{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:51:57Z","timestamp":1792785117727,"version":"4.5.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","award":["22JCQNJC01090"],"award-info":[{"award-number":["22JCQNJC01090"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515110381"],"award-info":[{"award-number":["2022A1515110381"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009133","name":"Karlsruhe Institute of Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009133","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004945","name":"Nankai University","doi-asserted-by":"publisher","award":["63241469"],"award-info":[{"award-number":["63241469"]}],"id":[{"id":"10.13039\/501100004945","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004945","name":"Nankai University","doi-asserted-by":"publisher","award":["63231202"],"award-info":[{"award-number":["63231202"]}],"id":[{"id":"10.13039\/501100004945","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fundamentals Research Funds for the Central Universities, Nankai University","id":[{"id":"https:\/\/ror.org\/01y1kjr75","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.canlet.2025.217848","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T21:40:23Z","timestamp":1749159623000},"page":"217848","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Adipocytes promote cancer stemness properties in oral squamous cell carcinoma through C3\/C3AR axis and sphingolipid metabolism"],"prefix":"10.1016","volume":"628","author":[{"given":"Tian Xu","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying Ying","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai Hoe","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siew Kit","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Fey","family":"Chek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai Dun","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2025.217848_bib1","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.canlet.2025.217848_bib2","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/jop.12726","article-title":"Prevalence of oral potentially malignant disorders: a systematic review and meta-analysis","volume":"47","author":"Mello","year":"2018","journal-title":"J. Oral Pathol. Med."},{"key":"10.1016\/j.canlet.2025.217848_bib3","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/ijc.28754","article-title":"Potentially malignant disorders of the oral cavity: current practice and future directions in the clinic and laboratory","volume":"136","author":"Dionne","year":"2015","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.canlet.2025.217848_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0175148","article-title":"Influence of time interval from diagnosis to treatment on survival for oral cavity cancer: a nationwide cohort study","volume":"12","author":"Tsai","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.canlet.2025.217848_bib5","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1172\/JCI82066","article-title":"Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma","volume":"126","author":"Hedberg","year":"2016","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.canlet.2025.217848_bib6","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1083\/jcb.201202014","article-title":"The evolving concept of cancer and metastasis stem cells","volume":"198","author":"Baccelli","year":"2012","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.canlet.2025.217848_bib7","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1073\/pnas.0610117104","article-title":"Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma","volume":"104","author":"Prince","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.canlet.2025.217848_bib8","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1002\/ijc.27720","article-title":"Expression patterns of cancer stem cell markers ALDH1 and CD133 correlate with a high risk of malignant transformation of oral leukoplakia","volume":"132","author":"Liu","year":"2013","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.canlet.2025.217848_bib9","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.cell.2008.03.027","article-title":"The epithelial-mesenchymal transition generates cells with properties of stem cells","volume":"133","author":"Mani","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2025.217848_bib10","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.stem.2017.02.003","article-title":"Targeting BMI1(+) cancer stem cells overcomes chemoresistance and inhibits metastases in squamous cell carcinoma","volume":"20","author":"Chen","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.canlet.2025.217848_bib11","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.stem.2015.02.015","article-title":"The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells?","volume":"16","author":"Plaks","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.canlet.2025.217848_bib12","author":"Federation"},{"key":"10.1016\/j.canlet.2025.217848_bib13","doi-asserted-by":"crossref","first-page":"866","DOI":"10.3390\/cancers13040866","article-title":"Precision nutrition to activate thermogenesis as a complementary approach to target obesity and associated-metabolic-disorders","volume":"13","author":"Reguero","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.canlet.2025.217848_bib14","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.jand.2017.08.112","article-title":"Translating mechanism-based strategies to break the obesity\u2212 cancer link: a narrative review","volume":"118","author":"Smith","year":"2018","journal-title":"J. Acad. Nutr. Diet."