{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T21:59:55Z","timestamp":1785275995545,"version":"3.55.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"publisher","award":["CA21116"],"award-info":[{"award-number":["CA21116"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010783","name":"Slovak Academy of Sciences","doi-asserted-by":"publisher","award":["NExT-0711"],"award-info":[{"award-number":["NExT-0711"]}],"id":[{"id":"10.13039\/100010783","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PT23\/00098"],"award-info":[{"award-number":["PT23\/00098"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003448","name":"General Secretariat for Research and Innovation","doi-asserted-by":"publisher","award":["\\u03A49\\u0395\\u0420\\u04103-00012"],"award-info":[{"award-number":["\\u03A49\\u0395\\u0420\\u04103-00012"]}],"id":[{"id":"10.13039\/501100003448","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010684","name":"EU Framework Programme for Research and Innovation Spreading Excellence and Widening Participation","doi-asserted-by":"publisher","award":["857381\/VISION"],"award-info":[{"award-number":["857381\/VISION"]}],"id":[{"id":"10.13039\/100010684","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017519","name":"Werner Otto Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017519","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006408","name":"Ministry of National Education and Religious Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006408","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010676","name":"EU Framework Programme for Research and Innovation Societal Challenges","doi-asserted-by":"publisher","award":["1.1.1.5\/ERANET\/20\/03"],"award-info":[{"award-number":["1.1.1.5\/ERANET\/20\/03"]}],"id":[{"id":"10.13039\/100010676","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003446","name":"Hellenic Republic Ministry of Education and Religious Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003446","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005357","name":"Slovak Research and Development Agency","doi-asserted-by":"publisher","award":["APVV-20-0143"],"award-info":[{"award-number":["APVV-20-0143"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005357","name":"Slovak Research and Development Agency","doi-asserted-by":"publisher","award":["APVV-21-0197"],"award-info":[{"award-number":["APVV-21-0197"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.canlet.2025.218033","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T12:20:42Z","timestamp":1758025242000},"page":"218033","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Aurora kinase A inhibition as a synthetic lethality strategy in ARID1A-mutated gastroenteropancreatic neuroendocrine carcinoma"],"prefix":"10.1016","volume":"634","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0931-0032","authenticated-orcid":false,"given":"Maria","family":"Urbanova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Viol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Ruiz-Ca\u00f1as","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7804-1472","authenticated-orcid":false,"given":"Efthymios","family":"Koniaris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5017-5688","authenticated-orcid":false,"given":"Rihards","family":"Saksis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Batres-Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Earl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8930-5383","authenticated-orcid":false,"given":"Agapi","family":"Kataki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2466-9126","authenticated-orcid":false,"given":"Verona","family":"Buocikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Burikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Cihova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Rojikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Makovicky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslava","family":"Matuskova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8119-5441","authenticated-orcid":false,"given":"Yvonne","family":"Kohl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Riedmayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0716-9565","authenticated-orcid":false,"given":"Marianna","family":"Makova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ladislav","family":"Baciak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Gogola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2161-0433","authenticated-orcid":false,"given":"Olesja","family":"Rogoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9368-5210","authenticated-orcid":false,"given":"Vita","family":"Rovite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Bruno","family":"Sainz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4906-5652","authenticated-orcid":false,"given":"Bozena","family":"Smolkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joerg","family":"Schrader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2025.218033_bib1","first-page":"471","article-title":"Gastroenteropancreatic neuroendocrine tumors","volume":"68","author":"Cives","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.canlet.2025.218033_bib2","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1002\/cncr.28721","article-title":"Gastroenteropancreatic high-grade neuroendocrine carcinoma","volume":"120","author":"Sorbye","year":"2014","journal-title":"Cancer"},{"key":"10.1016\/j.canlet.2025.218033_bib3","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1159\/000493318","article-title":"Unmet needs in high-grade gastroenteropancreatic neuroendocrine neoplasms (WHO G3)","volume":"108","author":"Sorbye","year":"2019","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.canlet.2025.218033_bib4","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1007\/s10555-023-10121-2","article-title":"Potent molecular-targeted therapies for gastro-entero-pancreatic neuroendocrine carcinoma","volume":"42","author":"Ooki","year":"2023","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.canlet.2025.218033_bib5","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1007\/s13402-022-00727-z","article-title":"Novel preclinical gastroenteropancreatic neuroendocrine neoplasia models demonstrate the feasibility of mutation-based targeted therapy","volume":"45","author":"Viol","year":"2022","journal-title":"Cell. Oncol."