{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T04:20:18Z","timestamp":1792383618471,"version":"4.4.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007419","name":"National Institute of Agrobiological Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007419","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970492"],"award-info":[{"award-number":["81970492"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.canlet.2021.12.034","type":"journal-article","created":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T10:38:48Z","timestamp":1640947128000},"page":"1-10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":92,"special_numbering":"C","title":["Radiosensitivity of colorectal cancer and radiation-induced gut damages are regulated by gasdermin E"],"prefix":"10.1016","volume":"529","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6959-2249","authenticated-orcid":false,"given":"Gao","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunjing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongyang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingxia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaye","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqiang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fachao","family":"Zhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2021.12.034_bib1","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nrd.2017.59","article-title":"Colorectal cancer drugs market, Nature reviews","volume":"16","author":"Cassidy","year":"2017","journal-title":"Drug discovery"},{"key":"10.1016\/j.canlet.2021.12.034_bib2","series-title":"Cancer Statistics","author":"Siegel","year":"2020"},{"key":"10.1016\/j.canlet.2021.12.034_bib3","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.bbrc.2003.09.170","article-title":"Photofrin as a radiosensitizer in an in vitro cell survival assay","volume":"311","author":"Kulka","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.canlet.2021.12.034_bib4","first-page":"5132","article-title":"Radiosensitizing effect of 5-aminolevulinic acid in colorectal cancer in vitro and in vivo","volume":"17","author":"Yamada","year":"2019","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.canlet.2021.12.034_bib5","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2021.12.034_bib6","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.tibs.2016.10.004","article-title":"Pyroptosis: gasdermin-mediated programmed necrotic cell death","volume":"42","author":"Shi","year":"2017","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.canlet.2021.12.034_bib7","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.cell.2020.02.002","article-title":"Structural mechanism for GSDMD targeting by autoprocessed caspases in pyroptosis","volume":"180","author":"Wang","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2021.12.034_bib8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nature18590","article-title":"Pore-forming activity and structural autoinhibition of the gasdermin family","volume":"535","author":"Ding","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2021.12.034_bib9","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nature18629","article-title":"Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores","volume":"535","author":"Liu","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2021.12.034_bib10","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature22393","article-title":"Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin","volume":"547","author":"Wang","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2021.12.034_bib11","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1349-7006.2006.00351.x","article-title":"Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer","volume":"98","author":"Akino","year":"2007","journal-title":"Cancer Sci."},{"key":"10.1016\/j.canlet.2021.12.034_bib12","doi-asserted-by":"crossref","first-page":"3624","DOI":"10.1038\/sj.onc.1211021","article-title":"Aberrant promoter methylation and tumor suppressive activity of the DFNA5 gene in colorectal carcinoma","volume":"27","author":"Kim","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2021.12.034_bib13","first-page":"1319","article-title":"Methylation of the DFNA5 gene is frequently detected in colorectal cancer","volume":"32","author":"Yokomizo","year":"2012","journal-title":"Anticancer Res."},{"key":"10.1016\/j.canlet.2021.12.034_bib14","doi-asserted-by":"crossref","first-page":"4664","DOI":"10.1111\/jcmm.13688","article-title":"Transcription factor ATF3 mediates the radioresistance of breast cancer","volume":"22","author":"Zhao","year":"2018","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.canlet.2021.12.034_bib15","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/dju403","article-title":"Induced phenotype targeted therapy: radiation-induced apoptosis-targeted chemotherapy","volume":"107","author":"Lee","year":"2015","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.canlet.2021.12.034_bib16","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ejcb.2014.10.007","article-title":"Regulation of human enteric alpha-defensins by NOD2 in the Paneth cell lineage","volume":"94","author":"Tan","year":"2015","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.canlet.2021.12.034_bib17","doi-asserted-by":"crossref","first-page":"8383","DOI":"10.1038\/srep08383","article-title":"Down-regulation of human enteric antimicrobial peptides by NOD2 during differentiation of the paneth cell lineage","volume":"5","author":"Tan","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.canlet.2021.12.034_bib18","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.ygeno.2007.01.003","article-title":"Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner","volume":"89","author":"Tamura","year":"2007","journal-title":"Genomics"},{"key":"10.1016\/j.canlet.2021.12.034_bib19","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/gcc.20636","article-title":"Distinctive expression and function of four GSDM family genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium","volume":"48","author":"Saeki","year":"2009","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.canlet.2021.12.034_bib20","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/2503","article-title":"Nonsyndromic hearing impairment is associated with a mutation in DFNA5","volume":"20","author":"Van Laer","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.canlet.2021.12.034_bib21","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41586-020-2071-9","article-title":"Gasdermin E suppresses tumour growth by activating anti-tumour immunity","volume":"579","author":"Zhang","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2021.12.034_bib22","doi-asserted-by":"crossref","first-page":"14128","DOI":"10.1038\/ncomms14128","article-title":"Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic\/pyroptotic cell death","volume":"8","author":"Rogers","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2021.12.034_bib23","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41577-019-0228-2","article-title":"The gasdermins, a protein family executing cell death and inflammation","volume":"20","author":"Broz","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.canlet.2021.12.034_bib24","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1080\/10428194.2016.1228927","article-title":"Hypomethylating agent combination strategies in myelodysplastic syndromes: hopes and shortcomings","volume":"58","author":"Ball","year":"2017","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.canlet.2021.12.034_bib25","doi-asserted-by":"crossref","first-page":"14105","DOI":"10.3390\/ijms140714105","article-title":"Resveratrol inhibits ionising irradiation-induced inflammation in MSCs by activating SIRT1 and limiting NLRP-3 inflammasome activation","volume":"14","author":"Fu","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.canlet.2021.12.034_bib26","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jgr.2014.02.001","article-title":"Korean Red Ginseng saponin fraction modulates radiation effects on lipopolysaccharide-stimulated nitric oxide production in RAW264.7 macrophage cells","volume":"38","author":"Lee","year":"2014","journal-title":"Journal of ginseng research"},{"key":"10.1016\/j.canlet.2021.12.034_bib27","doi-asserted-by":"crossref","first-page":"109265","DOI":"10.1016\/j.celrep.2021.109265","article-title":"Gasdermin-E-mediated pyroptosis participates in the pathogenesis of Crohn's disease by promoting intestinal inflammation","volume":"35","author":"Tan","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.canlet.2021.12.034_bib28","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s13045-020-00985-0","article-title":"HMGB1 released from GSDME-mediated pyroptotic epithelial cells participates in the tumorigenesis of colitis-associated colorectal cancer through the ERK1\/2 pathway","volume":"13","author":"Tan","year":"2020","journal-title":"J. Hematol. Oncol."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383521006571?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383521006571?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T16:01:01Z","timestamp":1759593661000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383521006571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":28,"alternative-id":["S0304383521006571"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2021.12.034","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Radiosensitivity of colorectal cancer and radiation-induced gut damages are regulated by gasdermin E","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2021.12.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}