{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:04:32Z","timestamp":1793423072105,"version":"4.5.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.canlet.2024.216862","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T12:21:48Z","timestamp":1712233308000},"page":"216862","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["The mechanism of extracellular CypB promotes glioblastoma adaptation to glutamine deprivation microenvironment"],"prefix":"10.1016","volume":"597","author":[{"given":"Hang","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunji","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqiang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawen","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2024.216862_bib1","doi-asserted-by":"crossref","first-page":"6964","DOI":"10.1073\/pnas.1815968116","article-title":"Deprivation of glutamine in cell culture reveals its potential for treating cancer","volume":"116","author":"Rubin","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.canlet.2024.216862_bib2","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.tibs.2010.05.003","article-title":"Glutamine addiction: a new therapeutic target in cancer","volume":"35","author":"Wise","year":"2010","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.canlet.2024.216862_bib3","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1158\/0008-5472.CAN-14-2211","article-title":"Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein","volume":"75","author":"Kamphorst","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2024.216862_bib4","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.neo.2019.10.004","article-title":"Glutamine deprivation counteracts hypoxia-induced chemoresistance","volume":"22","author":"Wappler","year":"2020","journal-title":"Neoplasia"},{"key":"10.1016\/j.canlet.2024.216862_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12020310","article-title":"Targeting glutamine addiction in gliomas","volume":"12","author":"Obara-Michlewska","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.canlet.2024.216862_bib6","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1038\/ncb3272","article-title":"Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma","volume":"17","author":"Tardito","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.canlet.2024.216862_bib7","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1038\/ncb3410","article-title":"Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation","volume":"18","author":"Pan","year":"2016","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.canlet.2024.216862_bib8","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.4161\/cc.25729","article-title":"Targeting cancer cells resistant to hypoxia and nutrient starvation to improve anti-angiogeneic therapy","volume":"12","author":"Osawa","year":"2013","journal-title":"Cell Cycle"},{"key":"10.1016\/j.canlet.2024.216862_bib9","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1158\/1541-7786.MCR-19-0517","article-title":"Glutamine deprivation induces PD-L1 expression via activation of EGFR\/ERK\/c-Jun signaling in renal cancer","volume":"18","author":"Ma","year":"2020","journal-title":"Mol. Cancer Res. : Math. Control Relat. Field."},{"key":"10.1016\/j.canlet.2024.216862_bib10","doi-asserted-by":"crossref","first-page":"v1","DOI":"10.1093\/neuonc\/nox158","article-title":"CBTRUS Statistical Report: primary brain and other central nervous system tumors diagnosed in the United States in 2010-2014","volume":"19","author":"Ostrom","year":"2017","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.canlet.2024.216862_bib11","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa043330","article-title":"Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma","volume":"352","author":"Stupp","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.canlet.2024.216862_bib12","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1158\/2159-8290.CD-19-0400","article-title":"Circadian regulator CLOCK recruits immune-suppressive microglia into the GBM tumor microenvironment","volume":"10","author":"Chen","year":"2020","journal-title":"Cancer Discov."},{"key":"10.1016\/j.canlet.2024.216862_bib13","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrc3038","article-title":"Otto Warburg's contributions to current concepts of cancer metabolism","volume":"11","author":"Koppenol","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.canlet.2024.216862_bib14","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s10571-019-00659-7","article-title":"Mammalian target of rapamycin 2 (MTOR2) and C-myc modulate glucosamine-6-phosphate synthesis in glioblastoma (GBM) cells through glutamine: fructose-6-phosphate aminotransferase 1 (GFAT1)","volume":"39","author":"Liu","year":"2019","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.canlet.2024.216862_bib15","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/nature10642","article-title":"Reductive carboxylation supports growth in tumour cells with defective mitochondria","volume":"481","author":"Mullen","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2024.216862_bib16","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00109-011-0731-9","article-title":"Glutamine: pleiotropic roles in tumor growth and stress resistance","volume":"89","author":"Shanware","year":"2011","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.canlet.2024.216862_bib17","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.1038\/onc.2014.316","article-title":"Loss of the tumor suppressor Hace1 leads to ROS-dependent glutamine addiction","volume":"34","author":"Cetinbas","year":"2015","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2024.216862_bib18","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1186\/s13071-021-05098-2","article-title":"Trichomonas vaginalis induces apoptosis via ROS and ER stress response through ER-mitochondria crosstalk in SiHa cells","volume":"14","author":"Gao","year":"2021","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.canlet.2024.216862_bib19","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1073\/pnas.88.5.1903","article-title":"Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence","volume":"88","author":"Price","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.canlet.2024.216862_bib20","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1002\/hep.24539","article-title":"Role of cyclophilin B in tumorigenesis and cisplatin resistance in hepatocellular carcinoma in humans","volume":"54","author":"Kim","year":"2011","journal-title":"Comp. Hepatol."