{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:53:32Z","timestamp":1791111212870,"version":"4.1.0"},"reference-count":121,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T00:00:00Z","timestamp":1718755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014182","name":"Cancerop\u00f4le PACA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014182","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","award":["INCa_18364"],"award-info":[{"award-number":["INCa_18364"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","award":["_18364"],"award-info":[{"award-number":["_18364"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.canlet.2024.217024","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T16:11:14Z","timestamp":1718208674000},"page":"217024","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Lysosomal exocytosis: From cell protection to protumoral functions"],"prefix":"10.1016","volume":"597","author":[{"given":"Marie-Charlotte","family":"Trojani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Santucci-Darmanin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Breuil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges F.","family":"Carle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3399-2934","authenticated-orcid":false,"given":"Val\u00e9rie","family":"Pierrefite-Carle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.canlet.2024.217024_bib1","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1042\/bj0600604","article-title":"Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue","volume":"60","author":"De Duve","year":"1955","journal-title":"Biochem. J."},{"issue":"10","key":"10.1016\/j.canlet.2024.217024_bib2","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/ncb3409","article-title":"Turn up the lysosome","volume":"18","author":"Saftig","year":"2016","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.canlet.2024.217024_bib3","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/nyas.12953","article-title":"Targeting the lysosome in cancer","volume":"1371","author":"Piao","year":"2016","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"4","key":"10.1016\/j.canlet.2024.217024_bib4","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1002\/2211-5463.13372","article-title":"Lysosomal peptidases-intriguing roles in cancer progression and neurodegeneration","volume":"12","author":"Kos","year":"2022","journal-title":"FEBS Open Bio"},{"issue":"5","key":"10.1016\/j.canlet.2024.217024_bib5","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.3390\/cells9051131","article-title":"Lysosomal Biology and function: Modern view of cellular Debris Bin","volume":"9","author":"Trivedi","year":"2020","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.canlet.2024.217024_bib6","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1074\/mcp.M400128-MCP200","article-title":"A proteomic Analysis of lysosomal integral membrane proteins Reveals the Diverse Composition of the organelle","volume":"4","author":"Bagshaw","year":"2005","journal-title":"Mol. Cell. Proteomics"},{"issue":"6","key":"10.1016\/j.canlet.2024.217024_bib7","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202102001","article-title":"Lysosome biogenesis: regulation and functions","volume":"220","author":"Yang","year":"2021","journal-title":"J. Cell Biol."},{"issue":"3","key":"10.1016\/j.canlet.2024.217024_bib8","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1083\/jcb.39.3.676","article-title":"ON the mechanisms OF BONE RESORPTION","volume":"39","author":"Vaes","year":"1968","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.canlet.2024.217024_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.642494","article-title":"Lysosomes and cancer progression: a Malignant Liaison","volume":"9","author":"Machado","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.canlet.2024.217024_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ceb.2017.01.008","article-title":"Moving and positioning the endolysosomal system","volume":"47","author":"Bonifacino","year":"2017","journal-title":"Curr. Opin. Cell Biol."},{"issue":"12","key":"10.1016\/j.canlet.2024.217024_bib11","doi-asserted-by":"crossref","first-page":"406","DOI":"10.3390\/membranes10120406","article-title":"Lysosomal exocytosis: the extracellular role of an intracellular organelle","volume":"10","author":"Tancini","year":"2020","journal-title":"Membranes"},{"issue":"10","key":"10.1016\/j.canlet.2024.217024_bib12","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nrm2774","article-title":"Kinesin superfamily motor proteins and intracellular transport","volume":"10","author":"Hirokawa","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"10","key":"10.1016\/j.canlet.2024.217024_bib13","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1111\/tra.12587","article-title":"Mechanisms of lysosomal