{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:15:36Z","timestamp":1792196136614,"version":"4.4.0"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T00:00:00Z","timestamp":1745712000000},"content-version":"am","delay-in-days":330,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K08051"],"award-info":[{"award-number":["23K08051"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23H02998"],"award-info":[{"award-number":["23H02998"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21KK0153"],"award-info":[{"award-number":["21KK0153"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K08113"],"award-info":[{"award-number":["23K08113"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["220K09038"],"award-info":[{"award-number":["220K09038"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23H02772"],"award-info":[{"award-number":["23H02772"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018289","name":"Shinnihon Foundation of Advanced Medical Treatment Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJFR200H"],"award-info":[{"award-number":["JPMJFR200H"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["23ama221421"],"award-info":[{"award-number":["23ama221421"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007428","name":"Naito Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007434","name":"Suzuken Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007434","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.canlet.2024.216901","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T12:30:08Z","timestamp":1713357008000},"page":"216901","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["RAC1-mediated integrin alpha-6 expression in E-cadherin-deficient gastric cancer cells promotes interactions with the stroma and peritoneal dissemination"],"prefix":"10.1016","volume":"591","author":[{"given":"Jun","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingfeng","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaitao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuko","family":"Yonemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1987-1645","authenticated-orcid":false,"given":"Takashi","family":"Semba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Yasuda-Yoshihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7581-7125","authenticated-orcid":false,"given":"Akiho","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6758-4253","authenticated-orcid":false,"given":"Takuya","family":"Tajiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6395-6534","authenticated-orcid":false,"given":"Yilin","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4556-0100","authenticated-orcid":false,"given":"Tadahito","family":"Yasuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Uchihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4151-4983","authenticated-orcid":false,"given":"Masaya","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuya","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juntaro","family":"Yamasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Nagano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Baba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1852-1835","authenticated-orcid":false,"given":"Takatsugu","family":"Ishimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2024.216901_bib1","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA A Cancer J. Clin."},{"key":"10.1016\/j.canlet.2024.216901_bib2","first-page":"7","article-title":"Cancer statistics","volume":"72","author":"Siegel","year":"2022","journal-title":"CA A Cancer J. Clin."},{"key":"10.1016\/j.canlet.2024.216901_bib3","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/annonc\/mdz001","article-title":"Development and validation of an individualized nomogram to identify occult peritoneal metastasis in patients with advanced gastric cancer","volume":"30","author":"Dong","year":"2019","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.canlet.2024.216901_bib4","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1007\/s10120-021-01160-1","article-title":"Synchronous peritoneal metastases of gastric cancer origin: incidence, treatment and survival of a nationwide Dutch cohort","volume":"24","author":"Koemans","year":"2021","journal-title":"Gastric Cancer"},{"key":"10.1016\/j.canlet.2024.216901_bib5","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/apm.1965.64.1.31","article-title":"The two histological main types of gastric carcinoma: diffuse and SO-called intestinal-type carcinoma. AN attempt at a histo-clinical classification","volume":"64","author":"Lauren","year":"1965","journal-title":"Acta Pathol. Microbiol. Scand."},{"key":"10.1016\/j.canlet.2024.216901_bib6","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1053\/j.gastro.2017.03.046","article-title":"Activation of transforming growth factor beta 1 signaling in gastric cancer-associated fibroblasts increases their motility, via expression of rhomboid 5 homolog 2, and ability to induce invasiveness of gastric cancer cells","volume":"153","author":"Ishimoto","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.canlet.2024.216901_bib7","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/SLA.0000000000002040","article-title":"Lauren histologic type is the most important factor associated with pattern of recurrence following resection of gastric adenocarcinoma","volume":"267","author":"Lee","year":"2018","journal-title":"Ann. Surg."