{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:15:10Z","timestamp":1790046910296,"version":"4.0.1"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.canlet.2024.217404","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T03:09:23Z","timestamp":1734577763000},"page":"217404","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["A human-like glutaminase-free asparaginase is highly efficacious in ASNSlow leukemia and solid cancer mouse xenograft models"],"prefix":"10.1016","volume":"611","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7033-9569","authenticated-orcid":false,"given":"Maaike","family":"Van Trimpont","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda M.","family":"Schalk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Hofkens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelien","family":"Peeters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"T'Sas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0220-6892","authenticated-orcid":false,"given":"Katrien","family":"Vandemeulebroecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"De Loera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8733-4027","authenticated-orcid":false,"given":"Tim","family":"Lammens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter","family":"Van Vlierberghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5693-8570","authenticated-orcid":false,"given":"Steven","family":"Goossens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnon","family":"Lavie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.canlet.2024.217404_bib1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.4103\/0976-500X.184769","article-title":"L-asparaginase in the treatment of patients with acute lymphoblastic leukemia","volume":"7","author":"Egler","year":"2016","journal-title":"J. Pharmacol. Pharmacother."},{"issue":"4","key":"10.1016\/j.canlet.2024.217404_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14040902","article-title":"Novel insights on the use of L-asparaginase as an efficient and safe anti-cancer therapy","volume":"14","author":"Van Trimpont","year":"2022","journal-title":"Cancers"},{"issue":"20","key":"10.1016\/j.canlet.2024.217404_bib3","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1021\/acs.biochem.0c00116","article-title":"Mechanism of catalysis by l-asparaginase","volume":"59","author":"Lubkowski","year":"2020","journal-title":"Biochemistry"},{"key":"10.1016\/j.canlet.2024.217404_bib4","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.3389\/fonc.2019.01480","article-title":"Asparagine synthetase in cancer: beyond acute lymphoblastic leukemia","volume":"9","author":"Chiu","year":"2019","journal-title":"Front. Oncol."},{"issue":"49","key":"10.1016\/j.canlet.2024.217404_bib5","doi-asserted-by":"crossref","first-page":"19952","DOI":"10.1074\/jbc.R117.819060","article-title":"Asparagine synthetase: function, structure, and role in disease","volume":"292","author":"Lomelino","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.canlet.2024.217404_bib6","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.htct.2019.07.010","article-title":"Asparaginase: an old drug with new questions","volume":"42","author":"Cecconello","year":"2020","journal-title":"Hematol. Transf. Cell Therapy"},{"issue":"1","key":"10.1016\/j.canlet.2024.217404_bib7","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.htct.2019.01.013","article-title":"PEG-asparaginase and native Escherichia coli L-asparaginase in acute lymphoblastic leukemia in children and adolescents: a systematic review","volume":"42","author":"Medawar","year":"2020","journal-title":"Hematol Transfus. Cell Ther."},{"key":"10.1016\/j.canlet.2024.217404_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2022.902117","article-title":"Current use of asparaginase in acute lymphoblastic leukemia\/lymphoblastic lymphoma","volume":"10","author":"Maese","year":"2022","journal-title":"Front Pediatr"},{"issue":"10","key":"10.1016\/j.canlet.2024.217404_bib9","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.29169","article-title":"Can recombinant technology address asparaginase Erwinia chrysanthemi shortages?","volume":"68","author":"Maese","year":"2021","journal-title":"Pediatr. Blood Cancer"},{"issue":"10","key":"10.1016\/j.canlet.2024.217404_bib10","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.3324\/haematol.2022.282324","article-title":"Back to the future: the amazing journey of the therapeutic anti-leukemia enzyme