{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:39:20Z","timestamp":1793414360030,"version":"4.5.0"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Foundation for Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004955","name":"Austrian Research Promotion Agency","doi-asserted-by":"publisher","award":["868 039"],"award-info":[{"award-number":["868 039"]}],"id":[{"id":"10.13039\/501100004955","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.canlet.2025.217686","type":"journal-article","created":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T16:55:07Z","timestamp":1744476907000},"page":"217686","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Colorectal cancer peritoneal metastasis is promoted by tissue-specific fibroblasts that can arise in response to various local disorders"],"prefix":"10.1016","volume":"633","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3822-2835","authenticated-orcid":false,"given":"Cristiano","family":"Ramos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Walterskirchen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoria","family":"Kn\u00f6bl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Zotter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8551-2739","authenticated-orcid":false,"given":"Vasileios","family":"Gerakopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0906-7307","authenticated-orcid":false,"given":"Anna","family":"Rauch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2798-8237","authenticated-orcid":false,"given":"Lena","family":"Falk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3693-4396","authenticated-orcid":false,"given":"Monika","family":"Sachet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"D'Angelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7578-1233","authenticated-orcid":false,"given":"Marco","family":"Agostini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8355-0977","authenticated-orcid":false,"given":"Dietmar","family":"Pils","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Aust","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Grusch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Herzog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Kratochwill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solange","family":"Le Blanc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristiaan J.","family":"Lenos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Vermeulen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4039-2849","authenticated-orcid":false,"given":"Stefan","family":"Riss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Bachleitner-Hofmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Strobel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Dolznig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bergmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Brostjan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas W.","family":"Unger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2891-7155","authenticated-orcid":false,"given":"Rudolf","family":"Oehler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.canlet.2025.217686_bib1","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1200\/JCO.2008.19.7160","article-title":"Complete cytoreductive surgery plus intraperitoneal chemohyperthermia with oxaliplatin for peritoneal carcinomatosis of colorectal origin","volume":"27","author":"Elias","year":"2009","journal-title":"J. Clin. Oncol."},{"issue":"2","key":"10.1016\/j.canlet.2025.217686_bib2","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S1470-2045(20)30599-4","article-title":"Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy versus cytoreductive surgery alone for colorectal peritoneal metastases (PRODIGE 7): a multicentre, randomised, open-label, phase 3 trial","volume":"22","author":"Qu\u00e9net","year":"2021","journal-title":"Lancet Oncol."},{"issue":"11","key":"10.1016\/j.canlet.2025.217686_bib3","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/nm.3967","article-title":"The consensus molecular subtypes of colorectal cancer","volume":"21","author":"Guinney","year":"2015","journal-title":"Nat. Med."