{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:04:51Z","timestamp":1791821091422,"version":"4.3.4"},"reference-count":270,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007927","name":"The University of Oklahoma Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007927","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013030","name":"William and Ella Owens Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.canlet.2025.218076","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T22:49:20Z","timestamp":1760222960000},"page":"218076","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Tumor microenvironment and macroenvironment: A new perspective on holistic oncology"],"prefix":"10.1016","volume":"634","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9034-9825","authenticated-orcid":false,"given":"Qun","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuirong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Bronze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney W.","family":"Houchen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2025.218076_bib1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/s41571-020-0378-y","article-title":"The changing landscape of cancer in the USA - opportunities for advancing prevention and treatment","volume":"17","author":"Islami","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.canlet.2025.218076_bib2","first-page":"243","article-title":"Novel clinical trial designs emerging from the molecular reclassification of cancer","volume":"75","author":"Nikanjam","year":"2025","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.canlet.2025.218076_bib3","first-page":"308","article-title":"Cancer treatment and survivorship statistics, 2025","volume":"75","author":"Wagle","year":"2025","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.canlet.2025.218076_bib4","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.trecan.2024.06.010","article-title":"Mind the gap: why we need to consider teenage and young adult cancers across the research pipeline","volume":"10","author":"Danielson","year":"2024","journal-title":"Trends Cancer"},{"key":"10.1016\/j.canlet.2025.218076_bib5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/526029a","article-title":"Human Genome Project: Twenty-five years of big biology","volume":"526","author":"Green","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2025.218076_bib6","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.annonc.2024.04.005","article-title":"Recommendations for the use of next-generation sequencing (NGS) for patients with advanced cancer in 2024: a report from the ESMO Precision Medicine Working Group","volume":"35","author":"Mosele","year":"2024","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.canlet.2025.218076_bib7","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.annonc.2022.05.522","article-title":"Whole-genome and transcriptome analysis enhances precision cancer treatment options","volume":"33","author":"Pleasance","year":"2022","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.canlet.2025.218076_bib8","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1056\/NEJMoa2402604","article-title":"Neoadjuvant nivolumab and ipilimumab in resectable stage III melanoma","volume":"391","author":"Blank","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.canlet.2025.218076_bib9","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1182\/blood-2017-09-772673","article-title":"Transplant strategies in relapsed\/refractory Hodgkin lymphoma","volume":"131","author":"Shah","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.canlet.2025.218076_bib10","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0140-6736(10)60280-2","article-title":"Gestational trophoblastic disease","volume":"376","author":"Seckl","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.canlet.2025.218076_bib11","doi-asserted-by":"crossref","first-page":"4976","DOI":"10.1097\/JS9.0000000000001586","article-title":"Research hotspots and frontiers of neoadjuvant therapy in triple-negative breast cancer: a bibliometric analysis of publications between 2002 and 2023","volume":"110","author":"Yang","year":"2024","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.canlet.2025.218076_bib12","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1200\/JCO.22.00454","article-title":"Is neoadjuvant chemoradiotherapy beneficial for patients with pancreatic cancer?","volume":"40","author":"Mroczkowski","year":"2022","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.canlet.2025.218076_bib13","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1053\/j.seminoncol.2024.08.003","article-title":"Integrated profile of tumor stage and mutational burden predicts disparate clinical responses to immune checkpoint inhibitors: a risk-benefit study","volume":"51","author":"Zheng","year":"2024","journal-title":"Semin. Oncol."