positioning and movement","volume":"19","author":"Cabukusta","year":"2018","journal-title":"Traffic"},{"issue":"6","key":"10.1016\/j.canlet.2024.217024_bib14","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.devcel.2011.10.007","article-title":"Arl8 and SKIP act together to link lysosomes to kinesin-1","volume":"21","author":"Rosa-Ferreira","year":"2011","journal-title":"Dev. Cell"},{"issue":"2","key":"10.1016\/j.canlet.2024.217024_bib15","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.devcel.2015.02.011","article-title":"BORC, a multisubunit complex that regulates lysosome positioning","volume":"33","author":"Pu","year":"2015","journal-title":"Dev. Cell"},{"key":"10.1016\/j.canlet.2024.217024_bib16","first-page":"awad427","article-title":"Biallelic BORCS8 variants cause an infantile-onset neurodegenerative disorder with altered lysosome dynamics","author":"De Pace","year":"2023","journal-title":"Brain J Neurol"},{"issue":"8","key":"10.1016\/j.canlet.2024.217024_bib17","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1016\/j.celrep.2016.10.062","article-title":"BORC functions upstream of kinesins 1 and 3 to Coordinate Regional movement of lysosomes along different microtubule Tracks","volume":"17","author":"Guardia","year":"2016","journal-title":"Cell Rep."},{"issue":"5\u20136","key":"10.1016\/j.canlet.2024.217024_bib18","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.mam.2006.08.005","article-title":"Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy","volume":"27","author":"Eskelinen","year":"2006","journal-title":"Mol Aspects Med"},{"issue":"3","key":"10.1016\/j.canlet.2024.217024_bib19","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0962-8924(03)00005-9","article-title":"At the acidic edge: emerging functions for lysosomal membrane proteins","volume":"13","author":"Eskelinen","year":"2003","journal-title":"Trends Cell Biol."},{"issue":"11","key":"10.1016\/j.canlet.2024.217024_bib20","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1500603","article-title":"Regulated lysosomal exocytosis mediates cancer progression","volume":"1","author":"Machado","year":"2015","journal-title":"Sci. Adv."},{"issue":"6","key":"10.1016\/j.canlet.2024.217024_bib21","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1083\/jcb.201511093","article-title":"A Rab3a-dependent complex essential for lysosome positioning and plasma membrane repair","volume":"213","author":"Encarna\u00e7\u00e3o","year":"2016","journal-title":"J. Cell Biol."},{"issue":"11","key":"10.1016\/j.canlet.2024.217024_bib22","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.246694","article-title":"Rab11 is required for lysosome exocytosis through the interaction with Rab3a, Sec15 and GRAB","volume":"134","author":"Escrevente","year":"2021","journal-title":"J. Cell Sci."},{"issue":"8","key":"10.1016\/j.canlet.2024.217024_bib23","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2207425120","article-title":"Spatial organization of lysosomal exocytosis relies on membrane tension gradients","volume":"120","author":"Lachuer","year":"2023","journal-title":"Proc Natl Acad Sci"},{"issue":"4","key":"10.1016\/j.canlet.2024.217024_bib24","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202051932","article-title":"USP17 is required for peripheral trafficking of lysosomes","volume":"23","author":"Lin","year":"2022","journal-title":"EMBO Rep."},{"issue":"20","key":"10.1016\/j.canlet.2024.217024_bib25","doi-asserted-by":"crossref","first-page":"3859","DOI":"10.1242\/jcs.190322","article-title":"Endo-lysosomal TRP mucolipin-1 channels trigger global ER Ca2+ release and Ca2+ influx","volume":"129","author":"Kilpatrick","year":"2016","journal-title":"J. Cell Sci."},{"issue":"3","key":"10.1016\/j.canlet.2024.217024_bib26","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.devcel.2011.07.016","article-title":"Transcriptional activation of lysosomal exocytosis promotes cellular clearance","volume":"21","author":"Medina","year":"2011","journal-title":"Dev. Cell"},{"key":"10.1016\/j.canlet.2024.217024_bib27","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ceca.2017.06.006","article-title":"TRPML1: the Ca(2+)retaker of the lysosome","volume":"69","author":"Di Paola","year":"2018","journal-title":"Cell Calcium"},{"issue":"3","key":"10.1016\/j.canlet.2024.217024_bib28","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.devcel.2011.07.016","article-title":"Transcriptional activation of lysosomal exocytosis promotes cellular clearance","volume":"21","author":"Medina","year":"2011","journal-title":"Dev. Cell"},{"key":"10.1016\/j.canlet.2024.217024_bib29","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/978-1-4939-9018-4_12","article-title":"TRPML1-\/TFEB-Dependent regulation of lysosomal exocytosis","volume":"1925","author":"Di Paola","year":"2019","journal-title":"Methods Mol Biol Clifton NJ"},{"key":"10.1016\/j.canlet.2024.217024_bib30","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/978-3-642-54215-2_24","article-title":"TRPML1: an ion channel in the lysosome","volume":"222","author":"Wang","year":"2014","journal-title":"Handb. Exp. Pharmacol."