{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T02:25:15Z","timestamp":1787883915705,"version":"build-2784847793"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005984","name":"Dr. Miriam and Sheldon G. Adelson Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005984","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"publisher","award":["PA210068"],"award-info":[{"award-number":["PA210068"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007316","name":"National Cancer Institute Division of Cancer Prevention","doi-asserted-by":"publisher","award":["U01 CA224012"],"award-info":[{"award-number":["U01 CA224012"]}],"id":[{"id":"10.13039\/100007316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007316","name":"National Cancer Institute Division of Cancer Prevention","doi-asserted-by":"publisher","award":["U01 CA281902"],"award-info":[{"award-number":["U01 CA281902"]}],"id":[{"id":"10.13039\/100007316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007316","name":"National Cancer Institute Division of Cancer Prevention","doi-asserted-by":"publisher","award":["U01 CA278923"],"award-info":[{"award-number":["U01 CA278923"]}],"id":[{"id":"10.13039\/100007316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007316","name":"National Cancer Institute Division of Cancer Prevention","doi-asserted-by":"publisher","award":["R01 CA186241"],"award-info":[{"award-number":["R01 CA186241"]}],"id":[{"id":"10.13039\/100007316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001006","name":"Breast Cancer Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.canlet.2025.218009","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:32:48Z","timestamp":1756945968000},"page":"218009","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Nuclear cGAS mediated replication stress and mitotic catastrophe can overcome gemcitabine resistance"],"prefix":"10.1016","volume":"633","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6594-6364","authenticated-orcid":false,"given":"Soon Young","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7552-4448","authenticated-orcid":false,"given":"Kang Jin","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Poire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9308-4786","authenticated-orcid":false,"given":"Bo Young","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7861-6759","authenticated-orcid":false,"given":"Tugba Y.","family":"Ozmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Rames","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0566-9585","authenticated-orcid":false,"given":"Isabel A.","family":"English","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan R.","family":"Brody","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalie C.","family":"Sears","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0144-9614","authenticated-orcid":false,"given":"Gordon B.","family":"Mills","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2025.218009_bib1","first-page":"7","article-title":"Cancer statistics","volume":"71","author":"Siegel","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.canlet.2025.218009_bib2","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1056\/NEJMoa1011923","article-title":"FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer","volume":"364","author":"Conroy","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.canlet.2025.218009_bib3","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1056\/NEJMoa1304369","article-title":"Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine","volume":"369","author":"Von Hoff","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.canlet.2025.218009_bib4","doi-asserted-by":"crossref","first-page":"146","DOI":"10.2174\/1574892818666230327134746","article-title":"Chlorogenic acid inhibits proliferation, migration and invasion of pancreatic cancer cells via AKT\/GSK-3beta\/beta-catenin signaling pathway","volume":"19","author":"Chen","year":"2024","journal-title":"Recent Pat. Anticancer Drug Discov."},{"key":"10.1016\/j.canlet.2025.218009_bib5","doi-asserted-by":"crossref","first-page":"8360","DOI":"10.18632\/oncotarget.7073","article-title":"Toward targeted therapy in chemotherapy-resistant pancreatic cancer with a smart triptolide nanomedicine","volume":"7","author":"Wang","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.canlet.2025.218009_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2024.101079","article-title":"TRIM29 facilitates gemcitabine resistance via MEK\/ERK pathway and is modulated by circRPS29\/miR-770-5p axis in PDAC","volume":"74","author":"Huang","year":"2024","journal-title":"Drug Resist. Updates"},{"key":"10.1016\/j.canlet.2025.218009_bib7","first-page":"274","article-title":"Methylation of FAM110C is a synthetic lethal marker for ATR\/CHK1 inhibitors in pancreatic cancer","volume":"12","author":"Liu","year":"2024","journal-title":"J Transl Int Med"},{"key":"10.1016\/j.canlet.2025.218009_bib8","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1038\/onc.2014.155","article-title":"Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies","volume":"34","author":"Aye","year":"2015","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2025.218009_bib9","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1021\/ar4000407","article-title":"Reversible, long-range radical transfer in E. coli class Ia ribonucleotide reductase","volume":"46","author":"Minnihan","year":"2013","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.canlet.2025.218009_bib10","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.cell.2011.03.044","article-title":"Nucleotide