{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:25:34Z","timestamp":1792513534155,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.canlet.2025.217534","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T02:58:39Z","timestamp":1738897119000},"page":"217534","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["YTHDF3 drives tumor growth and metastasis by recruiting eIF4B to promote Notch2 translation in breast cancer"],"prefix":"10.1016","volume":"614","author":[{"given":"Hongyu","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linling","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zishan","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangliang","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengxi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5182-5887","authenticated-orcid":false,"given":"Guojun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2025.217534_bib1","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1002\/ijc.35278","article-title":"The GLOBOCAN 2022 cancer estimates: data sources, methods, and a snapshot of the cancer burden worldwide","volume":"156","author":"Filho","year":"2025","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.canlet.2025.217534_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2023.216262","article-title":"The NF-Y splicing signature controls hybrid EMT and ECM-related pathways to promote aggressiveness of colon cancer","volume":"567","author":"Rigillo","year":"2023","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2025.217534_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217153","article-title":"TGF-beta-induced lncRNA TBUR1 promotes EMT and metastasis in lung adenocarcinoma via hnRNPC-mediated GRB2 mRNA stabilization","volume":"600","author":"Huang","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2025.217534_bib4","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.tcb.2018.12.001","article-title":"EMT transition states during tumor progression and metastasis","volume":"29","author":"Pastushenko","year":"2019","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.canlet.2025.217534_bib5","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.canlet.2019.10.013","article-title":"Communication between EMT and PD-L1 signaling: new insights into tumor immune evasion","volume":"468","author":"Jiang","year":"2020","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2025.217534_bib6","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s40164-022-00298-7","article-title":"Role of m6A writers, erasers and readers in cancer","volume":"11","author":"Fang","year":"2022","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.canlet.2025.217534_bib7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s40164-023-00386-2","article-title":"Emerging roles of m6A RNA modification in cancer therapeutic resistance","volume":"12","author":"Liu","year":"2023","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.canlet.2025.217534_bib8","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.canlet.2021.07.041","article-title":"Isorhapontigenin (ISO) inhibits EMT through FOXO3A\/METTL14\/VIMENTIN pathway in bladder cancer cells","volume":"520","author":"Zhang","year":"2021","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2025.217534_bib9","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202205091","article-title":"N(6) -Methyladenosine-Modified CBX1 regulates nasopharyngeal carcinoma progression through heterochromatin formation and STAT1 activation","volume":"9","author":"Zhao","year":"2022","journal-title":"Adv. Sci."},{"key":"10.1016\/j.canlet.2025.217534_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217186","article-title":"YTHDF1 regulates GID8-mediated glutamine metabolism to promote colorectal cancer progression in m6A-dependent manner","volume":"601","author":"Han","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2025.217534_bib11","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/cr.2017.15","article-title":"YTHDF3 facilitates translation and decay of N(6)-methyladenosine-modified RNA","volume":"27","author":"Shi","year":"2017","journal-title":"Cell Res."},{"key":"10.1016\/j.canlet.2025.217534_bib12","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/cr.2017.10","article-title":"Cytoplasmic m(6)A reader YTHDF3 promotes mRNA translation","volume":"27","author":"Li","year":"2017","journal-title":"Cell Res."