},{"issue":"19","key":"10.1016\/j.canlet.2024.217024_bib31","doi-asserted-by":"crossref","first-page":"20471","DOI":"10.1074\/jbc.M400798200","article-title":"Identification of SNAREs involved in synaptotagmin VII-regulated lysosomal exocytosis","volume":"279","author":"Rao","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2024.217024_bib32","series-title":"Lysosomes: Methods and Protocols [Internet]","first-page":"205","article-title":"Detection of lysosomal exocytosis by surface exposure of Lamp1 luminal Epitopes","author":"Andrews","year":"2017"},{"issue":"7","key":"10.1016\/j.canlet.2024.217024_bib33","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aav3270","article-title":"Excessive exosome release is the pathogenic pathway linking a lysosomal deficiency to generalized fibrosis","volume":"5","author":"van de Vlekkert","year":"2019","journal-title":"Sci. Adv."},{"issue":"20","key":"10.1016\/j.canlet.2024.217024_bib34","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adf8169","article-title":"Structure of the immunoregulatory sialidase NEU1","volume":"9","author":"Gorelik","year":"2023","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.canlet.2024.217024_bib35","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.devcel.2008.05.005","article-title":"Neuraminidase 1 is a negative regulator of lysosomal exocytosis","volume":"15","author":"Yogalingam","year":"2008","journal-title":"Dev. Cell"},{"issue":"11","key":"10.1016\/j.canlet.2024.217024_bib36","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1007\/s00018-013-1538-3","article-title":"Lysosomal multienzyme complex: pros and cons of working together","volume":"71","author":"Bonten","year":"2014","journal-title":"Cell Mol Life Sci CMLS"},{"issue":"2","key":"10.1016\/j.canlet.2024.217024_bib37","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3390\/diagnostics8020029","article-title":"Sialidosis: a review of Morphology and molecular Biology of a Rare Pediatric disorder","volume":"8","author":"Khan","year":"2018","journal-title":"Diagnostics"},{"issue":"5676","key":"10.1016\/j.canlet.2024.217024_bib38","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1126\/science.1098371","article-title":"A process for controlling intracellular bacterial infections induced by membrane injury","volume":"304","author":"Roy","year":"2004","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.canlet.2024.217024_bib39","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.immuni.2005.08.001","article-title":"Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis","volume":"23","author":"Keefe","year":"2005","journal-title":"Immunity"},{"issue":"4","key":"10.1016\/j.canlet.2024.217024_bib40","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.chom.2011.03.011","article-title":"Imaging host cell-Leishmania interaction dynamics implicates parasite motility, lysosome recruitment, and host cell wounding in the infection process","volume":"9","author":"Forestier","year":"2011","journal-title":"Cell Host Microbe"},{"issue":"6","key":"10.1016\/j.canlet.2024.217024_bib41","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1083\/jcb.201003053","article-title":"Exocytosis of acid sphingomyelinase by wounded cells promotes endocytosis and plasma membrane repair","volume":"189","author":"Tam","year":"2010","journal-title":"J. Cell Biol."},{"issue":"3","key":"10.1016\/j.canlet.2024.217024_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0152583","article-title":"Plasma membrane repair is regulated extracellularly by proteases released from lysosomes","volume":"11","author":"Castro-Gomes","year":"2016","journal-title":"PLoS One"},{"issue":"33","key":"10.1016\/j.canlet.2024.217024_bib43","doi-asserted-by":"crossref","first-page":"25103","DOI":"10.1074\/jbc.R109.041087","article-title":"Cellular and molecular mechanisms of bone remodeling","volume":"285","author":"Raggatt","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.canlet.2024.217024_bib44","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.bbrc.2016.05.019","article-title":"Osteoclast function and bone-resorbing activity: an overview","volume":"476","author":"Soysa","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.canlet.2024.217024_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2022.116538","article-title":"The origins and formation of bone-resorbing osteoclasts","volume":"164","author":"Elson","year":"2022","journal-title":"Bone"},{"issue":"6","key":"10.1016\/j.canlet.2024.217024_bib46","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1083\/jcb.106.6.1863","article-title":"Polarized secretion of lysosomal enzymes: co-distribution of cation-independent mannose-6-phosphate receptors and lysosomal enzymes along the osteoclast exocytic pathway","volume":"106","author":"Baron","year":"1988","journal-title":"J. Cell Biol."