{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T11:28:54Z","timestamp":1784719734874,"version":"3.55.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T00:00:00Z","timestamp":1702598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002822","name":"Central South University","doi-asserted-by":"publisher","award":["ZLXD2017004"],"award-info":[{"award-number":["ZLXD2017004"]}],"id":[{"id":"10.13039\/501100002822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972198"],"award-info":[{"award-number":["81972198"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8177314 7"],"award-info":[{"award-number":["8177314 7"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2023JJ40853"],"award-info":[{"award-number":["2023JJ40853"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2023JJ30972"],"award-info":[{"award-number":["2023JJ30972"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["kq2208299"],"award-info":[{"award-number":["kq2208299"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["kq2208337"],"award-info":[{"award-number":["kq2208337"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011790","name":"Xiangya Hospital, Central South University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011790","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.canlet.2023.216567","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T02:52:21Z","timestamp":1701917541000},"page":"216567","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["EphB1 promotes the differentiation and maturation of dendritic cells in non-small cell lung cancer"],"prefix":"10.1016","volume":"582","author":[{"given":"Yaohuan","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4054-1667","authenticated-orcid":false,"given":"Liyang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lujuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anqi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqi","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingqun","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8712-8952","authenticated-orcid":false,"given":"Juanjuan","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.canlet.2023.216567_bib1","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a009159","article-title":"Eph receptor signaling and ephrins","volume":"5","author":"Lisabeth","year":"2013","journal-title":"Cold Spring Harbor Perspect. Biol."},{"issue":"39","key":"10.1016\/j.canlet.2023.216567_bib2","doi-asserted-by":"crossref","first-page":"6567","DOI":"10.1038\/s41388-019-0931-2","article-title":"Eph receptor signalling: from catalytic to non-catalytic functions","volume":"38","author":"Liang","year":"2019","journal-title":"Oncogene"},{"issue":"11","key":"10.1016\/j.canlet.2023.216567_bib3","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1038\/s41419-022-05385-5","article-title":"Cell-cell contact-driven EphB1 cis- and trans- signalings regulate cancer stem cells enrichment after chemotherapy","volume":"13","author":"Wang","year":"2022","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.canlet.2023.216567_bib4","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1101\/gad.1630408","article-title":"Eph\/ephrin signaling: networks","volume":"22","author":"Arvanitis","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.canlet.2023.216567_bib5","article-title":"Eph\/ephrin-based protein complexes: the importance of cis interactions in guiding cellular processes","volume":"8","author":"Cecchini","year":"2021","journal-title":"Front. Mol. Biosci."},{"issue":"1","key":"10.1016\/j.canlet.2023.216567_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuron.2011.06.030","article-title":"The axon's balancing act: cis- and trans-interactions between Ephs and ephrins","volume":"71","author":"Dudanova","year":"2011","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.canlet.2023.216567_bib7","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0092-8674(01)00314-2","article-title":"EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin","volume":"105","author":"Shamah","year":"2001","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.canlet.2023.216567_bib8","doi-asserted-by":"crossref","first-page":"8929","DOI":"10.18632\/oncotarget.3369","article-title":"Knockdown of EphB1 receptor decreases medulloblastoma cell growth and migration and increases cellular radiosensitization","volume":"6","author":"Bhatia","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.canlet.2023.216567_bib9","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12935-017-0384-z","article-title":"Paradoxes of the EphB1 receptor in malignant brain tumors","volume":"17","author":"Wei","year":"2017","journal-title":"Cancer Cell Int."