{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:07:29Z","timestamp":1793293649660,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.canlet.2024.216674","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T12:18:33Z","timestamp":1706185113000},"page":"216674","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Direct interaction of platelet with tumor cell aggravates hepatocellular carcinoma metastasis by activating TLR4\/ADAM10\/CX3CL1 axis"],"prefix":"10.1016","volume":"585","author":[{"given":"Jia-Hui","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ao-Di","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu-Man","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Jun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Wei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Bin","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Jie","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Fang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bi-Xiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru-Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8773-3930","authenticated-orcid":false,"given":"Zhang-Yin","family":"Ming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2024.216674_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13045-022-01396-z","article-title":"The development of a cSMART-based integrated model for hepatocellular carcinoma diagnosis","volume":"16","author":"Wu","year":"2023","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.canlet.2024.216674_bib2","doi-asserted-by":"crossref","first-page":"5104","DOI":"10.1158\/1078-0432.CCR-23-0060","article-title":"Lenvatinib, toripalimab plus folfox chemotherapy in hepatocellular carcinoma patients with extrahepatic metastasis: a biomolecular exploratory, phase II trial (ltsc)","volume":"29","author":"He","year":"2023","journal-title":"Clin. Cancer Res. : an official journal of the American Association for Cancer Research"},{"key":"10.1016\/j.canlet.2024.216674_bib3","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.jhep.2021.11.018","article-title":"BCLC strategy for prognosis prediction and treatment recommendation: the 2022 update","volume":"76","author":"Reig","year":"2022","journal-title":"J. Hepatol."},{"key":"10.1016\/j.canlet.2024.216674_bib4","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1186\/s13046-023-02856-1","article-title":"Tumor cell-induced platelet aggregation accelerates hematogenous metastasis of malignant melanoma by triggering macrophage recruitment","volume":"42","author":"Chen","year":"2023","journal-title":"J. Exp. Clin. Cancer Res. : CR"},{"key":"10.1016\/j.canlet.2024.216674_bib5","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.7150\/ijbs.85986","article-title":"Coculture of cancer cells with platelets increases their survival and metastasis by activating the TGF\u03b2\/Smad\/PAI-1 and PI3K\/AKT pathways","volume":"19","author":"Tong","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.canlet.2024.216674_bib6","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1038\/s41388-023-02647-0","article-title":"The platelet pannexin 1-IL-1\u03b2 axis orchestrates pancreatic ductal adenocarcinoma invasion and metastasis","volume":"42","author":"Li","year":"2023","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2024.216674_bib7","doi-asserted-by":"crossref","first-page":"216260","DOI":"10.1016\/j.canlet.2023.216260","article-title":"Dual antiplatelet therapy inhibits neutrophil extracellular traps to reduce liver micrometastases of intrahepatic cholangiocarcinoma","volume":"567","author":"Yoshimoto","year":"2023","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2024.216674_bib8","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1021\/acsnano.1c06022","article-title":"Targeted inhibition of tumor inflammation and tumor-platelet crosstalk by nanoparticle-mediated drug delivery mitigates cancer metastasis","volume":"16","author":"Li","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.canlet.2024.216674_bib9","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1084\/jem.20031023","article-title":"LPS-TLR4 signaling to IRF-3\/7 and NF-kappaB involves the toll adapters TRAM and TRIF","volume":"198","author":"Fitzgerald","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.canlet.2024.216674_bib10","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.canlet.2016.02.005","article-title":"Macrophage migration inhibitory factor promotes breast cancer metastasis via activation of HMGB1\/TLR4\/NF kappa B axis","volume":"375","author":"Lv","year":"2016","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2024.216674_bib11","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1089\/ars.2015.6505","article-title":"An endothelial hsp70-TLR4 Axis limits Nox 3 expression and protects against oxidant injury in lungs","volume":"24","author":"Zhang","year":"2016","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.canlet.2024.216674_bib12","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-005551","article-title":"HSP90\u03b1 