},{"issue":"6","key":"10.1016\/j.canlet.2024.217024_bib47","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.devcel.2008.03.022","article-title":"Synaptotagmin VII regulates bone remodeling by modulating osteoclast and osteoblast secretion","volume":"14","author":"Zhao","year":"2008","journal-title":"Dev. Cell"},{"issue":"10","key":"10.1016\/j.canlet.2024.217024_bib48","first-page":"3051","article-title":"Myoferlin-mediated lysosomal exocytosis regulates cytotoxicity by phagocytes","volume":"201","author":"Miyatake","year":"1950","journal-title":"J Immunol Baltim Md"},{"issue":"3","key":"10.1016\/j.canlet.2024.217024_bib49","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.immuni.2011.07.008","article-title":"Polarized secretion of lysosomes at the B cell synapse couples antigen extraction to processing and presentation","volume":"35","author":"Yuseff","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.canlet.2024.217024_bib50","doi-asserted-by":"crossref","unstructured":"Maeda FY, van Haaren JJ, Langley DB, Christ D, Andrews NW, Song W. Surface-associated antigen induces permeabilization of primary mouse B-cells and lysosome exocytosis facilitating antigen uptake and presentation to T-cells. Elife. 10:e66984.","DOI":"10.7554\/eLife.66984"},{"issue":"4","key":"10.1016\/j.canlet.2024.217024_bib51","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1093\/emboj\/19.4.513","article-title":"B cells extract and present immobilized antigen: implications for affinity discrimination","volume":"19","author":"Batista","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.canlet.2024.217024_bib52","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.bbrc.2022.08.024","article-title":"Lysosome exocytosis is required for mitosis in mammalian cells","volume":"626","author":"Nugues","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"12","key":"10.1016\/j.canlet.2024.217024_bib53","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1038\/s41419-022-05504-2","article-title":"Iron-induced cytotoxicity mediated by endolysosomal TRPML1 channels is reverted by TFEB","volume":"13","author":"Fern\u00e1ndez","year":"2022","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.canlet.2024.217024_bib54","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.devcel.2014.04.033","article-title":"Wilson disease protein ATP7B utilizes lysosomal exocytosis to maintain copper homeostasis","volume":"29","author":"Polishchuk","year":"2014","journal-title":"Dev. Cell"},{"issue":"4","key":"10.1016\/j.canlet.2024.217024_bib55","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.ceca.2015.01.005","article-title":"Brief exposure to copper activates lysosomal exocytosis","volume":"57","author":"Pe\u00f1a","year":"2015","journal-title":"Cell Calcium"},{"issue":"5","key":"10.1016\/j.canlet.2024.217024_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.104663","article-title":"Microtubule-associated protein MAP1LC3C regulates lysosomal exocytosis and induces zinc reprogramming in renal cancer cells","volume":"299","author":"Verma","year":"2023","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.canlet.2024.217024_bib57","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1038\/s41467-023-39716-7","article-title":"Induction of lysosomal exocytosis and biogenesis via TRPML1 activation for the treatment of uranium-induced nephrotoxicity","volume":"14","author":"Zhong","year":"2023","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.canlet.2024.217024_bib58","doi-asserted-by":"crossref","first-page":"4918","DOI":"10.1038\/s41467-022-32625-1","article-title":"Lysosomal exocytosis releases pathogenic \u03b1-synuclein species from neurons in synucleinopathy models","volume":"13","author":"Xie","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2024.217024_bib59","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2019.01258","article-title":"Seeding activity-based Detection Uncovers the different release mechanisms of Seed-Competent tau versus Inert tau via lysosomal exocytosis","author":"Tanaka","year":"2019","journal-title":"Front Neurosci [Internet]"},{"issue":"10","key":"10.1016\/j.canlet.2024.217024_bib60","doi-asserted-by":"crossref","first-page":"5925","DOI":"10.1038\/s41380-020-0738-0","article-title":"TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading","volume":"26","author":"Xu","year":"2021","journal-title":"Mol Psychiatry"},{"issue":"5","key":"10.1016\/j.canlet.2024.217024_bib61","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1084\/jem.173.5.1099","article-title":"Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes","volume":"173","author":"Peters","year":"1991","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.canlet.2024.217024_bib62","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.804895","article-title":"Intra- and