{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T20:22:29Z","timestamp":1782591749121,"version":"3.54.5"},"reference-count":101,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.canlet.2024.217327","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T15:50:08Z","timestamp":1732290608000},"page":"217327","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Local ablation disrupts immune evasion in pancreatic cancer"],"prefix":"10.1016","volume":"609","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1647-5708","authenticated-orcid":false,"given":"Chiara","family":"Musiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Adamo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Caligola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Agostini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0273-381X","authenticated-orcid":false,"given":"Cristina","family":"Frusteri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Lupo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Boschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Busato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ornella","family":"Poffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Anselmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9598-2673","authenticated-orcid":false,"given":"Antonio","family":"Vella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4385-3782","authenticated-orcid":false,"given":"Tian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Dusi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3708-5397","authenticated-orcid":false,"given":"Geny","family":"Piro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5168-747X","authenticated-orcid":false,"given":"Carmine","family":"Carbone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giampaolo","family":"Tortora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6936-8901","authenticated-orcid":false,"given":"Pasquina","family":"Marzola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirko","family":"D'Onofrio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4560-8741","authenticated-orcid":false,"given":"Stefano Francesco","family":"Crin\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6340-8009","authenticated-orcid":false,"given":"Vincenzo","family":"Corbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo","family":"Scarpa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3514-8473","authenticated-orcid":false,"given":"Roberto","family":"Salvia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Malleo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4635-3680","authenticated-orcid":false,"given":"Gabriella","family":"Lionetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Sartoris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6639-7608","authenticated-orcid":false,"given":"Stefano","family":"Ugel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Bassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Bronte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6893-8618","authenticated-orcid":false,"given":"Salvatore","family":"Paiella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7232-7585","authenticated-orcid":false,"given":"Francesco","family":"De Sanctis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2024.217327_bib1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21708","article-title":"Cancer statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA A Cancer J. Clin."},{"key":"10.1016\/j.canlet.2024.217327_bib2","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1056\/NEJMoa1809775","article-title":"FOLFIRINOX or gemcitabine as adjuvant therapy for pancreatic cancer","volume":"379","author":"Conroy","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.canlet.2024.217327_bib3","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S1470-2045(16)00172-8","article-title":"FOLFIRINOX for locally advanced pancreatic cancer: a systematic review and patient-level meta-analysis","volume":"17","author":"Suker","year":"2016","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.canlet.2024.217327_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.688377","article-title":"The current treatment paradigm for pancreatic ductal adenocarcinoma and barriers to therapeutic efficacy","volume":"11","author":"Principe","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.canlet.2024.217327_bib5","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1056\/NEJMoa1200694","article-title":"Safety and activity of anti-PD-L1 antibody in patients with advanced cancer","volume":"366","author":"Brahmer","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.canlet.2024.217327_bib6","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/nature24462","article-title":"Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer","volume":"551","author":"Balachandran","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2024.217327_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/genes12010033","article-title":"Immune-based therapies and the role of microsatellite instability in pancreatic cancer","volume":"12","author":"Ghidini","year":"2020","journal-title":"Genes"},{"key":"10.1016\/j.canlet.2024.217327_bib8","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1001\/jama.2021.13027","article-title":"Pancreatic cancer: a review","volume":"326","author":"Park","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.canlet.2024.217327_bib9","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1053\/j.gastro.2018.12.038","article-title":"Broadening the impact of immunotherapy to pancreatic cancer: challenges and opportunities","volume":"156","author":"Balachandran","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.canlet.2024.217327_bib10","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","article-title":"Hallmarks of cancer: new dimensions","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discov."