},{"issue":"7","key":"10.1016\/j.canlet.2025.217686_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0255049","article-title":"Abundant intratumoral fibrosis prevents lymphocyte infiltration into peritoneal metastases of colorectal cancer","volume":"16","author":"Wang","year":"2021","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.canlet.2025.217686_bib5","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41568-019-0238-1","article-title":"A framework for advancing our understanding of cancer-associated fibroblasts","volume":"20","author":"Sahai","year":"2020","journal-title":"Nat. Rev. Cancer"},{"issue":"3","key":"10.1016\/j.canlet.2025.217686_bib6","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.trecan.2023.11.004","article-title":"It's all about the base: stromal cells are central orchestrators of metastasis","volume":"10","author":"Monteran","year":"2024","journal-title":"Trends in cancer"},{"issue":"1","key":"10.1016\/j.canlet.2025.217686_bib7","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s40364-021-00305-9","article-title":"Metastasis-associated fibroblasts: an emerging target for metastatic cancer","volume":"9","author":"Wang","year":"2021","journal-title":"Biomark. Res."},{"key":"10.1016\/j.canlet.2025.217686_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2022.215737","article-title":"Metastatic colorectal carcinoma-associated fibroblasts have immunosuppressive properties related to increased IGFBP2 expression","volume":"540","author":"Walterskirchen","year":"2022","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.canlet.2025.217686_bib9","doi-asserted-by":"crossref","first-page":"4443","DOI":"10.1038\/s41467-022-32198-z","article-title":"Molecular characterization of colorectal cancer related peritoneal metastatic disease","volume":"13","author":"Lenos","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2025.217686_bib10","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.canlet.2021.07.006","article-title":"Stromal fibroblasts shape the myeloid phenotype in normal colon and colorectal cancer and induce CD163 and CCL2 expression in macrophages","volume":"520","author":"Stadler","year":"2021","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.canlet.2025.217686_bib11","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13046-022-02582-0","article-title":"Mesothelioma-associated fibroblasts enhance proliferation and migration of pleural mesothelioma cells via c-Met\/PI3K and WNT signaling but do not protect against cisplatin","volume":"42","author":"Ries","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.canlet.2025.217686_bib12","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1186\/s13046-022-02519-7","article-title":"Patient-specific modeling of stroma-mediated chemoresistance of pancreatic cancer using a three-dimensional organoid-fibroblast co-culture system","volume":"41","author":"Schuth","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"19","key":"10.1016\/j.canlet.2025.217686_bib13","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.3390\/cells11192945","article-title":"Bio-engineered scaffolds derived from decellularized human esophagus for functional organ reconstruction","volume":"11","author":"Barbon","year":"2022","journal-title":"Cells"},{"issue":"6","key":"10.1016\/j.canlet.2025.217686_bib14","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/s41587-020-0497-0","article-title":"Single-cell RNA counting at allele and isoform resolution using Smart-seq3","volume":"38","author":"Hagemann-Jensen","year":"2020","journal-title":"Nat. Biotechnol."},{"issue":"3","key":"10.1016\/j.canlet.2025.217686_bib15","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/s41587-020-0439-x","article-title":"The nf-core framework for community-curated bioinformatics pipelines","volume":"38","author":"Ewels","year":"2020","journal-title":"Nat. Biotechnol."},{"issue":"1","key":"10.1016\/j.canlet.2025.217686_bib16","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"issue":"7","key":"10.1016\/j.canlet.2025.217686_bib17","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"issue":"4","key":"10.1016\/j.canlet.2025.217686_bib18","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nmeth.4197","article-title":"Salmon provides fast and bias-aware quantification of transcript expression","volume":"14","author":"Patro","year":"2017","journal-title":"Nat. Methods"},{"issue":"12","key":"10.1016\/j.canlet.2025.217686_bib19","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"issue":"11","key":"10.1016\/j.canlet.2025.217686_bib20","doi-asserted-by":"crossref","first-page":"3054","DOI":"10.1158\/1078-0432.CCR-11-1078","article-title":"Microarray analysis of colorectal cancer stromal tissue reveals upregulation of two oncogenic miRNA clusters","volume":"18","author":"Nishida","year":"2012","journal-title":"Clin. Cancer Res."},{"issue":"6","key":"10.1016\/j.canlet.2025.217686_bib21","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1002\/ijc.29095","article-title":"Inhibition of glioma progression by a newly discovered CD38 inhibitor","volume":"136","author":"Blacher","year":"2015","journal-title":"Int. J. Cancer"},{"issue":"6","key":"10.1016\/j.canlet.2025.217686_bib22","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/nprot.2010.74","article-title":"Efficient siRNA-mediated prolonged gene silencing in human amniotic fluid stem cells","volume":"5","author":"Rosner","year":"2010","journal-title":"Nat. Protoc."