deficiency promotes genomic instability in early stages of cancer development","volume":"145","author":"Bester","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2025.218009_bib11","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/nature11935","article-title":"Replication stress links structural and numerical cancer chromosomal instability","volume":"494","author":"Burrell","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2025.218009_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111919","article-title":"Pristimerin synergizes with gemcitabine through abrogating Chk1\/53BP1-mediated DNA repair in pancreatic cancer cells","volume":"147","author":"Jiang","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.canlet.2025.218009_bib13","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/nrm.2017.67","article-title":"The essential kinase ATR: ensuring faithful duplication of a challenging genome","volume":"18","author":"Saldivar","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.canlet.2025.218009_bib14","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1126\/science.aap9346","article-title":"An intrinsic S\/G(2) checkpoint enforced by ATR","volume":"361","author":"Saldivar","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.canlet.2025.218009_bib15","doi-asserted-by":"crossref","first-page":"3762","DOI":"10.1158\/0008-5472.CAN-18-2480","article-title":"Differential activity of ATR and WEE1 inhibitors in a highly sensitive subpopulation of DLBCL linked to replication stress","volume":"79","author":"Young","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2025.218009_bib16","doi-asserted-by":"crossref","first-page":"13660","DOI":"10.1073\/pnas.1007856107","article-title":"Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling","volume":"107","author":"Choi","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.canlet.2025.218009_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021424","article-title":"DNA-PK-dependent RPA2 hyperphosphorylation facilitates DNA repair and suppresses sister chromatid exchange","volume":"6","author":"Liaw","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.canlet.2025.218009_bib18","doi-asserted-by":"crossref","first-page":"4070","DOI":"10.1242\/jcs.053702","article-title":"Human RPA phosphorylation by ATR stimulates DNA synthesis and prevents ssDNA accumulation during DNA-replication stress","volume":"122","author":"Vassin","year":"2009","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.canlet.2025.218009_bib19","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/cr.2014.147","article-title":"RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response","volume":"25","author":"Marechal","year":"2015","journal-title":"Cell Res."},{"key":"10.1016\/j.canlet.2025.218009_bib20","doi-asserted-by":"crossref","first-page":"39517","DOI":"10.1074\/jbc.M605121200","article-title":"RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint","volume":"281","author":"Olson","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2025.218009_bib21","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.cell.2013.10.043","article-title":"ATR prohibits replication catastrophe by preventing global exhaustion of RPA","volume":"155","author":"Toledo","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2025.218009_bib22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cell.2010.11.055","article-title":"Massive genomic rearrangement acquired in a single catastrophic event during cancer development","volume":"144","author":"Stephens","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2025.218009_bib23","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1126\/science.1232458","article-title":"Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway","volume":"339","author":"Sun","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.canlet.2025.218009_bib24","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1126\/science.1229963","article-title":"Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA","volume":"339","author":"Wu","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.canlet.2025.218009_bib25","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nature23470","article-title":"Mitotic progression following DNA damage enables pattern recognition within micronuclei","volume":"548","author":"Harding","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2025.218009_bib26","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41586-018-0629-6","article-title":"Nuclear cGAS suppresses DNA repair and promotes tumorigenesis","volume":"563","author":"Liu","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2025.218009_bib27","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41421-020-0162-2","article-title":"Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis","volume":"6","author":"Zhong","year":"2020","journal-title":"Cell Discov"},{"key":"10.1016\/j.canlet.2025.218009_bib28","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/s41586-020-2748-0","article-title":"Structural basis for sequestration and autoinhibition of cGAS by chromatin","volume":"587","author":"Michalski","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2025.218009_bib29","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abb8941","article-title":"cGAS suppresses genomic instability as a decelerator of replication