{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:49:06Z","timestamp":1790390946791,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82203427"],"award-info":[{"award-number":["82203427"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.canlet.2025.217729","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T11:50:28Z","timestamp":1744890628000},"page":"217729","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["The m6A hypermethylation-induced PIR overexpression regulates H3K4me3 and promotes tumorigenesis of uveal melanoma"],"prefix":"10.1016","volume":"623","author":[{"given":"Hao","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1295-859X","authenticated-orcid":false,"given":"Ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaokang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianqun","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruobing","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.canlet.2025.217729_bib1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1136\/bjophthalmol-2016-309034","article-title":"Metastatic disease from uveal melanoma: treatment options and future prospects","volume":"101","author":"Carvajal","year":"2017","journal-title":"Br. J. Ophthalmol."},{"issue":"4","key":"10.1016\/j.canlet.2025.217729_bib2","doi-asserted-by":"crossref","first-page":"304","DOI":"10.3109\/08820538.2016.1154175","article-title":"Tumor characteristics, genetics, management, and the risk of metastasis in uveal melanoma","volume":"31","author":"Nichols","year":"2016","journal-title":"Semin. Ophthalmol."},{"issue":"7","key":"10.1016\/j.canlet.2025.217729_bib3","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1007\/s00262-019-02352-6","article-title":"Pembrolizumab as first-line treatment for metastatic uveal melanoma","volume":"68","author":"Rossi","year":"2019","journal-title":"Cancer Immunol. Immunother."},{"issue":"1","key":"10.1016\/j.canlet.2025.217729_bib4","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/s41467-019-14256-1","article-title":"Single-cell analysis reveals new evolutionary complexity in uveal melanoma","volume":"11","author":"Durante","year":"2020","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.canlet.2025.217729_bib5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41392-021-00824-9","article-title":"Integrated single-cell RNA sequencing analysis reveals distinct cellular and transcriptional modules associated with survival in lung cancer","volume":"7","author":"Zhang","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"2","key":"10.1016\/j.canlet.2025.217729_bib6","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.tig.2021.06.014","article-title":"Crosstalk between epitranscriptomic and epigenetic mechanisms in gene regulation","volume":"38","author":"Kan","year":"2022","journal-title":"Trends Genet."},{"issue":"11","key":"10.1016\/j.canlet.2025.217729_bib7","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1002\/cac2.12471","article-title":"Targeting histone deacetylase suppresses tumor growth through eliciting METTL14-modified m(6) A RNA methylation in ocular melanoma","volume":"43","author":"Zhuang","year":"2023","journal-title":"Cancer Commun."},{"issue":"3","key":"10.1016\/j.canlet.2025.217729_bib8","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/s41556-018-0045-z","article-title":"Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation","volume":"20","author":"Huang","year":"2018","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.canlet.2025.217729_bib9","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/s12943-019-1088-x","article-title":"m(6)A modification suppresses ocular melanoma through modulating HINT2 mRNA translation","volume":"18","author":"Jia","year":"2019","journal-title":"Mol. Cancer"},{"issue":"4","key":"10.1016\/j.canlet.2025.217729_bib10","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.molcel.2017.10.013","article-title":"Determinants of histone H3K4 methylation patterns","volume":"68","author":"Soares","year":"2017","journal-title":"Mol. Cell"},{"issue":"9","key":"10.1016\/j.canlet.2025.217729_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1410","article-title":"Long noncoding RNA Regulating ImMune Escape regulates mixed lineage leukaemia protein-1-H3K4me3-mediated immune escape in oesophageal squamous cell carcinoma","volume":"13","author":"Liu","year":"2023","journal-title":"Clin. Transl. Med."},{"issue":"1","key":"10.1016\/j.canlet.2025.217729_bib12","doi-asserted-by":"crossref","first-page":"9561","DOI":"10.1038\/s41598-023-36684-2","article-title":"Pirin is a prognostic marker of human melanoma that dampens the proliferation of malignant cells by downregulating JARID1B\/KDM5B expression","volume":"13","author":"Penas","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.canlet.2025.217729_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2023.154543","article-title":"Immunohistochemical expression of PRAME is a marker of poor prognosis in uveal melanoma: a clinico-pathologic and immunohistochemical study on a series of 85 cases","volume":"247","author":"Broggi","year":"2023","journal-title":"Pathol. Res. Pract."},{"issue":"9","key":"10.1016\/j.canlet.2025.217729_bib14","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nchembio.423","article-title":"A small-molecule inhibitor shows that pirin regulates migration of melanoma cells","volume":"6","author":"Miyazaki","year":"2010","journal-title":"Nat. Chem. Biol."