},{"issue":"13","key":"10.1016\/j.canlet.2025.217686_bib23","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.canlet.2025.217686_bib24","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. Methods"},{"issue":"1","key":"10.1016\/j.canlet.2025.217686_bib25","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1038\/s41467-022-28803-w","article-title":"Fully-automated and ultra-fast cell-type identification using specific marker combinations from single-cell transcriptomic data","volume":"13","author":"Ianevski","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2025.217686_bib26","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.cca.2022.11.009","article-title":"Circulating caspase-cleaved cytokeratin 18 correlates with tumour burden and response to therapy in patients with colorectal cancer liver metastasis","volume":"538","author":"Singh Bhangu","year":"2023","journal-title":"Clin. Chim. Acta"},{"issue":"11","key":"10.1016\/j.canlet.2025.217686_bib27","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1038\/s41374-020-0448-x","article-title":"A mouse model for peritoneal metastases of colorectal origin recapitulates patient heterogeneity","volume":"100","author":"Bastiaenen","year":"2020","journal-title":"Lab. Invest."},{"issue":"10","key":"10.1016\/j.canlet.2025.217686_bib28","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1016\/j.ejso.2017.05.010","article-title":"An 18 year population-based study on site of origin and outcome of patients with peritoneal malignancy in Ireland","volume":"43","author":"Solon","year":"2017","journal-title":"Eur. J. Surg. Oncol."},{"issue":"608","key":"10.1016\/j.canlet.2025.217686_bib29","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaz9705","article-title":"Lithium preserves peritoneal membrane integrity by suppressing mesothelial cell \u03b1B-crystallin","volume":"13","author":"Herzog","year":"2021","journal-title":"Sci. Transl. Med."},{"issue":"3","key":"10.1016\/j.canlet.2025.217686_bib30","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.ejso.2018.06.039","article-title":"Inflammatory bowel disease with peritoneal metastases: a complex and extremely variable disease","volume":"45","author":"Tuech","year":"2019","journal-title":"Eur. J. Surg. Oncol."},{"key":"10.1016\/j.canlet.2025.217686_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexmp.2020.104442","article-title":"The role of the peritoneal microenvironment in the pathogenesis of colorectal peritoneal carcinomatosis","volume":"115","author":"Demuytere","year":"2020","journal-title":"Exp. Mol. Pathol."},{"issue":"5","key":"10.1016\/j.canlet.2025.217686_bib32","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/bjs.8679","article-title":"Incidence, prevalence and risk factors for peritoneal carcinomatosis from colorectal cancer","volume":"99","author":"Segelman","year":"2012","journal-title":"Br. J. Surg."},{"issue":"10","key":"10.1016\/j.canlet.2025.217686_bib33","doi-asserted-by":"crossref","first-page":"3607","DOI":"10.1182\/blood.V89.10.3607","article-title":"Involvement of retinoic acid receptor-alpha-mediated signaling pathway in induction of CD38 cell-surface antigen","volume":"89","author":"Mehta","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.canlet.2025.217686_bib34","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.imlet.2018.03.007","article-title":"Canonical and non-canonical adenosinergic pathways","volume":"205","author":"Ferretti","year":"2019","journal-title":"Immunol. Lett."},{"issue":"9","key":"10.1016\/j.canlet.2025.217686_bib35","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1158\/2159-8290.CD-17-1033","article-title":"CD38-Mediated immunosuppression as a mechanism of tumor cell escape from PD-1\/PD-L1 blockade","volume":"8","author":"Chen","year":"2018","journal-title":"Cancer Discov."},{"issue":"10","key":"10.1016\/j.canlet.2025.217686_bib36","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/s41571-020-0382-2","article-title":"The adenosine pathway in immuno-oncology","volume":"17","author":"Allard","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"12","key":"10.1016\/j.canlet.2025.217686_bib37","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/nrc3613","article-title":"Immunity, inflammation and cancer: a leading role for adenosine","volume":"13","author":"Antonioli","year":"2013","journal-title":"Nat. Rev. Cancer"},{"issue":"6","key":"10.1016\/j.canlet.2025.217686_bib38","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/j.jcmgh.2023.02.014","article-title":"Mimicking tumor cell heterogeneity of colorectal cancer in a patient-derived