asparaginase","volume":"108","author":"Tong","year":"2023","journal-title":"Haematologica"},{"issue":"8","key":"10.1016\/j.canlet.2024.217404_bib11","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.3109\/10428194.2014.1003056","article-title":"Asparaginase pharmacokinetics and implications of therapeutic drug monitoring","volume":"56","author":"Asselin","year":"2015","journal-title":"Leuk. Lymphoma"},{"issue":"17","key":"10.1016\/j.canlet.2024.217404_bib12","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1200\/JCO.19.03024","article-title":"Impact of asparaginase discontinuation on outcome in childhood acute lymphoblastic leukemia: a report from the children's Oncology group","volume":"38","author":"Gupta","year":"2020","journal-title":"J. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.canlet.2024.217404_bib13","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1038\/s41375-024-02201-1","article-title":"Asparaginase completion among adults including older patients with acute lymphoblastic leukemia treated with a modified DFCI protocol","volume":"38","author":"Perusini","year":"2024","journal-title":"Leukemia"},{"issue":"2","key":"10.1016\/j.canlet.2024.217404_bib14","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/cncr.25489","article-title":"L-asparaginase treatment in acute lymphoblastic leukemia: a focus on Erwinia asparaginase","volume":"117","author":"Pieters","year":"2011","journal-title":"Cancer"},{"key":"10.1016\/j.canlet.2024.217404_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111616","article-title":"Circumventing the side effects of L-asparaginase","volume":"139","author":"Fonseca","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.canlet.2024.217404_bib16","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3389\/fimmu.2016.00021","article-title":"Immunogenicity to biotherapeutics - the role of anti-drug immune complexes","volume":"7","author":"Krishna","year":"2016","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.canlet.2024.217404_bib17","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.2217\/fon-2021-1288","article-title":"Hypersensitivity reactions to asparaginase therapy in acute lymphoblastic leukemia: immunology and clinical consequences","volume":"18","author":"Burke","year":"2022","journal-title":"Future Oncol."},{"issue":"21","key":"10.1016\/j.canlet.2024.217404_bib18","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/S1359-6446(05)03575-0","article-title":"PEGylation, successful approach to drug delivery","volume":"10","author":"Veronese","year":"2005","journal-title":"Drug Discov. Today"},{"issue":"1\u20132","key":"10.1016\/j.canlet.2024.217404_bib19","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0378-5173(02)00046-7","article-title":"Effects of polyethylene glycol attachment on physicochemical and biological stability of E. coli L-asparaginase","volume":"237","author":"Soares","year":"2002","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.canlet.2024.217404_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/btm2.10600","article-title":"PEGylated therapeutics in the clinic","volume":"9","author":"Gao","year":"2024","journal-title":"Bioeng. Transl. Med."},{"issue":"Suppl","key":"10.1016\/j.canlet.2024.217404_bib21","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3109\/10428199309149129","article-title":"L-asparaginase and PEG asparaginase--past, present, and future","volume":"10","author":"Keating","year":"1993","journal-title":"Leuk. Lymphoma"},{"issue":"1","key":"10.1016\/j.canlet.2024.217404_bib22","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/cncr.22739","article-title":"Antibody against poly(ethylene glycol) adversely affects PEG-asparaginase therapy in acute lymphoblastic leukemia patients","volume":"110","author":"Armstrong","year":"2007","journal-title":"Cancer"},{"issue":"11","key":"10.1016\/j.canlet.2024.217404_bib23","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1517\/17425247.2012.720969","article-title":"Antibodies against polyethylene glycol in healthy subjects and in patients treated with PEG-conjugated agents","volume":"9","author":"Garay","year":"2012","journal-title":"Expet Opin. Drug Deliv."