forks","volume":"6","author":"Chen","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.canlet.2025.218009_bib30","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.4161\/cbt.21093","article-title":"The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy","volume":"13","author":"Prevo","year":"2012","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.canlet.2025.218009_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2012.181","article-title":"Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation","volume":"3","author":"Fokas","year":"2012","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.canlet.2025.218009_bib32","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.3892\/or.2017.5580","article-title":"Inhibition of ATR potentiates the cytotoxic effect of gemcitabine on pancreatic cancer cells through enhancement of DNA damage and abrogation of ribonucleotide reductase induction by gemcitabine","volume":"37","author":"Liu","year":"2017","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.canlet.2025.218009_bib33","doi-asserted-by":"crossref","first-page":"104","DOI":"10.4161\/cc.6.1.3699","article-title":"Pharmacological abrogation of S-phase checkpoint enhances the anti-tumor activity of gemcitabine in vivo","volume":"6","author":"Matthews","year":"2007","journal-title":"Cell Cycle"},{"key":"10.1016\/j.canlet.2025.218009_bib34","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.1158\/0008-5472.CAN-14-3347","article-title":"CHK1 inhibition synergizes with gemcitabine initially by destabilizing the DNA replication apparatus","volume":"75","author":"Koh","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2025.218009_bib35","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1038\/s41467-017-01967-6","article-title":"MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance","volume":"8","author":"Farrell","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2025.218009_bib36","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1158\/0008-5472.CAN-09-1947","article-title":"Drug combination studies and their synergy quantification using the Chou-Talalay method","volume":"70","author":"Chou","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2025.218009_bib37","first-page":"13","article-title":"Cancer drug resistance: targeting proliferation or programmed cell death","author":"Sazonova","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.canlet.2025.218009_bib38","first-page":"915","article-title":"Establishment and characterization of multidrug-resistant gastric cancer cell lines","volume":"30","author":"Zhang","year":"2010","journal-title":"Anticancer Res."},{"key":"10.1016\/j.canlet.2025.218009_bib39","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/bs.mie.2017.03.019","article-title":"DNA fiber analysis: mind the gap","volume":"591","author":"Quinet","year":"2017","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.canlet.2025.218009_bib40","doi-asserted-by":"crossref","first-page":"5806","DOI":"10.1128\/MCB.02278-06","article-title":"The intra-S-phase checkpoint affects both DNA replication initiation and elongation: single-cell and -DNA fiber analyses","volume":"27","author":"Seiler","year":"2007","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.canlet.2025.218009_bib41","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41571-018-0114-z","article-title":"State-of-the-art strategies for targeting the DNA damage response in cancer","volume":"16","author":"Pilie","year":"2019","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.canlet.2025.218009_bib42","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/nrm2450","article-title":"ATR: an essential regulator of genome integrity","volume":"9","author":"Cimprich","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.canlet.2025.218009_bib43","doi-asserted-by":"crossref","first-page":"5723","DOI":"10.1158\/0008-5472.CAN-19-0960","article-title":"Deoxycytidine release from pancreatic stellate cells promotes gemcitabine resistance","volume":"79","author":"Dalin","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2025.218009_bib44","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/35048096","article-title":"Mitotic kinases as regulators of cell division and its checkpoints","volume":"2","author":"Nigg","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.canlet.2025.218009_bib45","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1128\/MCB.22.3.874-885.2002","article-title":"Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases","volume":"22","author":"Crosio","year":"2002","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.canlet.2025.218009_bib46","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1054\/drup.2001.0213","article-title":"If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells","volume":"4","author":"Roninson","year":"2001","journal-title":"Drug Resist. Updates"},{"key":"10.1016\/j.canlet.2025.218009_bib47","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/onc.2008.369","article-title":"Generation of an indestructible cyclin B1 by caspase-6-dependent cleavage during mitotic catastrophe","volume":"28","author":"Chan","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2025.218009_bib48","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1242\/jcs.081612","article-title":"Chromosomal breaks during mitotic catastrophe trigger gammaH2AX-ATM-p53-mediated apoptosis","volume":"124","author":"Imreh","year":"2011","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.canlet.2025.218009_bib49","doi-asserted-by":"crossref","first-page":"12741","DOI":"10.18632\/oncotarget.14405","article-title":"Mitotic catastrophe and cell cycle