{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:49:12Z","timestamp":1787986152803,"version":"build-2784847793"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.canlet.2023.216155","type":"journal-article","created":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T11:42:40Z","timestamp":1680781360000},"page":"216155","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["Metformin inhibits neutrophil extracellular traps-promoted pancreatic carcinogenesis in obese mice"],"prefix":"10.1016","volume":"562","author":[{"given":"Guangfu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangnan","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingna","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingdi","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuirong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5694-1422","authenticated-orcid":false,"given":"Zipeng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.canlet.2023.216155_bib1","first-page":"7","article-title":"Cancer statistics, 2021","volume":"71","author":"Siegel","year":"2021","journal-title":"Ca - Cancer J. Clin."},{"issue":"5","key":"10.1016\/j.canlet.2023.216155_bib2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2188\/jea.JE20160193","article-title":"Body-mass index and pancreatic cancer incidence: a pooled analysis of nine population-based cohort studies with more than 340,000 Japanese subjects","volume":"28","author":"Koyanagi","year":"2018","journal-title":"J. Epidemiol."},{"issue":"1","key":"10.1016\/j.canlet.2023.216155_bib3","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/cncr.31764","article-title":"Adolescent overweight and obesity and the risk for pancreatic cancer among men and women: a nationwide study of 1.79 million Israeli adolescents","volume":"125","author":"Zohar","year":"2019","journal-title":"Cancer"},{"issue":"4","key":"10.1016\/j.canlet.2023.216155_bib4","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.cell.2020.03.062","article-title":"Endocrine-exocrine signaling drives obesity-associated pancreatic ductal adenocarcinoma","volume":"181","author":"Chung","year":"2020","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.canlet.2023.216155_bib5","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1158\/2159-8290.CD-13-0593","article-title":"Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D","volume":"4","author":"Baumgart","year":"2014","journal-title":"Cancer Discov."},{"issue":"12","key":"10.1016\/j.canlet.2023.216155_bib6","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1158\/1078-0432.CCR-15-1839","article-title":"PlGF\/VEGFR-1 signaling promotes macrophage polarization and accelerated tumor progression in obesity","volume":"22","author":"Incio","year":"2016","journal-title":"Clin. Cancer Res."},{"issue":"3","key":"10.1016\/j.canlet.2023.216155_bib7","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/s41574-018-0126-x","article-title":"The obese adipose tissue microenvironment in cancer development and progression","volume":"15","author":"Quail","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"issue":"8","key":"10.1016\/j.canlet.2023.216155_bib8","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1158\/2159-8290.CD-15-1177","article-title":"Obesity-induced inflammation and desmoplasia promote pancreatic cancer progression and resistance to chemotherapy","volume":"6","author":"Incio","year":"2016","journal-title":"Cancer Discov."},{"issue":"15","key":"10.1016\/j.canlet.2023.216155_bib9","doi-asserted-by":"crossref","first-page":"4895","DOI":"10.1158\/1078-0432.CCR-03-0760","article-title":"The potential role of neutrophils in promoting the metastatic phenotype of tumors releasing interleukin-8","volume":"10","author":"De Larco","year":"2004","journal-title":"Clin. Cancer Res."},{"issue":"15","key":"10.1016\/j.canlet.2023.216155_bib10","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1158\/1078-0432.CCR-14-2385","article-title":"Obesity and fatty pancreatic infiltration are risk factors for pancreatic precancerous lesions (PanIN)","volume":"21","author":"Rebours","year":"2015","journal-title":"Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.canlet.2023.216155_bib11","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12943-021-01373-z","article-title":"Histone citrullination: a new target for tumors","volume":"20","author":"Zhu","year":"2021","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.canlet.2023.216155_bib12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13045-019-0836-0","article-title":"Increased neutrophil extracellular traps promote metastasis potential of hepatocellular carcinoma via provoking tumorous inflammatory response","volume":"13","author":"Yang","year":"2020","journal-title":"J. Hematol. Oncol."