},{"key":"10.1016\/j.canlet.2025.217848_bib15","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1158\/1055-9965.EPI-11-0935","article-title":"Prospective studies of body mass index with head and neck cancer incidence and mortality","volume":"21","author":"Gaudet","year":"2012","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.canlet.2025.217848_bib16","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1002\/hed.23052","article-title":"Tobacco, alcohol, body mass index, physical activity, and the risk of head and neck cancer in the prostate, lung, colorectal, and ovarian (PLCO) cohort","volume":"35","author":"Hashibe","year":"2013","journal-title":"Head Neck"},{"key":"10.1016\/j.canlet.2025.217848_bib17","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1002\/cncr.28532","article-title":"Impact of obesity on the survival of patients with early\u2010stage squamous cell carcinoma of the oral tongue","volume":"120","author":"Iyengar","year":"2014","journal-title":"Cancer"},{"key":"10.1016\/j.canlet.2025.217848_bib18","doi-asserted-by":"crossref","first-page":"3794","DOI":"10.1002\/cncr.30251","article-title":"White adipose tissue inflammation and cancer-specific survival in patients with squamous cell carcinoma of the oral tongue","volume":"122","author":"Iyengar","year":"2016","journal-title":"Cancer"},{"key":"10.1016\/j.canlet.2025.217848_bib19","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12916-020-01877-3","article-title":"Body mass index and waist circumference in relation to the risk of 26 types of cancer: a prospective cohort study of 3.5 million adults in Spain","volume":"19","author":"Recalde","year":"2021","journal-title":"BMC Med."},{"key":"10.1016\/j.canlet.2025.217848_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2024.1390824","article-title":"The role of neck adipose tissue in lymph node metastasis of head and neck cancer","volume":"14","author":"Pan","year":"2024","journal-title":"Front. Oncol."},{"key":"10.1016\/j.canlet.2025.217848_bib21","doi-asserted-by":"crossref","DOI":"10.1177\/1010428317699130","article-title":"Leptin acts on neoplastic behavior and expression levels of genes related to hypoxia, angiogenesis, and invasiveness in oral squamous cell carcinoma","volume":"39","author":"Sobrinho Santos","year":"2017","journal-title":"Tumour Biol"},{"key":"10.1016\/j.canlet.2025.217848_bib22","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1042\/CS20181023","article-title":"The serum biomarker chemerin promotes tumorigenesis and metastasis in oral squamous cell carcinoma","volume":"133","author":"Lu","year":"2019","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.canlet.2025.217848_bib23","doi-asserted-by":"crossref","first-page":"4939","DOI":"10.18632\/oncotarget.6643","article-title":"Adipocytes promote prostate cancer stem cell self-renewal through amplification of the cholecystokinin autocrine loop","volume":"7","author":"Tang","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.canlet.2025.217848_bib24","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s40291-021-00538-2","article-title":"Proteomic alterations in salivary exosomes derived from human papillomavirus-driven oropharyngeal cancer","volume":"25","author":"Tang","year":"2021","journal-title":"Mol. Diagn. Ther."},{"key":"10.1016\/j.canlet.2025.217848_bib25","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.18632\/oncotarget.3950","article-title":"Tie-2 regulates the stemness and metastatic properties of prostate cancer cells","volume":"7","author":"Tang","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.canlet.2025.217848_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.143690","article-title":"NF-kappa-B inhibitor alpha mediates cancer stemness characteristics in oral squamous cell carcinoma by interacting with cathepsin B","volume":"311","author":"Qin","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.canlet.2025.217848_bib27","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nature04005","article-title":"Structures of complement component C3 provide insights into the function and evolution of immunity","volume":"437","author":"Janssen","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2025.217848_bib28","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.canlet.2025.217848_bib29","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.canlet.2025.217848_bib30","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/prot.10104","article-title":"Increasing the precision of comparative models with YASARA NOVA--a self-parameterizing force