{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T04:22:35Z","timestamp":1793247755487,"version":"4.5.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.canlet.2024.216621","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T04:33:12Z","timestamp":1705552392000},"page":"216621","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":85,"special_numbering":"C","title":["Icaritin with autophagy\/mitophagy inhibitors synergistically enhances anticancer efficacy and apoptotic effects through PINK1\/Parkin-mediated mitophagy in hepatocellular carcinoma"],"prefix":"10.1016","volume":"587","author":[{"given":"Piao","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehai","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingqian","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin-Kwan","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingnan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zipeng","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfeng","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0575-0105","authenticated-orcid":false,"given":"Jigang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2024.216621_bib1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/s41575-019-0186-y","article-title":"A global view of hepatocellular carcinoma: trends, risk, prevention and management","volume":"16","author":"Yang","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.canlet.2024.216621_bib2","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1097\/JCMA.0000000000000915","article-title":"Minimally invasive surgery for hepatocellular carcinoma","volume":"86","author":"Li","year":"2023","journal-title":"J. Chin. Med. Assoc. : J. Chin. Med. Assoc."},{"key":"10.1016\/j.canlet.2024.216621_bib3","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/s41571-018-0073-4","article-title":"Molecular therapies and precision medicine for hepatocellular carcinoma","volume":"15","author":"Llovet","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.canlet.2024.216621_bib4","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ccr.2006.06.001","article-title":"Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis","volume":"10","author":"Degenhardt","year":"2006","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2024.216621_bib5","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41580-018-0092-0","article-title":"Mitochondrial proteins: from biogenesis to functional networks","volume":"20","author":"Pfanner","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.canlet.2024.216621_bib6","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/nrd.2018.174","article-title":"Mitochondria as a therapeutic target for common pathologies","volume":"17","author":"Murphy","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.canlet.2024.216621_bib7","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/s41556-018-0176-2","article-title":"Mechanisms of mitophagy in cellular homeostasis, physiology and pathology","volume":"20","author":"Palikaras","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.canlet.2024.216621_bib8","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1515\/hsz-2017-0228","article-title":"Mechanisms, pathophysiological roles and methods for analyzing mitophagy - recent insights","volume":"399","author":"Williams","year":"2018","journal-title":"Biol. Chem."},{"key":"10.1016\/j.canlet.2024.216621_bib9","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.tcb.2016.05.008","article-title":"Deciphering the molecular signals of PINK1\/parkin mitophagy","volume":"26","author":"Nguyen","year":"2016","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.canlet.2024.216621_bib10","doi-asserted-by":"crossref","first-page":"3966","DOI":"10.1016\/j.apsb.2021.06.007","article-title":"Synergistic effects of autophagy\/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy","volume":"11","author":"Tang","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.canlet.2024.216621_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000298","article-title":"PINK1 is selectively stabilized on impaired mitochondria to activate Parkin","volume":"8","author":"Narendra","year":"2010","journal-title":"PLoS Biol."},{"key":"10.1016\/j.canlet.2024.216621_bib12","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1038\/srep01002","article-title":"PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy","volume":"2","author":"Shiba-Fukushima","year":"2012","journal-title":"Sci. Rep."},{"key":"10.1016\/j.canlet.2024.216621_bib13","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.120080","article-title":"PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65","volume":"2","author":"Kondapalli","year":"2012","journal-title":"Open biology"},{"key":"10.1016\/j.canlet.2024.216621_bib14","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.molcel.2014.09.007","article-title":"Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis","volume":"56","author":"Ordureau","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.canlet.2024.216621_bib15","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nature14893","article-title":"The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy","volume":"524","author":"Lazarou","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2024.216621_bib16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.molcel.2015.08.016","article-title":"The PINK1-PARKIN mitochondrial ubiquitylation pathway drives a Program of OPTN\/NDP52 recruitment and TBK1 activation to promote mitophagy","volume":"60","author":"Heo","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.canlet.2024.216621_bib17","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/s41467-019-08335-6","article-title":"LC3\/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy","volume":"10","author":"Padman","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2024.216621_bib18","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S1534-5807(04)00099-1","article-title":"Development by self-digestion: molecular mechanisms and biological functions of autophagy","volume":"6","author":"Levine","year":"2004","journal-title":"Dev. Cell"},{"key":"10.1016\/j.canlet.2024.216621_bib19","doi-asserted-by":"crossref","first-page":"4816","DOI":"10.1021\/acsnano.0c00708","article-title":"Icaritin exacerbates mitophagy and synergizes with doxorubicin to induce immunogenic cell death in hepatocellular carcinoma","volume":"14","author":"Yu","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.canlet.2024.216621_bib20","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.semcancer.2019.04.006","article-title":"Epigenetic