},{"issue":"13","key":"10.1016\/j.canlet.2024.217404_bib24","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1182\/blood-2013-10-534347","article-title":"A prospective study on drug monitoring of PEGasparaginase and Erwinia asparaginase and asparaginase antibodies in pediatric acute lymphoblastic leukemia","volume":"123","author":"Tong","year":"2014","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.canlet.2024.217404_bib25","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/00043426-200404000-00002","article-title":"Asparaginase antibody and asparaginase activity in children with higher-risk acute lymphoblastic leukemia: children's Cancer Group Study CCG-1961","volume":"26","author":"Panosyan","year":"2004","journal-title":"J. Pediatr. Hematol. Oncol."},{"issue":"16","key":"10.1016\/j.canlet.2024.217404_bib26","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.2217\/fon.14.138","article-title":"How to manage asparaginase hypersensitivity in acute lymphoblastic leukemia","volume":"10","author":"Burke","year":"2014","journal-title":"Future Oncol."},{"issue":"3","key":"10.1016\/j.canlet.2024.217404_bib27","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3324\/haematol.2015.137380","article-title":"Consensus expert recommendations for identification and management of asparaginase hypersensitivity and silent inactivation","volume":"101","author":"van der Sluis","year":"2016","journal-title":"Haematologica"},{"issue":"1","key":"10.1016\/j.canlet.2024.217404_bib28","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/bjh.16495","article-title":"Prospective, real-time monitoring of pegylated Escherichia coli and Erwinia asparaginase therapy in childhood acute lymphoblastic leukaemia and non-Hodgkin lymphoma in Belgium","volume":"190","author":"Mondelaers","year":"2020","journal-title":"Br. J. Haematol."},{"issue":"4","key":"10.1016\/j.canlet.2024.217404_bib29","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1021\/bc00028a001","article-title":"Stabilization of L-asparaginase modified with comb-shaped poly(ethylene glycol) derivatives, in vivo and in vitro","volume":"5","author":"Kodera","year":"1994","journal-title":"Bioconjugate Chem."},{"issue":"5\u20136","key":"10.1016\/j.canlet.2024.217404_bib30","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1515\/znc-2012-5-611","article-title":"A PEGylation technology of L-asparaginase with monomethoxy polyethylene glycol-propionaldehyde","volume":"67","author":"Wang","year":"2012","journal-title":"Z. Naturforsch., C: J. Biosci."},{"issue":"2","key":"10.1016\/j.canlet.2024.217404_bib31","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3324\/haematol.2022.281390","article-title":"In vivo stabilization of a less toxic asparaginase variant leads to a durable anti-tumor response in acute leukemia","volume":"108","author":"Van Trimpont","year":"2022","journal-title":"Haematologica"},{"issue":"19","key":"10.1016\/j.canlet.2024.217404_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10194419","article-title":"L-asparaginase toxicity in the treatment of children and adolescents with acute lymphoblastic leukemia","volume":"10","author":"Schmidt","year":"2021","journal-title":"J. Clin. Med."},{"issue":"11","key":"10.1016\/j.canlet.2024.217404_bib33","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.clml.2021.07.009","article-title":"SOHO state of the art updates and next questions: management of asparaginase toxicity in adolescents and young adults with acute lymphoblastic leukemia","volume":"21","author":"Schmiegelow","year":"2021","journal-title":"Clin. Lymphoma, Myeloma & Leukemia"},{"issue":"3","key":"10.1016\/j.canlet.2024.217404_bib34","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1007\/s12185-023-03591-1","article-title":"L-asparaginase as an efficient salvage therapy for refractory acute myeloid leukemia with chromosome 7 abnormalities: a case series","volume":"118","author":"Noguchi","year":"2023","journal-title":"Int. J. Hematol."},{"issue":"7","key":"10.1016\/j.canlet.2024.217404_bib35","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1038\/s41375-020-01080-6","article-title":"Venetoclax and pegcrisantaspase for complex karyotype acute myeloid leukemia","volume":"35","author":"Emadi","year":"2021","journal-title":"Leukemia"},{"issue":"66","key":"10.1016\/j.canlet.2024.217404_bib36","doi-asserted-by":"crossref","first-page":"109915","DOI":"10.18632\/oncotarget.18565","article-title":"Identification of a cytogenetic and molecular subgroup of acute myeloid leukemias showing sensitivity to L-Asparaginase","volume":"8","author":"Bertuccio","year":"2017","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.canlet.2024.217404_bib37","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1358\/dnp.2009.22.1.1303820","article-title":"Asparagine synthetase: a new potential biomarker in ovarian cancer","volume":"22","author":"Lorenzi","year":"2009","journal-title":"Drug News Perspect."