},{"key":"10.1016\/j.canlet.2025.218076_bib14","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.biocel.2014.04.010","article-title":"TRAF6 is upregulated in colon cancer and promotes proliferation of colon cancer cells","volume":"53","author":"Sun","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.canlet.2025.218076_bib15","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1038\/483S2a","article-title":"Cancer: solving an age-old problem","volume":"483","author":"Dunn","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2025.218076_bib16","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1001\/jama.2011.1059","article-title":"Evidence-based medicine in surgery: the importance of both experimental and observational study designs","volume":"306","author":"Merkow","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.canlet.2025.218076_bib17","doi-asserted-by":"crossref","first-page":"e489","DOI":"10.1016\/S1470-2045(24)00264-X","volume":"25","author":"Zumsteg","year":"2024","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.canlet.2025.218076_bib18","doi-asserted-by":"crossref","DOI":"10.6004\/jnccn.2024.7093","article-title":"Prognosis after pathologic complete response to neoadjuvant therapy in early-stage breast cancer: a population-based Study","volume":"23","author":"Boman","year":"2025","journal-title":"J Natl Compr Canc Netw"},{"key":"10.1016\/j.canlet.2025.218076_bib19","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cytogfr.2024.08.006","article-title":"Biomarker discovery in hepatocellular carcinoma (HCC) for personalized treatment and enhanced prognosis","volume":"79","author":"Yu","year":"2024","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.canlet.2025.218076_bib20","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1038\/s41588-024-01785-9","article-title":"Analysis of 10,478 cancer genomes identifies candidate driver genes and opportunities for precision oncology","volume":"56","author":"Kinnersley","year":"2024","journal-title":"Nat. Genet."},{"key":"10.1016\/j.canlet.2025.218076_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.seminoncol.2025.152338","article-title":"Integrated analysis of scRNA-seq and bulk RNA-seq data identifies BHLHE40 as a key gene in pancreatic cancer progression and gemcitabine resistance","volume":"52","author":"Wu","year":"2025","journal-title":"Semin. Oncol."},{"key":"10.1016\/j.canlet.2025.218076_bib22","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1053\/j.seminoncol.2024.09.001","article-title":"Role of neoadjuvant pembrolizumab in advanced melanoma","volume":"51","author":"Amir","year":"2024","journal-title":"Semin. Oncol."},{"key":"10.1016\/j.canlet.2025.218076_bib23","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0140-6736(24)01029-8","article-title":"New promises and challenges in the treatment of advanced non-small-cell lung cancer","volume":"404","author":"Meyer","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.canlet.2025.218076_bib24","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/s43018-025-00986-3","article-title":"The tumor microenvironment's role in the response to immune checkpoint blockade","volume":"6","author":"Aliazis","year":"2025","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.canlet.2025.218076_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.seminoncol.2025.152349","article-title":"Advancements and implications of artificial intelligence for early detection, diagnosis and tailored treatment of cancer","volume":"52","author":"Chadha","year":"2025","journal-title":"Semin. Oncol."},{"key":"10.1016\/j.canlet.2025.218076_bib26","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/j.cell.2024.02.009","article-title":"Embracing cancer complexity: hallmarks of systemic disease","volume":"187","author":"Swanton","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2025.218076_bib27","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1080\/15384101.2018.1520566","article-title":"The macroenviromental control of cancer metabolism by p62","volume":"17","author":"Huang","year":"2018","journal-title":"Cell Cycle"},{"key":"10.1016\/j.canlet.2025.218076_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107817","article-title":"Cellular senescence and hematological malignancies: from pathogenesis to therapeutics","volume":"223","author":"Hu","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.canlet.2025.218076_bib29","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s40168-021-01046-5","article-title":"Androgen-induced gut dysbiosis disrupts glucolipid metabolism and endocrinal functions in polycystic ovary syndrome","volume":"9","author":"Han","year":"2021","journal-title":"Microbiome"},{"key":"10.1016\/j.canlet.2025.218076_bib30","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.cmet.2024.04.019","article-title":"Dysfunctional circadian clock accelerates cancer metastasis by intestinal microbiota triggering accumulation of myeloid-derived suppressor cells","volume":"36","author":"Liu","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.canlet.2025.218076_bib31","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/s41591-022-01779-2","article-title":"Targeting the gut and tumor microbiota in