field","volume":"47","author":"Krieger","year":"2002","journal-title":"Proteins"},{"key":"10.1016\/j.canlet.2025.217848_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22052622","article-title":"TNMplot.com: a web tool for the comparison of gene expression in normal, tumor and metastatic tissues","volume":"22","author":"Bartha","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.canlet.2025.217848_bib32","article-title":"Integrated analysis of public datasets for the discovery and validation of survival-associated genes in solid tumors","volume":"5","author":"Gyorffy","year":"2024","journal-title":"Innovation"},{"key":"10.1016\/j.canlet.2025.217848_bib33","doi-asserted-by":"crossref","first-page":"W98","DOI":"10.1093\/nar\/gkx247","article-title":"GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses","volume":"45","author":"Tang","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.canlet.2025.217848_bib34","doi-asserted-by":"crossref","DOI":"10.1177\/1533033820970668","article-title":"Down-regulation of C3aR\/C5aR inhibits cell proliferation and EMT in hepatocellular carcinoma","volume":"19","author":"Chen","year":"2020","journal-title":"Technol. Cancer Res. Treat."},{"key":"10.1016\/j.canlet.2025.217848_bib35","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13046-019-1515-2","article-title":"C3a-C3aR signaling promotes breast cancer lung metastasis via modulating carcinoma associated fibroblasts","volume":"39","author":"Shu","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2025.217848_bib36","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1111\/jcmm.13959","article-title":"Complement C3a promotes proliferation, migration and stemness in cutaneous squamous cell carcinoma","volume":"23","author":"Fan","year":"2019","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.canlet.2025.217848_bib37","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.semcdb.2017.10.025","article-title":"The complement system is dysfunctional in metabolic disease: evidences in plasma and adipose tissue from obese and insulin resistant subjects","volume":"85","author":"Moreno-Navarrete","year":"2019","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.canlet.2025.217848_bib38","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.178925","article-title":"Adipsin and adipocyte-derived C3aR1 regulate thermogenic fat in a sex-dependent fashion","volume":"9","author":"Ma","year":"2024","journal-title":"JCI Insight"},{"key":"10.1016\/j.canlet.2025.217848_bib39","article-title":"Small molecule-induced complement factor D (adipsin) promotes lipid accumulation and adipocyte differentiation","volume":"11","author":"Song","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.canlet.2025.217848_bib40","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nrc.2017.96","article-title":"Sphingolipid metabolism in cancer signalling and therapy","volume":"18","author":"Ogretmen","year":"2018","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.canlet.2025.217848_bib41","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3892\/ijmm.2013.1541","article-title":"DMS triggers apoptosis associated with the inhibition of SPHK1\/NF-kappaB activation and increase in intracellular Ca2+ concentration in human cancer cells","volume":"33","author":"Chen","year":"2014","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.canlet.2025.217848_bib42","first-page":"655","article-title":"Evaluation of chemotherapeutic and cancer-protective properties of sphingosine and C2-ceramide in a human breast stem cell derived carcinogenesis model","volume":"54","author":"Ahn","year":"2019","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.canlet.2025.217848_bib43","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.trecan.2023.07.001","article-title":"Sphingolipid metabolism and complement signaling in cancer progression","volume":"9","author":"Janneh","year":"2023","journal-title":"Trends Cancer"},{"key":"10.1016\/j.canlet.2025.217848_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111742","article-title":"Crosstalk between pro-survival sphingolipid metabolism and complement signaling induces inflammasome-mediated tumor metastasis","volume":"41","author":"Janneh","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.canlet.2025.217848_bib45","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.3390\/ijms20051146","article-title":"Obesity, DNA damage, and development of obesity-related diseases","volume":"20","author":"W\u0142odarczyk","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.canlet.2025.217848_bib46","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1186\/s12935-024-03481-4","article-title":"Lipid metabolism associated crosstalk: the bidirectional interaction between cancer cells and immune\/stromal cells within the tumor microenvironment for prognostic insight","volume":"24","author":"Lin","year":"2024","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.canlet.2025.217848_bib47","doi-asserted-by":"crossref","first-page":"8352","DOI":"10.3390\/ijms25158352","article-title":"The role of adipocytes recruited as part of tumor microenvironment in promoting colorectal cancer metastases","volume":"25","author":"Ma","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.canlet.2025.217848_bib48","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1111\/odi.13513","article-title":"Oral cancer stem cells drive tumourigenesis through activation of stromal fibroblasts","volume":"27","author":"Al-Magsoosi","year":"2021","journal-title":"Oral Dis."