extracellular effector vesicles from human T and NK cells: same-same, but different?","volume":"12","author":"Lettau","year":"2021","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.canlet.2024.217024_bib63","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/nrm732","article-title":"Secretory lysosomes","volume":"3","author":"Blott","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.canlet.2024.217024_bib64","doi-asserted-by":"crossref","first-page":"A85","DOI":"10.1186\/1478-811X-7-S1-A85","article-title":"Proteomic profiling of secretory granules of different T cell subpopulations","volume":"7","author":"Schmidt","year":"2009","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.canlet.2024.217024_bib65","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1478-811X-9-4","article-title":"Effector granules in human T lymphocytes: the luminal proteome of secretory lysosomes from human T cells","volume":"9","author":"Schmidt","year":"2011","journal-title":"Cell Commun Signal CCS"},{"issue":"3","key":"10.1016\/j.canlet.2024.217024_bib66","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/sji.12337","article-title":"Lysosome-related effector vesicles in T lymphocytes and NK cells","volume":"82","author":"Lettau","year":"2015","journal-title":"Scand. J. Immunol."},{"issue":"13","key":"10.1016\/j.canlet.2024.217024_bib67","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.15252\/embj.201796697","article-title":"Molecular definitions of autophagy and related processes","volume":"36","author":"Galluzzi","year":"2017","journal-title":"EMBO J."},{"issue":"10","key":"10.1016\/j.canlet.2024.217024_bib68","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1080\/15548627.2019.1596479","article-title":"Autophagy-dependent secretion: mechanism, factors secreted, and disease implications","volume":"15","author":"New","year":"2019","journal-title":"Autophagy"},{"key":"10.1016\/j.canlet.2024.217024_bib69","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ceb.2015.04.016","article-title":"Secretory autophagy","volume":"35","author":"Ponpuak","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"issue":"4","key":"10.1016\/j.canlet.2024.217024_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101189","article-title":"TFEB insufficiency promotes cardiac hypertrophy by blocking autophagic degradation of GATA4","volume":"297","author":"Song","year":"2021","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.canlet.2024.217024_bib71","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1080\/15548627.2019.1586261","article-title":"An autophagy-independent role for ATG16L1: promoting lysosome-mediated plasma membrane repair","volume":"15","author":"Tan","year":"2019","journal-title":"Autophagy"},{"issue":"5","key":"10.1016\/j.canlet.2024.217024_bib72","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.devcel.2011.08.016","article-title":"Autophagy proteins regulate the secretory component of osteoclastic bone resorption","volume":"21","author":"DeSelm","year":"2011","journal-title":"Dev. Cell"},{"key":"10.1016\/j.canlet.2024.217024_bib73","doi-asserted-by":"crossref","unstructured":"Lapaquette P, Ducreux A, Basmaciyan L, Paradis T, Bon F, Bataille A, et al. Membrane protective role of autophagic machinery during infection of epithelial cells by Candida albicans. Gut Microb. 14(1):2004798.","DOI":"10.1080\/19490976.2021.2004798"},{"issue":"12","key":"10.1016\/j.canlet.2024.217024_bib74","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1038\/s41564-018-0293-5","article-title":"An ATG16L1-dependent pathway promotes plasma membrane repair and limits Listeria monocytogenes cell-to-cell spread","volume":"3","author":"Tan","year":"2018","journal-title":"Nat Microbiol"},{"issue":"24","key":"10.1016\/j.canlet.2024.217024_bib75","doi-asserted-by":"crossref","first-page":"5937","DOI":"10.1242\/jcs.109421","article-title":"Mechanism of polarized lysosome exocytosis in epithelial cells","volume":"125","author":"Xu","year":"2012","journal-title":"J. Cell Sci."