cancer","volume":"28","author":"Park","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.canlet.2025.218076_bib32","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.cgh.2018.07.012","article-title":"Environmental factors, Gut Microbiota, and colorectal cancer prevention","volume":"17","author":"Song","year":"2019","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.canlet.2025.218076_bib33","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nature12626","article-title":"Influence of tumour micro-environment heterogeneity on therapeutic response","volume":"501","author":"Junttila","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2025.218076_bib34","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.immuni.2024.04.021","article-title":"Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer","volume":"57","author":"De Sanctis","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.canlet.2025.218076_bib35","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.1038\/s41388-022-02378-8","article-title":"The multifaceted role of EGLN family prolyl hydroxylases in cancer: going beyond HIF regulation","volume":"41","author":"Strocchi","year":"2022","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2025.218076_bib36","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1152\/physrev.00048.2019","article-title":"Diversity and biology of cancer-associated fibroblasts","volume":"101","author":"Biffi","year":"2021","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.canlet.2025.218076_bib37","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.cell.2023.03.016","article-title":"Fibroblasts in cancer: unity in heterogeneity","volume":"186","author":"Chhabra","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2025.218076_bib38","article-title":"Unmasking carcinoma-associated fibroblasts: key transformation player within the tumor microenvironment","volume":"1874","author":"Meng","year":"2020","journal-title":"Biochim. Biophys. Acta Rev. Canc"},{"key":"10.1016\/j.canlet.2025.218076_bib39","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.molmed.2023.03.002","article-title":"Fibroblasts in pancreatic cancer: molecular and clinical perspectives","volume":"29","author":"Rebelo","year":"2023","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.canlet.2025.218076_bib40","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1084\/jem.20180818","article-title":"Bone marrow-derived fibroblasts are a functionally distinct stromal cell population in breast cancer","volume":"215","author":"Raz","year":"2018","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.canlet.2025.218076_bib41","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.trecan.2023.01.007","article-title":"From gatekeepers to providers: regulation of immune functions by cancer-associated fibroblasts","volume":"9","author":"Arpinati","year":"2023","journal-title":"Trends Cancer"},{"key":"10.1016\/j.canlet.2025.218076_bib42","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1158\/1541-7786.MCR-14-0542","article-title":"Membrane-to-Nucleus signals and epigenetic mechanisms for myofibroblastic activation and desmoplastic stroma: potential therapeutic targets for liver metastasis?","volume":"13","author":"Kang","year":"2015","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.canlet.2025.218076_bib43","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1084\/jem.20162024","article-title":"Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer","volume":"214","author":"\u00d6hlund","year":"2017","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.canlet.2025.218076_bib44","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.ccell.2022.04.011","article-title":"Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer","volume":"40","author":"Huang","year":"2022","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2025.218076_bib45","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/s43018-022-00411-z","article-title":"Cancer-associated fibroblasts in the single-cell era","volume":"3","author":"Lavie","year":"2022","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.canlet.2025.218076_bib46","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/s41392-021-00641-0","article-title":"Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer","volume":"6","author":"Wu","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.canlet.2025.218076_bib47","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20160470","article-title":"CAF-derived HGF promotes cell proliferation and drug resistance by up-regulating the c-Met\/PI3K\/Akt and GRP78 signalling in ovarian cancer cells","volume":"37","author":"Deying","year":"2017","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.canlet.2025.218076_bib48","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1016\/j.celrep.2019.07.092","article-title":"Dualism of FGF and TGF-\u03b2 signaling in heterogeneous cancer-associated fibroblast activation with ETV1 as a critical determinant","volume":"28","author":"Bordignon","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.canlet.2025.218076_bib49","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/s41368-023-00236-1","article-title":"Carcinoma-associated fibroblast-derived lysyl oxidase-rich extracellular vesicles mediate collagen crosslinking and promote epithelial-mesenchymal transition via p-FAK\/p-paxillin\/YAP signaling","volume":"15","author":"Liu","year":"2023","journal-title":"Int. J. Oral Sci."