},{"key":"10.1016\/j.canlet.2024.216862_bib21","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1126\/science.277.5332.1681","article-title":"Cysteine and glutathione secretion in response to protein disulfide bond formation in the ER","volume":"277","author":"Carelli","year":"1997","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.canlet.2024.216862_bib22","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1097-2765(00)80017-9","article-title":"The ERO1 gene of yeast is required for oxidation of protein dithiols in the endoplasmic reticulum","volume":"1","author":"Frand","year":"1998","journal-title":"Mol. Cell"},{"key":"10.1016\/j.canlet.2024.216862_bib23","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1002\/mc.23402","article-title":"CircTCF25 serves as a sponge for miR-206 to support proliferation, migration, and invasion of glioma via the Jak 2\/p-Stat 3\/CypB axis","volume":"61","author":"Yin","year":"2022","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.canlet.2024.216862_bib24","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1021\/pr200935y","article-title":"Biomarkers of breast cancer apoptosis induced by chemotherapy and TRAIL","volume":"11","author":"Leong","year":"2012","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.canlet.2024.216862_bib25","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/cdd.2013.164","article-title":"Cyclophilin B is involved in p300-mediated degradation of CHOP in tumor cell adaptation to hypoxia","volume":"21","author":"Jeong","year":"2014","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.canlet.2024.216862_bib26","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.3892\/ol.2015.3102","article-title":"Hypoxia induces cyclophilin B through the activation of transcription factor 6 in gastric adenocarcinoma cells","volume":"9","author":"Jeong","year":"2015","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.canlet.2024.216862_bib27","first-page":"784","article-title":"Release of overexpressed CypB activates ERK signaling through CD147 binding for hepatoma cell resistance to oxidative stress, Apoptosis","volume":"17","author":"Kim","year":"2012","journal-title":"Dialogic Pedagogy An Int. Online J."},{"key":"10.1016\/j.canlet.2024.216862_bib28","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1073\/pnas.1808950116","article-title":"Spatially resolved metabolomics to discover tumor-associated metabolic alterations","volume":"116","author":"Sun","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.canlet.2024.216862_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/biom10101429","article-title":"Role of glutathione in cancer: from mechanisms to therapies","volume":"10","author":"Kennedy","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.canlet.2024.216862_bib30","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3390\/ijms17030327","article-title":"Endoplasmic reticulum stress and associated ROS","volume":"17","author":"Zeeshan","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.canlet.2024.216862_bib31","doi-asserted-by":"crossref","first-page":"3931","DOI":"10.1073\/pnas.91.9.3931","article-title":"Cyclophilin B trafficking through the secretory pathway is altered by binding of cyclosporin A","volume":"91","author":"Price","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.canlet.2024.216862_bib32","doi-asserted-by":"crossref","first-page":"6790","DOI":"10.1073\/pnas.092160699","article-title":"The intranuclear prolactin\/cyclophilin B complex as a transcriptional inducer","volume":"99","author":"Rycyzyn","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.canlet.2024.216862_bib33","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jns.2009.11.013","article-title":"Methionine sulfoximine, an inhibitor of glutamine synthetase, lowers brain glutamine and glutamate in a mouse model of ALS","volume":"290","author":"Ghoddoussi","year":"2010","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.canlet.2024.216862_bib34","doi-asserted-by":"crossref","first-page":"6724","DOI":"10.1007\/s12035-022-02999-w","article-title":"Crucial role of RLIP76 in promoting glycolysis and tumorigenesis by stabilization of HIF-1\u03b1 in glioma cells under hypoxia","volume":"59","author":"Wang","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.canlet.2024.216862_bib35","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.canlet.2014.04.001","article-title":"The Warburg effect in tumor progression: mitochondrial oxidative metabolism as an anti-metastasis mechanism","volume":"356","author":"Lu","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2024.216862_bib36","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.apsb.2015.05.007","article-title":"HIF-1\u03b1 pathway: role, regulation and intervention for cancer therapy","volume":"5","author":"Masoud","year":"2015","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.canlet.2024.216862_bib37","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.ccr.2007.04.001","article-title":"HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity","volume":"11","author":"Zhang","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2024.216862_bib38","doi-asserted-by":"crossref","first-page":"4183","DOI":"10.1128\/JVI.02168-09","article-title":"CD147\/EMMPRIN acts as a functional entry receptor for measles virus on epithelial cells","volume":"84","author":"Watanabe","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.canlet.2024.216862_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2022.115929","article-title":"Carbon tetrachloride induced mitochondrial division, respiratory chain damage, abnormal intracellular [H+] and apoptosis are due to the activation of 5-HT degradation system in hepatocytes","volume":"439","author":"Zhang","year":"2022","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.canlet.2024.216862_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113880","article-title":"Cadmium exposure causes mitochondrial fission and fusion disorder in the pig hypothalamus via the PI3K\/AKT pathway","volume":"242","author":"Chen","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.canlet.2024.216862_bib41","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s13402-019-00479-3","article-title":"CD147 augmented monocarboxylate transporter-1\/4 expression through modulation of the Akt-FoxO3-NF-\u03baB pathway promotes cholangiocarcinoma migration and invasion","volume":"43","author":"Dana","year":"2020","journal-title":"Cell. Oncol."