induces immunosuppressive myeloid cells in melanoma via TLR4 signaling","volume":"10","author":"Arkhypov","year":"2022","journal-title":"Journal for immunotherapy of cancer"},{"key":"10.1016\/j.canlet.2024.216674_bib13","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s40164-023-00441-y","article-title":"The PTX3\/TLR4 autocrine loop as a novel therapeutic target in triple negative breast cancer","volume":"12","author":"Giacomini","year":"2023","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.canlet.2024.216674_bib14","doi-asserted-by":"crossref","first-page":"5008","DOI":"10.1038\/s41388-022-02496-3","article-title":"Intralesional TLR4 agonist treatment strengthens the organ defense against colonizing cancer cells in the brain","volume":"41","author":"Blazquez","year":"2022","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2024.216674_bib15","doi-asserted-by":"crossref","first-page":"5612","DOI":"10.1002\/jcb.27844","article-title":"Platelet-neutrophil interaction aggravates vascular in\ufb02ammation and promotes the progression of atherosclerosis by activating the TLR4\/NF-\u03baB pathway","volume":"120","author":"Liang","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.canlet.2024.216674_bib16","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.4049\/jimmunol.1600421","article-title":"The tetraspanin TSPAN33 controls TLR-triggered macrophage activation through modulation of NOTCH signaling","volume":"197","author":"Ruiz-Garc\u00eda","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.canlet.2024.216674_bib17","first-page":"4861","article-title":"Lysophosphatidic acid promotes expression and activation of matrix metalloproteinase 9 (MMP9) in THP-1 cells via toll-like receptor 4\/nuclear factor-\u03bab (TLR4\/NF-\u03baB) signaling pathway","volume":"24","author":"Zhou","year":"2018","journal-title":"Med. Sci. Mon. Int. Med. J. Exp. Clin. Res. : international medical journal of experimental and clinical research"},{"key":"10.1016\/j.canlet.2024.216674_bib18","doi-asserted-by":"crossref","first-page":"1064033","DOI":"10.3389\/fimmu.2022.1064033","article-title":"Immunomodulatory role of metalloproteases in cancers: current progress and future trends","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.canlet.2024.216674_bib19","doi-asserted-by":"crossref","first-page":"499","DOI":"10.3389\/fimmu.2020.00499","article-title":"Targeting ADAM10 in cancer and autoimmunity","volume":"11","author":"Smith","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.canlet.2024.216674_bib20","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1186\/s12885-019-6219-7","article-title":"Ionizing radiation increases the endothelial permeability and the transendothelial migration of tumor cells through ADAM10-activation and subsequent degradation of VE-cadherin","volume":"19","author":"Kouam","year":"2019","journal-title":"BMC Cancer"},{"key":"10.1016\/j.canlet.2024.216674_bib21","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1158\/0008-5472.CAN-20-3892","article-title":"Induction of ADAM10 by radiation therapy drives fibrosis, resistance, and epithelial-to-mesenchyal transition in pancreatic cancer","volume":"81","author":"Mueller","year":"2021","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2024.216674_bib22","doi-asserted-by":"crossref","first-page":"106132","DOI":"10.1016\/j.phrs.2022.106132","article-title":"Ido1 can impair NK cells function against non-small cell lung cancer by downregulation of NKG2D Ligand via ADAM10","volume":"177","author":"Fang","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.canlet.2024.216674_bib23","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s13046-016-0368-1","article-title":"MicroRNA-655-3p functions as a tumor suppressor by regulating ADAM10 and \u03b2-catenin pathway in Hepatocellular Carcinoma","volume":"35","author":"Wu","year":"2016","journal-title":"J. Exp. Clin. Cancer Res. : CR"},{"key":"10.1016\/j.canlet.2024.216674_bib24","doi-asserted-by":"crossref","first-page":"15479","DOI":"10.1007\/s00432-023-05334-5","article-title":"Predicting the prognosis of operable gastric cancer patients by dynamic changes in platelets before and after surgery: a retrospective cohort study","volume":"149","author":"Li","year":"2023","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.canlet.2024.216674_bib25","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1080\/17474124.2022.2031977","article-title":"High platelet count predicts poor prognosis in HCC patients undergoing TACE: a propensity score-matched analysis","volume":"16","author":"Li","year":"2022","journal-title":"Expet Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.canlet.2024.216674_bib26","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.ccr.2011.09.009","article-title":"Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis","volume":"20","author":"Labelle","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2024.216674_bib27","doi-asserted-by":"crossref","first-page":"106986","DOI":"10.1016\/j.phrs.2023.106986","article-title":"Ginsenoside