},{"issue":"10","key":"10.1016\/j.canlet.2024.217404_bib38","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1111\/j.1582-4934.2012.01547.x","article-title":"L-asparaginase inhibits invasive and angiogenic activity and induces autophagy in ovarian cancer","volume":"16","author":"Yu","year":"2012","journal-title":"J. Cell Mol. Med."},{"issue":"3","key":"10.1016\/j.canlet.2024.217404_bib39","doi-asserted-by":"crossref","first-page":"565","DOI":"10.3892\/mco.2013.99","article-title":"A phase II clinical trial of polyethylene glycol-conjugated L-asparaginase in patients with advanced ovarian cancer: early closure for safety","volume":"1","author":"Hays","year":"2013","journal-title":"Mol. Clin. Oncol."},{"issue":"2","key":"10.1016\/j.canlet.2024.217404_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2023.113568","article-title":"L-asparaginase anti-tumor activity in pancreatic cancer is dependent on its glutaminase activity and resistance is mediated by glutamine synthetase","volume":"426","author":"Blachier","year":"2023","journal-title":"Exp. Cell Res."},{"issue":"6","key":"10.1016\/j.canlet.2024.217404_bib41","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1097\/MPA.0b013e318247d903","article-title":"Pancreatic tumor sensitivity to plasma L-asparagine starvation","volume":"41","author":"Dufour","year":"2012","journal-title":"Pancreas"},{"issue":"7","key":"10.1016\/j.canlet.2024.217404_bib42","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1097\/MPA.0000000000000394","article-title":"Asparagine synthetase expression and phase I study with L-asparaginase encapsulated in red blood cells in patients with pancreatic adenocarcinoma","volume":"44","author":"Bachet","year":"2015","journal-title":"Pancreas"},{"issue":"1","key":"10.1016\/j.canlet.2024.217404_bib43","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/bjc.2013.293","article-title":"Asparagine synthetase is an independent predictor of surgical survival and a potential therapeutic target in hepatocellular carcinoma","volume":"109","author":"Zhang","year":"2013","journal-title":"Br. J. Cancer"},{"issue":"1","key":"10.1016\/j.canlet.2024.217404_bib44","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1186\/s12920-022-01380-z","article-title":"An asparagine metabolism-based classification reveals the metabolic and immune heterogeneity of hepatocellular carcinoma","volume":"15","author":"Bai","year":"2022","journal-title":"BMC Med. Genom."},{"key":"10.1016\/j.canlet.2024.217404_bib45","series-title":"Autoimmunity: from Bench to Bedside","year":"2013"},{"issue":"4","key":"10.1016\/j.canlet.2024.217404_bib46","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.ccell.2019.03.004","article-title":"Synthetic lethality of wnt pathway activation and asparaginase in drug-resistant acute leukemias","volume":"35","author":"Hinze","year":"2019","journal-title":"Cancer Cell"},{"issue":"11","key":"10.1016\/j.canlet.2024.217404_bib47","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1158\/2159-8290.CD-19-1472","article-title":"Exploiting the therapeutic interaction of WNT pathway activation and asparaginase for colorectal cancer therapy","volume":"10","author":"Hinze","year":"2020","journal-title":"Cancer Discov."},{"issue":"3","key":"10.1016\/j.canlet.2024.217404_bib48","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s41419-019-1481-9","article-title":"SOX12 promotes colorectal cancer cell proliferation and metastasis by regulating asparagine synthesis","volume":"10","author":"Du","year":"2019","journal-title":"Cell Death Dis."},{"issue":"7692","key":"10.1016\/j.canlet.2024.217404_bib49","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/nature25465","article-title":"Asparagine bioavailability governs metastasis in a model of breast cancer","volume":"554","author":"Knott","year":"2018","journal-title":"Nature"},{"issue":"34","key":"10.1016\/j.canlet.2024.217404_bib50","doi-asserted-by":"crossref","first-page":"17664","DOI":"10.1074\/jbc.M116.728485","article-title":"Design and characterization of Erwinia chrysanthemi l-asparaginase variants with diminished l-glutaminase activity","volume":"291","author":"Nguyen","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.canlet.2024.217404_bib51","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1158\/0008-5472.CAN-17-2106","article-title":"A novel l-asparaginase with low l-glutaminase coactivity is highly efficacious against both T- and B-cell acute lymphoblastic leukemias in vivo","volume":"78","author":"Nguyen","year":"2018","journal-title":"Cancer Res."