},{"key":"10.1016\/j.canlet.2025.218033_bib6","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1002\/cac2.12372","article-title":"Genomic characterization reveals distinct mutation landscapes and therapeutic implications in neuroendocrine carcinomas of the gastrointestinal tract","volume":"42","author":"Wu","year":"2022","journal-title":"Cancer Commun."},{"key":"10.1016\/j.canlet.2025.218033_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/ERC-21-0152","article-title":"The molecular characteristics of high-grade gastroenteropancreatic neuroendocrine neoplasms","volume":"29","author":"Venizelos","year":"2021","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.canlet.2025.218033_bib8","doi-asserted-by":"crossref","first-page":"5943","DOI":"10.1158\/1078-0432.CCR-20-1804","article-title":"Comprehensive genomic profiling of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs)","volume":"26","author":"Puccini","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2025.218033_bib9","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1158\/1078-0432.CCR-21-3058","article-title":"Expanding therapeutic opportunities for extrapulmonary neuroendocrine carcinoma","volume":"28","author":"Frizziero","year":"2022","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2025.218033_bib10","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1158\/2159-8290.CD-21-0669","article-title":"Comprehensive genomic profiling of neuroendocrine carcinomas of the gastrointestinal system","volume":"12","author":"Yachida","year":"2022","journal-title":"Cancer Discov."},{"key":"10.1016\/j.canlet.2025.218033_bib11","first-page":"5952","article-title":"Targeting the alterations of ARID1A in pancreatic cancer: tumorigenesis, prediction of treatment, and prognostic value","volume":"14","author":"Li","year":"2022","journal-title":"Am. J .Transl .Res."},{"key":"10.1016\/j.canlet.2025.218033_bib12","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2019-000438","article-title":"ARID1A alterations function as a biomarker for longer progression-free survival after anti-PD-1\/PD-L1 immunotherapy","volume":"8","author":"Okamura","year":"2020","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.canlet.2025.218033_bib13","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12929-022-00856-5","article-title":"Treating ARID1A mutated cancers by harnessing synthetic lethality and DNA damage response","volume":"29","author":"Mandal","year":"2022","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.canlet.2025.218033_bib14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12943-020-01305-3","article-title":"Targeting AURKA in cancer: molecular mechanisms and opportunities for cancer therapy","volume":"20","author":"Du","year":"2021","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.canlet.2025.218033_bib15","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/1440-1681.12571","article-title":"An update on the pharmacokinetics and pharmacodynamics of alisertib, a selective Aurora kinase A inhibitor","volume":"43","author":"Durlacher","year":"2016","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.canlet.2025.218033_bib16","doi-asserted-by":"crossref","first-page":"4513","DOI":"10.1128\/MCB.02364-06","article-title":"MLN8054, a small-molecule inhibitor of Aurora A, causes spindle pole and chromosome congression defects leading to aneuploidy","volume":"27","author":"Hoar","year":"2007","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.canlet.2025.218033_bib17","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1007\/s12672-024-01433-y","article-title":"AURKA inhibition shows promise as a therapeutic strategy for ARID1A-mutant colorectal cancer","volume":"15","author":"Qin","year":"2024","journal-title":"Discov. Oncol."},{"key":"10.1016\/j.canlet.2025.218033_bib18","doi-asserted-by":"crossref","first-page":"41","DOI":"10.36401\/JIPO-22-37","article-title":"Therapeutic role of synthetic lethality in ARID1A-Deficient malignancies","volume":"7","author":"Hein","year":"2024","journal-title":"J .Immunother .Precis .Oncol."},{"key":"10.1016\/j.canlet.2025.218033_bib19","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1186\/s12935-023-03154-8","article-title":"The effects of ARID1A mutation in gastric cancer and its significance for treatment","volume":"23","author":"Lu","year":"2023","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.canlet.2025.218033_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2021.102287","article-title":"Targeting ARID1A mutations in cancer","volume":"100","author":"Mullen","year":"2021","journal-title":"Cancer Treat Rev."},{"key":"10.1016\/j.canlet.2025.218033_bib21","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.1038\/s41467-018-05694-4","article-title":"Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells","volume":"9","author":"Wu","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2025.218033_bib22","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.canlet.2025.218033_bib23","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1002\/hep.24108","article-title":"Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells","volume":"53","author":"Schrader","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.canlet.2025.218033_bib24","doi-asserted-by":"crossref","first-page":"5415","DOI":"10.3390\/cancers15225415","article-title":"A comparative analysis of orthotopic and subcutaneous pancreatic tumour models: tumour microenvironment and drug delivery","volume":"15","author":"Fernandez","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.canlet.2025.218033_bib25","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.trecan.2021.06.010","article-title":"Modeling metastasis in mice: a closer look","volume":"7","author":"Giacobbe","year":"2021","journal-title":"Trends