targeting of autophagy for cancer prevention and treatment by natural compounds","volume":"66","author":"Vidoni","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.canlet.2024.216621_bib21","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.jep.2011.01.001","article-title":"The genus Epimedium: an ethnopharmacological and phytochemical review","volume":"134","author":"Ma","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.canlet.2024.216621_bib22","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1002\/eji.202048905","article-title":"Icaritin inhibits PD-L1 expression by targeting protein I\u03baB kinase \u03b1","volume":"51","author":"Mo","year":"2021","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.canlet.2024.216621_bib23","first-page":"5","article-title":"Antitumor effects of icaritin and the molecular mechanisms","volume":"29","author":"Zhang","year":"2020","journal-title":"Discov. Med."},{"key":"10.1016\/j.canlet.2024.216621_bib24","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1186\/s12885-021-08043-9","article-title":"Icaritin promotes apoptosis and inhibits proliferation by down-regulating AFP gene expression in hepatocellular carcinoma","volume":"21","author":"Li","year":"2021","journal-title":"BMC Cancer"},{"key":"10.1016\/j.canlet.2024.216621_bib25","doi-asserted-by":"crossref","first-page":"14736","DOI":"10.18632\/oncotarget.14718","article-title":"AMPK-autophagy inhibition sensitizes icaritin-induced anti-colorectal cancer cell activity","volume":"8","author":"Zhou","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.canlet.2024.216621_bib26","doi-asserted-by":"crossref","first-page":"334","DOI":"10.3892\/or.2015.4335","article-title":"Icaritin acts synergistically with epirubicin to suppress bladder cancer growth through inhibition of autophagy","volume":"35","author":"Pan","year":"2016","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.canlet.2024.216621_bib27","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.157360","article-title":"Integrated single-cell transcriptomics and proteomics reveal cellular-specific responses and microenvironment remodeling in aristolochic acid nephropathy","volume":"7","author":"Chen","year":"2022","journal-title":"JCI insight"},{"key":"10.1016\/j.canlet.2024.216621_bib28","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/s41422-018-0056-0","article-title":"PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy","volume":"28","author":"Wang","year":"2018","journal-title":"Cell Res."},{"key":"10.1016\/j.canlet.2024.216621_bib29","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.biopha.2016.11.023","article-title":"Icaritin induces mitochondrial apoptosis by up-regulating miR-124 in human oral squamous cell carcinoma cells","volume":"85","author":"Jin","year":"2017","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"key":"10.1016\/j.canlet.2024.216621_bib30","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.jep.2011.06.030","article-title":"Icaritin induces cell death in activated hepatic stellate cells through mitochondrial activated apoptosis and ameliorates the development of liver fibrosis in rats","volume":"137","author":"Li","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.canlet.2024.216621_bib31","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/B978-0-12-801415-8.00013-8","article-title":"Use of potentiometric fluorophores in the measurement of mitochondrial reactive oxygen species","volume":"547","author":"Polster","year":"2014","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.canlet.2024.216621_bib32","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s10571-015-0166-x","article-title":"ROS and autophagy: interactions and molecular regulatory mechanisms","volume":"35","author":"Li","year":"2015","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.canlet.2024.216621_bib33","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020104705","article-title":"Molecular mechanisms and physiological functions of mitophagy","volume":"40","author":"Onishi","year":"2021","journal-title":"EMBO J."},{"key":"10.1016\/j.canlet.2024.216621_bib34","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1083\/jcb.201008084","article-title":"Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL","volume":"191","author":"Jin","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.canlet.2024.216621_bib35","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/s41586-021-04340-2","article-title":"Activation mechanism of PINK1","volume":"602","author":"Gan","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2024.216621_bib36","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s00294-020-01062-2","article-title":"N-degron-mediated degradation and regulation of mitochondrial PINK1 kinase","volume":"66","author":"Eldeeb","year":"2020","journal-title":"Curr. Genet."},{"key":"10.1016\/j.canlet.2024.216621_bib37","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1083\/jcb.200910140","article-title":"PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy","volume":"189","author":"Matsuda","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.canlet.2024.216621_bib38","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.tibs.2019.08.002","article-title":"Post-translational modifications of key machinery in the control of mitophagy","volume":"45","author":"Wang","year":"2020","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.canlet.2024.216621_bib39","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1083\/jcb.201410050","article-title":"Phosphorylated ubiquitin chain is the genuine Parkin receptor","volume":"209","author":"Okatsu","year":"2015","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.canlet.2024.216621_bib40","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14697","article-title":"Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation","volume":"8","author":"Tang","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2024.216621_bib41","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/j.celrep.2016.06.064","article-title":"Synthesis of isomeric phosphoubiquitin chains reveals that phosphorylation controls deubiquitinase activity and specificity","volume":"16","author":"Huguenin-Dezot","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.canlet.2024.216621_bib42","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/s41556-018-0037-z","article-title":"Cargo recognition and degradation by selective autophagy","volume":"20","author":"Gatica","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.canlet.2024.216621_bib43","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201899916","article-title":"Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy","volume":"38","author":"Bernardini","year":"2019","journal-title":"EMBO J."