organoid-fibroblast model","volume":"15","author":"Atanasova","year":"2023","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.canlet.2025.217686_bib39","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1038\/s41467-020-15188-x","article-title":"Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs","volume":"11","author":"Pein","year":"2020","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.canlet.2025.217686_bib40","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.2353\/ajpath.2007.060661","article-title":"Stromal fibroblasts in colorectal liver metastases originate from resident fibroblasts and generate an inflammatory microenvironment","volume":"171","author":"Mueller","year":"2007","journal-title":"Am. J. Pathol."},{"issue":"27","key":"10.1016\/j.canlet.2025.217686_bib41","doi-asserted-by":"crossref","first-page":"7551","DOI":"10.1073\/pnas.1600363113","article-title":"Tumor-associated fibroblasts predominantly come from local and not circulating precursors","volume":"113","author":"Arina","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.canlet.2025.217686_bib42","doi-asserted-by":"crossref","DOI":"10.1038\/s41416-024-02717-4","article-title":"Metastasis-associated fibroblasts in peritoneal surface malignancies","author":"Ramos","year":"2024","journal-title":"Br. J. Cancer"},{"issue":"4","key":"10.1016\/j.canlet.2025.217686_bib43","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.kint.2017.02.037","article-title":"Biomarker research to improve clinical outcomes of peritoneal dialysis: consensus of the European Training and Research in Peritoneal Dialysis (EuTRiPD) network","volume":"92","author":"Aufricht","year":"2017","journal-title":"Kidney Int."},{"issue":"2","key":"10.1016\/j.canlet.2025.217686_bib44","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/path.4942","article-title":"The peritoneum: healing, immunity, and diseases","volume":"243","author":"Capobianco","year":"2017","journal-title":"J. Pathol."},{"key":"10.1016\/j.canlet.2025.217686_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2020.109778","article-title":"Molecular pathways in peritoneal fibrosis","volume":"75","author":"Balzer","year":"2020","journal-title":"Cell. Signal."},{"issue":"1","key":"10.1016\/j.canlet.2025.217686_bib46","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/s41572-021-00326-6","article-title":"Primary and metastatic peritoneal surface malignancies","volume":"7","author":"Cort\u00e9s-Guiral","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"6","key":"10.1016\/j.canlet.2025.217686_bib47","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1111\/cts.13259","article-title":"Evidence of depot\u2010specific regulation of all\u2010trans\u2010retinoic acid biosynthesis in human adipose tissue","volume":"15","author":"Rubinow","year":"2022","journal-title":"Clin. Transl. Sci."},{"issue":"1","key":"10.1016\/j.canlet.2025.217686_bib48","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.immuni.2019.05.010","article-title":"A stromal niche defined by expression of the transcription factor WT1 mediates programming and homeostasis of cavity-resident macrophages","volume":"51","author":"Buechler","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.canlet.2025.217686_bib49","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01187","article-title":"The multi-faceted ecto-enzyme CD38: roles in immunomodulation, cancer, aging, and metabolic diseases","volume":"10","author":"Hogan","year":"2019","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.canlet.2025.217686_bib50","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1038\/s41374-020-0458-8","article-title":"CD38 in cancer-associated fibroblasts promotes pro-tumoral activity","volume":"100","author":"Ben Baruch","year":"2020","journal-title":"Lab. Invest."},{"issue":"9","key":"10.1016\/j.canlet.2025.217686_bib51","doi-asserted-by":"crossref","DOI":"10.4161\/onci.26246","article-title":"A CD38\/CD203a\/CD73 ectoenzymatic pathway independent of CD39 drives a novel adenosinergic loop in human T lymphocytes","volume":"2","author":"Horenstein","year":"2013","journal-title":"OncoImmunology"},{"issue":"28","key":"10.1016\/j.canlet.2025.217686_bib52","doi-asserted-by":"crossref","first-page":"25602","DOI":"10.18632\/oncotarget.4693","article-title":"A non-canonical adenosinergic pathway led by CD38 in human melanoma cells induces suppression of T cell proliferation","volume":"6","author":"Morandi","year":"2015","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.canlet.2025.217686_bib53","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/s41467-019-14060-x","article-title":"CD73 on cancer-associated fibroblasts enhanced by the A2B-mediated feedforward circuit enforces an immune checkpoint","volume":"11","author":"Yu","year":"2020","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.canlet.2025.217686_bib54","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1182\/blood-2008-02-136325","article-title":"Adenosine receptors in regulation of dendritic cell differentiation and function","volume":"112","author":"Novitskiy","year":"2008","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.canlet.2025.217686_bib55","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1096\/fj.11-190934","article-title":"Adenosine promotes alternative macrophage activation via A2A and A2B receptors","volume":"26","author":"Cs\u00f3ka","year":"2012","journal-title":"FASEB J."