},{"key":"10.1016\/j.canlet.2025.218076_bib50","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1186\/s12967-025-06236-5","article-title":"Single-cell and spatial transcriptome profiling reveal CTHRC1+ fibroblasts promote EMT through WNT5A signaling in colorectal cancer","volume":"23","author":"Lu","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.canlet.2025.218076_bib51","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.cell.2018.01.009","article-title":"CD10(+)GPR77(+) cancer-associated fibroblasts promote cancer Formation and chemoresistance by sustaining cancer stemness","volume":"172","author":"Su","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2025.218076_bib52","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.146334","article-title":"Targeting senescence-like fibroblasts radiosensitizes non-small cell lung cancer and reduces radiation-induced pulmonary fibrosis","volume":"6","author":"Meng","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.canlet.2025.218076_bib53","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1053\/j.gastro.2022.07.076","article-title":"Combined MEK and STAT3 inhibition uncovers stromal plasticity by enriching for cancer-associated fibroblasts with mesenchymal stem cell-like features to overcome immunotherapy resistance in pancreatic cancer","volume":"163","author":"Datta","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.canlet.2025.218076_bib54","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev-pathmechdis-032221-115501","article-title":"Innate immunity and cancer pathophysiology","volume":"17","author":"Maiorino","year":"2022","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.canlet.2025.218076_bib55","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/s41573-022-00520-5","article-title":"Macrophages as tools and targets in cancer therapy","volume":"21","author":"Mantovani","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.canlet.2025.218076_bib56","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1053\/j.gastro.2023.02.005","article-title":"Disruption of SLFN11 deficiency-induced CCL2 signaling and macrophage M2 polarization potentiates Anti-PD-1 therapy efficacy in hepatocellular carcinoma","volume":"164","author":"Zhou","year":"2023","journal-title":"Gastroenterology"},{"key":"10.1016\/j.canlet.2025.218076_bib57","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1136\/gutjnl-2019-318419","article-title":"Disruption of tumour-associated macrophage trafficking by the osteopontin-induced colony-stimulating factor-1 signalling sensitises hepatocellular carcinoma to anti-PD-L1 blockade","volume":"68","author":"Zhu","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.canlet.2025.218076_bib58","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev-pathmechdis-012418-012718","article-title":"Diversity, mechanisms, and significance of macrophage plasticity","volume":"15","author":"Locati","year":"2020","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.canlet.2025.218076_bib59","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.it.2023.10.007","article-title":"Tumor macrophage functional heterogeneity can inform the development of novel cancer therapies","volume":"44","author":"Nasir","year":"2023","journal-title":"Trends Immunol."},{"key":"10.1016\/j.canlet.2025.218076_bib60","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.ccell.2024.04.011","article-title":"Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeutic efficacy","volume":"42","author":"van Elsas","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2025.218076_bib61","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2023-006808","article-title":"Chordoma recruits and polarizes tumor-associated macrophages via secreting CCL5 to promote malignant progression","volume":"11","author":"Xu","year":"2023","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.canlet.2025.218076_bib62","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/s41423-024-01134-0","article-title":"Targeting PHGDH reverses the immunosuppressive phenotype of tumor-associated macrophages through \u03b1-ketoglutarate and mTORC1 signaling","volume":"21","author":"Cai","year":"2024","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.canlet.2025.218076_bib63","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s40164-024-00550-2","article-title":"M2-like tumor-associated macrophage-secreted CCL2 facilitates gallbladder cancer stemness and metastasis","volume":"13","author":"Chen","year":"2024","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.canlet.2025.218076_bib64","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jare.2024.06.014","article-title":"Tumor microenvironment as