},{"issue":"10","key":"10.1016\/j.canlet.2024.217024_bib76","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.devcel.2023.03.014","article-title":"ATG5 provides host protection acting as a switch in the atg8ylation cascade between autophagy and secretion","volume":"58","author":"Wang","year":"2023","journal-title":"Dev. Cell"},{"issue":"2","key":"10.1016\/j.canlet.2024.217024_bib77","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/s41419-021-03511-3","article-title":"Sunitinib treatment promotes metastasis of drug-resistant renal cell carcinoma via TFE3 signaling pathway","volume":"12","author":"Li","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.canlet.2024.217024_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.110255","article-title":"TBBPA regulates calcium-mediated lysosomal exocytosis and thereby promotes invasion and migration in hepatocellular carcinoma","volume":"192","author":"Lyu","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"7","key":"10.1016\/j.canlet.2024.217024_bib79","first-page":"792","article-title":"Melanoma growth and progression after ultraviolet a irradiation: impact of lysosomal exocytosis and cathepsin proteases","volume":"95","author":"Eding","year":"2015","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.canlet.2024.217024_bib80","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-28265-5","article-title":"Dual role of HDAC10 in lysosomal exocytosis and DNA repair promotes neuroblastoma chemoresistance","volume":"8","author":"Ridinger","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.canlet.2024.217024_bib81","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.bbrc.2022.08.051","article-title":"TRPML3 enhances drug resistance in non-small cell lung cancer cells by promoting Ca2+-mediated lysosomal trafficking","volume":"627","author":"Kim","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.canlet.2024.217024_bib82","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/s42003-022-03968-8","article-title":"Haploinsufficiency of the lysosomal sialidase NEU1 results in a model of pleomorphic rhabdomyosarcoma in mice","volume":"5","author":"Machado","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.canlet.2024.217024_bib83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbrc.2023.05.021","article-title":"Role of ABCA2 and its single nucleotide polymorphisms (4873T>A and 4879G>C) in the regulation of multi-drug resistance in oral squamous carcinoma cells","volume":"666","author":"Kim","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"9","key":"10.1016\/j.canlet.2024.217024_bib84","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0045910","article-title":"Inhibition of glioma cell lysosome exocytosis inhibits glioma invasion","volume":"7","author":"Liu","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.canlet.2024.217024_bib85","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3390\/cells13020115","article-title":"Modulation of Cisplatin Sensitivity through TRPML1-mediated lysosomal exocytosis in Ovarian cancer cells: a comprehensive metabolomic approach","volume":"13","author":"Kim","year":"2024","journal-title":"Cells"},{"issue":"9","key":"10.1016\/j.canlet.2024.217024_bib86","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.3390\/cancers12092437","article-title":"Lysosome as a central Hub for rewiring PH homeostasis in tumors","volume":"12","author":"Chen","year":"2020","journal-title":"Cancers"},{"issue":"3","key":"10.1016\/j.canlet.2024.217024_bib87","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.bbrc.2016.05.019","article-title":"Osteoclast function and bone-resorbing activity: an overview","volume":"476","author":"Soysa","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.canlet.2024.217024_bib88","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1161\/ATVBAHA.119.313200","article-title":"TLR4 (Toll-Like receptor 4)-dependent signaling drives extracellular catabolism of LDL (Low-Density lipoprotein) aggregates","volume":"40","author":"Singh","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"3","key":"10.1016\/j.canlet.2024.217024_bib89","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.immuni.2011.07.008","article-title":"Polarized secretion of lysosomes at the B cell synapse couples antigen extraction to processing and presentation","volume":"35","author":"Yuseff","year":"2011","journal-title":"Immunity"},{"issue":"13","key":"10.1016\/j.canlet.2024.217024_bib90","doi-asserted-by":"crossref","first-page":"11368","DOI":"10.1074\/jbc.M108347200","article-title":"Acidic extracellular pH induces vascular endothelial growth factor (VEGF) in human glioblastoma cells via ERK1\/2 MAPK signaling pathway: mechanism of low pH-induced VEGF","volume":"277","author":"Xu","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.canlet.2024.217024_bib91","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s12943-023-01900-0","article-title":"Acidosis-mediated increase in IFN-\u03b3-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumors","volume":"22","author":"Knopf","year":"2023","journal-title":"Mol. Cancer"},{"issue":"9","key":"10.1016\/j.canlet.2024.217024_bib92","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.3390\/cancers15092572","article-title":"Acidic growth conditions promote epithelial-to-mesenchymal transition to select more aggressive PDAC cell phenotypes in