},{"issue":"48","key":"10.1016\/j.canlet.2024.217404_bib52","doi-asserted-by":"crossref","first-page":"33175","DOI":"10.1074\/jbc.M114.609552","article-title":"Identification and structural analysis of an L-asparaginase enzyme from Guinea pig with putative tumor cell killing properties","volume":"289","author":"Schalk","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.canlet.2024.217404_bib53","first-page":"478","article-title":"High-throughput asparaginase activity assay in serum of children with leukemia","volume":"6","author":"Fernandez","year":"2013","journal-title":"Int. J. Clin. Exp. Med."},{"issue":"5","key":"10.1016\/j.canlet.2024.217404_bib54","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/j.1365-2362.1988.tb01049.x","article-title":"Asparaginase-induced derangements of glutamine metabolism: the pathogenetic basis for some drug-related side-effects","volume":"18","author":"Ollenschl\u00e4ger","year":"1988","journal-title":"Eur. J. Clin. Invest."},{"issue":"42","key":"10.1016\/j.canlet.2024.217404_bib55","doi-asserted-by":"crossref","first-page":"31222","DOI":"10.1016\/S0021-9258(19)84035-8","article-title":"Role of glutamine depletion in directing tissue-specific nutrient stress responses to L-asparaginase","volume":"281","author":"Reinert","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"27","key":"10.1016\/j.canlet.2024.217404_bib56","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abn6491","article-title":"Tumoral microenvironment prevents de novo asparagine biosynthesis in B cell lymphoma, regardless of ASNS expression","volume":"8","author":"Grima-Reyes","year":"2022","journal-title":"Sci. Adv."},{"issue":"11","key":"10.1016\/j.canlet.2024.217404_bib57","doi-asserted-by":"crossref","first-page":"G1061","DOI":"10.1152\/ajpgi.00052.2016","article-title":"General control nonderepressible 2 deletion predisposes to asparaginase-associated pancreatitis in mice","volume":"310","author":"Phillipson-Weiner","year":"2016","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"7","key":"10.1016\/j.canlet.2024.217404_bib58","first-page":"1479","article-title":"Clinical evaluation of succinylated Acinetobacter glutaminase-asparaginase in adult leukemia","volume":"66","author":"Warrell","year":"1982","journal-title":"Cancer Treat Rep."},{"issue":"8","key":"10.1016\/j.canlet.2024.217404_bib59","first-page":"3145","article-title":"Human pharmacology and toxicology of succinylated Acinetobacter glutaminase-asparaginase","volume":"39","author":"Holcenberg","year":"1979","journal-title":"Cancer Res."},{"issue":"12","key":"10.1016\/j.canlet.2024.217404_bib60","first-page":"4546","article-title":"Phase I evaluation of succinylated Acinetobacter glutaminase-asparaginase in adults","volume":"40","author":"Warrell","year":"1980","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.canlet.2024.217404_bib61","first-page":"1602","article-title":"Kinetic analysis of hepatotoxicity associated with antineoplastic asparaginases","volume":"43","author":"Durden","year":"1983","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.canlet.2024.217404_bib62","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/ijc.2910270110","article-title":"Characterization of the effects of asparaginase from Escherichia coli and a glutaminase-free asparaginase from Vibrio succinogenes on specific ell-mediated cytotoxicity","volume":"27","author":"Durden","year":"1981","journal-title":"Int. J. Cancer"},{"issue":"3","key":"10.1016\/j.canlet.2024.217404_bib63","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/ijc.2910300314","article-title":"Glutaminase-free asparaginase from vibrio succinogenes: an antilymphoma enzyme lacking hepatotoxicity","volume":"30","author":"Distasio","year":"1982","journal-title":"Int. J. Cancer"},{"issue":"3","key":"10.1016\/j.canlet.2024.217404_bib64","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0378-4274(86)90113-X","article-title":"L-asparaginase effects on inhibition of protein synthesis and lowering of the glutamine content in cultured rat hepatocytes","volume":"32","author":"Villa","year":"1986","journal-title":"Toxicol. Lett."