},{"issue":"6","key":"10.1016\/j.canlet.2023.216155_bib13","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1158\/1078-0432.CCR-18-1226","article-title":"Neutrophil extracellular traps induced by IL8 promote diffuse large B-cell lymphoma progression via the TLR9 signaling","volume":"25","author":"Nie","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2023.216155_bib14","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1038\/ctg.2014.5","article-title":"Association of pancreatic Fatty infiltration with pancreatic ductal adenocarcinoma","volume":"5","author":"Hori","year":"2014","journal-title":"Clin. Transl. Gastroenterol."},{"issue":"10","key":"10.1016\/j.canlet.2023.216155_bib15","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1111\/cas.13766","article-title":"Fatty pancreas: a possible risk factor for pancreatic cancer in animals and humans","volume":"109","author":"Takahashi","year":"2018","journal-title":"Cancer Sci."},{"issue":"6","key":"10.1016\/j.canlet.2023.216155_bib16","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1172\/JCI39104","article-title":"The basics of epithelial-mesenchymal transition","volume":"119","author":"Kalluri","year":"2009","journal-title":"J. Clin. Invest."},{"issue":"9255","key":"10.1016\/j.canlet.2023.216155_bib17","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0140-6736(00)04046-0","article-title":"Inflammation and cancer: back to Virchow?","volume":"357","author":"Balkwill","year":"2001","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.canlet.2023.216155_bib18","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.immuni.2019.06.025","article-title":"Inflammation and cancer: triggers, mechanisms, and consequences","volume":"51","author":"Greten","year":"2019","journal-title":"Immunity"},{"issue":"24","key":"10.1016\/j.canlet.2023.216155_bib19","doi-asserted-by":"crossref","first-page":"3794","DOI":"10.1002\/cncr.30251","article-title":"White adipose tissue inflammation and cancer-specific survival in patients with squamous cell carcinoma of the oral tongue","volume":"122","author":"Iyengar","year":"2016","journal-title":"Cancer"},{"issue":"9","key":"10.1016\/j.canlet.2023.216155_bib20","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1158\/1078-0432.CCR-15-2239","article-title":"Systemic correlates of white adipose tissue inflammation in early-stage breast cancer","volume":"22","author":"Iyengar","year":"2016","journal-title":"Clin. Cancer Res."},{"issue":"4","key":"10.1016\/j.canlet.2023.216155_bib21","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/pcan.2017.31","article-title":"Periprostatic adipose inflammation is associated with high-grade prostate cancer","volume":"20","author":"Gucalp","year":"2017","journal-title":"Prostate Cancer Prostatic Dis."},{"issue":"9","key":"10.1016\/j.canlet.2023.216155_bib22","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/nm.2885","article-title":"Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase","volume":"18","author":"Talukdar","year":"2012","journal-title":"Nat. Med."},{"issue":"7","key":"10.1016\/j.canlet.2023.216155_bib23","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nrc.2016.52","article-title":"Neutrophils in cancer: neutral no more","volume":"16","author":"Coffelt","year":"2016","journal-title":"Nat. Rev. Cancer"},{"issue":"10","key":"10.1016\/j.canlet.2023.216155_bib24","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s41571-019-0222-4","article-title":"Tumour-associated neutrophils in patients with cancer","volume":"16","author":"Shaul","year":"2019","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"6","key":"10.1016\/j.canlet.2023.216155_bib25","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1097\/SLA.0000000000001044","article-title":"Tumor-associated neutrophils and malignant progression in intraductal papillary mucinous neoplasms: an opportunity for identification of high-risk disease","volume":"262","author":"Sadot","year":"2015","journal-title":"Ann. Surg."},{"issue":"3","key":"10.1016\/j.canlet.2023.216155_bib26","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/cncr.21838","article-title":"Intraductal papillary mucinous neoplasm of the pancreas: cytologic features predict histologic grade","volume":"108","author":"Michaels","year":"2006","journal-title":"Cancer"},{"issue":"3","key":"10.1016\/j.canlet.2023.216155_bib27","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/s41577-021-00571-6","article-title":"Neutrophils in cancer: heterogeneous and multifaceted","volume":"22","author":"Hedrick","year":"2022","journal-title":"Nat. Rev. Immunol."