{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:20:31Z","timestamp":1792603231107,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.canlet.2023.216589","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T13:06:37Z","timestamp":1702386397000},"page":"216589","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Preclinical evidence for preventive and curative effects of resveratrol on xenograft cholangiocarcinogenesis"],"prefix":"10.1016","volume":"582","author":[{"given":"Suyanee","family":"Thongchot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7192-9672","authenticated-orcid":false,"given":"Alessandra","family":"Ferraresi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Vidoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7662-4907","authenticated-orcid":false,"given":"Amreen","family":"Salwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letizia","family":"Vallino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingpinyapat","family":"Kittirat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Watcharin","family":"Loilome","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisana","family":"Namwat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5494-3034","authenticated-orcid":false,"given":"Ciro","family":"Isidoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.canlet.2023.216589_bib1","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/s41575-020-0310-z","article-title":"Cholangiocarcinoma 2020: the next horizon in mechanisms and management","volume":"17","author":"Banales","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.canlet.2023.216589_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107517","article-title":"The choice for the optimal therapy in advanced biliary tract cancers: chemotherapy, targeted therapies or immunotherapy","volume":"210","author":"Palmieri","year":"2020","journal-title":"Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.canlet.2023.216589_bib3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.5009\/gnl15568","article-title":"Cholangiocarcinoma: current knowledge and new developments","volume":"11","author":"Blechacz","year":"2017","journal-title":"Gut Liver"},{"issue":"1","key":"10.1016\/j.canlet.2023.216589_bib4","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jhep.2019.03.013","article-title":"Global trends in mortality from intrahepatic and extrahepatic cholangiocarcinoma","volume":"71","author":"Bertuccio","year":"2019","journal-title":"J. Hepatol."},{"issue":"10","key":"10.1016\/j.canlet.2023.216589_bib5","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.pt.2012.07.006","article-title":"The tumorigenic liver fluke Opisthorchis viverrini--multiple pathways to cancer","volume":"28","author":"Sripa","year":"2012","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.canlet.2023.216589_bib6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.20517\/2394-5079.2021.130","article-title":"Epidemiology of cholangiocarcinoma","volume":"8","author":"Turati","year":"2022","journal-title":"Hepatoma Res"},{"issue":"5","key":"10.1016\/j.canlet.2023.216589_bib7","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2188\/jea.JE20180007","article-title":"Cholangiocarcinoma trends, incidence, and relative survival in Khon kaen, Thailand from 1989 through 2013: a population-based cancer registry study","volume":"29","author":"Kamsa-Ard","year":"2019","journal-title":"J. Epidemiol."},{"issue":"17","key":"10.1016\/j.canlet.2023.216589_bib8","doi-asserted-by":"crossref","first-page":"4154","DOI":"10.1158\/1078-0432.CCR-18-0078","article-title":"Comprehensive molecular profiling of intrahepatic and extrahepatic cholangiocarcinomas: potential targets for intervention","volume":"24","author":"Lowery","year":"2018","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2023.216589_bib9","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.suronc.2020.08.008","article-title":"Emerging pathways for precision medicine in management of cholangiocarcinoma","volume":"35","author":"Rahnemai-Azar","year":"2020","journal-title":"Surg Oncol"},{"issue":"9","key":"10.1016\/j.canlet.2023.216589_bib10","doi-asserted-by":"crossref","first-page":"455","DOI":"10.4254\/wjh.v9.i9.455","article-title":"Tumor reactive stroma in cholangiocarcinoma: the fuel behind cancer aggressiveness","volume":"9","author":"Brivio","year":"2017","journal-title":"World J. Hepatol."},{"issue":"6","key":"10.1016\/j.canlet.2023.216589_bib11","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1002\/hep.26762","article-title":"Desmoplastic stroma and cholangiocarcinoma: clinical implications and therapeutic targeting","volume":"59","author":"Sirica","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.canlet.2023.216589_bib12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.20517\/2394-5079.2022.98","article-title":"The role of tumor microenvironment in cholangiocarcinoma","volume":"9","author":"Argenziano","year":"2023","journal-title":"Hepatoma Res"},{"issue":"10","key":"10.1016\/j.canlet.2023.216589_bib13","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.3390\/ijms19102885","article-title":"The role of stroma in cholangiocarcinoma: the intriguing interplay between fibroblastic component, immune cell subsets and tumor epithelium","volume":"19","author":"Gentilini","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"4 Pt B","key":"10.1016\/j.canlet.2023.216589_bib14","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/j.bbadis.2017.07.028","article-title":"The deleterious interplay between tumor epithelia and stroma in cholangiocarcinoma","volume":"1864","author":"Cadamuro","year":"2018","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"issue":"1","key":"10.1016\/j.canlet.2023.216589_bib15","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nrgastro.2011.222","article-title":"The