{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:53:38Z","timestamp":1786985618303,"version":"build-2736575974"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFA1107402"],"award-info":[{"award-number":["2024YFA1107402"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070008"],"award-info":[{"award-number":["82070008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32271201"],"award-info":[{"award-number":["32271201"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32471206"],"award-info":[{"award-number":["32471206"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32070724"],"award-info":[{"award-number":["32070724"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010104","name":"Tianjin Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010104","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004517","name":"Tianjin University","doi-asserted-by":"publisher","award":["C20240705-1"],"award-info":[{"award-number":["C20240705-1"]}],"id":[{"id":"10.13039\/501100004517","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","award":["24JCZDJC00460"],"award-info":[{"award-number":["24JCZDJC00460"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.canlet.2025.218037","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T07:11:19Z","timestamp":1758784279000},"page":"218037","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Oncoprotein SND1-enriched exosomes facilitate melanoma lung metastasis by regulating CD47-SIRP\u03b1-mediated macrophage reprogramming"],"prefix":"10.1016","volume":"634","author":[{"given":"Yuankun","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongshuai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixiang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingbiao","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingjie","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihui","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5301-7610","authenticated-orcid":false,"given":"Jie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2025.218037_bib1","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/j.cell.2023.03.003","article-title":"Metastasis","volume":"186","author":"Gerstberger","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2025.218037_bib2","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/s41572-025-00642-1","article-title":"Lung metastases","volume":"11","author":"Zullo","year":"2025","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.canlet.2025.218037_bib3","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s12943-025-02318-6","article-title":"Lung-specific metastasis: the coevolution of tumor cells and lung microenvironment","volume":"24","author":"Xiao","year":"2025","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.canlet.2025.218037_bib4","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1016\/j.ymthe.2022.01.046","article-title":"Role of exosomal non-coding RNAs from tumor cells and tumor-associated macrophages in the tumor microenvironment","volume":"30","author":"Xu","year":"2022","journal-title":"Mol. Ther."},{"key":"10.1016\/j.canlet.2025.218037_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217735","article-title":"Extracellular vesicles: hermes between cancers and lymph nodes","volume":"623","author":"Cao","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2025.218037_bib6","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1002\/cac2.12605","article-title":"Local TSH\/TSHR signaling promotes CD8(+) T cell exhaustion and immune evasion in colorectal carcinoma","volume":"44","author":"Zeng","year":"2024","journal-title":"Cancer Commun."},{"key":"10.1016\/j.canlet.2025.218037_bib7","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/s41419-024-07020-x","article-title":"LncRNA HAGLROS promotes breast cancer evolution through miR-135b-3p\/COL10A1 axis and exosome-mediated macrophage M2 polarization","volume":"15","author":"Meng","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.canlet.2025.218037_bib8","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/s41419-023-06007-4","article-title":"Exosomal PGAM1 promotes prostate cancer angiogenesis and metastasis by interacting with ACTG1","volume":"14","author":"Luo","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.canlet.2025.218037_bib9","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s11658-024-00612-7","article-title":"LncRNA TRPM2-AS promotes endometrial carcinoma progression and angiogenesis via targeting miR-497-5p\/SPP1 axis","volume":"29","author":"Ma","year":"2024","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.canlet.2025.218037_bib10","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.7150\/thno.79250","article-title":"Tumor-derived Cav-1 promotes pre-metastatic niche formation and lung metastasis in breast cancer","volume":"13","author":"Wang","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.canlet.2025.218037_bib11","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202006049","article-title":"PINK1 drives production of mtDNA-containing extracellular vesicles to promote invasiveness","volume":"220","author":"Rabas","year":"2021","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.canlet.2025.218037_bib12","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.tcb.2023.06.006","article-title":"The ins-and-outs of exosome biogenesis, secretion, and internalization","volume":"34","author":"Arya","year":"2024","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.canlet.2025.218037_bib13","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s12943-022-01671-0","article-title":"Exosome biogenesis: machinery, regulation, and therapeutic implications in cancer","volume":"21","author":"Han","year":"2022","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.canlet.2025.218037_bib14","doi-asserted-by":"crossref","first-page":"4078","DOI":"10.1038\/s41467-022-31713-6","article-title":"HRS phosphorylation drives immunosuppressive exosome secretion and restricts CD8(+) T-cell infiltration into tumors","volume":"13","author":"Guan","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2025.218037_bib15","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.devcel.2023.01.006","article-title":"GPR143 controls ESCRT-Dependent exosome biogenesis and promotes cancer metastasis","volume":"58","author":"Lee","year":"2023","journal-title":"Dev. Cell"},{"key":"10.1016\/j.canlet.2025.218037_bib16","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s41590-021-00899-0","article-title":"Extracellular vesicles in immunomodulation and tumor progression","volume":"22","author":"Marar","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.canlet.2025.218037_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217636","article-title":"Lactate accumulation