},{"key":"10.1016\/j.canlet.2025.217534_bib13","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.ccell.2020.10.004","article-title":"YTHDF3 induces the translation of m(6)a-enriched gene transcripts to promote breast cancer brain metastasis","volume":"38","author":"Chang","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2025.217534_bib14","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12943-024-01979-z","article-title":"Exosomal long non-coding RNA TRPM2-AS promotes angiogenesis in gallbladder cancer through interacting with PABPC1 to activate NOTCH1 signaling pathway","volume":"23","author":"He","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.canlet.2025.217534_bib15","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1186\/s13046-021-02137-9","article-title":"M6A associated TSUC7 inhibition contributed to Erlotinib resistance in lung adenocarcinoma through a notch signaling activation dependent way","volume":"40","author":"Li","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2025.217534_bib16","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.omtn.2021.07.007","article-title":"METTL3-mediated m(6)A mRNA modification promotes esophageal cancer initiation and progression via Notch signaling pathway","volume":"26","author":"Han","year":"2021","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.canlet.2025.217534_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1793","article-title":"The IGF2BP3\/Notch\/Jag1 pathway: a key regulator of hepatic stellate cell ferroptosis in liver fibrosis","volume":"14","author":"Li","year":"2024","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.canlet.2025.217534_bib18","article-title":"m(6) A-dependent modulation via IGF2BP3\/MCM5\/notch Axis promotes partial EMT and LUAD metastasis","volume":"10","author":"Yang","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.canlet.2025.217534_bib19","doi-asserted-by":"crossref","first-page":"3564","DOI":"10.1038\/s41388-023-02865-6","article-title":"The m6A reader IGF2BP3 preserves NOTCH3 mRNA stability to sustain Notch3 signaling and promote tumor metastasis in nasopharyngeal carcinoma","volume":"42","author":"Chen","year":"2023","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2025.217534_bib20","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1186\/s13046-019-1463-x","article-title":"NOTCH2 negatively regulates metastasis and epithelial-Mesenchymal transition via TRAF6\/AKT in nasopharyngeal carcinoma","volume":"38","author":"Zou","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2025.217534_bib21","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1038\/s41388-017-0114-y","article-title":"FYN promotes mesenchymal phenotypes of basal type breast cancer cells through STAT5\/NOTCH2 signaling node","volume":"37","author":"Lee","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2025.217534_bib22","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1038\/s41388-021-02146-0","article-title":"The m(6)A reading protein YTHDF3 potentiates tumorigenicity of cancer stem-like cells in ocular melanoma through facilitating CTNNB1 translation","volume":"41","author":"Xu","year":"2022","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2025.217534_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118082","article-title":"circ_KIAA1429 accelerates hepatocellular carcinoma advancement through the mechanism of m(6)A-YTHDF3-Zeb1","volume":"257","author":"Wang","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.canlet.2025.217534_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1075","article-title":"N6-methyladenosine reader YTHDF3 regulates melanoma metastasis via its 'executor'LOXL3","volume":"12","author":"Shi","year":"2022","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.canlet.2025.217534_bib25","doi-asserted-by":"crossref","first-page":"916","DOI":"10.7150\/ijbs.87203","article-title":"The inhibition of YTHDF3\/m(6)A\/LRP6 reprograms fatty acid metabolism and suppresses lymph node metastasis in cervical cancer","volume":"20","author":"Zhong","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.canlet.2025.217534_bib26","doi-asserted-by":"crossref","first-page":"83","DOI":"10.21037\/atm-21-6857","article-title":"YTHDF3 facilitates triple-negative breast cancer progression and metastasis by stabilizing ZEB1 mRNA in an m(6)A-dependent manner","volume":"10","author":"Lin","year":"2022","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.canlet.2025.217534_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.216647","article-title":"Notch signaling and targeted therapy in non-small cell lung cancer","volume":"585","author":"Sun","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2025.217534_bib28","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.canlet.2018.09.031","article-title":"Major vault protein is a direct target of Notch1 signaling and contributes to chemoresistance in triple-negative breast cancer cells","volume":"440\u2013441","author":"Xiao","year":"2019","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2025.217534_bib29","article-title":"Notch3 transactivates glycogen synthase kinase-3-beta and inhibits epithelial-to-mesenchymal transition in breast cancer cells","volume":"11","author":"Chen","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.canlet.2025.217534_bib30","first-page":"8749","article-title":"The association between Notch4 expression, and clinicopathological characteristics and clinical outcomes in patients with breast cancer","volume":"15","author":"Wang","year":"2018","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.canlet.2025.217534_bib31","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1158\/1078-0432.CCR-15-2360","article-title":"Not