},{"key":"10.1016\/j.canlet.2024.217327_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/cells10102700","article-title":"A complex metabolic network confers immunosuppressive functions to myeloid-derived suppressor cells (MDSCs) within the tumour microenvironment","volume":"10","author":"Hofer","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.canlet.2024.217327_bib12","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3389\/fonc.2020.00165","article-title":"The engagement between MDSCs and metastases: partners in crime","volume":"10","author":"Trovato","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.canlet.2024.217327_bib13","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1186\/s40425-019-0734-6","article-title":"Immunosuppression by monocytic myeloid-derived suppressor cells in patients with pancreatic ductal carcinoma is orchestrated by STAT3","volume":"7","author":"Trovato","year":"2019","journal-title":"J Immunother Cancer"},{"key":"10.1016\/j.canlet.2024.217327_bib14","doi-asserted-by":"crossref","first-page":"5193","DOI":"10.1038\/s41467-018-07654-4","article-title":"Induction of immunosuppressive functions and NF-kappaB by FLIP in monocytes","volume":"9","author":"Fiore","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2024.217327_bib15","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1172\/JCI80006","article-title":"Tumor-induced myeloid deviation: when myeloid-derived suppressor cells meet tumor-associated macrophages","volume":"125","author":"Ugel","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.canlet.2024.217327_bib16","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3389\/fimmu.2014.00069","article-title":"The emerging immunological role of post-translational modifications by reactive nitrogen species in cancer microenvironment","volume":"5","author":"De Sanctis","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.canlet.2024.217327_bib17","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1084\/jem.20101956","article-title":"Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells","volume":"208","author":"Molon","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.canlet.2024.217327_bib18","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41571-018-0142-8","article-title":"Cancer immunoediting and resistance to T cell-based immunotherapy","volume":"16","author":"O'Donnell","year":"2019","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.canlet.2024.217327_bib19","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.cell.2017.01.017","article-title":"Primary, adaptive, and acquired resistance to cancer immunotherapy","volume":"168","author":"Sharma","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2024.217327_bib20","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-002876","article-title":"Intratumoral injection of TLR9 agonist promotes an immunopermissive microenvironment transition and causes cooperative antitumor activity in combination with anti-PD1 in pancreatic cancer","volume":"9","author":"Carbone","year":"2021","journal-title":"J Immunother Cancer"},{"key":"10.1016\/j.canlet.2024.217327_bib21","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1126\/science.1198443","article-title":"CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans","volume":"331","author":"Beatty","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.canlet.2024.217327_bib22","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S1470-2045(20)30532-5","article-title":"CD40 agonistic monoclonal antibody APX005M (sotigalimab) and chemotherapy, with or without nivolumab, for the treatment of metastatic pancreatic adenocarcinoma: an open-label, multicentre, phase 1b study","volume":"22","author":"O'Hara","year":"2021","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.canlet.2024.217327_bib23","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aau9240","article-title":"Agonism of CD11b reprograms innate immunity to sensitize pancreatic cancer to immunotherapies","volume":"11","author":"Panni","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.canlet.2024.217327_bib24","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-003005","article-title":"GB1275, a first-in-class CD11b modulator: rationale for immunotherapeutic combinations in solid tumors","volume":"9","author":"DeNardo","year":"2021","journal-title":"J Immunother Cancer"},{"key":"10.1016\/j.canlet.2024.217327_bib25","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature12477","article-title":"Signatures of mutational processes in human cancer","volume":"500","author":"Alexandrov","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2024.217327_bib26","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1056\/NEJMc1713444","article-title":"Tumor mutational burden and response rate to PD-1 inhibition","volume":"377","author":"Yarchoan","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.canlet.2024.217327_bib27","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-003549","article-title":"Interrupting the nitrosative stress fuels tumor-specific cytotoxic T lymphocytes in pancreatic cancer","volume":"10","author":"De Sanctis","year":"2022","journal-title":"J Immunother Cancer"},{"key":"10.1016\/j.canlet.2024.217327_bib28","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.ccell.2015.09.022","article-title":"T cells engineered against a native antigen can surmount immunologic and physical barriers to treat pancreatic ductal adenocarcinoma","volume":"28","author":"Stromnes","year":"2015","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2024.217327_bib29","doi-asserted-by":"crossref","DOI":"10.1245\/s10434-021-09662-z","article-title":"The landmark series: locally advanced pancreatic cancer and ablative therapy options","author":"White","year":"2021","journal-title":"Ann. Surg Oncol."