},{"key":"10.1016\/j.canlet.2024.216862_bib42","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.jhep.2015.07.039","article-title":"CD147 reprograms fatty acid metabolism in hepatocellular carcinoma cells through Akt\/mTOR\/SREBP1c and P38\/PPAR\u03b1 pathways","volume":"63","author":"Li","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.canlet.2024.216862_bib43","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s11060-020-03602-9","article-title":"AKT\/GSK-3\u03b2\/\u03b2-catenin signaling pathway participates in erythropoietin-promoted glioma proliferation","volume":"149","author":"Tang","year":"2020","journal-title":"J. Neuro Oncol."},{"key":"10.1016\/j.canlet.2024.216862_bib44","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20191115","article-title":"\u03b2-Catenin induces transcriptional expression of PD-L1 to promote glioblastoma immune evasion","volume":"217","author":"Du","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.canlet.2024.216862_bib45","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.canlet.2019.10.029","article-title":"SIK2 promotes reprogramming of glucose metabolism through PI3K\/AKT\/HIF-1\u03b1 pathway and Drp1-mediated mitochondrial fission in ovarian cancer","volume":"469","author":"Gao","year":"2020","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2024.216862_bib46","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/nrc.2016.71","article-title":"From Krebs to clinic: glutamine metabolism to cancer therapy","volume":"16","author":"Altman","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.canlet.2024.216862_bib47","doi-asserted-by":"crossref","first-page":"e2253","DOI":"10.1038\/cddis.2016.105","article-title":"ROS homeostasis and metabolism: a dangerous liaison in cancer cells","volume":"7","author":"Panieri","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.canlet.2024.216862_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19041099","article-title":"Oligodendroglioma cells lack glutamine synthetase and are auxotrophic for glutamine, but do not depend on glutamine anaplerosis for growth","volume":"19","author":"Chiu","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.canlet.2024.216862_bib49","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1146\/annurev.biochem.73.011303.074134","article-title":"The mammalian unfolded protein response","volume":"74","author":"Schr\u00f6der","year":"2005","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.canlet.2024.216862_bib50","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1146\/annurev.cellbio.22.010305.104656","article-title":"Cholesterol sensing, trafficking, and esterification","volume":"22","author":"Chang","year":"2006","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.canlet.2024.216862_bib51","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1126\/science.123.3191.309","article-title":"On the origin of cancer cells","volume":"123","author":"Warburg","year":"1956","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.canlet.2024.216862_bib52","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/onc.2009.441","article-title":"Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics","volume":"29","author":"Semenza","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2024.216862_bib53","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/978-3-319-12048-5_2","article-title":"Glioma biology and molecular markers","volume":"163","author":"Cohen","year":"2015","journal-title":"Cancer Treat Res."},{"key":"10.1016\/j.canlet.2024.216862_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20070389","article-title":"Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1","volume":"405","author":"Semenza","year":"2007","journal-title":"Biochem. J."},{"key":"10.1016\/j.canlet.2024.216862_bib55","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cmet.2009.08.015","article-title":"MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1\/2","volume":"10","author":"Chan","year":"2009","journal-title":"Cell Metabol."},{"key":"10.1016\/j.canlet.2024.216862_bib56","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1016\/j.bbadis.2015.08.027","article-title":"Critical role of AMP-activated protein kinase in the balance between mitophagy and mitochondrial biogenesis in MELAS disease","volume":"1852","author":"Garrido-Maraver","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.canlet.2024.216862_bib57","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s11010-019-03640-6","article-title":"Silibinin inhibits migration and invasion of breast cancer MDA-MB-231 cells through induction of mitochondrial fusion","volume":"463","author":"Si","year":"2020","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.canlet.2024.216862_bib58","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.tox.2017.07.019","article-title":"Mitochondrial fusion, fission, and mitochondrial toxicity","volume":"391","author":"Meyer","year":"2017","journal-title":"Toxicology"},{"key":"10.1016\/j.canlet.2024.216862_bib59","doi-asserted-by":"crossref","first-page":"4748","DOI":"10.1038\/onc.2012.500","article-title":"BIRC5\/Survivin enhances aerobic glycolysis and drug resistance by altered regulation of the mitochondrial fusion\/fission machinery","volume":"32","author":"Hagenbuchner","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2024.216862_bib60","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1172\/JCI59309","article-title":"An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice","volume":"122","author":"Kinross","year":"2012","journal-title":"J. Clin. Invest."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383524002556?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383524002556?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T22:58:11Z","timestamp":1760741891000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383524002556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":60,"alternative-id":["S0304383524002556"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2024.216862","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The mechanism of extracellular CypB promotes glioblastoma adaptation to glutamine deprivation microenvironment","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2024.216862","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"216862"}}