niche constructed by cancer stem cells: breaking the ecosystem to combat cancer","volume":"71","author":"Zhong","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.canlet.2025.218076_bib65","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2300846","article-title":"Gut microbiome-derived butyrate inhibits the immunosuppressive factors PD-L1 and IL-10 in tumor-associated macrophages in gastric cancer","volume":"16","author":"Lee","year":"2024","journal-title":"Gut Microbes"},{"key":"10.1016\/j.canlet.2025.218076_bib66","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1016\/j.immuni.2022.10.002","article-title":"Tumor-associated macrophages expressing the transcription factor IRF8 promote T cell exhaustion in cancer","volume":"55","author":"Nixon","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.canlet.2025.218076_bib67","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.ccell.2021.04.016","article-title":"The loss of RNA N(6)-adenosine methyltransferase Mettl14 in tumor-associated macrophages promotes CD8(+) T cell dysfunction and tumor growth","volume":"39","author":"Dong","year":"2021","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2025.218076_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217096","article-title":"Gut microbial metabolites in lung cancer development and immunotherapy: novel insights into gut-lung axis","volume":"598","author":"Li","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2025.218076_bib69","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.jconrel.2021.11.028","article-title":"Nanomaterials targeting tumor associated macrophages for cancer immunotherapy","volume":"341","author":"Zhao","year":"2022","journal-title":"J Control Release"},{"key":"10.1016\/j.canlet.2025.218076_bib70","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.actbio.2021.10.048","article-title":"Synergistic interventional photothermal therapy and immunotherapy using an iron oxide nanoplatform for the treatment of pancreatic cancer","volume":"138","author":"Wang","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.canlet.2025.218076_bib71","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/s41571-024-00859-1","article-title":"Dendritic cells as orchestrators of anticancer immunity and immunotherapy","volume":"21","author":"Heras-Murillo","year":"2024","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.canlet.2025.218076_bib72","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1146\/annurev-immunol-090222-110914","volume":"42","author":"Baessler","year":"2024","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.canlet.2025.218076_bib73","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41573-019-0052-1","article-title":"NK cells for cancer immunotherapy","volume":"19","author":"Shimasaki","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.canlet.2025.218076_bib74","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-001223","article-title":"Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation","volume":"8","author":"Cassetta","year":"2020","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.canlet.2025.218076_bib75","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/s41568-023-00549-7","article-title":"The advent of immune stimulating CAFs in cancer","volume":"23","author":"Tsoumakidou","year":"2023","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.canlet.2025.218076_bib76","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/s41423-024-01195-1","article-title":"BAG6 restricts pancreatic cancer progression by suppressing the release of IL33-presenting extracellular vesicles and the activation of mast cells","volume":"21","author":"Alashkar Alhamwe","year":"2024","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.canlet.2025.218076_bib77","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/s13045-021-01208-w","article-title":"Mesenchymal stem\/stromal cells in cancer therapy","volume":"14","author":"Lan","year":"2021","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.canlet.2025.218076_bib78","doi-asserted-by":"crossref","first-page":"6223","DOI":"10.1073\/pnas.0700690104","article-title":"Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production","volume":"104","author":"Funes","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.canlet.2025.218076_bib79","article-title":"Mechanisms of regulation of the chemokine-receptor network","volume":"18","author":"Stone","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.canlet.2025.218076_bib80","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1111\/jcmm.12391","article-title":"Endothelial and cancer cells interact with mesenchymal stem cells via both microparticles and secreted factors","volume":"18","author":"Lozito","year":"2014","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.canlet.2025.218076_bib81","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13046-019-1027-0","article-title":"Extracellular vesicles secreted by hypoxia pre-challenged mesenchymal stem cells promote non-small cell lung cancer cell growth and mobility as well as macrophage M2 polarization via miR-21-5p delivery","volume":"38","author":"Ren","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2025.218076_bib82","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1097\/SLA.0b013e3181fcb5d8","article-title":"Linking transgene expression of engineered mesenchymal stem cells and angiopoietin-1-induced differentiation to target cancer angiogenesis","volume":"253","author":"Conrad","year":"2011","journal-title":"Ann. Surg."