},{"key":"10.1016\/j.canlet.2024.216901_bib8","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1038\/s41388-022-02270-5","article-title":"Transferrin receptor 1 promotes the fibroblast growth factor receptor-mediated oncogenic potential of diffused-type gastric cancer","volume":"41","author":"Shirakihara","year":"2022","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2024.216901_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19082424","article-title":"Diffuse gastric cancer: a summary of analogous contributing factors for its molecular pathogenicity","volume":"19","author":"Ansari","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.canlet.2024.216901_bib10","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/nature13480","article-title":"Comprehensive molecular characterization of gastric adenocarcinoma","volume":"513","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2024.216901_bib11","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1158\/2159-8290.CD-19-0811","article-title":"Gain-of-Function RHOA mutations promote focal adhesion kinase activation and dependency in diffuse gastric cancer","volume":"10","author":"Zhang","year":"2020","journal-title":"Cancer Discov."},{"key":"10.1016\/j.canlet.2024.216901_bib12","doi-asserted-by":"crossref","first-page":"5349","DOI":"10.1158\/0008-5472.CAN-17-0061","article-title":"Oncogenic KRAS and p53 loss drive gastric tumorigenesis in mice that can Be attenuated by E-cadherin expression","volume":"77","author":"Till","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2024.216901_bib13","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1002\/hep.29209","article-title":"H19 promotes cholestatic liver fibrosis by preventing ZEB1-mediated inhibition of epithelial cell adhesion molecule","volume":"66","author":"Song","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.canlet.2024.216901_bib14","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.cell.2019.12.024","article-title":"Astrocytic trans-differentiation completes a multicellular paracrine feedback loop required for medulloblastoma tumor growth","volume":"180","author":"Yao","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2024.216901_bib15","doi-asserted-by":"crossref","first-page":"4734","DOI":"10.1016\/j.cell.2021.08.003","article-title":"Spatially organized multicellular immune hubs in human colorectal cancer","volume":"184","author":"Pelka","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2024.216901_bib16","doi-asserted-by":"crossref","first-page":"4887","DOI":"10.1038\/s41388-019-0765-y","article-title":"Biological heterogeneity and versatility of cancer-associated fibroblasts in the tumor microenvironment","volume":"38","author":"Bu","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2024.216901_bib17","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.1158\/0008-5472.CAN-19-3803","article-title":"Extracellular vesicles from cancer-associated fibroblasts containing annexin A6 induces FAK-YAP activation by stabilizing \u03b21 integrin, enhancing drug resistance","volume":"80","author":"Uchihara","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2024.216901_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.108779","article-title":"Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination","volume":"34","author":"Yasuda","year":"2021","journal-title":"Cell Rep."},{"issue":"2","key":"10.1016\/j.canlet.2024.216901_bib19","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s10120-022-01352-3","article-title":"IL-1\u03b2 derived from mixed-polarized macrophages activates fibroblasts and synergistically forms a cancer-promoting microenvironment","volume":"26","author":"Zhang","year":"2023","journal-title":"Gastric Cancer"},{"key":"10.1016\/j.canlet.2024.216901_bib20","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1158\/1078-0432.CCR-17-1776","article-title":"Vimentin is required for lung adenocarcinoma metastasis via heterotypic tumor cell-cancer-associated fibroblast interactions during collective invasion","volume":"24","author":"Richardson","year":"2018","journal-title":"Clin. Cancer Res. : an official journal of the American Association for Cancer Research"},{"key":"10.1016\/j.canlet.2024.216901_bib21","doi-asserted-by":"crossref","first-page":"4381","DOI":"10.1111\/cas.14664","article-title":"Collective cancer cell invasion in contact with fibroblasts through integrin-\u03b15\u03b21\/fibronectin interaction in collagen matrix","volume":"111","author":"Miyazaki","year":"2020","journal-title":"Cancer Sci."},{"key":"10.1016\/j.canlet.2024.216901_bib22","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/ncb3478","article-title":"A mechanically active heterotypic E-cadherin\/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion","volume":"19","author":"Labernadie","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.canlet.2024.216901_bib23","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1053\/j.gastro.2006.07.014","article-title":"Carcinogenesis in mouse stomach by simultaneous activation of the Wnt signaling and prostaglandin E2 pathway","volume":"131","author":"Oshima","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.canlet.2024.216901_bib24","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ccr.2011.01.038","article-title":"CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth","volume":"19","author":"Ishimoto","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2024.216901_bib25","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1111\/cas.15244","article-title":"MEK inhibition suppresses metastatic progression of KRAS-mutated gastric cancer","volume":"113","author":"Yamasaki","year":"2022","journal-title":"Cancer Sci."},{"key":"10.1016\/j.canlet.2024.216901_bib26","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1111\/febs.16712","article-title":"A novel tdTomato transgenic mouse model to visualize FAP-positive cancer-associated fibroblasts","volume":"290","author":"Wei","year":"2023","journal-title":"FEBS J."