},{"key":"10.1016\/j.canlet.2024.217327_bib30","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/4508376","article-title":"Local ablative strategies for ductal pancreatic cancer (radiofrequency ablation, irreversible electroporation): a review","volume":"2016","author":"Paiella","year":"2016","journal-title":"Gastroenterol Res Pract"},{"key":"10.1016\/j.canlet.2024.217327_bib31","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1001\/jamasurg.2019.2277","article-title":"Outcomes of primary chemotherapy for borderline resectable and locally advanced pancreatic ductal adenocarcinoma","volume":"154","author":"Maggino","year":"2019","journal-title":"JAMA Surg"},{"key":"10.1016\/j.canlet.2024.217327_bib32","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nrc3672","article-title":"Thermal ablation of tumours: biological mechanisms and advances in therapy","volume":"14","author":"Chu","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.canlet.2024.217327_bib33","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1007\/s00432-020-03332-5","article-title":"Immunological combination treatment holds the key to improving survival in pancreatic cancer","volume":"146","author":"Sodergren","year":"2020","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.canlet.2024.217327_bib34","article-title":"Immunologic response to tumor ablation with irreversible electroporation","volume":"7","author":"Li","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.canlet.2024.217327_bib35","doi-asserted-by":"crossref","first-page":"80","DOI":"10.21037\/tgh.2018.10.05","article-title":"Palliative therapy in pancreatic cancer-interventional treatment with radiofrequency ablation\/irreversible electroporation","volume":"3","author":"Paiella","year":"2018","journal-title":"Transl Gastroenterol Hepatol"},{"key":"10.1016\/j.canlet.2024.217327_bib36","doi-asserted-by":"crossref","first-page":"5931","DOI":"10.1038\/onc.2016.104","article-title":"Damage-associated molecular patterns in cancer: a double-edged sword","volume":"35","author":"Hernandez","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2024.217327_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13112511","article-title":"Ablation in pancreatic cancer: past, present and future","volume":"13","author":"Narayanan","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.canlet.2024.217327_bib38","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.1016\/j.vaccine.2018.05.010","article-title":"Hyperthermic treatment at 56 degrees C induces tumour-specific immune protection in a mouse model of prostate cancer in both prophylactic and therapeutic immunization regimens","volume":"36","author":"De Sanctis","year":"2018","journal-title":"Vaccine"},{"key":"10.1016\/j.canlet.2024.217327_bib39","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/s43018-021-00269-7","article-title":"Radiation therapy enhances immunotherapy response in microsatellite stable colorectal and pancreatic adenocarcinoma in a phase II trial","volume":"2","author":"Parikh","year":"2021","journal-title":"Nat. Can. (Ott.)"},{"key":"10.1016\/j.canlet.2024.217327_bib40","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.ccr.2005.04.023","article-title":"Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice","volume":"7","author":"Hingorani","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2024.217327_bib41","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.6004\/jnccn.2017.0131","article-title":"Pancreatic adenocarcinoma, version 2.2017, NCCN clinical practice guidelines in oncology","volume":"15","author":"Tempero","year":"2017","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"10.1016\/j.canlet.2024.217327_bib42","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.pan.2021.06.005","article-title":"Open radiofrequency ablation as upfront treatment for locally advanced pancreatic cancer: requiem from a randomized controlled trial","volume":"21","author":"Frigerio","year":"2021","journal-title":"Pancreatology"},{"key":"10.1016\/j.canlet.2024.217327_bib43","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1007\/s11605-013-2309-z","article-title":"Irreversible electroporation of locally advanced pancreatic head adenocarcinoma","volume":"17","author":"Martin","year":"2013","journal-title":"J. Gastrointest. Surg."},{"key":"10.1016\/j.canlet.2024.217327_bib44","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000375323","article-title":"Safety and feasibility of Irreversible Electroporation (IRE) in patients with locally advanced pancreatic cancer: results of a prospective study","volume":"32","author":"Paiella","year":"2015","journal-title":"Dig. Surg."