{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:43:52Z","timestamp":1791917032812,"version":"4.3.4"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007313","name":"University of Texas MD Anderson Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-19-KCRP-IDA"],"award-info":[{"award-number":["W81XWH-19-KCRP-IDA"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-20-1-0895"],"award-info":[{"award-number":["W81XWH-20-1-0895"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.canlet.2024.217009","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T13:43:36Z","timestamp":1717595016000},"page":"217009","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["BIGH3 mediates apoptosis and gap junction failure in osteocytes during renal cell carcinoma bone metastasis progression"],"prefix":"10.1016","volume":"596","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6891-2063","authenticated-orcid":false,"given":"Tianhong","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4651-7710","authenticated-orcid":false,"given":"Fengshuo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxin","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0321-6670","authenticated-orcid":false,"given":"Murtaza","family":"Wasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian H.","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerae O.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick P.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin E.","family":"Bird","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theocharis","family":"Panaretakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue-Hwa","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3386-8239","authenticated-orcid":false,"given":"Danielle","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4526-3088","authenticated-orcid":false,"given":"Mary C.","family":"Farach-Carson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang H.-F.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Satcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2024.217009_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.567844","article-title":"Osteocytes and bone metastasis","volume":"11","author":"Riquelme","year":"2020","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.canlet.2024.217009_bib2","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.ctrv.2011.06.011","article-title":"Skeletal metastasis in renal cell carcinoma: current and future management options","volume":"38","author":"Wood","year":"2012","journal-title":"Cancer Treat Rev."},{"key":"10.1016\/j.canlet.2024.217009_bib3","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.eururo.2014.02.040","article-title":"Prognostic significance of bone metastases and bisphosphonate therapy in patients with renal cell carcinoma","volume":"66","author":"McKay","year":"2014","journal-title":"Eur. Urol."},{"key":"10.1016\/j.canlet.2024.217009_bib4","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.neo.2017.11.002","article-title":"BIGH3 promotes osteolytic lesions in renal cell carcinoma bone metastasis by inhibiting osteoblast differentiation","volume":"20","author":"Pan","year":"2018","journal-title":"Neoplasia"},{"key":"10.1016\/j.canlet.2024.217009_bib5","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1089\/dna.1994.13.571","article-title":"Beta ig-h3: a transforming growth factor-beta-responsive gene encoding a secreted protein that inhibits cell attachment in vitro and suppresses the growth of CHO cells in nude mice","volume":"13","author":"Skonier","year":"1994","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.canlet.2024.217009_bib6","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/(SICI)1097-4644(20000201)76:2<231::AID-JCB7>3.0.CO;2-X","article-title":"Differential display of human marrow stromal cells reveals unique mRNA expression patterns in response to dexamethasone","volume":"76","author":"Dieudonne","year":"1999","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.canlet.2024.217009_bib7","doi-asserted-by":"crossref","first-page":"46159","DOI":"10.1074\/jbc.M207055200","article-title":"Identification of motifs in the fasciclin domains of the transforming growth factor-beta-induced matrix protein betaig-h3 that interact with the alphavbeta5 integrin","volume":"277","author":"Kim","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2024.217009_bib8","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1158\/1535-7163.MCT-19-0174","article-title":"Cabozantinib reverses renal cell carcinoma-mediated osteoblast inhibition in three-dimensional Coculture in vitro and reduces bone osteolysis in vivo","volume":"19","author":"Pan","year":"2020","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.canlet.2024.217009_bib9","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/jbmr.320","article-title":"The amazing osteocyte","volume":"26","author":"Bonewald","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.canlet.2024.217009_bib10","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00223-013-9790-y","article-title":"Osteocytes: master orchestrators of bone","volume":"94","author":"Schaffler","year":"2014","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.canlet.2024.217009_bib11","doi-asserted-by":"crossref","first-page":"857","DOI":"10.3892\/ol.2016.5471","article-title":"Influence of gap junction intercellular communication composed of connexin 43 on the antineoplastic effect of adriamycin in breast cancer cells","volume":"13","author":"Jiang","year":"2017","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.canlet.2024.217009_bib12","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1016\/j.celrep.2017.10.115","article-title":"Osteocyte-intrinsic TGF-beta signaling regulates bone Quality through perilacunar\/canalicular remodeling","volume":"21","author":"Dole","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.canlet.2024.217009_bib13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41413-019-0050-2","article-title":"Connexin 43 hemichannels protect bone loss during estrogen deficiency","volume":"7","author":"Ma","year":"2019","journal-title":"Bone Res"},{"key":"10.1016\/j.canlet.2024.217009_bib14","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/jbmr.548","article-title":"Cell autonomous requirement of connexin 43 for osteocyte survival: consequences for endocortical resorption and periosteal bone formation","volume":"27","author":"Bivi","year":"2012","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.canlet.2024.217009_bib15","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1359\/jbmr.1997.12.12.2014","article-title":"Establishment of an osteocyte-like cell line, MLO-Y4","volume":"12","author":"Kato","year":"1997","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.canlet.2024.217009_bib16","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1002\/jbmr.465","article-title":"Cell line IDG-SW3 replicates osteoblast-to-late-osteocyte differentiation in vitro and accelerates bone formation in vivo","volume":"26","author":"Woo","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.canlet.2024.217009_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0089880","article-title":"Cadherin-11 in renal