},{"key":"10.1016\/j.canlet.2025.218076_bib83","doi-asserted-by":"crossref","first-page":"8703","DOI":"10.1111\/jcmm.15502","article-title":"Growth differentiation factor 11 promotes differentiation of MSCs into endothelial-like cells for angiogenesis","volume":"24","author":"Zhang","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.canlet.2025.218076_bib84","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0135111","article-title":"Neuronal differentiation of human mesenchymal stem cells using exosomes derived from differentiating neuronal cells","volume":"10","author":"Takeda","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.canlet.2025.218076_bib85","doi-asserted-by":"crossref","DOI":"10.1088\/1748-6041\/11\/2\/025021","article-title":"A thermoresponsive polydiolcitrate-gelatin scaffold and delivery system mediates effective bone formation from BMP9-transduced mesenchymal stem cells","volume":"11","author":"Ye","year":"2016","journal-title":"Biomed Mater"},{"key":"10.1016\/j.canlet.2025.218076_bib86","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41418-023-01238-6","article-title":"Epitranscriptomic modifications in mesenchymal stem cell differentiation: advances, mechanistic insights, and beyond","volume":"31","author":"Zheng","year":"2024","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.canlet.2025.218076_bib87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12272-023-01477-8","article-title":"Gastric cancer and mesenchymal stem cell-derived exosomes: from pro-tumorigenic effects to anti-cancer vehicles","volume":"47","author":"Dolatshahi","year":"2024","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.canlet.2025.218076_bib88","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/s41388-020-01566-8","article-title":"STAT3 phosphorylation at Ser727 and Tyr705 differentially regulates the EMT-MET switch and cancer metastasis","volume":"40","author":"Lin","year":"2021","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2025.218076_bib89","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.actbio.2022.11.029","article-title":"Porous composite hydrogels with improved MSC survival for robust epithelial sealing around implants and M2 macrophage polarization","volume":"157","author":"Li","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.canlet.2025.218076_bib90","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13073-023-01272-6","article-title":"Single-cell analysis of immune and stroma cell remodeling in clear cell renal cell carcinoma primary tumors and bone metastatic lesions","volume":"16","author":"Mei","year":"2024","journal-title":"Genome Med."},{"key":"10.1016\/j.canlet.2025.218076_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106891","article-title":"Administration of intestinal mesenchymal stromal cells reduces colitis-associated cancer in C57BL\/6J mice modulating the immune response and gut dysbiosis","volume":"195","author":"Hidalgo-Garc\u00eda","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.canlet.2025.218076_bib92","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107753","article-title":"Tumor microenvironment as a therapeutic target in cancer","volume":"221","author":"Xiao","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.canlet.2025.218076_bib93","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.ccell.2023.01.010","article-title":"Spatial profiling technologies illuminate the tumor microenvironment","volume":"41","author":"Elhanani","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2025.218076_bib94","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00268-004-7818-1","article-title":"Roles of neuropilins in neuronal development, angiogenesis, and cancers","volume":"29","author":"Chen","year":"2005","journal-title":"World J. Surg."},{"key":"10.1016\/j.canlet.2025.218076_bib95","doi-asserted-by":"crossref","first-page":"eadg3840","DOI":"10.1126\/scitranslmed.adg3840","article-title":"The extracellular matrix as hallmark of cancer and metastasis: from biomechanics to therapeutic targets","volume":"16","author":"Sleeboom","year":"2024","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.canlet.2025.218076_bib96","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13045-025-01717-y","article-title":"Extracellular matrix dynamics in tumor immunoregulation: from tumor microenvironment to immunotherapy","volume":"18","author":"Hu","year":"2025","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.canlet.2025.218076_bib97","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1158\/2159-8290.CD-24-0002","article-title":"The interplay between extracellular matrix remodeling and cancer therapeutics","volume":"14","author":"Prakash","year":"2024","journal-title":"Cancer Discov."