},{"key":"10.1016\/j.canlet.2024.217327_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jss.2020.10.027","article-title":"Laser treatment of pancreatic cancer with immunostimulating interstitial laser thermotherapy protocol: safety and feasibility results from two phase 2a studies","volume":"259","author":"Paiella","year":"2021","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.canlet.2024.217327_bib46","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1055\/a-1178-0474","article-title":"US-guided percutaneous radiofrequency ablation of locally advanced pancreatic adenocarcinoma: a 5-year high-volume center experience","volume":"43","author":"D'Onofrio","year":"2022","journal-title":"Ultraschall der Med."},{"key":"10.1016\/j.canlet.2024.217327_bib47","doi-asserted-by":"crossref","first-page":"67","DOI":"10.15403\/jgld.2014.1121.271.eus","article-title":"EUS-Guided radiofrequency ablation (EUS-RFA) of solid pancreatic neoplasm using an 18-gauge needle electrode: feasibility, safety, and technical success","volume":"27","author":"Crino","year":"2018","journal-title":"J Gastrointestin Liver Dis"},{"key":"10.1016\/j.canlet.2024.217327_bib48","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/s12885-020-6690-1","article-title":"Outcomes of patients with initially locally advanced pancreatic adenocarcinoma who did not benefit from resection: a prospective cohort study","volume":"20","author":"Garnier","year":"2020","journal-title":"BMC Cancer"},{"key":"10.1016\/j.canlet.2024.217327_bib49","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1093\/annonc\/mdt239","article-title":"Neoadjuvant treatment of borderline resectable and non-resectable pancreatic cancer","volume":"24","author":"Heinemann","year":"2013","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.canlet.2024.217327_bib50","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1084\/jem.176.6.1693","article-title":"Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte\/macrophage colony-stimulating factor","volume":"176","author":"Inaba","year":"1992","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.canlet.2024.217327_bib51","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1084\/jem.185.2.317","article-title":"Maturation stages of mouse dendritic cells in growth factor-dependent long-term cultures","volume":"185","author":"Winzler","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.canlet.2024.217327_bib52","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1084\/jem.188.11.2175","article-title":"Dendritic cell survival and maturation are regulated by different signaling pathways","volume":"188","author":"Rescigno","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.canlet.2024.217327_bib53","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2017.1326442","article-title":"Local endothelial complement activation reverses endothelial quiescence, enabling t-cell homing, and tumor control during t-cell immunotherapy","volume":"6","author":"Facciabene","year":"2017","journal-title":"OncoImmunology"},{"key":"10.1016\/j.canlet.2024.217327_bib56","first-page":"3","volume":"vol. 17","author":"Martin","year":"2011"},{"key":"10.1016\/j.canlet.2024.217327_bib57","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.canlet.2024.217327_bib58","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.canlet.2024.217327_bib59","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.12688\/f1000research.7563.1","article-title":"Differential analyses for RNA-seq: transcript-level estimates improve gene-level inferences","volume":"4","author":"Soneson","year":"2015","journal-title":"F1000Res"},{"key":"10.1016\/j.canlet.2024.217327_bib60","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.canlet.2024.217327_bib61","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1093\/bioinformatics\/bti525","article-title":"BioMart and Bioconductor: a powerful link between biological databases and microarray data analysis","volume":"21","author":"Durinck","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.canlet.2024.217327_bib63","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.canlet.2024.217327_bib64","article-title":"GSVA: gene set variation analysis for microarray and RNA-seq data","volume":"14","author":"Hanzelmann","year":"2013","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.canlet.2024.217327_bib65","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular Signatures Database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst"},{"key":"10.1016\/j.canlet.2024.217327_bib66","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nature16965","article-title":"Genomic analyses identify molecular subtypes of pancreatic cancer","volume":"531","author":"Bailey","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2024.217327_bib67","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.cell.2014.12.033","article-title":"Molecular and genetic properties of tumors associated with local immune cytolytic activity","volume":"160","author":"Rooney","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2024.217327_bib68","article-title":"ggplot2 \u2013 elegant graphics for data analysis (2nd edition)","author":"Wickham","year":"2016","journal-title":"Journal of Statistical Software 77"},{"key":"10.1016\/j.canlet.2024.217327_bib71","article-title":"Stereopy: modeling comparative and spatiotemporal cellular heterogeneity via multi-sample spatial