role of cancer-associated myofibroblasts in intrahepatic cholangiocarcinoma","volume":"9","author":"Sirica","year":"2011","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"9","key":"10.1016\/j.canlet.2023.216589_bib16","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.3390\/cancers13092134","article-title":"Cancer-associated fibroblast-derived IL-6 determines unfavorable prognosis in cholangiocarcinoma by affecting autophagy-associated chemoresponse","volume":"13","author":"Thongchot","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.canlet.2023.216589_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.897368","article-title":"Interleukin-6-derived cancer-associated fibroblasts activate STAT3 pathway contributing to gemcitabine resistance in cholangiocarcinoma","volume":"13","author":"Kittirat","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"21","key":"10.1016\/j.canlet.2023.216589_bib18","doi-asserted-by":"crossref","first-page":"6498","DOI":"10.3390\/jcm11216498","article-title":"Cancer-associated fibroblasts in cholangiocarcinoma: current knowledge and possible implications for therapy","volume":"11","author":"Montori","year":"2022","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.canlet.2023.216589_bib19","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.canlet.2018.05.031","article-title":"Resveratrol interrupts the pro-invasive communication between cancer associated fibroblasts and cholangiocarcinoma cells","volume":"430","author":"Thongchot","year":"2018","journal-title":"Cancer Lett."},{"issue":"12","key":"10.1016\/j.canlet.2023.216589_bib20","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1002\/mc.22711","article-title":"The protein restriction mimetic Resveratrol is an autophagy inducer stronger than amino acid starvation in ovarian cancer cells","volume":"56","author":"Ferraresi","year":"2017","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.canlet.2023.216589_bib21","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.canlet.2021.05.001","article-title":"Resveratrol for cancer therapy: challenges and future perspectives","volume":"515","author":"Ren","year":"2021","journal-title":"Cancer Lett."},{"issue":"10","key":"10.1016\/j.canlet.2023.216589_bib22","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.3390\/cancers15102758","article-title":"Inhibitory potential of resveratrol in cancer metastasis: from biology to therapy","volume":"15","author":"Song","year":"2023","journal-title":"Cancers"},{"issue":"Suppl 4","key":"10.1016\/j.canlet.2023.216589_bib23","first-page":"65","article-title":"Growth rate analysis and efficient experimental design for tumor xenograft studies","volume":"13","author":"Hather","year":"2014","journal-title":"Cancer Inf."},{"issue":"11","key":"10.1016\/j.canlet.2023.216589_bib24","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.3390\/cells10113213","article-title":"Resveratrol contrasts LPA-induced ovarian cancer cell migration and platinum resistance by rescuing hedgehog-mediated autophagy","volume":"10","author":"Ferraresi","year":"2021","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.canlet.2023.216589_bib25","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1093\/carcin\/bgm271","article-title":"Resveratrol-induced apoptosis depends on the lipid kinase activity of Vps34 and on the formation of autophagolysosomes","volume":"29","author":"Trincheri","year":"2008","journal-title":"Carcinogenesis"},{"issue":"8","key":"10.1016\/j.canlet.2023.216589_bib26","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.3390\/biomedicines10081784","article-title":"Resveratrol and its analogue 4,4'-Dihydroxy-trans-stilbene inhibit lewis lung carcinoma growth in vivo through apoptosis, autophagy and modulation of the tumour microenvironment in a murine model","volume":"10","author":"Savio","year":"2022","journal-title":"Biomedicines"},{"issue":"5","key":"10.1016\/j.canlet.2023.216589_bib27","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1002\/cncr.29793","article-title":"Resveratrol inhibits ovarian tumor growth in an in vivo mouse model","volume":"122","author":"Tan","year":"2016","journal-title":"Cancer"},{"issue":"1","key":"10.1016\/j.canlet.2023.216589_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15548627.2020.1797280","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1","volume":"17","author":"Klionsky","year":"2021","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.canlet.2023.216589_bib29","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/med.21531","article-title":"The multifaceted role of autophagy in cancer and the microenvironment","volume":"39","author":"Folkerts","year":"2019","journal-title":"Med. Res. Rev."},{"issue":"2","key":"10.1016\/j.canlet.2023.216589_bib30","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1080\/15548627.2017.1345412","article-title":"Inflammatory signaling cascades and autophagy in cancer","volume":"14","author":"Monkkonen","year":"2018","journal-title":"Autophagy"},{"issue":"4","key":"10.1016\/j.canlet.2023.216589_bib31","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1002\/med.21473","article-title":"The metabolic cross-talk between epithelial cancer cells and stromal fibroblasts in ovarian cancer progression: autophagy plays a role","volume":"38","author":"Thuwajit","year":"2018","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.canlet.2023.216589_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.599915","article-title":"How autophagy shapes the tumor microenvironment in ovarian cancer","volume":"10","author":"Ferraresi","year":"2020","journal-title":"Front. Oncol."