},{"key":"10.1016\/j.canlet.2024.216621_bib44","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.4161\/auto.21376","article-title":"Autophagy is a protective response to ethanol neurotoxicity","volume":"8","author":"Chen","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.canlet.2024.216621_bib45","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1080\/15548627.2018.1474314","article-title":"Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion","volume":"14","author":"Mauthe","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.canlet.2024.216621_bib46","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1158\/1078-0432.CCR-19-4042","article-title":"A randomized phase II preoperative study of autophagy inhibition with high-dose hydroxychloroquine and gemcitabine\/nab-paclitaxel in pancreatic cancer patients","volume":"26","author":"Zeh","year":"2020","journal-title":"Clin. Cancer Res. : an official journal of the American Association for Cancer Research"},{"issue":"Suppl 1","key":"10.1016\/j.canlet.2024.216621_bib47","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/hep.31288","article-title":"Epidemiology of hepatocellular carcinoma","volume":"73","author":"McGlynn","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.canlet.2024.216621_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2023.110794","article-title":"Mitochondria as intracellular signalling organelles. An update","volume":"109","author":"Popov","year":"2023","journal-title":"Cell. Signal."},{"key":"10.1016\/j.canlet.2024.216621_bib49","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nrm.2017.129","article-title":"Building and decoding ubiquitin chains for mitophagy","volume":"19","author":"Harper","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.canlet.2024.216621_bib50","doi-asserted-by":"crossref","first-page":"3094","DOI":"10.3892\/mmr.2014.3007","article-title":"Anticancer agent icaritin induces apoptosis through caspase-dependent pathways in human hepatocellular carcinoma cells","volume":"11","author":"Sun","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.canlet.2024.216621_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2020.104840","article-title":"Blocking Parkin\/PINK1-mediated mitophagy sensitizes hepatocellular carcinoma cells to sanguinarine-induced mitochondrial apoptosis","volume":"66","author":"Su","year":"2020","journal-title":"Toxicol. Vitro : an international journal published in association with BIBRA"},{"key":"10.1016\/j.canlet.2024.216621_bib52","doi-asserted-by":"crossref","first-page":"600","DOI":"10.3892\/ijo.2013.1959","article-title":"Magnolol inhibits angiogenesis by regulating ROS-mediated apoptosis and the PI3K\/AKT\/mTOR signaling pathway in mES\/EB-derived endothelial-like cells","volume":"43","author":"Kim","year":"2013","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.canlet.2024.216621_bib53","first-page":"3433","article-title":"Neuroprotective role of icariin in experimental spinal cord injury via its antioxidant, anti-neuroinflammatory and anti-apoptotic properties","volume":"20","author":"Jia","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.canlet.2024.216621_bib54","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1042\/BJ20140334","article-title":"Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65","volume":"460","author":"Kazlauskaite","year":"2014","journal-title":"Biochem. J."},{"key":"10.1016\/j.canlet.2024.216621_bib55","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1080\/15548627.2020.1725381","article-title":"Autophagy-based unconventional secretion of HMGB1 by keratinocytes plays a pivotal role in psoriatic skin in\ufb02ammation","volume":"17","author":"Wang","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.canlet.2024.216621_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105582","article-title":"Chloroquine and hydroxychloroquine in antitumor therapies based on autophagy-related mechanisms","volume":"168","author":"Ferreira","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.canlet.2024.216621_bib57","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1080\/15548627.2019.1687210","article-title":"Manipulation of Mitophagy by \"All-in-One\" nanosensitizer augments sonodynamic glioma therapy","volume":"16","author":"Qu","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.canlet.2024.216621_bib58","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/nchembio.2287","article-title":"The pharmacological regulation of cellular mitophagy","volume":"13","author":"Georgakopoulos","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.canlet.2024.216621_bib59","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/s41420-022-01074-6","article-title":"The combination of hydroxychloroquine and 2-deoxyglucose enhances apoptosis in breast cancer cells by blocking protective autophagy and sustaining endoplasmic reticulum stress","volume":"8","author":"Zhou","year":"2022","journal-title":"Cell death discovery"},{"key":"10.1016\/j.canlet.2024.216621_bib60","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1046\/j.1471-4159.1998.70041376.x","article-title":"Cyclic AMP protects against staurosporine and wortmannin-induced apoptosis and opioid-enhanced apoptosis in both embryonic and immortalized (F-11kappa7) neurons","volume":"70","author":"Goswami","year":"1998","journal-title":"J. Neurochem."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383524000156?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383524000156?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T16:16:41Z","timestamp":1759594601000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383524000156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":60,"alternative-id":["S0304383524000156"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2024.216621","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Icaritin with autophagy\/mitophagy inhibitors synergistically enhances anticancer efficacy and apoptotic effects through PINK1\/Parkin-mediated mitophagy in hepatocellular carcinoma","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2024.216621","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"216621"}}