},{"issue":"6","key":"10.1016\/j.canlet.2024.217404_bib65","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/bjc.2014.425","article-title":"Glutamine depletion by crisantaspase hinders the growth of human hepatocellular carcinoma xenografts","volume":"111","author":"Chiu","year":"2014","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.canlet.2024.217404_bib66","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.enzmictec.2015.08.009","article-title":"Amino acid residues adjacent to the catalytic cavity of tetramer l-asparaginase II contribute significantly to its catalytic efficiency and thermostability","volume":"82","author":"Long","year":"2016","journal-title":"Enzym. Microb. Technol."},{"issue":"5","key":"10.1016\/j.canlet.2024.217404_bib67","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1182\/blood-2010-07-298422","article-title":"Rational engineering of L-asparaginase reveals importance of dual activity for cancer cell toxicity","volume":"117","author":"Offman","year":"2011","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.canlet.2024.217404_bib68","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.leukres.2015.04.008","article-title":"Glutaminase activity determines cytotoxicity of L-asparaginases on most leukemia cell lines","volume":"39","author":"Parmentier","year":"2015","journal-title":"Leuk. Res."},{"issue":"2","key":"10.1016\/j.canlet.2024.217404_bib69","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0117025","article-title":"Engineering of Helicobacter pylori L-asparaginase: characterization of two functionally distinct groups of mutants","volume":"10","author":"Maggi","year":"2015","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.canlet.2024.217404_bib70","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1158\/1535-7163.MCT-18-1329","article-title":"Glutaminase activity of L-asparaginase contributes to durable preclinical activity against acute lymphoblastic leukemia","volume":"18","author":"Chan","year":"2019","journal-title":"Mol. Cancer Therapeut."},{"issue":"23","key":"10.1016\/j.canlet.2024.217404_bib71","doi-asserted-by":"crossref","first-page":"3596","DOI":"10.1182\/blood-2013-10-535112","article-title":"The glutaminase activity of L-asparaginase is not required for anticancer activity against ASNS-negative cells","volume":"123","author":"Chan","year":"2014","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.canlet.2024.217404_bib72","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1021\/acsptsci.0c00196","article-title":"Therapeutic assessment of targeting ASNS combined with l-asparaginase treatment in solid tumors and investigation of resistance mechanisms","volume":"4","author":"Apfel","year":"2021","journal-title":"ACS Pharmacol. Transl. Sci."},{"issue":"5","key":"10.1016\/j.canlet.2024.217404_bib73","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/s41591-019-0404-8","article-title":"The landscape of cancer cell line metabolism","volume":"25","author":"Li","year":"2019","journal-title":"Nat. Med."},{"issue":"33","key":"10.1016\/j.canlet.2024.217404_bib74","doi-asserted-by":"crossref","first-page":"E7776","DOI":"10.1073\/pnas.1805523115","article-title":"Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response","volume":"115","author":"Nakamura","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"8","key":"10.1016\/j.canlet.2024.217404_bib75","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1007\/s12325-019-00988-5","article-title":"Development of a lyophilized formulation of pegaspargase and comparability versus liquid pegaspargase","volume":"36","author":"Faschinger","year":"2019","journal-title":"Adv. Ther."},{"issue":"3","key":"10.1016\/j.canlet.2024.217404_bib76","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.critrevonc.2006.07.009","article-title":"Pharmacological and clinical evaluation of L-asparaginase in the treatment of leukemia","volume":"61","author":"Narta","year":"2007","journal-title":"Crit. Rev. Oncol. Hematol."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383524007997?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383524007997?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T22:56:23Z","timestamp":1760741783000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383524007997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":76,"alternative-id":["S0304383524007997"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2024.217404","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A human-like glutaminase-free asparaginase is highly efficacious in ASNSlow leukemia and solid cancer mouse xenograft models","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2024.217404","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"217404"}}