},{"issue":"5663","key":"10.1016\/j.canlet.2023.216155_bib28","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.canlet.2023.216155_bib29","article-title":"Increased plasmatic NETs by-products in patients in severe obesity","volume":"9","author":"D'Abbondanza","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.canlet.2023.216155_bib30","doi-asserted-by":"crossref","first-page":"4881","DOI":"10.1038\/s41598-018-23256-y","article-title":"Obesity-induced endothelial dysfunction is prevented by neutrophil extracellular trap inhibition","volume":"8","author":"Wang","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.canlet.2023.216155_bib31","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3389\/fimmu.2016.00289","article-title":"Effect of high-fat diet on the formation of pulmonary neutrophil extracellular traps during influenza pneumonia in BALB\/c mice","volume":"7","author":"Moorthy","year":"2016","journal-title":"Front. Immunol."},{"issue":"361","key":"10.1016\/j.canlet.2023.216155_bib32","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aag1711","article-title":"Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps","volume":"8","author":"Park","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.canlet.2023.216155_bib33","article-title":"Primary tumors induce neutrophil extracellular traps with targetable metastasis promoting effects","volume":"5","author":"Rayes","year":"2019","journal-title":"JCI Insight"},{"issue":"123","key":"10.1016\/j.canlet.2023.216155_bib34","doi-asserted-by":"crossref","first-page":"3446","DOI":"10.1172\/JCI67484","article-title":"Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis","volume":"8","author":"Cools-Lartigue","year":"2013","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.canlet.2023.216155_bib35","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/s00018-020-03656-y","article-title":"TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling","volume":"78","author":"Ciesielska","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.canlet.2023.216155_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101581","article-title":"Chemical modification of pro-inflammatory proteins by peroxynitrite increases activation of TLR4 and NF-kappaB: implications for the health effects of air pollution and oxidative stress","volume":"37","author":"Ziegler","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.canlet.2023.216155_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101186","article-title":"TLR4 participates in sympathetic hyperactivity Post-MI in the PVN by regulating NF-kappaB pathway and ROS production","volume":"24","author":"Wang","year":"2019","journal-title":"Redox Biol."},{"issue":"5","key":"10.1016\/j.canlet.2023.216155_bib38","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1158\/0008-5472.CAN-19-2080","article-title":"Tumor cell-derived IL1beta promotes desmoplasia and immune suppression in pancreatic cancer","volume":"80","author":"Das","year":"2020","journal-title":"Cancer Res."},{"issue":"8","key":"10.1016\/j.canlet.2023.216155_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19082155","article-title":"Interleukin-1 beta-A friend or foe in malignancies?","volume":"19","author":"Bent","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.canlet.2023.216155_bib40","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1593\/neo.11332","article-title":"Interleukin 1alpha sustains the expression of inflammatory factors in human pancreatic cancer microenvironment by targeting cancer-associated fibroblasts","volume":"13","author":"Tjomsland","year":"2011","journal-title":"Neoplasia"},{"issue":"1","key":"10.1016\/j.canlet.2023.216155_bib41","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.cell.2014.08.007","article-title":"Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy","volume":"159","author":"Sherman","year":"2014","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.canlet.2023.216155_bib42","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.canep.2012.12.009","article-title":"Association of metformin use with cancer incidence and mortality: a meta-analysis","volume":"37","author":"Zhang","year":"2013","journal-title":"Cancer Epidemiol"},{"issue":"5","key":"10.1016\/j.canlet.2023.216155_bib43","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1158\/1940-6207.CAPR-16-0277","article-title":"No decreased risk of gastrointestinal cancers in users of metformin in The Netherlands; A time-varying analysis of metformin exposure","volume":"10","author":"de Jong","year":"2017","journal-title":"Cancer Prev. Res."