},{"issue":"4","key":"10.1016\/j.canlet.2025.217686_bib56","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s10753-013-9621-3","article-title":"The adenosine-dependent angiogenic switch of macrophages to an M2-like phenotype is independent of interleukin-4 receptor alpha (IL-4R\u03b1) signaling","volume":"36","author":"Ferrante","year":"2013","journal-title":"Inflammation"},{"issue":"19","key":"10.1016\/j.canlet.2025.217686_bib57","doi-asserted-by":"crossref","first-page":"4074","DOI":"10.1158\/0008-5472.CAN-14-3639","article-title":"CD38-Expressing myeloid-derived suppressor cells promote tumor growth in a murine model of esophageal cancer","volume":"75","author":"Karakasheva","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2025.217686_bib58","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.canlet.2020.12.008","article-title":"IGFBP2 promotes tumor progression by inducing alternative polarization of macrophages in pancreatic ductal adenocarcinoma through the STAT3 pathway","volume":"500","author":"Sun","year":"2021","journal-title":"Cancer Lett."},{"issue":"6","key":"10.1016\/j.canlet.2025.217686_bib59","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1002\/jso.23681","article-title":"Recent insights into the pathophysiology of omental metastases","volume":"110","author":"Koppe","year":"2014","journal-title":"J. Surg. Oncol."},{"issue":"1","key":"10.1016\/j.canlet.2025.217686_bib60","doi-asserted-by":"crossref","DOI":"10.1002\/cam4.70521","article-title":"Enrichment of cancer-associated fibroblasts, macrophages, and up-regulated TNF-\u03b1 signaling in the tumor microenvironment of CMS4 colorectal peritoneal metastasis","volume":"14","author":"H\u00f8ye","year":"2025","journal-title":"Cancer Med."},{"issue":"1","key":"10.1016\/j.canlet.2025.217686_bib61","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1186\/s12885-019-5462-2","article-title":"Increased expression of cancer-associated fibroblast markers at the invasive front and its association with tumor-stroma ratio in colorectal cancer","volume":"19","author":"Sandberg","year":"2019","journal-title":"BMC Cancer"},{"key":"10.1016\/j.canlet.2025.217686_bib62","article-title":"Development and validation of a novel prognostic nomogram combined with desmoplastic reaction for synchronous colorectal peritoneal metastasis","volume":"12","author":"Qin","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.canlet.2025.217686_bib63","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.908156","article-title":"Targeting tumour-associated fibroblasts in cancers","volume":"12","author":"Shah","year":"2022","journal-title":"Front. Oncol."},{"issue":"7","key":"10.1016\/j.canlet.2025.217686_bib64","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1038\/s12276-023-01013-0","article-title":"Cancer-associated fibroblasts: from basic science to anticancer therapy","volume":"55","author":"Yang","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.canlet.2025.217686_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.blre.2021.100808","article-title":"Improving outcomes for patients with relapsed multiple myeloma: challenges and considerations of current and emerging treatment options","volume":"49","author":"Ramasamy","year":"2021","journal-title":"Blood Rev."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383525002526?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383525002526?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:07:16Z","timestamp":1777550836000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383525002526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":65,"alternative-id":["S0304383525002526"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2025.217686","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Colorectal cancer peritoneal metastasis is promoted by tissue-specific fibroblasts that can arise in response to various local disorders","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2025.217686","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"217686"}}