all NOTCH is created equal: the oncogenic role of NOTCH2 in bladder cancer and its implications for targeted therapy","volume":"22","author":"Hayashi","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2025.217534_bib32","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.yexcr.2017.01.022","article-title":"miR-598 inhibits metastasis in colorectal cancer by suppressing JAG1\/Notch2 pathway stimulating EMT","volume":"352","author":"Chen","year":"2017","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.canlet.2025.217534_bib33","doi-asserted-by":"crossref","first-page":"53430","DOI":"10.18632\/oncotarget.10802","article-title":"Radiation driven epithelial-mesenchymal transition is mediated by Notch signaling in breast cancer","volume":"7","author":"Kim","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.canlet.2025.217534_bib34","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.2353\/ajpath.2007.061029","article-title":"Notch2 signaling induces apoptosis and inhibits human MDA-MB-231 xenograft growth","volume":"171","author":"O'Neill","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.canlet.2025.217534_bib35","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1158\/1078-0432.CCR-14-2808","article-title":"Targeting Notch signaling with a Notch2\/Notch3 antagonist (tarextumab) inhibits tumor growth and decreases tumor-initiating cell frequency","volume":"21","author":"Yen","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2025.217534_bib36","article-title":"Carrier strategies boost the application of CRISPR\/Cas system in gene therapy","volume":"2","author":"Xu","year":"2022","journal-title":"Exploration (Beijing)"},{"key":"10.1016\/j.canlet.2025.217534_bib37","article-title":"Nucleus-specific RNAi nanoplatform for targeted regulation of nuclear lncRNA function and effective cancer therapy","volume":"2","author":"Huang","year":"2022","journal-title":"Exploration (Beijing)"},{"key":"10.1016\/j.canlet.2025.217534_bib38","doi-asserted-by":"crossref","first-page":"e136","DOI":"10.1002\/mco2.136","article-title":"In vivo visualization of fluorescence reflecting CDK4 activity in a breast cancer mouse model","volume":"3","author":"Gao","year":"2020","journal-title":"MedComm"},{"key":"10.1016\/j.canlet.2025.217534_bib39","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.canlet.2021.10.005","article-title":"RNA-based gene targeting therapies for human papillomavirus driven cancers","volume":"523","author":"Salinas-Montalvo","year":"2021","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2025.217534_bib40","doi-asserted-by":"crossref","first-page":"e330","DOI":"10.1038\/oncsis.2017.38","article-title":"The zinc-finger transcriptional factor Slug transcriptionally downregulates ERalpha by recruiting lysine-specific demethylase 1 in human breast cancer","volume":"6","author":"Bai","year":"2017","journal-title":"Oncogenesis"},{"key":"10.1016\/j.canlet.2025.217534_bib41","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/978-1-4939-7219-7_17","article-title":"Analysis of epithelial-mesenchymal transition induced by overexpression of twist","volume":"1652","author":"Bai","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.canlet.2025.217534_bib42","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13578-022-00759-w","article-title":"YTHDF1 promotes breast cancer progression by facilitating FOXM1 translation in an m6A-dependent manner","volume":"12","author":"Chen","year":"2022","journal-title":"Cell Biosci."},{"key":"10.1016\/j.canlet.2025.217534_bib43","doi-asserted-by":"crossref","first-page":"e403","DOI":"10.1002\/mco2.403","article-title":"Methylation of ESR1 promoter induced by SNAI2-DNMT3B complex promotes epithelial-mesenchymal transition and correlates with poor prognosis in ERalpha-positive breast cancers","volume":"4","author":"Li","year":"2020","journal-title":"MedComm"},{"key":"10.1016\/j.canlet.2025.217534_bib44","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1038\/s41556-019-0415-1","article-title":"Translational reprogramming marks adaptation to asparagine restriction in cancer","volume":"21","author":"Pathria","year":"2019","journal-title":"Nat. Cell Biol."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383525000989?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383525000989?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T22:57:03Z","timestamp":1760741823000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383525000989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":44,"alternative-id":["S0304383525000989"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2025.217534","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"YTHDF3 drives tumor growth and metastasis by recruiting eIF4B to promote Notch2 translation in breast cancer","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2025.217534","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"217534"}}