},{"issue":"1","key":"10.1016\/j.canlet.2024.216901_bib27","doi-asserted-by":"crossref","first-page":"113613","DOI":"10.1016\/j.celrep.2023.113613","article-title":"Mesothelial-mesenchymal transition induced mesothelial cells enhance peritoneal dissemination through forming protumorigenic microenvironment","volume":"43","author":"Yonemura","year":"2024","journal-title":"Cell Rep"},{"key":"10.1016\/j.canlet.2024.216901_bib28","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1038\/s41467-020-18883-x","article-title":"Identification of 31 loci for mammographic density phenotypes and their associations with breast cancer risk","volume":"11","author":"Sieh","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2024.216901_bib29","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.biomaterials.2016.11.043","article-title":"Protein-crystal interface mediates cell adhesion and proangiogenic secretion","volume":"116","author":"Wu","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.canlet.2024.216901_bib30","doi-asserted-by":"crossref","first-page":"eabp8964","DOI":"10.1126\/science.abp8964","article-title":"The extracellular matrix and the immune system: a mutually dependent relationship","volume":"379","author":"Sutherland","year":"2023","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.canlet.2024.216901_bib31","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/s41556-018-0223-z","article-title":"Integrin trafficking in cells and tissues","volume":"21","author":"Moreno-Layseca","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.canlet.2024.216901_bib32","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0092-8674(04)00003-0","article-title":"Rho and Rac take center stage","volume":"116","author":"Burridge","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2024.216901_bib33","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0140-6736(20)31288-5","article-title":"Gastric cancer","volume":"396","author":"Smyth","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.canlet.2024.216901_bib34","doi-asserted-by":"crossref","first-page":"6529","DOI":"10.1158\/1078-0432.CCR-21-0792","article-title":"Spatially distinct reprogramming of the tumor microenvironment based on tumor invasion in diffuse-type gastric cancers","volume":"27","author":"Jeong","year":"2021","journal-title":"Clin. Cancer Res. : an official journal of the American Association for Cancer Research"},{"key":"10.1016\/j.canlet.2024.216901_bib35","first-page":"527","article-title":"The tumour microenvironment in pancreatic cancer - clinical challenges and opportunities, Nature reviews","volume":"17","author":"Ho","year":"2020","journal-title":"Clin. Oncol."},{"key":"10.1016\/j.canlet.2024.216901_bib36","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.canlet.2021.11.008","article-title":"Integrin \u03b15 mediates cancer cell-fibroblast adhesion and peritoneal dissemination of diffuse-type gastric carcinoma","volume":"526","author":"Miyamoto","year":"2022","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2024.216901_bib37","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.tcb.2020.07.003","article-title":"EMT, MET, plasticity, and tumor metastasis","volume":"30","author":"Bakir","year":"2020","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.canlet.2024.216901_bib38","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1093\/annonc\/mdg486","article-title":"The role of the E-cadherin gene (CDH1) in diffuse gastric cancer susceptibility: from the laboratory to clinical practice","volume":"14","author":"Graziano","year":"2003","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.canlet.2024.216901_bib39","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/gb-2007-8-5-215","article-title":"The integrins","volume":"8","author":"Takada","year":"2007","journal-title":"Genome Biol."},{"key":"10.1016\/j.canlet.2024.216901_bib40","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0092-8674(02)00971-6","article-title":"Integrins: bidirectional, allosteric signaling machines","volume":"110","author":"Hynes","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2024.216901_bib41","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41580-019-0134-2","article-title":"Integrins as biomechanical sensors of the microenvironment","volume":"20","author":"Kechagia","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.canlet.2024.216901_bib42","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/nrm2871","article-title":"The final steps of integrin activation: the end game","volume":"11","author":"Shattil","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.canlet.2024.216901_bib43","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nrm3624","article-title":"Talins and kindlins: partners in integrin-mediated adhesion","volume":"14","author":"Calderwood","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.canlet.2024.216901_bib44","doi-asserted-by":"crossref","first-page":"R1092","DOI":"10.1016\/j.cub.2015.09.049","article-title":"Endocytic trafficking of integrins in cell migration","volume":"25","author":"Paul","year":"2015","journal-title":"Curr. Biol."},{"key":"10.1016\/j.canlet.2024.216901_bib45","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1083\/jcb.200509019","article-title":"Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins","volume":"173","author":"Pellinen","year":"2006","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.canlet.2024.216901_bib46","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.devcel.2011.11.008","article-title":"Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes\/lysosomes and drive cancer progression","volume":"22","author":"Dozynkiewicz","year":"2012","journal-title":"Dev. Cell"},{"key":"10.1016\/j.canlet.2024.216901_bib47","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.1038\/s41388-018-0202-7","article-title":"Rab34 regulates adhesion, migration, and invasion of breast cancer cells","volume":"37","author":"Sun","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2024.216901_bib48","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1016\/j.cub.2020.03.042","article-title":"RhoJ regulates \u03b15\u03b21 integrin trafficking to control fibronectin remodeling during angiogenesis","volume":"30","author":"Sundararaman","year":"2020","journal-title":"Curr. Biol."