drives hepatocellular carcinoma metastasis through facilitating tumor-derived exosome biogenesis by Rab7A lactylation","volume":"627","author":"Jiang","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2025.218037_bib18","article-title":"Chronic stress-induced and tumor derived SP1(+) exosomes polarizing IL-1beta(+) neutrophils to increase lung metastasis of breast cancer","volume":"12","author":"Zhang","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.canlet.2025.218037_bib19","article-title":"Tumor-derived miR-9-5p-loaded EVs regulate cholesterol homeostasis to promote breast cancer liver metastasis in mice","volume":"15","author":"Li","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2025.218037_bib20","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/s41419-024-07191-7","article-title":"PD-L2 of tumor-derived exosomes mediates the immune escape of cancer cells via the impaired T cell function","volume":"15","author":"Liu","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.canlet.2025.218037_bib21","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12943-024-01979-z","article-title":"Exosomal long non-coding RNA TRPM2-AS promotes angiogenesis in gallbladder cancer through interacting with PABPC1 to activate NOTCH1 signaling pathway","volume":"23","author":"He","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.canlet.2025.218037_bib22","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13046-024-02991-3","article-title":"Tumor-derived exosomal ADAM17 promotes pre-metastatic niche formation by enhancing vascular permeability in colorectal cancer","volume":"43","author":"Li","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2025.218037_bib23","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s12943-024-02084-x","article-title":"The role of microRNAs in the gastric cancer tumor microenvironment","volume":"23","author":"Yu","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.canlet.2025.218037_bib24","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s11658-024-00676-5","article-title":"Exosome-derived proteins in gastric cancer progression, drug resistance, and immune response","volume":"29","author":"Wang","year":"2024","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.canlet.2025.218037_bib25","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.devcel.2022.01.002","article-title":"ICAM-1-mediated adhesion is a prerequisite for exosome-induced T cell suppression","volume":"57","author":"Zhang","year":"2022","journal-title":"Dev. Cell"},{"key":"10.1016\/j.canlet.2025.218037_bib26","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/s41586-018-0392-8","article-title":"Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response","volume":"560","author":"Chen","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2025.218037_bib27","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/nm.2753","article-title":"Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET","volume":"18","author":"Peinado","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.canlet.2025.218037_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217596","article-title":"Tumor-derived exosomal LINC01812 induces M2 macrophage polarization to promote perineural invasion in cholangiocarcinoma","volume":"617","author":"Wang","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2025.218037_bib29","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12943-024-01966-4","article-title":"Exosome circATP8A1 induces macrophage M2 polarization by regulating the miR-1-3p\/STAT6 axis to promote gastric cancer progression","volume":"23","author":"Deng","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.canlet.2025.218037_bib30","doi-asserted-by":"crossref","first-page":"848","DOI":"10.7150\/ijbs.91154","article-title":"Tumor-derived exosomal ENO2 modulates polarization of tumor-associated macrophages through reprogramming glycolysis to promote progression of diffuse large B-cell lymphoma","volume":"20","author":"Shao","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.canlet.2025.218037_bib31","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.ccell.2024.04.002","article-title":"A temporal perspective for tumor-associated macrophage identities and functions","volume":"42","author":"Bleriot","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2025.218037_bib32","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/s41392-023-01365-z","article-title":"Emerging phagocytosis checkpoints in cancer immunotherapy","volume":"8","author":"Liu","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.canlet.2025.218037_bib33","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.immuni.2020.04.011","article-title":"The CD47-SIRPalpha immune checkpoint","volume":"52","author":"Logtenberg","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.canlet.2025.218037_bib34","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.drudis.2020.11.003","article-title":"The development of small-molecule inhibitors targeting CD47","volume":"26","author":"Yu","year":"2021","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.canlet.2025.218037_bib35","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/j.chembiol.2020.06.008","article-title":"Macrocyclic peptide-mediated blockade of the CD47-SIRPalpha interaction as a potential cancer immunotherapy","volume":"27","author":"Hazama","year":"2020","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.canlet.2025.218037_bib36","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-000905","article-title":"CD47\/SIRPalpha blocking peptide identification and synergistic effect with irradiation for cancer immunotherapy","volume":"8","author":"Wang","year":"2020","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.canlet.2025.218037_bib37","doi-asserted-by":"crossref","first-page":"4564","DOI":"10.1038\/s41467-025-59621-5","article-title":"USP2 inhibition unleashes CD47-restrained phagocytosis and enhances anti-tumor immunity","volume":"16","author":"Dai","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2025.218037_bib38","article-title":"Oncoprotein SND1 hijacks nascent MHC-I heavy chain to ER-associated degradation, leading to impaired CD8(+) T cell response in tumor","volume":"6","author":"Wang","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.canlet.2025.218037_bib39","doi-asserted-by":"crossref","first-page":"5759","DOI":"10.1111\/febs.16940","article-title":"SND1, a novel co-activator of HIF1alpha, promotes tumor initiation in PyMT-induced breast tumor","volume":"290","author":"Hu","year":"2023","journal-title":"FEBS J."},{"key":"10.1016\/j.canlet.2025.218037_bib40","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1042\/BCJ20230384","article-title":"Loss of the methylarginine reader function of SND1 confers resistance to hepatocellular carcinoma","volume":"480","author":"Wright","year":"2023","journal-title":"Biochem. J."