arrest are alternative cell death pathways executed by bortezomib in rituximab resistant B-cell lymphoma cells","volume":"8","author":"Gu","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.canlet.2025.218009_bib50","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1038\/cddis.2010.6","article-title":"An automated fluorescence videomicroscopy assay for the detection of mitotic catastrophe","volume":"1","author":"Rello-Varona","year":"2010","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.canlet.2025.218009_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20051229","article-title":"Mitotic catastrophe induced in HeLa tumor cells by photodynamic therapy with methyl-aminolevulinate","volume":"20","author":"Mascaraque","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.canlet.2025.218009_bib52","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/ncb3586","article-title":"Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence","volume":"19","author":"Gluck","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.canlet.2025.218009_bib53","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1093\/nar\/gkac079","article-title":"NBS1-CtIP-mediated DNA end resection suppresses cGAS binding to micronuclei","volume":"50","author":"Abdisalaam","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.canlet.2025.218009_bib54","doi-asserted-by":"crossref","first-page":"3798","DOI":"10.1016\/j.celrep.2019.03.049","article-title":"The N-Terminal domain of cGAS determines preferential association with centromeric DNA and innate immune activation in the nucleus","volume":"26","author":"Gentili","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.canlet.2025.218009_bib55","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.167270","article-title":"The proto-oncogene SRC phosphorylates cGAS to inhibit an antitumor immune response","volume":"8","author":"Dunker","year":"2023","journal-title":"JCI Insight"},{"key":"10.1016\/j.canlet.2025.218009_bib56","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s12943-019-1100-5","article-title":"MRE11-RAD50-NBS1 complex alterations and DNA damage response: implications for cancer treatment","volume":"18","author":"Bian","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.canlet.2025.218009_bib57","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1128\/MCB.01131-08","article-title":"Nuclear export of NBN is required for normal cellular responses to radiation","volume":"29","author":"Vissinga","year":"2009","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.canlet.2025.218009_bib58","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/nature03442","article-title":"Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage","volume":"434","author":"Falck","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2025.218009_bib59","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.molcel.2013.11.003","article-title":"DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities","volume":"53","author":"Shibata","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.canlet.2025.218009_bib60","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41698-022-00298-0","article-title":"Targeting Mre11 overcomes platinum resistance and induces synthetic lethality in XRCC1 deficient epithelial ovarian cancers","volume":"6","author":"Alblihy","year":"2022","journal-title":"npj Precis. Oncol."},{"key":"10.1016\/j.canlet.2025.218009_bib61","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nchembio.63","article-title":"A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex","volume":"4","author":"Dupre","year":"2008","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.canlet.2025.218009_bib62","doi-asserted-by":"crossref","first-page":"5574","DOI":"10.1038\/s41467-021-25904-w","article-title":"A replication stress biomarker is associated with response to gemcitabine versus combined gemcitabine and ATR inhibitor therapy in ovarian cancer","volume":"12","author":"Konstantinopoulos","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2025.218009_bib63","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1053\/j.gastro.2020.09.043","article-title":"Targeting DNA damage response and replication stress in pancreatic cancer","volume":"160","author":"Dreyer","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.canlet.2025.218009_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.108169","article-title":"Replicative stress in gastroesophageal cancer is associated with chromosomal instability and sensitivity to DNA damage response inhibitors","volume":"26","author":"Sahgal","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.canlet.2025.218009_bib65","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/s41586-020-03114-6","article-title":"Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition","volume":"590","author":"Cohen-Sharir","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2025.218009_bib66","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0266476","article-title":"Ataxia telangiectasia and Rad3-related inhibition by AZD6738 enhances gemcitabine-induced cytotoxic effects in bladder cancer cells","volume":"17","author":"Isono","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.canlet.2025.218009_bib67","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1158\/1535-7163.MCT-18-0010","article-title":"The ATR inhibitor AZD6738 synergizes with gemcitabine in vitro and in vivo to induce pancreatic ductal adenocarcinoma regression","volume":"17","author":"Wallez","year":"2018","journal-title":"Mol. Cancer Therapeut."