transcriptomics","volume":"2023","author":"Fang","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.canlet.2024.217327_bib72","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.cell.2015.05.047","article-title":"Data-driven phenotypic dissection of AML reveals progenitor-like cells that correlate with prognosis","volume":"162","author":"Levine","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2024.217327_bib73","doi-asserted-by":"crossref","DOI":"10.1093\/database\/baz046","article-title":"PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data","volume":"2019","author":"Franz\u00e9n","year":"2019","journal-title":"Database"},{"key":"10.1016\/j.canlet.2024.217327_bib74","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","article-title":"Dictionary learning for integrative, multimodal and scalable single-cell analysis","volume":"42","author":"Hao","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.canlet.2024.217327_bib75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v080.i01","article-title":"Brms: an R package for bayesian multilevel models using stan","volume":"80","author":"B\u00fcrkner","year":"2017","journal-title":"J. Stat. Software"},{"key":"10.1016\/j.canlet.2024.217327_bib77","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aay8416","article-title":"Rebalancing expression of HMGB1 redox isoforms to counteract muscular dystrophy","volume":"13","author":"Careccia","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.canlet.2024.217327_bib78","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1084\/jem.20120189","article-title":"Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release","volume":"209","author":"Venereau","year":"2012","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.canlet.2024.217327_bib79","doi-asserted-by":"crossref","DOI":"10.2144\/fsoa-2022-0052","article-title":"Reappraisal of oxidized HMGB1 as a mediator and biomarker","volume":"8","author":"Pirnie","year":"2022","journal-title":"Future Sci OA"},{"key":"10.1016\/j.canlet.2024.217327_bib80","doi-asserted-by":"crossref","first-page":"11942","DOI":"10.1073\/pnas.1003893107","article-title":"A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release","volume":"107","author":"Yang","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.canlet.2024.217327_bib81","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-001341","article-title":"Tumor-associated macrophages: potential therapeutic strategies and future prospects in cancer","volume":"9","author":"Li","year":"2021","journal-title":"J Immunother Cancer"},{"key":"10.1016\/j.canlet.2024.217327_bib82","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1038\/ng.3398","article-title":"Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma","volume":"47","author":"Moffitt","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.canlet.2024.217327_bib83","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ccell.2020.02.008","article-title":"Dendritic cell paucity leads to dysfunctional immune surveillance in pancreatic cancer","volume":"37","author":"Hegde","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2024.217327_bib84","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.immuni.2024.04.021","article-title":"Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer","volume":"57","author":"De Sanctis","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.canlet.2024.217327_bib85","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1341079","article-title":"Cellular collusion: cracking the code of immunosuppression and chemo resistance in PDAC","volume":"15","author":"Musiu","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.canlet.2024.217327_bib86","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s13045-020-00920-3","article-title":"High mobility group box 1 (HMGB1): a pivotal regulator of hematopoietic malignancies","volume":"13","author":"Yuan","year":"2020","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.canlet.2024.217327_bib87","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3389\/fimmu.2013.00068","article-title":"HMGB1: the central cytokine for all lymphoid cells","volume":"4","author":"Li","year":"2013","journal-title":"Front. Immunol."},{"key":"10.1016\/j.canlet.2024.217327_bib88","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/j.1365-2141.2006.06335.x","article-title":"Elevation of serum high-mobility group box 1 protein during granulocyte colony-stimulating factor-induced peripheral blood stem cell mobilisation","volume":"135","author":"Tagami","year":"2006","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.canlet.2024.217327_bib89","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1600-065X.2007.00579.x","article-title":"The grateful dead: damage-associated molecular pattern molecules and reduction\/oxidation regulate immunity","volume":"220","author":"Lotze","year":"2007","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.canlet.2024.217327_bib90","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15041026","article-title":"The receptor for advanced glycation endproducts (RAGE) and its ligands S100a8\/A9 and high mobility group box protein 1 (HMGB1) are key regulators of myeloid-derived suppressor cells","volume":"15","author":"Ostrand-Rosenberg","year":"2023","journal-title":"Cancers"},{"key":"10.1016\/j.canlet.2024.217327_bib91","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s11912-021-01057-3","article-title":"Locally advanced pancreatic cancer: percutaneous management using ablation, brachytherapy, intra-arterial chemotherapy, and intra-tumoral immunotherapy","volume":"23","author":"Timmer","year":"2021","journal-title":"Curr. Oncol. Rep."