cell carcinoma bone metastasis","volume":"9","author":"Satcher","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.canlet.2024.217009_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/srep44618","article-title":"Glucocorticoid suppression of osteocyte perilacunar remodeling is associated with subchondral bone degeneration in osteonecrosis","volume":"7","author":"Fowler","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.canlet.2024.217009_bib19","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1158\/1541-7786.MCR-08-0077","article-title":"Cadherin-11 promotes the metastasis of prostate cancer cells to bone","volume":"6","author":"Chu","year":"2008","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.canlet.2024.217009_bib20","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1038\/onc.2014.116","article-title":"Talin1 phosphorylation activates beta1 integrins: a novel mechanism to promote prostate cancer bone metastasis","volume":"34","author":"Jin","year":"2015","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2024.217009_bib21","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.canlet.2015.05.019","article-title":"Three-dimensional (3D) culture of bone-derived human 786-O renal cell carcinoma retains relevant clinical characteristics of bone metastases","volume":"365","author":"Pan","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2024.217009_bib22","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1359\/jbmr.2000.15.2.209","article-title":"Functional gap junctions between osteocytic and osteoblastic cells","volume":"15","author":"Yellowley","year":"2000","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.canlet.2024.217009_bib23","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1089\/adt.2019.927","article-title":"High-content Screening Identifies new inhibitors of connexin 43 gap junctions","volume":"17","author":"Picoli","year":"2019","journal-title":"Assay Drug Dev. Technol."},{"key":"10.1016\/j.canlet.2024.217009_bib24","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/j.febslet.2014.01.049","article-title":"Specific Cx43 phosphorylation events regulate gap junction turnover in vivo","volume":"588","author":"Solan","year":"2014","journal-title":"FEBS Lett."},{"key":"10.1016\/j.canlet.2024.217009_bib25","article-title":"Hydroxychloroquine Destabilizes Phospho-S6 in human renal carcinoma cells","volume":"10","author":"Lee","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.canlet.2024.217009_bib26","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s11914-014-0194-3","article-title":"Apoptotic osteocytes and the control of targeted bone resorption","volume":"12","author":"Plotkin","year":"2014","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.canlet.2024.217009_bib27","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.2741\/2159","article-title":"Roles of gap junctions and hemichannels in bone cell functions and in signal transmission of mechanical stress","volume":"12","author":"Jiang","year":"2007","journal-title":"Front. Biosci."},{"key":"10.1016\/j.canlet.2024.217009_bib28","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s10495-014-1052-6","article-title":"BIGH3 protein and macrophages in retinal endothelial cell apoptosis","volume":"20","author":"Mondragon","year":"2015","journal-title":"Apoptosis"},{"key":"10.1016\/j.canlet.2024.217009_bib29","doi-asserted-by":"crossref","first-page":"496","DOI":"10.4236\/ijcm.2016.77055","article-title":"Macrophage TGF-beta1 and the Proapoptotic extracellular matrix protein BIGH3 induce renal cell apoptosis in Prediabetic and Diabetic conditions","volume":"7","author":"Moritz","year":"2016","journal-title":"Int. J. Clin. Med."},{"key":"10.1016\/j.canlet.2024.217009_bib30","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.bone.2004.08.007","article-title":"Beta ig-h3 mediates osteoblast adhesion and inhibits differentiation","volume":"36","author":"Thapa","year":"2005","journal-title":"Bone"},{"key":"10.1016\/j.canlet.2024.217009_bib31","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/1476-4598-9-130","article-title":"TGFBI expression is associated with a better response to chemotherapy in NSCLC","volume":"9","author":"Irigoyen","year":"2010","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.canlet.2024.217009_bib32","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/ar.20869","article-title":"Attachment of osteocyte cell processes to the bone matrix","volume":"292","author":"McNamara","year":"2009","journal-title":"Anat. Rec."},{"key":"10.1016\/j.canlet.2024.217009_bib33","doi-asserted-by":"crossref","first-page":"15941","DOI":"10.1073\/pnas.0707246104","article-title":"A model for the role of integrins in flow induced mechanotransduction in osteocytes","volume":"104","author":"Wang","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.canlet.2024.217009_bib34","doi-asserted-by":"crossref","first-page":"21012","DOI":"10.1073\/pnas.1321210110","article-title":"Mechanosensory responses of osteocytes to physiological forces occur along processes and not cell body and require alphaVbeta3 integrin","volume":"110","author":"Thi","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.canlet.2024.217009_bib35","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1073\/pnas.1115967109","article-title":"Mechanical stress-activated integrin alpha5beta1 induces opening of connexin 43 hemichannels","volume":"109","author":"Batra","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.canlet.2024.217009_bib36","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jmbbm.2014.11.001","article-title":"The role of integrin alpha(V)beta(3) in osteocyte mechanotransduction","volume":"42","author":"Haugh","year":"2015","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.canlet.2024.217009_bib37","doi-asserted-by":"crossref","first-page":"24120","DOI":"10.1074\/jbc.M611435200","article-title":"Glucocorticoids induce osteocyte apoptosis by blocking focal adhesion kinase-mediated survival. Evidence for inside-out signaling leading to anoikis","volume":"282","author":"Plotkin","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2024.217009_bib38","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00223-012-9628-z","article-title":"Deletion of Cx43 from osteocytes results in defective bone material properties but does not decrease extrinsic strength in cortical bone","volume":"91","author":"Bivi","year":"2012","journal-title":"Calcif. Tissue Int."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383524004038?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383524004038?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:15:42Z","timestamp":1778742942000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383524004038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":38,"alternative-id":["S0304383524004038"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2024.217009","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"BIGH3 mediates apoptosis and gap junction failure in osteocytes during renal cell carcinoma bone metastasis progression","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2024.217009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"217009"}}