},{"key":"10.1016\/j.canlet.2025.218076_bib98","doi-asserted-by":"crossref","first-page":"4587","DOI":"10.1038\/s41467-022-32255-7","article-title":"Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis","volume":"13","author":"Papanicolaou","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2025.218076_bib99","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s12943-022-01658-x","article-title":"CREB3L1 promotes tumor growth and metastasis of anaplastic thyroid carcinoma by remodeling the tumor microenvironment","volume":"21","author":"Pan","year":"2022","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.canlet.2025.218076_bib100","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1158\/0008-5472.CAN-21-1012","article-title":"T cells promote metastasis by regulating extracellular matrix remodeling following chemotherapy","volume":"82","author":"Haj-Shomaly","year":"2022","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2025.218076_bib101","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/s41586-025-08741-5","article-title":"Matrix-producing neutrophils populate and shield the skin","volume":"641","author":"Vicanolo","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2025.218076_bib102","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1038\/s41551-023-01052-y","article-title":"Generation of functionally distinct T-cell populations by altering the viscoelasticity of their extracellular matrix","volume":"7","author":"Adu-Berchie","year":"2023","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.canlet.2025.218076_bib103","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jare.2024.08.021","article-title":"Matrix stiffness-dependent PD-L2 deficiency improves SMYD3\/xCT-mediated ferroptosis and the efficacy of anti-PD-1 in HCC","volume":"73","author":"Wang","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.canlet.2025.218076_bib104","article-title":"Aligned fibrous scaffolds promote directional migration of breast cancer cells via caveolin-1\/YAP-mediated mechanosensing","volume":"28","author":"Li","year":"2024","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.canlet.2025.218076_bib105","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.immuni.2024.02.001","article-title":"Interleukin-2 signaling in the regulation of T cell biology in autoimmunity and cancer","volume":"57","author":"Shouse","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.canlet.2025.218076_bib106","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ccell.2024.11.011","article-title":"Cytokines in cancer","volume":"43","author":"Kureshi","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2025.218076_bib107","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s40364-020-00228-x","article-title":"Roles of IFN-\u03b3 in tumor progression and regression: a review","volume":"8","author":"Jorgovanovic","year":"2020","journal-title":"Biomark. Res."},{"key":"10.1016\/j.canlet.2025.218076_bib108","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1053\/j.gastro.2021.04.064","article-title":"TGF-\u03b2 signaling in liver, pancreas, and gastrointestinal diseases and cancer","volume":"161","author":"Gough","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.canlet.2025.218076_bib109","article-title":"Hepatocyte nuclear factor 1A (HNF1A) as a possible tumor suppressor in pancreatic cancer","volume":"10","author":"Luo","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.canlet.2025.218076_bib110","doi-asserted-by":"crossref","first-page":"419","DOI":"10.4161\/cbt.7.3.5415","article-title":"Thymosin Beta 4 is overexpressed in human pancreatic cancer cells and stimulates proinflammatory cytokine secretion and JNK activation","volume":"7","author":"Zhang","year":"2008","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.canlet.2025.218076_bib111","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/cac2.12416","article-title":"Tumor microenvironment signaling and therapeutics in cancer progression","volume":"43","author":"Goenka","year":"2023","journal-title":"Cancer Commun."},{"key":"10.1016\/j.canlet.2025.218076_bib112","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.jhep.2023.03.039","article-title":"A TNF\u03b1\/Miz1-positive feedback loop inhibits mitophagy in hepatocytes and propagates non-alcoholic steatohepatitis","volume":"79","author":"Jin","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.canlet.2025.218076_bib113","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13045-020-01030-w","article-title":"Targeting hypoxic tumor microenvironment in pancreatic cancer","volume":"14","author":"Tao","year":"2021","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.canlet.2025.218076_bib114","doi-asserted-by":"crossref","first-page":"5074","DOI":"10.1172\/JCI137552","article-title":"HIFs, angiogenesis, and metabolism: elusive enemies in breast cancer","volume":"130","author":"de