxia-resistant metabolism","volume":"9","author":"Liao","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.canlet.2021.01.024_bib33","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ygyno.2003.12.034","article-title":"Ovarian carcinoma ascites spheroids adhere to extracellular matrix components and mesothelial cell monolayers","volume":"93","author":"Burleson","year":"2004","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.canlet.2021.01.024_bib34","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/1471-2164-9-99","article-title":"Global gene expression analysis of early response to chemotherapy treatment in ovarian cancer spheroids","volume":"9","author":"L'Esperance","year":"2008","journal-title":"BMC Genom."},{"key":"10.1016\/j.canlet.2021.01.024_bib35","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ygyno.2008.11.032","article-title":"Multicellular spheroids in ovarian cancer metastases: biology and pathology","volume":"113","author":"Shield","year":"2009","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.canlet.2021.01.024_bib36","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1002\/ijc.24188","article-title":"Compact spheroid formation by ovarian cancer cells is associated with contractile behavior and an invasive phenotype","volume":"124","author":"Sodek","year":"2009","journal-title":"Int. J. Canc."},{"key":"10.1016\/j.canlet.2021.01.024_bib37","doi-asserted-by":"crossref","first-page":"5840","DOI":"10.1038\/onc.2017.171","article-title":"Cadherin composition and multicellular aggregate invasion in organotypic models of epithelial ovarian cancer intraperitoneal metastasis","volume":"36","author":"Klymenko","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2021.01.024_bib38","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.neo.2017.04.002","article-title":"Heterogeneous cadherin expression and multicellular aggregate dynamics in ovarian cancer dissemination","volume":"19","author":"Klymenko","year":"2017","journal-title":"Neoplasia"},{"key":"10.1016\/j.canlet.2021.01.024_bib39","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1083\/jcb.200209074","article-title":"AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats","volume":"160","author":"Kuja-Panula","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.canlet.2021.01.024_bib40","doi-asserted-by":"crossref","first-page":"5056","DOI":"10.1038\/sj.onc.1207681","article-title":"DEGA\/AMIGO-2, a leucine-rich repeat family member, differentially expressed in human gastric adenocarcinoma: effects on ploidy, chromosomal stability, cell adhesion\/migration and tumorigenicity","volume":"23","author":"Rabenau","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2021.01.024_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0188697","article-title":"Colorectal cancer stages transcriptome analysis","volume":"12","author":"Huo","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.canlet.2021.01.024_bib42","doi-asserted-by":"crossref","first-page":"43567","DOI":"10.1038\/srep43567","article-title":"Amigo2-upregulation in tumour cells facilitates their attachment to liver endothelial cells resulting in liver metastases","volume":"7","author":"Kanda","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.canlet.2021.01.024_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2004049","article-title":"Reporters to mark and eliminate basal or luminal epithelial cells in culture and in vivo","volume":"16","author":"Sonzogni","year":"2018","journal-title":"PLoS Biol."},{"key":"10.1016\/j.canlet.2021.01.024_bib44","series-title":"FAK Activity Sustains Intrinsic and Acquired Ovarian Cancer Resistance to Platinum Chemotherapy, Elife","volume":"vol. 8","author":"Diaz Osterman","year":"2019"},{"key":"10.1016\/j.canlet.2021.01.024_bib45","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1083\/jcb.201503113","article-title":"AMIGO2, a novel membrane anchor of PDK1, controls cell survival and angiogenesis via Akt activation","volume":"211","author":"Park","year":"2015","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.canlet.2021.01.024_bib46","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.molcel.2017.11.004","article-title":"Harnessing BET inhibitor sensitivity reveals AMIGO2 as a melanoma survival gene","volume":"68","author":"Fontanals-Cirera","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.canlet.2021.01.024_bib47","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/S0002-9378(13)90451-8","article-title":"Coordinate expression of urinary-type plasminogen activator and its receptor accompanies malignant transformation of the ovarian surface epithelium","volume":"170","author":"Young","year":"1994","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.canlet.2021.01.024_bib48","first-page":"2396","article-title":"Increased expression of matrix metalloproteinases (MMP)-2, MMP-9, and the urokinase-type plasminogen activator is associated with progression from benign to advanced ovarian cancer","volume":"7","author":"Schmalfeldt","year":"2001","journal-title":"Clin. Canc. Res."},{"key":"10.1016\/j.canlet.2021.01.024_bib49","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1158\/1535-7163.MCT-13-0204","article-title":"Urokinase plasminogen activator system-targeted delivery of nanobins as a novel ovarian cancer therapy","volume":"12","author":"Zhang","year":"2013","journal-title":"Mol. Canc. Therapeut."},{"key":"10.1016\/j.canlet.2021.01.024_bib50","doi-asserted-by":"crossref","first-page":"4664","DOI":"10.1038\/onc.2014.391","article-title":"Matriptase promotes inflammatory cell accumulation and progression of established epidermal tumors","volume":"34","author":"Sales","year":"2015","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2021.01.024_bib51","doi-asserted-by":"crossref","first-page":"29495","DOI":"10.1074\/jbc.M801970200","article-title":"Potent inhibition and global co-localization implicate the transmembrane Kunitz-type serine protease inhibitor hepatocyte growth factor activator inhibitor-2 in the regulation of epithelial matriptase activity","volume":"283","author":"Szabo","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2021.01.024_bib52","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/s42003-019-0464-9","article-title":"High throughput proteomics identifies a high-accuracy 11 plasma protein biomarker signature for ovarian cancer","volume":"2","author":"Enroth","year":"2019","journal-title":"Commun Biol"},{"key":"10.1016\/j.canlet.2021.01.024_bib53","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1158\/2159-8290.CD-17-0284","article-title":"Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers","volume":"8","author":"Pearce","year":"2018","journal-title":"Canc. Discov."},{"key":"10.1016\/j.canlet.2021.01.024_bib54","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1158\/1078-0432.CCR-13-1256","article-title":"A collagen-remodeling gene signature regulated by TGF-beta signaling is associated with metastasis and poor survival in serous ovarian cancer","volume":"20","author":"Cheon","year":"2014","journal-title":"Clin. Canc. Res."},{"key":"10.1016\/j.canlet.2021.01.024_bib55","doi-asserted-by":"crossref","first-page":"747","DOI":"10.3892\/ijmm.2013.1472","article-title":"The Kiss-1\/Kiss-1R complex as a negative regulator of cell motility and cancer metastasis (Review)","volume":"32","author":"Ji","year":"2013","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.canlet.2021.01.024_bib56","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s10585-005-8186-4","article-title":"KiSS1 suppresses metastasis in human ovarian cancer via inhibition of protein kinase C alpha","volume":"22","author":"Jiang","year":"2005","journal-title":"Clin. Exp. Metastasis"}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383521000483?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383521000483?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T15:55:07Z","timestamp":1759593307000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383521000483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":56,"alternative-id":["S0304383521000483"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2021.01.024","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vivo selection of highly metastatic human ovarian cancer sublines reveals role for AMIGO2 in intra-peritoneal metastatic regulation","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2021.01.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}