},{"key":"10.1016\/j.canlet.2024.217327_bib92","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.pan.2017.09.008","article-title":"Immunomodulation after radiofrequency ablation of locally advanced pancreatic cancer by monitoring the immune response in 10 patients","volume":"17","author":"Giardino","year":"2017","journal-title":"Pancreatology"},{"key":"10.1016\/j.canlet.2024.217327_bib93","doi-asserted-by":"crossref","first-page":"50417","DOI":"10.18632\/oncotarget.10413","article-title":"HMGB1 overexpression as a prognostic factor for survival in cancer: a meta-analysis and systematic review","volume":"7","author":"Wu","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.canlet.2024.217327_bib94","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-003521","article-title":"Immune cell and tumor cell-derived CXCL10 is indicative of immunotherapy response in metastatic melanoma","volume":"9","author":"Reschke","year":"2021","journal-title":"J Immunother Cancer"},{"key":"10.1016\/j.canlet.2024.217327_bib95","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abq6509","article-title":"CXCL9 and CXCL10 bring the heat to tumors","volume":"7","author":"Reschke","year":"2022","journal-title":"Sci Immunol"},{"key":"10.1016\/j.canlet.2024.217327_bib96","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.cell.2021.01.002","article-title":"Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition","volume":"184","author":"Litchfield","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2024.217327_bib97","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1158\/1078-0432.CCR-19-1868","article-title":"Macrophage-derived CXCL9 and CXCL10 are required for antitumor immune responses following immune checkpoint blockade","volume":"26","author":"House","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2024.217327_bib98","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s40425-019-0511-6","article-title":"Cancer-cell-secreted CXCL11 promoted CD8(+) T cells infiltration through docetaxel-induced-release of HMGB1 in NSCLC","volume":"7","author":"Gao","year":"2019","journal-title":"J Immunother Cancer"},{"key":"10.1016\/j.canlet.2024.217327_bib99","doi-asserted-by":"crossref","DOI":"10.1038\/s41591-022-01916-x","article-title":"Tumor immune contexture is a determinant of anti-CD19 CAR T cell efficacy in large B cell lymphoma","author":"Scholler","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.canlet.2024.217327_bib100","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112732","article-title":"Tumor-specific CD4 T cells instruct monocyte fate in pancreatic ductal adenocarcinoma","volume":"42","author":"Patterson","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.canlet.2024.217327_bib101","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41586-023-06685-2","article-title":"IL-1beta(+) macrophages fuel pathogenic inflammation in pancreatic cancer","volume":"623","author":"Caronni","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2024.217327_bib102","doi-asserted-by":"crossref","DOI":"10.1136\/gutjnl-2023-329807","article-title":"Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC","author":"Lupo","year":"2024","journal-title":"Gut"},{"key":"10.1016\/j.canlet.2024.217327_bib103","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1158\/2326-6066.CIR-22-0379","article-title":"Radiofrequency ablation remodels the tumor microenvironment and promotes neutrophil-mediated abscopal immunomodulation in pancreatic cancer","volume":"11","author":"Faraoni","year":"2023","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.canlet.2024.217327_bib104","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/s41588-022-01134-8","article-title":"Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment","volume":"54","author":"Hwang","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.canlet.2024.217327_bib105","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1097\/SLA.0000000000002734","article-title":"Defining and predicting early recurrence in 957 patients with resected pancreatic ductal adenocarcinoma","volume":"269","author":"Groot","year":"2019","journal-title":"Ann. Surg."},{"key":"10.1016\/j.canlet.2024.217327_bib106","article-title":"Early recurrence after resection of locally advanced pancreatic cancer following induction therapy: an international multicenter study","author":"Seelen","year":"2022","journal-title":"Ann. Surg."},{"key":"10.1016\/j.canlet.2024.217327_bib107","first-page":"213","article-title":"Variation of tumoral marker after radiofrequency ablation of pancreatic adenocarcinoma","volume":"7","author":"D'Onofrio","year":"2016","journal-title":"J. Gastrointest. Oncol."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383524007225?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383524007225?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T20:28:14Z","timestamp":1733516894000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383524007225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":101,"alternative-id":["S0304383524007225"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2024.217327","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Local ablation disrupts immune evasion in pancreatic cancer","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2024.217327","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"217327"}}