},{"issue":"37","key":"10.1016\/j.canlet.2023.216155_bib44","article-title":"Relationships are between metformin use and survival in pancreatic cancer patients concurrent with diabetes: a systematic review and meta-analysis","volume":"99","author":"Shi","year":"2020","journal-title":"Medicine (Baltim.)"},{"issue":"2","key":"10.1016\/j.canlet.2023.216155_bib45","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1053\/j.gastro.2009.04.013","article-title":"Antidiabetic therapies affect risk of pancreatic cancer","volume":"137","author":"Li","year":"2009","journal-title":"Gastroenterology"},{"issue":"11","key":"10.1016\/j.canlet.2023.216155_bib46","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1158\/1940-6207.CAPR-10-0157","article-title":"Metformin and cancer risk in diabetic patients: a systematic review and meta-analysis","volume":"3","author":"Decensi","year":"2010","journal-title":"Cancer Prev. Res."},{"issue":"9","key":"10.1016\/j.canlet.2023.216155_bib47","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/ajg.2016.288","article-title":"Metformin improves survival in patients with pancreatic ductal adenocarcinoma and pre-existing diabetes: a propensity score analysis","volume":"111","author":"Amin","year":"2016","journal-title":"Am. J. Gastroenterol."},{"issue":"10","key":"10.1016\/j.canlet.2023.216155_bib48","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1158\/1078-0432.CCR-11-2994","article-title":"Metformin use is associated with better survival of diabetic patients with pancreatic cancer","volume":"18","author":"Sadeghi","year":"2012","journal-title":"Clin. Cancer Res."},{"issue":"5","key":"10.1016\/j.canlet.2023.216155_bib49","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1158\/1078-0432.CCR-15-1722","article-title":"(Ir)relevance of metformin treatment in patients with metastatic pancreatic cancer: an open-label, randomized phase II trial","volume":"22","author":"Reni","year":"2016","journal-title":"Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.canlet.2023.216155_bib50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0147113","article-title":"Metformin treatment does not inhibit growth of pancreatic cancer patient-derived xenografts","volume":"11","author":"Lipner","year":"2016","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.canlet.2023.216155_bib51","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.ccell.2019.03.007","article-title":"Combination of hypoglycemia and metformin impairs tumor metabolic plasticity and growth by modulating the PP2A-GSK3beta-MCL-1 Axis","volume":"35","author":"Elgendy","year":"2019","journal-title":"Cancer Cell"},{"issue":"4","key":"10.1016\/j.canlet.2023.216155_bib52","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.jhep.2018.11.034","article-title":"Metformin modulates innate immune-mediated inflammation and early progression of NAFLD-associated hepatocellular carcinoma in zebrafish","volume":"70","author":"de Oliveira","year":"2019","journal-title":"J. Hepatol."},{"issue":"7","key":"10.1016\/j.canlet.2023.216155_bib53","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.immuni.2021.05.004","article-title":"Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation","volume":"54","author":"Xian","year":"2021","journal-title":"Immunity"},{"issue":"22","key":"10.1016\/j.canlet.2023.216155_bib54","doi-asserted-by":"crossref","first-page":"5622","DOI":"10.1158\/1078-0432.CCR-18-0420","article-title":"Metformin inhibits prostate cancer progression by targeting tumor-associated inflammatory infiltration","volume":"24","author":"Liu","year":"2018","journal-title":"Clin. Cancer Res."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383523001064?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383523001064?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T16:11:25Z","timestamp":1759594285000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383523001064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":54,"alternative-id":["S0304383523001064"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2023.216155","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metformin inhibits neutrophil extracellular traps-promoted pancreatic carcinogenesis in obese mice","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2023.216155","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"216155"}}