},{"issue":"9","key":"10.1016\/j.canlet.2025.217729_bib15","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1080\/15384101.2019.1609830","article-title":"A novel function of anaphase promoting complex subunit 10 in tumor progression in non-small cell lung cancer","volume":"18","author":"Wang","year":"2019","journal-title":"Cell Cycle"},{"issue":"24","key":"10.1016\/j.canlet.2025.217729_bib16","doi-asserted-by":"crossref","first-page":"9722","DOI":"10.1073\/pnas.1221743110","article-title":"Pirin is an iron-dependent redox regulator of NF-\u03baB","volume":"110","author":"Liu","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.canlet.2025.217729_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/biology10020116","article-title":"Role of pirin, an oxidative stress sensor protein, in epithelial carcinogenesis","volume":"10","author":"Perez-Dominguez","year":"2021","journal-title":"Biology"},{"issue":"21","key":"10.1016\/j.canlet.2025.217729_bib18","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.1080\/15384101.2019.1662259","article-title":"PIR promotes tumorigenesis of breast cancer by upregulating cell cycle activator E2F1","volume":"18","author":"Suleman","year":"2019","journal-title":"Cell Cycle"},{"issue":"2","key":"10.1016\/j.canlet.2025.217729_bib19","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/1878-0261.12405","article-title":"Pirin: a potential novel therapeutic target for castration-resistant prostate cancer regulated by miR-455-5p","volume":"13","author":"Arai","year":"2019","journal-title":"Mol. Oncol."},{"issue":"7","key":"10.1016\/j.canlet.2025.217729_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12071904","article-title":"Human papillomavirus 16 E7 promotes EGFR\/PI3K\/AKT1\/NRF2 signaling pathway contributing to PIR\/NF-\u03baB activation in oral cancer cells","volume":"12","author":"Carrillo-Beltr\u00e1n","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.canlet.2025.217729_bib21","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12943-020-01194-6","article-title":"Novel insight into the regulatory roles of diverse RNA modifications: Re-defining the bridge between transcription and translation","volume":"19","author":"Shi","year":"2020","journal-title":"Mol. Cancer"},{"issue":"6","key":"10.1016\/j.canlet.2025.217729_bib22","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1016\/j.ymthe.2021.02.014","article-title":"m(6)A RNA hypermethylation-induced BACE2 boosts intracellular calcium release and accelerates tumorigenesis of ocular melanoma","volume":"29","author":"He","year":"2021","journal-title":"Mol. Ther."},{"issue":"1","key":"10.1016\/j.canlet.2025.217729_bib23","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13059-021-02308-z","article-title":"Histone lactylation drives oncogenesis by facilitating m(6)A reader protein YTHDF2 expression in ocular melanoma","volume":"22","author":"Yu","year":"2021","journal-title":"Genome Biol."},{"issue":"6","key":"10.1016\/j.canlet.2025.217729_bib24","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1093\/nar\/gkaa051","article-title":"WDR5 is a conserved regulator of protein synthesis gene expression","volume":"48","author":"Bryan","year":"2020","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"10.1016\/j.canlet.2025.217729_bib25","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.bbadis.2017.03.009","article-title":"Assessment of histone tail modifications and transcriptional profiling during colon cancer progression reveals a global decrease in H3K4me3 activity","volume":"1863","author":"Triff","year":"2017","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"issue":"6","key":"10.1016\/j.canlet.2025.217729_bib26","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/s41418-024-01294-6","article-title":"The PML1-WDR5 axis regulates H3K4me3 marks and promotes stemness of estrogen receptor-positive breast cancer","volume":"31","author":"Pai","year":"2024","journal-title":"Cell Death Differ."},{"issue":"45","key":"10.1016\/j.canlet.2025.217729_bib27","doi-asserted-by":"crossref","DOI":"10.3346\/jkms.2023.38.e381","article-title":"Promoter-specific variants in NeuroD1 and H3K4me3 coincident regions and clinical outcomes of small cell lung cancer","volume":"38","author":"Yoo","year":"2023","journal-title":"J. Kor. Med. Sci."},{"issue":"11","key":"10.1016\/j.canlet.2025.217729_bib28","article-title":"Cfp1 controls cardiomyocyte maturation by modifying histone H3K4me3 of structural, metabolic, and contractile related genes","volume":"11","author":"Li","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"7786","key":"10.1016\/j.canlet.2025.217729_bib29","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/s41586-019-1814-y","article-title":"Developmental ROS individualizes organismal stress resistance and lifespan","volume":"576","author":"Bazopoulou","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2025.217729_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2020.02.038","article-title":"Ectopic HOTTIP expression induces noncanonical transactivation pathways to promote growth and invasiveness in pancreatic ductal adenocarcinoma","volume":"477","author":"Wong","year":"2020","journal-title":"Cancer Lett."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383525002952?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383525002952?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T23:01:39Z","timestamp":1760742099000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383525002952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":30,"alternative-id":["S0304383525002952"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2025.217729","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The m6A hypermethylation-induced PIR overexpression regulates H3K4me3 and promotes tumorigenesis of uveal melanoma","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2025.217729","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"217729"}}