},{"key":"10.1016\/j.canlet.2025.217848_bib49","doi-asserted-by":"crossref","first-page":"4185","DOI":"10.1158\/0008-5472.CAN-20-1079","article-title":"Cancer cell CD44 mediates macrophage\/monocyte-driven regulation of head and neck cancer stem cells","volume":"80","author":"Gomez","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2025.217848_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113917","article-title":"The ending is not the end: lymph node metastasis in oral squamous cell carcinoma","volume":"146","author":"Wei","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.canlet.2025.217848_bib51","doi-asserted-by":"crossref","first-page":"39","DOI":"10.4331\/wjbc.v6.i2.39","article-title":"Adipocyte activation of cancer stem cell signaling in breast cancer","volume":"6","author":"Wolfson","year":"2015","journal-title":"World J. Biol. Chem."},{"key":"10.1016\/j.canlet.2025.217848_bib52","doi-asserted-by":"crossref","first-page":"3634","DOI":"10.1016\/j.csbj.2024.09.032","article-title":"The complement C3a\/C3aR pathway is associated with treatment resistance to gemcitabine-based neoadjuvant therapy in pancreatic cancer","volume":"23","author":"Shi","year":"2024","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.canlet.2025.217848_bib53","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1158\/0008-5472.CAN-17-0240","article-title":"Complement activation via a C3a receptor pathway alters CD4(+) T lymphocytes and mediates lung cancer progression","volume":"78","author":"Kwak","year":"2018","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2025.217848_bib54","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.semcdb.2017.11.023","article-title":"Complement anaphylatoxins C3a and C5a: emerging roles in cancer progression and treatment","volume":"85","author":"Ajona","year":"2019","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.canlet.2025.217848_bib55","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.trecan.2018.03.004","article-title":"Cancer as a matter of fat: the crosstalk between adipose tissue and tumors","volume":"4","author":"Lengyel","year":"2018","journal-title":"Trends Cancer"},{"key":"10.1016\/j.canlet.2025.217848_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.coph.2022.102322","article-title":"Metabolic crosstalk between thermogenic adipocyte and cancer cell: dysfunction and therapeutics","volume":"68","author":"Dong","year":"2023","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.canlet.2025.217848_bib57","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s12935-024-03221-8","article-title":"The emerging roles of sphingosine 1-phosphate and SphK1 in cancer resistance: a promising therapeutic target","volume":"24","author":"Alkafaas","year":"2024","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.canlet.2025.217848_bib58","doi-asserted-by":"crossref","DOI":"10.1038\/srep25650","article-title":"Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2","volume":"6","author":"Patmanathan","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.canlet.2025.217848_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2023.119616","article-title":"Accumulation of sphingosine kinase 2 protein induces malignant transformation in oral keratinocytes associated with stemness, autophagy, senescence, and proliferation","volume":"1871","author":"Fugio","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.canlet.2025.217848_bib60","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/s41419-024-07134-2","article-title":"A sphingolipid rheostat controls apoptosis versus apical cell extrusion as alternative tumour-suppressive mechanisms","volume":"15","author":"Armistead","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.canlet.2025.217848_bib61","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.yexcr.2015.02.025","article-title":"Revisiting the sphingolipid rheostat: evolving concepts in cancer therapy","volume":"333","author":"Newton","year":"2015","journal-title":"Exp. Cell Res."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030438352500415X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030438352500415X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T20:35:50Z","timestamp":1762288550000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030438352500415X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":61,"alternative-id":["S030438352500415X"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2025.217848","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adipocytes promote cancer stemness properties in oral squamous cell carcinoma through C3\/C3AR axis and sphingolipid metabolism","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2025.217848","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"217848"}}