vitro","volume":"15","author":"Audero","year":"2023","journal-title":"Cancers"},{"issue":"19","key":"10.1016\/j.canlet.2024.217024_bib93","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1080\/15384101.2016.1231284","article-title":"Phenotypic changes of acid-adapted cancer cells push them toward aggressiveness in their evolution in the tumor microenvironment","volume":"16","author":"Damaghi","year":"2017","journal-title":"Cell Cycle Georget Tex"},{"key":"10.1016\/j.canlet.2024.217024_bib94","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/1218297","article-title":"Unravelling the interplay between extracellular acidosis and immune cells","volume":"2018","author":"Erra D\u00edaz","year":"2018","journal-title":"Mediators Inflamm"},{"issue":"4","key":"10.1016\/j.canlet.2024.217024_bib95","doi-asserted-by":"crossref","first-page":"R1552","DOI":"10.1152\/ajpregu.00423.2007","article-title":"Temporal extracellular matrix adaptations in ligament during wound healing and hindlimb unloading","volume":"293","author":"Martinez","year":"2007","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"6","key":"10.1016\/j.canlet.2024.217024_bib96","first-page":"3686","article-title":"Acid-sensing ion channels contribute to the effect of acidosis on the function of dendritic cells","volume":"186","author":"Tong","year":"1950","journal-title":"J Immunol Baltim Md"},{"issue":"5","key":"10.1016\/j.canlet.2024.217024_bib97","first-page":"3196","article-title":"Acidosis improves uptake of antigens and MHC class I-restricted presentation by dendritic cells","volume":"172","author":"Vermeulen","year":"1950","journal-title":"J Immunol Baltim Md"},{"issue":"7","key":"10.1016\/j.canlet.2024.217024_bib98","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/s41416-019-0542-2","article-title":"Acidity promotes tumour progression by altering macrophage phenotype in prostate cancer","volume":"121","author":"El-Kenawi","year":"2019","journal-title":"Br. J. Cancer"},{"issue":"11","key":"10.1016\/j.canlet.2024.217024_bib99","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1158\/0008-5472.CAN-11-1272","article-title":"Modulation of microenvironment acidity reverses anergy in human and murine tumor-infiltrating T lymphocytes","volume":"72","author":"Calcinotto","year":"2012","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.canlet.2024.217024_bib100","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1006\/clim.2000.4904","article-title":"Acidic pH inhibits non-MHC-restricted killer cell functions","volume":"96","author":"Fischer","year":"2000","journal-title":"Clin Immunol Orlando Fla"},{"issue":"7","key":"10.1016\/j.canlet.2024.217024_bib101","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.3390\/cells9071679","article-title":"The ins and outs of cathepsins: physiological function and role in disease Management","volume":"9","author":"Yadati","year":"2020","journal-title":"Cells"},{"issue":"28","key":"10.1016\/j.canlet.2024.217024_bib102","doi-asserted-by":"crossref","first-page":"45117","DOI":"10.18632\/oncotarget.15155","article-title":"Lysosomal accumulation of anticancer drugs triggers lysosomal exocytosis","volume":"8","author":"Zhitomirsky","year":"2017","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.canlet.2024.217024_bib103","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.canlet.2005.06.007","article-title":"Cathepsin D: newly discovered functions of a long-standing aspartic protease in cancer and apoptosis","volume":"237","author":"Liaudet-Coopman","year":"2006","journal-title":"Cancer Lett."},{"issue":"10","key":"10.1016\/j.canlet.2024.217024_bib104","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/nrc1949","article-title":"Cysteine cathepsins: multifunctional enzymes in cancer","volume":"6","author":"Mohamed","year":"2006","journal-title":"Nat. Rev. Cancer"},{"issue":"7","key":"10.1016\/j.canlet.2024.217024_bib105","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s10585-013-9590-9","article-title":"Cathepsin L inhibition by the small molecule KGP94 suppresses tumor microenvironment enhanced metastasis associated cell functions of prostate and breast cancer cells","volume":"30","author":"Sudhan","year":"2013","journal-title":"Clin. Exp. Metastasis"},{"issue":"1","key":"10.1016\/j.canlet.2024.217024_bib106","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1038\/s41467-018-05013-x","article-title":"TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins","volume":"9","author":"Kundu","year":"2018","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.canlet.2024.217024_bib107","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1002\/ijc.24095","article-title":"Radiation-induced cathepsin S is involved in radioresistance","volume":"124","author":"Seo","year":"2009","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.canlet.2024.217024_bib108","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.canlet.2018.08.029","article-title":"Lysosomes contribute to radioresistance in cancer","volume":"439","author":"Zhang","year":"2018","journal-title":"Cancer Lett."