{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:54:06Z","timestamp":1789736046702,"version":"4.0.1"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.canlet.2022.215652","type":"journal-article","created":{"date-parts":[[2022,3,19]],"date-time":"2022-03-19T11:51:00Z","timestamp":1647690660000},"page":"215652","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Long term outcome of prevention of liver cancer by hepatitis B vaccine: Results from an RCT with 37\u00a0years"],"prefix":"10.1016","volume":"536","author":[{"given":"Maomao","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunsun","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taoyang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changfa","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1159-1884","authenticated-orcid":false,"given":"Wanqing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunfeng","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2022.215652_bib1","series-title":"Global Cancer Observatory: Cancer Today","author":"Ferlay","year":"2020"},{"key":"10.1016\/j.canlet.2022.215652_bib2","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1002\/hep.27969","article-title":"World-wide relative contribution of hepatitis B and C viruses in hepatocellular carcinoma","volume":"62","author":"de Martel","year":"2015","journal-title":"Hepatology (Baltimore, Md"},{"key":"10.1016\/j.canlet.2022.215652_bib3","unstructured":"World Organization Health. Hepatitis B. Accessed August 17, 2021. Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hepatitis-b."},{"key":"10.1016\/j.canlet.2022.215652_bib4","author":"Centers for Diseases Control and Prevention"},{"key":"10.1016\/j.canlet.2022.215652_bib5","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0928-4346(96)82012-3","article-title":"Prevalence of hepatitis B and C virus infections in the general Chinese population. Results from a nationwide cross-sectional seroepidemiologic study of hepatitis A, B, C, D, and E virus infections in China, 1992","volume":"5","author":"Xia","year":"1996","journal-title":"Int. Hepatol. Commun."},{"key":"10.1016\/j.canlet.2022.215652_bib6","doi-asserted-by":"crossref","first-page":"8131","DOI":"10.1016\/j.vaccine.2018.10.005","article-title":"Vaccine-preventable disease control in the People's Republic of China: 1949\u20132016","volume":"36","author":"Yu","year":"2018","journal-title":"Vaccine"},{"key":"10.1016\/j.canlet.2022.215652_bib7","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1056\/NEJM199706263362602","article-title":"Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. Taiwan childhood hepatoma study group","volume":"336","author":"Chang","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.canlet.2022.215652_bib8","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1001\/jama.2013.276701","article-title":"Thirty-year outcomes of the national hepatitis B immunization program in Taiwan","volume":"310","author":"Chiang","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.canlet.2022.215652_bib9","first-page":"2205","article-title":"Hepatitis B vaccination and liver cancer mortality reduction in Korean children and adolescents","volume":"12","author":"Gwack","year":"2011","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.canlet.2022.215652_bib10","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/jmv.10094","article-title":"Prevention and control of hepatitis B in China","volume":"67","author":"Sun","year":"2002","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.canlet.2022.215652_bib11","article-title":"Efficacy of neonatal HBV vaccination on liver cancer and other liver diseases over 30-year follow-up of the Qidong hepatitis B intervention study: a cluster randomized controlled trial","volume":"11","author":"Chunfeng","year":"2014","journal-title":"PloS Med."},{"key":"10.1016\/j.canlet.2022.215652_bib12","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/j.vaccine.2011.12.116","article-title":"Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity","volume":"30","author":"Ott","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.canlet.2022.215652_bib13","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/jcp.1041290415","article-title":"A pilot study on universal immunization of newborn infants in an area of hepatitis B virus and primary hepatocellular carcinoma prevalence with a low dose of hepatitis B vaccine","volume":"129","author":"Tsung-Tang","year":"1986","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.canlet.2022.215652_bib14","doi-asserted-by":"crossref","first-page":"228","DOI":"10.20517\/2394-5079.2017.41","article-title":"Reducing liver cancer risk beginning at birth: experiences of preventing chronic hepatitis B virus infection in China","volume":"3","author":"Qu","year":"2017","journal-title":"Hepatoma Res."