},{"issue":"14","key":"10.1016\/j.canlet.2023.216567_bib10","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.7150\/jca.44576","article-title":"Ligand-independent EphB1 signaling mediates TGF-beta-activated CDH2 and promotes lung cancer cell invasion and migration","volume":"11","author":"Wang","year":"2020","journal-title":"J. Cancer"},{"issue":"22","key":"10.1016\/j.canlet.2023.216567_bib11","doi-asserted-by":"crossref","first-page":"6452","DOI":"10.1158\/0008-5472.CAN-16-1521","article-title":"Eph receptor tyrosine kinases in tumor immunity","volume":"76","author":"Shiuan","year":"2016","journal-title":"Cancer Res."},{"issue":"7","key":"10.1016\/j.canlet.2023.216567_bib12","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1002\/cncr.22958","article-title":"Immunotherapy of murine colon cancer using receptor tyrosine kinase EphA2-derived peptide-pulsed dendritic cell vaccines","volume":"110","author":"Yamaguchi","year":"2007","journal-title":"Cancer"},{"issue":"1","key":"10.1016\/j.canlet.2023.216567_bib13","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1479-5876-2-40","article-title":"Vaccination with EphA2-derived T cell-epitopes promotes immunity against both EphA2-expressing and EphA2-negative tumors","volume":"2","author":"Hatano","year":"2004","journal-title":"J. Transl. Med."},{"issue":"10","key":"10.1016\/j.canlet.2023.216567_bib14","doi-asserted-by":"crossref","first-page":"7961","DOI":"10.1007\/s13277-015-3486-z","article-title":"Treatment of Dutch rat models of glioma using EphrinA1-PE38\/GM-CSF chitosan nanoparticles by in situ activation of dendritic cells","volume":"36","author":"Li","year":"2015","journal-title":"Tumour Biol."},{"key":"10.1016\/j.canlet.2023.216567_bib15","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.3389\/fimmu.2019.01473","article-title":"Emerging roles for Eph receptors and ephrin ligands in immunity","volume":"10","author":"Darling","year":"2019","journal-title":"Front. Immunol."},{"issue":"9","key":"10.1016\/j.canlet.2023.216567_bib16","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1182\/blood-2002-02-0638","article-title":"Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells","volume":"100","author":"Rissoan","year":"2002","journal-title":"Blood"},{"issue":"15","key":"10.1016\/j.canlet.2023.216567_bib17","doi-asserted-by":"crossref","first-page":"10222","DOI":"10.1074\/jbc.M510320200","article-title":"Ephrin-B1 is critical in T-cell development","volume":"281","author":"Yu","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"20","key":"10.1016\/j.canlet.2023.216567_bib18","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1089\/scd.2012.0676","article-title":"EphB and Ephrin-B interactions mediate human mesenchymal stem cell suppression of activated T-cells","volume":"22","author":"Nguyen","year":"2013","journal-title":"Stem Cell. Dev."},{"issue":"6","key":"10.1016\/j.canlet.2023.216567_bib19","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1002\/eji.201142175","article-title":"A novel feedback mechanism by Ephrin-B1\/B2 in T-cell activation involves a concentration-dependent switch from costimulation to inhibition","volume":"42","author":"Kawano","year":"2012","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.canlet.2023.216567_bib20","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.canlet.2020.12.013","article-title":"A novel integrated system using patient-derived glioma cerebral organoids and xenografts for disease modeling and drug screening","volume":"500","author":"Zhang","year":"2021","journal-title":"Cancer Lett."},{"issue":"12","key":"10.1016\/j.canlet.2023.216567_bib21","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. Methods"},{"issue":"5","key":"10.1016\/j.canlet.2023.216567_bib22","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nbt.3192","article-title":"Spatial reconstruction of single-cell gene expression data","volume":"33","author":"Satija","year":"2015","journal-title":"Nat. Biotechnol."},{"issue":"11","key":"10.1016\/j.canlet.2023.216567_bib23","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/nmeth.4463","article-title":"SCENIC: single-cell regulatory network inference and clustering","volume":"14","author":"Aibar","year":"2017","journal-title":"Nat. Methods"},{"issue":"1","key":"10.1016\/j.canlet.2023.216567_bib24","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1038\/s41467-020-15816-6","article-title":"Accurate estimation of cell composition in bulk expression through robust integration of single-cell information","volume":"11","author":"Jew","year":"2020","journal-title":"Nat. Commun."},{"issue":"23","key":"10.1016\/j.canlet.2023.216567_bib25","doi-asserted-by":"crossref","first-page":"6575","DOI":"10.1158\/0008-5472.CAN-18-0689","article-title":"TIP: a web server for resolving tumor immunophenotype profiling","volume":"78","author":"Xu","year":"2018","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.canlet.2023.216567_bib26","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s40880-019-0427-z","article-title":"The immune landscape of esophageal cancer","volume":"39","author":"Huang","year":"2019","journal-title":"Cancer Commun."