},{"key":"10.1016\/j.canlet.2024.216901_bib49","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/ng.2984","article-title":"Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma","volume":"46","author":"Kakiuchi","year":"2014","journal-title":"Nat. Genet."},{"key":"10.1016\/j.canlet.2024.216901_bib50","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.cellsig.2011.08.011","article-title":"Rac signaling in breast cancer: a tale of GEFs and GAPs","volume":"24","author":"Wertheimer","year":"2012","journal-title":"Cell. Signal."},{"key":"10.1016\/j.canlet.2024.216901_bib51","doi-asserted-by":"crossref","first-page":"3422","DOI":"10.1016\/j.celrep.2019.05.058","article-title":"Acquired resistance of EGFR-mutated lung cancer to tyrosine kinase inhibitor treatment promotes PARP inhibitor sensitivity","volume":"27","author":"Marcar","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.canlet.2024.216901_bib52","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nature01148","article-title":"Rho GTPases in cell biology","volume":"420","author":"Etienne-Manneville","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2024.216901_bib53","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/374457a0","article-title":"An essential role for Rac in Ras transformation","volume":"374","author":"Qiu","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2024.216901_bib54","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.trecan.2020.02.021","article-title":"RAC1 as a therapeutic target in malignant melanoma","volume":"6","author":"Cannon","year":"2020","journal-title":"Trends Cancer"},{"key":"10.1016\/j.canlet.2024.216901_bib55","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/s41419-017-0258-2","article-title":"miR-143-3p targeting of ITGA6 suppresses tumour growth and angiogenesis by downregulating PLGF expression via the PI3K\/AKT pathway in gallbladder carcinoma","volume":"9","author":"Jin","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.canlet.2024.216901_bib56","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1038\/s41416-021-01362-5","article-title":"Downregulation of ITGA6 confers to the invasion of multiple myeloma and promotes progression to plasma cell leukaemia","volume":"124","author":"Song","year":"2021","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.canlet.2024.216901_bib57","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1182\/blood.2019001417","article-title":"Integrin \u03b16 mediates the drug resistance of acute lymphoblastic B-cell leukemia","volume":"136","author":"Gang","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.canlet.2024.216901_bib58","doi-asserted-by":"crossref","first-page":"428","DOI":"10.2174\/1574888X13666181002151330","article-title":"Integrin \u03b16 (CD49f), the microenvironment and cancer stem cells","volume":"14","author":"Bigoni-Ord\u00f3\u00f1ez","year":"2019","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"10.1016\/j.canlet.2024.216901_bib59","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/s41573-021-00284-4","article-title":"Emerging therapeutic opportunities for integrin inhibitors","volume":"21","author":"Slack","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.canlet.2024.216901_bib60","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.tips.2012.04.002","article-title":"Integrins as therapeutic targets","volume":"33","author":"Goodman","year":"2012","journal-title":"Trends Pharmacol. Sci."},{"issue":"Suppl 1","key":"10.1016\/j.canlet.2024.216901_bib61","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s00259-006-0136-0","article-title":"Alphavbeta3-integrin imaging: a new approach to characterise angiogenesis?","volume":"33","author":"Haubner","year":"2006","journal-title":"Eur. J. Nucl. Med. Mol. Imag."},{"key":"10.1016\/j.canlet.2024.216901_bib62","doi-asserted-by":"crossref","first-page":"20141","DOI":"10.1073\/pnas.1901931116","article-title":"\u03b1v\u03b23-integrin regulates PD-L1 expression and is involved in cancer immune evasion","volume":"116","author":"Vannini","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.canlet.2024.216901_bib63","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.122591","article-title":"Integrin \u03b1v\u03b28-expressing tumor cells evade host immunity by regulating TGF-\u03b2 activation in immune cells","volume":"3","author":"Takasaka","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.canlet.2024.216901_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109309","article-title":"Integrin \u03b1v\u03b28 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy","volume":"36","author":"Dodagatta-Marri","year":"2021","journal-title":"Cell Rep."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383524002945?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383524002945?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T02:11:16Z","timestamp":1784945476000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383524002945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":64,"alternative-id":["S0304383524002945"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2024.216901","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RAC1-mediated integrin alpha-6 expression in E-cadherin-deficient gastric cancer cells promotes interactions with the stroma and peritoneal dissemination","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2024.216901","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"216901"}}