},{"key":"10.1016\/j.canlet.2025.218037_bib41","doi-asserted-by":"crossref","DOI":"10.1051\/vcm\/2023001","article-title":"Friend or Foe? The fascinating Tudor-SN protein","volume":"4","author":"Gao","year":"2023","journal-title":"Vis. Cancer Med."},{"key":"10.1016\/j.canlet.2025.218037_bib42","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abm1140","article-title":"LAMP2A regulates the loading of proteins into exosomes","volume":"8","author":"Ferreira","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.canlet.2025.218037_bib43","article-title":"Hepatic phospholipid remodeling modulates insulin sensitivity and systemic metabolism","volume":"10","author":"Tian","year":"2023","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.canlet.2025.218037_bib44","article-title":"Exosome release delays senescence by disposing of obsolete biomolecules","volume":"10","author":"Zou","year":"2023","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.canlet.2025.218037_bib45","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2019.1703244","article-title":"Inhibiting extracellular vesicles formation and release: a review of EV inhibitors","volume":"9","author":"Catalano","year":"2020","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.canlet.2025.218037_bib46","article-title":"Effect of extracellular vesicles derived from tumor cells on immune evasion","volume":"12","author":"Liu","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.canlet.2025.218037_bib47","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/s13045-021-01197-w","article-title":"Targeting CD47 for cancer immunotherapy","volume":"14","author":"Jiang","year":"2021","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.canlet.2025.218037_bib48","doi-asserted-by":"crossref","DOI":"10.1126\/science.abl7207","article-title":"Aberrant hyperexpression of the RNA binding protein FMRP in tumors mediates immune evasion","volume":"378","author":"Zeng","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.canlet.2025.218037_bib49","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-001341","article-title":"Tumor-associated macrophages: potential therapeutic strategies and future prospects in cancer","volume":"9","author":"Li","year":"2021","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.canlet.2025.218037_bib50","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s43018-025-00909-2","article-title":"Linking macrophage metabolism to function in the tumor microenvironment","volume":"6","author":"Jin","year":"2025","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.canlet.2025.218037_bib51","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1038\/s41467-022-30568-1","article-title":"STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer","volume":"13","author":"Wang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2025.218037_bib52","doi-asserted-by":"crossref","first-page":"5338","DOI":"10.1016\/j.cell.2021.09.019","article-title":"Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment","volume":"184","author":"Lam","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2025.218037_bib53","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/cr.2014.44","article-title":"Double-stranded DNA in exosomes: a novel biomarker in cancer detection","volume":"24","author":"Thakur","year":"2014","journal-title":"Cell Res."},{"key":"10.1016\/j.canlet.2025.218037_bib54","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.ccell.2022.05.006","article-title":"Exercise-induced engagement of the IL-15\/IL-15Ralpha axis promotes anti-tumor immunity in pancreatic cancer","volume":"40","author":"Kurz","year":"2022","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2025.218037_bib55","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.jconrel.2022.03.021","article-title":"Intratumoral delivery of IL-12 and IL-27 mRNA using lipid nanoparticles for cancer immunotherapy","volume":"345","author":"Liu","year":"2022","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.canlet.2025.218037_bib56","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.trecan.2025.04.014","article-title":"Immunocytokines and cytokine neutralization for cancer immunotherapy","volume":"11","author":"Berraondo","year":"2025","journal-title":"Trends Cancer"},{"key":"10.1016\/j.canlet.2025.218037_bib57","article-title":"Engineered extracellular vesicles for cancer therapy","volume":"33","author":"Zhang","year":"2021","journal-title":"Adv. Mater."},{"key":"10.1016\/j.canlet.2025.218037_bib58","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.7150\/thno.52570","article-title":"Engineering exosomes for targeted drug delivery","volume":"11","author":"Liang","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.canlet.2025.218037_bib59","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1016\/j.apsb.2021.01.001","article-title":"The biology, function, and applications of exosomes in cancer","volume":"11","author":"Liu","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.canlet.2025.218037_bib60","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41422-020-00409-1","article-title":"RAB31 marks and controls an ESCRT-independent exosome pathway","volume":"31","author":"Wei","year":"2021","journal-title":"Cell Res."},{"key":"10.1016\/j.canlet.2025.218037_bib61","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.3389\/fimmu.2018.02286","article-title":"Macropinocytosis: new insights into its underappreciated role in innate immune cell surveillance","volume":"9","author":"Canton","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.canlet.2025.218037_bib62","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41590-022-01398-6","article-title":"YTHDF2 orchestrates tumor-associated macrophage reprogramming and controls antitumor immunity through CD8(+) T cells","volume":"24","author":"Ma","year":"2023","journal-title":"Nat. Immunol."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030438352500607X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030438352500607X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T21:20:36Z","timestamp":1785273636000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030438352500607X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":62,"alternative-id":["S030438352500607X"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2025.218037","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oncoprotein SND1-enriched exosomes facilitate melanoma lung metastasis by regulating CD47-SIRP\u03b1-mediated macrophage reprogramming","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2025.218037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"218037"}}