},{"key":"10.1016\/j.canlet.2022.215652_bib15","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0140-6736(20)32661-1","article-title":"Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK","volume":"397","author":"Voysey","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.canlet.2022.215652_bib16","doi-asserted-by":"crossref","first-page":"4","DOI":"10.20517\/2394-5079.2017.50","article-title":"Qidong hepatitis B virus infection cohort: a 25-year prospective study in high risk area of primary liver cancer","volume":"4","author":"Chen","year":"2018","journal-title":"Hepatomal. Res."},{"key":"10.1016\/j.canlet.2022.215652_bib17","doi-asserted-by":"crossref","first-page":"24","DOI":"10.20892\/j.issn.2095-3941.2018.0394","article-title":"Qidong: a crucible for studies on liver cancer etiology and prevention","volume":"16","author":"Chen","year":"2019","journal-title":"Cancer Biol. Med."},{"key":"10.1016\/j.canlet.2022.215652_bib18","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.cgh.2016.04.030","article-title":"Continuing decrease in hepatitis B virus infection 30 Years after initiation of infant vaccination program in Taiwan","volume":"14","author":"Ni","year":"2016","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.canlet.2022.215652_bib19","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1440-1746.2004.03153.x","article-title":"Legend of hepatitis B vaccination: the Taiwan experience","volume":"19","author":"Chan","year":"2004","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.canlet.2022.215652_bib20","doi-asserted-by":"crossref","first-page":"815","DOI":"10.3390\/v12080815","article-title":"Elimination of hepatitis B in highly endemic settings: lessons learned in Taiwan and challenges ahead","volume":"12","author":"Liu","year":"2020","journal-title":"Viruses"},{"key":"10.1016\/j.canlet.2022.215652_bib21","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1053\/j.gastro.2016.05.048","article-title":"Long-term effects of hepatitis B immunization of infants in preventing liver cancer","volume":"151","author":"Chang","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.canlet.2022.215652_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0150499","article-title":"The success of a universal hepatitis B immunization program as part of Thailand's EPI after 22 Years' implementation","volume":"11","author":"Posuwan","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.canlet.2022.215652_bib23","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/nrgastro.2015.28","article-title":"HBV vaccine\u2014the first vaccine to prevent cancer","volume":"12","author":"Pol","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.canlet.2022.215652_bib24","unstructured":"National Notifiable Diseases Surveillance System. Hepatitis B, perinatal infection 2017 case Definition. Accessed August 17, 2021. Available from: https:\/\/ndc.services.cdc.gov\/case-definitions\/hepatitis-b-perinatal-virus-infection-2017\/."},{"issue":"Suppl 2","key":"10.1016\/j.canlet.2022.215652_bib25","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1136\/gut.38.Suppl_2.S37","article-title":"Perinatal transmission of hepatitis B virus infection and vaccination in China","volume":"38","author":"Yao","year":"1996","journal-title":"Gut"},{"key":"10.1016\/j.canlet.2022.215652_bib26","first-page":"291","article-title":"Clinical guidelines on prevention of mother-to-child transmission of hepatitis B virus (2020)","volume":"55","year":"2020","journal-title":"Chin. J. Obstet. Gynecol."},{"key":"10.1016\/j.canlet.2022.215652_bib27","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1080\/21645515.2016.1274475","article-title":"Influences of obesity on the immunogenicity of Hepatitis B vaccine","volume":"13","author":"Liu","year":"2017","journal-title":"Hum. Vaccines Immunother."},{"key":"10.1016\/j.canlet.2022.215652_bib28","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/QAD.0000000000001311","article-title":"Immune activation, smoking, and vaccine response","volume":"31","author":"Younas","year":"2017","journal-title":"AIDS"},{"key":"10.1016\/j.canlet.2022.215652_bib29","doi-asserted-by":"crossref","first-page":"10052","DOI":"10.12998\/wjcc.v9.i33.10052","article-title":"Effects of alcohol consumption on viral hepatitis B and C","volume":"9","author":"Xu","year":"2021","journal-title":"World J. Clin. Cases"}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383522001355?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383522001355?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T16:03:41Z","timestamp":1759593821000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383522001355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":29,"alternative-id":["S0304383522001355"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2022.215652","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long term outcome of prevention of liver cancer by hepatitis B vaccine: Results from an RCT with 37\u00a0years","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2022.215652","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"215652"}}