},{"issue":"3","key":"10.1016\/j.canlet.2023.216589_bib33","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1002\/mc.22582","article-title":"Resveratrol inhibits IL-6-induced ovarian cancer cell migration through epigenetic up-regulation of autophagy","volume":"56","author":"Ferraresi","year":"2017","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.canlet.2023.216589_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114762","article-title":"The \"Self-eating\" of cancer-associated fibroblast: a potential target for cancer","volume":"163","author":"Chen","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.canlet.2023.216589_bib35","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.canlet.2005.01.031","article-title":"Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo","volume":"231","author":"Garvin","year":"2006","journal-title":"Cancer Lett."},{"issue":"6","key":"10.1016\/j.canlet.2023.216589_bib36","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.3390\/molecules25061412","article-title":"Resveratrol and its nanoformulation attenuate growth and the angiogenesis of xenograft and orthotopic colon cancer models","volume":"25","author":"Sudha","year":"2020","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.canlet.2023.216589_bib37","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.3390\/ijms24021723","article-title":"Glycolysis inhibition of autophagy drives malignancy in ovarian cancer: exacerbation by IL-6 and attenuation by resveratrol","volume":"24","author":"Vidoni","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.canlet.2023.216589_bib38","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.3389\/fphar.2019.01238","article-title":"Pterostilbene, an active constituent of blueberries, suppresses proliferation potential of human cholangiocarcinoma via enhancing the autophagic flux","volume":"10","author":"Wang","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.canlet.2023.216589_bib39","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.abb.2018.02.011","article-title":"Resveratrol suppresses migration, invasion and stemness of human breast cancer cells by interfering with tumor-stromal cross-talk","volume":"643","author":"Suh","year":"2018","journal-title":"Arch. Biochem. Biophys."},{"issue":"2","key":"10.1016\/j.canlet.2023.216589_bib40","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.humpath.2014.09.016","article-title":"Autophagy may occur at an early stage of cholangiocarcinogenesis via biliary intraepithelial neoplasia","volume":"46","author":"Sasaki","year":"2015","journal-title":"Hum. Pathol."},{"issue":"11","key":"10.1016\/j.canlet.2023.216589_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0080317","article-title":"Beclin 1 deficiency correlated with lymph node metastasis, predicts a distinct outcome in intrahepatic and extrahepatic cholangiocarcinoma","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.canlet.2023.216589_bib42","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1186\/s12885-021-08553-6","article-title":"Role of autophagy-related protein in the prognosis of combined hepatocellular carcinoma and cholangiocarcinoma after surgical resection","volume":"21","author":"Perng","year":"2021","journal-title":"BMC Cancer"},{"issue":"6","key":"10.1016\/j.canlet.2023.216589_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0253065","article-title":"Autophagy activity in cholangiocarcinoma is associated with anatomical localization of the tumor","volume":"16","author":"Lendvai","year":"2021","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.canlet.2023.216589_bib44","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.3390\/cancers14092142","article-title":"Resveratrol contrasts IL-6 pro-growth effects and promotes autophagy-mediated cancer cell dormancy in 3D ovarian cancer: role of miR-1305 and of its target ARH-I","volume":"14","author":"Esposito","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.canlet.2023.216589_bib45","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/978-1-4614-1445-2_5","article-title":"Regulation of tumor cell dormancy by tissue microenvironments and autophagy","volume":"734","author":"Sosa","year":"2013","journal-title":"Adv. Exp. Med. Biol."},{"issue":"9","key":"10.1016\/j.canlet.2023.216589_bib46","doi-asserted-by":"crossref","first-page":"3746","DOI":"10.3390\/molecules28093746","article-title":"Combination chemotherapy with selected polyphenols in preclinical and clinical studies-an update overview","volume":"28","author":"Jakobu\u0161i\u0107 Brala","year":"2023","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.canlet.2023.216589_bib47","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/psp4.12172","article-title":"Systems pharmacology-based discovery of natural products for precision oncology through targeting cancer mutated genes","volume":"6","author":"Fang","year":"2017","journal-title":"CPT Pharmacometrics Syst. Pharmacol."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383523005402?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383523005402?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T16:15:12Z","timestamp":1759594512000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383523005402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":47,"alternative-id":["S0304383523005402"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2023.216589","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preclinical evidence for preventive and curative effects of resveratrol on xenograft cholangiocarcinogenesis","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2023.216589","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"216589"}}