},{"issue":"3","key":"10.1016\/j.canlet.2024.217024_bib109","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/bjc.2016.202","article-title":"Repression of the autophagic response sensitises lung cancer cells to radiation and chemotherapy","volume":"115","author":"Karagounis","year":"2016","journal-title":"Br. J. Cancer"},{"issue":"1","key":"10.1016\/j.canlet.2024.217024_bib110","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/s42003-020-01339-9","article-title":"Lysosomal trafficking mediated by Arl8b and BORC promotes invasion of cancer cells that survive radiation","volume":"3","author":"Wu","year":"2020","journal-title":"Commun. Biol."},{"issue":"23","key":"10.1016\/j.canlet.2024.217024_bib111","doi-asserted-by":"crossref","first-page":"7337","DOI":"10.1158\/1078-0432.CCR-11-1667","article-title":"Lysosomal sequestration of sunitinib: a novel mechanism of drug resistance","volume":"17","author":"Gotink","year":"2011","journal-title":"Clin Cancer Res Off J Am Assoc Cancer Res."},{"issue":"3","key":"10.1016\/j.canlet.2024.217024_bib112","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.bbrc.2019.01.115","article-title":"Exosomal release through TRPML1-mediated lysosomal exocytosis is required for adipogenesis","volume":"510","author":"Kim","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.canlet.2024.217024_bib113","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.652651","article-title":"Ceramide-induced lysosomal biogenesis and exocytosis in early-onset Preeclampsia promotes exosomal release of SMPD1 Causing endothelial Dysfunction","volume":"9","author":"Ermini","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"3","key":"10.1016\/j.canlet.2024.217024_bib114","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.jhep.2018.05.020","article-title":"The P2X4 purinergic receptor regulates hepatic myofibroblast activation during liver fibrogenesis","volume":"69","author":"Le Guilcher","year":"2018","journal-title":"J. Hepatol."},{"issue":"15","key":"10.1016\/j.canlet.2024.217024_bib115","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.215210","article-title":"The interplay between exosomes and autophagy - partners in crime","volume":"131","author":"Xu","year":"2018","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.canlet.2024.217024_bib116","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/978-1-0716-0759-6_10","article-title":"Extracellular vesicles and their roles in cancer progression","volume":"2174","author":"Chang","year":"2021","journal-title":"Methods Mol Biol Clifton NJ"},{"key":"10.1016\/j.canlet.2024.217024_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2023.216481","article-title":"Small extracellular vesicles: non-negligible vesicles in tumor progression, diagnosis, and therapy","volume":"580","author":"Zhou","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2024.217024_bib118","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1326023","article-title":"TRPML1 as a potential therapeutic target for triple-negative breast cancer: a review","volume":"13","author":"Pan","year":"2023","journal-title":"Front. Oncol."},{"issue":"3","key":"10.1016\/j.canlet.2024.217024_bib119","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109848","article-title":"Lysosomal Zn2+ release triggers rapid, mitochondria-mediated, non-apoptotic cell death in metastatic melanoma","volume":"37","author":"Du","year":"2021","journal-title":"Cell Rep."},{"issue":"7\u20138","key":"10.1016\/j.canlet.2024.217024_bib120","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.lfs.2009.11.016","article-title":"Cathepsin L, target in cancer treatment?","volume":"86","author":"Lankelma","year":"2010","journal-title":"Life Sci."},{"issue":"8","key":"10.1016\/j.canlet.2024.217024_bib121","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.3390\/ijms19082256","article-title":"Typical and Atypical Inducers of lysosomal cell death: a promising anticancer Strategy","volume":"19","author":"Domagala","year":"2018","journal-title":"Int. J. Mol. Sci."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030438352400418X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030438352400418X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:06:30Z","timestamp":1778544390000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030438352400418X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":121,"alternative-id":["S030438352400418X"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2024.217024","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lysosomal exocytosis: From cell protection to protumoral functions","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2024.217024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"217024"}}