Rh1, a novel casein kinase II subunit alpha (CK2\u03b1) inhibitor, retards metastasis via disrupting HHEX\/CCL20 signaling cascade involved in tumor cell extravasation across endothelial barrier","volume":"198","author":"Zheng","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.canlet.2024.216674_bib28","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1186\/s12964-022-00872-w","article-title":"M2 macrophage-secreted exosomes promote metastasis and increase vascular permeability in hepatocellular carcinoma","volume":"21","author":"Lu","year":"2023","journal-title":"Cell Commun. Signal. : CCS"},{"key":"10.1016\/j.canlet.2024.216674_bib29","doi-asserted-by":"crossref","first-page":"4206","DOI":"10.1158\/0008-5472.CAN-22-1199","article-title":"Postoperative plasmacytoid dendritic cells secrete IFN\u03b1 to promote recruitment of myeloid-derived suppressor cells and drive hepatocellular carcinoma recurrence","volume":"82","author":"Pang","year":"2022","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2024.216674_bib30","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.tcb.2018.12.001","article-title":"EMT transition states during tumor progression and metastasis","volume":"29","author":"Pastushenko","year":"2019","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.canlet.2024.216674_bib31","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s40164-022-00344-4","article-title":"RHO GTPase family in hepatocellular carcinoma","volume":"11","author":"Wang","year":"2022","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.canlet.2024.216674_bib32","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.7150\/thno.17908","article-title":"Inhibition of platelet function using liposomal nanoparticles blocks tumor metastasis","volume":"7","author":"Zhang","year":"2017","journal-title":"Theranostics"},{"key":"10.1016\/j.canlet.2024.216674_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0172788","article-title":"Platelet GPIIb supports initial pulmonary retention but inhibits subsequent proliferation of melanoma cells during hematogenic metastasis","volume":"12","author":"Echtler","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.canlet.2024.216674_bib34","doi-asserted-by":"crossref","first-page":"4353","DOI":"10.1038\/onc.2009.289","article-title":"TLR4 signaling induced by lipopolysaccharide or paclitaxel regulates tumor survival and chemoresistance in ovarian cancer","volume":"28","author":"Szajnik","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2024.216674_bib35","doi-asserted-by":"crossref","first-page":"4042","DOI":"10.7150\/thno.84388","article-title":"HMGB1-mediated elevation of KLF7 facilitates hepatocellular carcinoma progression and metastasis through upregulating TLR4 and PTK2","volume":"13","author":"Feng","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.canlet.2024.216674_bib36","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1038\/s41593-019-0419-y","article-title":"Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling","volume":"22","author":"Gunner","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.canlet.2024.216674_bib37","doi-asserted-by":"crossref","first-page":"7648","DOI":"10.1038\/s41467-022-35331-0","article-title":"Targeting cardiomyocyte ADAM10 ectodomain shedding promotes survival early after myocardial infarction","volume":"13","author":"Klapproth","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2024.216674_bib38","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.celrep.2018.03.092","article-title":"Platelets promote metastasis via binding tumor CD97 leading to bidirectional signaling that coordinates transendothelial migration","volume":"23","author":"Ward","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.canlet.2024.216674_bib39","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1160\/TH13-08-0640","article-title":"Fractalkine promotes platelet activation and vascular dysfunction in congestive heart failure","volume":"111","author":"Hildemann","year":"2014","journal-title":"Thromb. Haemostasis"}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383524000673?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383524000673?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T04:36:22Z","timestamp":1719635782000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383524000673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":39,"alternative-id":["S0304383524000673"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2024.216674","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Direct interaction of platelet with tumor cell aggravates hepatocellular carcinoma metastasis by activating TLR4\/ADAM10\/CX3CL1 axis","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2024.216674","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"216674"}}