Cancer"},{"key":"10.1016\/j.canlet.2025.218033_bib26","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1002\/cncr.27801","article-title":"The combination of alisertib, an investigational Aurora kinase A inhibitor, and docetaxel promotes cell death and reduces tumor growth in preclinical cell models of upper gastrointestinal adenocarcinomas","volume":"119","author":"Sehdev","year":"2013","journal-title":"Cancer"},{"key":"10.1016\/j.canlet.2025.218033_bib27","doi-asserted-by":"crossref","first-page":"3953","DOI":"10.2147\/OTT.S228656","article-title":"Inhibition of Aurora kinase A by alisertib reduces cell proliferation and induces apoptosis and autophagy in HuH-6 human hepatoblastoma cells","volume":"13","author":"Tan","year":"2020","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.canlet.2025.218033_bib28","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3892\/mmr.2016.5249","article-title":"Alisertib induces apoptosis and autophagy through targeting the AKT\/mTOR\/AMPK\/p38 pathway in leukemic cells","volume":"14","author":"Fu","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.canlet.2025.218033_bib29","first-page":"845","article-title":"Alisertib induces G(2)\/M arrest, apoptosis, and autophagy via PI3K\/Akt\/mTOR- and p38 MAPK-Mediated pathways in human glioblastoma cells","volume":"9","author":"Liu","year":"2017","journal-title":"Am. J .Transl .Res."},{"key":"10.1016\/j.canlet.2025.218033_bib30","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.omtn.2018.08.014","article-title":"A novel Aurora-A inhibitor (MLN8237) synergistically enhances the antitumor activity of sorafenib in hepatocellular carcinoma","volume":"13","author":"Zhang","year":"2018","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.canlet.2025.218033_bib31","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1158\/1535-7163.MCT-12-1232","article-title":"Response to MLN8237 in pancreatic cancer is not dependent on RalA phosphorylation","volume":"13","author":"Neel","year":"2014","journal-title":"Mol. Cancer Therapeut."},{"key":"10.1016\/j.canlet.2025.218033_bib32","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1053\/j.gastro.2018.10.030","article-title":"Inhibition of AURKA reduces proliferation and survival of gastrointestinal cancer cells with activated KRAS by preventing activation of RPS6KB1","volume":"156","author":"Wang-Bishop","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.canlet.2025.218033_bib33","doi-asserted-by":"crossref","first-page":"4633","DOI":"10.1158\/1078-0432.CCR-19-3498","article-title":"Preclinical and dose-finding phase I trial results of combined treatment with a TORC1\/2 inhibitor (TAK-228) and Aurora A kinase inhibitor (alisertib) in solid tumors","volume":"26","author":"Davis","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2025.218033_bib34","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1001\/jamaoncol.2022.7949","article-title":"Evaluation of alisertib alone or combined with fulvestrant in patients with endocrine-resistant advanced breast cancer: the phase 2 TBCRC041 randomized clinical trial","volume":"9","author":"Haddad","year":"2023","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.canlet.2025.218033_bib35","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1158\/2159-8290.CD-14-0849","article-title":"ARID1A deficiency impairs the DNA damage checkpoint and sensitizes cells to PARP inhibitors","volume":"5","author":"Shen","year":"2015","journal-title":"Cancer Discov."},{"key":"10.1016\/j.canlet.2025.218033_bib36","doi-asserted-by":"crossref","first-page":"5295","DOI":"10.18632\/oncotarget.2092","article-title":"Loss of ARID1A expression sensitizes cancer cells to PI3K- and AKT-Inhibition","volume":"5","author":"Samartzis","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.canlet.2025.218033_bib37","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.70394","article-title":"Arid1a deficiency sensitises pancreatic cancer to fatty acid synthase inhibition","volume":"15","author":"Kuo","year":"2025","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.canlet.2025.218033_bib38","doi-asserted-by":"crossref","first-page":"4464","DOI":"10.1073\/pnas.1600007113","article-title":"Identification of tumorigenic cells and therapeutic targets in pancreatic neuroendocrine tumors","volume":"113","author":"Krampitz","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.canlet.2025.218033_bib39","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1158\/1535-7163.MCT-17-1204","article-title":"A patient-derived xenograft model of pancreatic neuroendocrine tumors identifies sapanisertib as a possible new treatment for everolimus-resistant tumors","volume":"17","author":"Chamberlain","year":"2018","journal-title":"Mol. Cancer Therapeut."},{"key":"10.1016\/j.canlet.2025.218033_bib40","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-90049-1","article-title":"Patient-derived tumor xenograft and organoid models established from resected pancreatic, duodenal and biliary cancers","volume":"11","author":"Pham","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.canlet.2025.218033_bib41","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s12022-016-9429-4","article-title":"Establishment and characterization of a human neuroendocrine tumor xenograft","volume":"27","author":"Yang","year":"2016","journal-title":"Endocr. Pathol."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383525006032?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383525006032?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T21:20:50Z","timestamp":1785273650000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383525006032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":41,"alternative-id":["S0304383525006032"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2025.218033","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aurora kinase A inhibition as a synthetic lethality strategy in ARID1A-mutated gastroenteropancreatic neuroendocrine carcinoma","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2025.218033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"218033"}}