},{"key":"10.1016\/j.canlet.2025.218009_bib68","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1038\/emboj.2010.112","article-title":"Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest","volume":"29","author":"Harley","year":"2010","journal-title":"EMBO J."},{"key":"10.1016\/j.canlet.2025.218009_bib69","doi-asserted-by":"crossref","first-page":"4362","DOI":"10.1038\/sj.onc.1207572","article-title":"Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy","volume":"23","author":"Castedo","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2025.218009_bib70","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1038\/sj.onc.1207528","article-title":"Cell death by mitotic catastrophe: a molecular definition","volume":"23","author":"Castedo","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2025.218009_bib71","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13062-021-00313-7","article-title":"A link between mitotic defects and mitotic catastrophe: detection and cell fate","volume":"16","author":"Sazonova","year":"2021","journal-title":"Biol. Direct"},{"key":"10.1016\/j.canlet.2025.218009_bib72","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1076784","article-title":"cGAS in nucleus: the link between immune response and DNA damage repair","volume":"13","author":"Song","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.canlet.2025.218009_bib73","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/s13238-021-00869-0","article-title":"Nuclear cGAS: sequestration and beyond","volume":"13","author":"Bai","year":"2022","journal-title":"Protein Cell"},{"key":"10.1016\/j.canlet.2025.218009_bib74","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2019102718","article-title":"Chromatin-bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death","volume":"38","author":"Jiang","year":"2019","journal-title":"EMBO J."},{"key":"10.1016\/j.canlet.2025.218009_bib75","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nature23449","article-title":"cGAS surveillance of micronuclei links genome instability to innate immunity","volume":"548","author":"Mackenzie","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2025.218009_bib76","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.yexcr.2009.02.010","article-title":"Nuclear localization of Src-family tyrosine kinases is required for growth factor-induced euchromatinization","volume":"315","author":"Takahashi","year":"2009","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.canlet.2025.218009_bib77","doi-asserted-by":"crossref","first-page":"12313","DOI":"10.1074\/jbc.M113.533752","article-title":"Src family kinases promote silencing of ATR-Chk1 signaling in termination of DNA damage checkpoint","volume":"289","author":"Fukumoto","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2025.218009_bib78","doi-asserted-by":"crossref","first-page":"20739","DOI":"10.1016\/S0021-9258(17)32054-9","article-title":"Activation of src-like p56\/p53lyn tyrosine kinase by ionizing radiation","volume":"269","author":"Kharbanda","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2025.218009_bib79","doi-asserted-by":"crossref","first-page":"R455","DOI":"10.1016\/j.cub.2008.03.040","article-title":"The MRN complex","volume":"18","author":"Rupnik","year":"2008","journal-title":"Curr. Biol."},{"key":"10.1016\/j.canlet.2025.218009_bib80","doi-asserted-by":"crossref","first-page":"4815","DOI":"10.1093\/nar\/gkf612","article-title":"Functional analysis of FHA and BRCT domains of NBS1 in chromatin association and DNA damage responses","volume":"30","author":"Zhao","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.canlet.2025.218009_bib81","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1146\/annurev-biochem-062917-012415","article-title":"The MRE11-RAD50-NBS1 complex conducts the orchestration of damage signaling and outcomes to stress in DNA replication and repair","volume":"87","author":"Syed","year":"2018","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.canlet.2025.218009_bib82","doi-asserted-by":"crossref","first-page":"5678","DOI":"10.1093\/nar\/gkn550","article-title":"Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin","volume":"36","author":"Kinner","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.canlet.2025.218009_bib83","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1002\/embj.201386064","article-title":"Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks","volume":"33","author":"Wang","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.canlet.2025.218009_bib84","doi-asserted-by":"crossref","first-page":"8967","DOI":"10.1038\/sj.onc.1206136","article-title":"Nijmegen breakage syndrome gene, NBS1, and molecular links to factors for genome stability","volume":"21","author":"Tauchi","year":"2002","journal-title":"Oncogene"}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383525005798?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383525005798?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T21:35:56Z","timestamp":1772832956000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383525005798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":84,"alternative-id":["S0304383525005798"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2025.218009","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nuclear cGAS mediated replication stress and mitotic catastrophe can overcome gemcitabine resistance","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2025.218009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"218009"}}