},{"issue":"49","key":"10.1016\/j.canlet.2023.216567_bib27","doi-asserted-by":"crossref","first-page":"13481","DOI":"10.1523\/JNEUROSCI.4158-07.2007","article-title":"EphB receptors regulate stem\/progenitor cell proliferation, migration, and polarity during hippocampal neurogenesis","volume":"27","author":"Chumley","year":"2007","journal-title":"J. Neurosci."},{"issue":"11","key":"10.1016\/j.canlet.2023.216567_bib28","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1091\/mbc.E19-12-0713","article-title":"EphB1 interaction with caveolin-1 in endothelial cells modulates caveolae biogenesis","volume":"31","author":"Tiruppathi","year":"2020","journal-title":"Mol. Biol. Cell"},{"issue":"17","key":"10.1016\/j.canlet.2023.216567_bib29","doi-asserted-by":"crossref","first-page":"7591","DOI":"10.1158\/0008-5472.CAN-05-1855","article-title":"Somatic mutations of the protein kinase gene family in human lung cancer","volume":"65","author":"Davies","year":"2005","journal-title":"Cancer Res."},{"issue":"22","key":"10.1016\/j.canlet.2023.216567_bib30","doi-asserted-by":"crossref","first-page":"10170","DOI":"10.1158\/0008-5472.CAN-05-2580","article-title":"Mechanisms of inactivation of the receptor tyrosine kinase EPHB2 in colorectal tumors","volume":"65","author":"Alazzouzi","year":"2005","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.canlet.2023.216567_bib31","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s40478-018-0618-x","article-title":"EphrinB\/EphB forward signaling in Muller cells causes apoptosis of retinal ganglion cells by increasing tumor necrosis factor alpha production in rat experimental glaucomatous model","volume":"6","author":"Liu","year":"2018","journal-title":"Acta Neuropathol. Commun."},{"issue":"1","key":"10.1016\/j.canlet.2023.216567_bib32","doi-asserted-by":"crossref","first-page":"C189","DOI":"10.1152\/ajpcell.00314.2007","article-title":"Enhancement of lymphocyte migration and cytokine production by ephrinB1 system in rheumatoid arthritis","volume":"294","author":"Kitamura","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"5","key":"10.1016\/j.canlet.2023.216567_bib33","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.ajpath.2012.06.043","article-title":"Eph\/Ephrin signaling in injury and inflammation","volume":"181","author":"Coulthard","year":"2012","journal-title":"Am. J. Pathol."},{"issue":"1","key":"10.1016\/j.canlet.2023.216567_bib34","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1038\/s41467-017-01283-z","article-title":"A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models","volume":"8","author":"Tyzack","year":"2017","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.canlet.2023.216567_bib35","doi-asserted-by":"crossref","first-page":"5321","DOI":"10.4049\/jimmunol.150.12.5321","article-title":"Prostaglandin E2 differentially modulates cytokine secretion profiles of human T helper lymphocytes","volume":"150","author":"Snijdewint","year":"1993","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.canlet.2023.216567_bib36","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12865-020-00347-y","article-title":"Prostaglandin E2 stimulates COX-2 expression via mitogen-activated protein kinase p38 but not ERK in human follicular dendritic cell-like cells","volume":"21","author":"Cho","year":"2020","journal-title":"BMC Immunol."},{"issue":"2","key":"10.1016\/j.canlet.2023.216567_bib37","doi-asserted-by":"crossref","first-page":"146","DOI":"10.2174\/157340911795677602","article-title":"Molecular docking: a powerful approach for structure-based drug discovery","volume":"7","author":"Meng","year":"2011","journal-title":"Curr. Comput. Aided Drug Des."},{"issue":"11","key":"10.1016\/j.canlet.2023.216567_bib38","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/nrd1549","article-title":"Docking and scoring in virtual screening for drug discovery: methods and applications","volume":"3","author":"Kitchen","year":"2004","journal-title":"Nat. Rev. Drug Discov."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383523005189?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383523005189?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:39:32Z","timestamp":1778632772000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383523005189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":38,"alternative-id":["S0304383523005189"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2023.216567","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"EphB1 promotes the differentiation and maturation of dendritic cells in non-small cell lung cancer","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2023.216567","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"216567"}}