Heer","year":"2020","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.canlet.2025.218076_bib115","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/s41573-023-00848-6","article-title":"Targeting hypoxia-inducible factors: therapeutic opportunities and challenges","volume":"23","author":"Yuan","year":"2024","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.canlet.2025.218076_bib116","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1089\/ars.2019.7935","article-title":"Targeting hypoxia-inducible Factor-1-Mediated metastasis for cancer therapy","volume":"34","author":"Ma","year":"2021","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.canlet.2025.218076_bib117","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s13045-022-01292-6","article-title":"Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape","volume":"15","author":"Wu","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.canlet.2025.218076_bib118","doi-asserted-by":"crossref","DOI":"10.1172\/JCI159839","article-title":"Hypoxia-inducible factors: cancer progression and clinical translation","volume":"132","author":"Wicks","year":"2022","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.canlet.2025.218076_bib119","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1681\/ASN.2020111638","article-title":"Roxadustat Versus Epoetin Alfa for treating anemia in patients with chronic kidney disease on dialysis: results from the randomized phase 3 ROCKIES Study","volume":"33","author":"Fishbane","year":"2022","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.canlet.2025.218076_bib120","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev-physiol-021119-034627","article-title":"The acidic tumor microenvironment as a driver of cancer","volume":"82","author":"Boedtkjer","year":"2020","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.canlet.2025.218076_bib121","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2023.108519","article-title":"Lactate acidosis and simultaneous recruitment of TGF-\u03b2 leads to alter plasticity of hypoxic cancer cells in tumor microenvironment","volume":"250","author":"Rastogi","year":"2023","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.canlet.2025.218076_bib122","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1038\/onc.2010.574","article-title":"Na(V)1.5 enhances breast cancer cell invasiveness by increasing NHE1-dependent H(+) efflux in caveolae","volume":"30","author":"Brisson","year":"2011","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2025.218076_bib123","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jconrel.2022.05.056","article-title":"Preparation and application of pH-responsive drug delivery systems","volume":"348","author":"Ding","year":"2022","journal-title":"J Control Release"},{"key":"10.1016\/j.canlet.2025.218076_bib124","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1021\/acs.accounts.0c00475","article-title":"Nano-Immune-Engineering approaches to advance cancer immunotherapy: lessons from ultra-ph-sensitive nanoparticles","volume":"53","author":"Li","year":"2020","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.canlet.2025.218076_bib125","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/med.22072","article-title":"Targeting tumor microenvironment with photodynamic nanomedicine","volume":"45","author":"Modi","year":"2025","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.canlet.2025.218076_bib126","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1038\/s41591-020-0892-6","article-title":"Systemic dysfunction and plasticity of the immune macroenvironment in cancer models","volume":"26","author":"Allen","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.canlet.2025.218076_bib127","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/bs.acr.2015.04.011","article-title":"The Tumor macroenvironment: Cancer-Promoting networks beyond Tumor beds","volume":"128","author":"Rutkowski","year":"2015","journal-title":"Adv. Cancer Res."},{"key":"10.1016\/j.canlet.2025.218076_bib128","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/s41573-024-01074-4","article-title":"Senescence as a therapeutic target in cancer and age-related diseases","volume":"24","author":"McHugh","year":"2025","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.canlet.2025.218076_bib129","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/s41586-024-07931-x","article-title":"Genetic links between ovarian ageing, cancer risk and de novo mutation rates","volume":"633","author":"Stankovic","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2025.218076_bib130","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s43587-024-00750-9","article-title":"A chimeric peptide promotes immune surveillance of senescent cells in injury, fibrosis, tumorigenesis and aging","volume":"5","author":"Ming","year":"2025","journal-title":"Nat Aging"},{"key":"10.1016\/j.canlet.2025.218076_bib131","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1158\/2159-8290.CD-18-0193","article-title":"Remodeling of the collagen matrix in aging skin promotes Melanoma metastasis and affects immune cell motility","volume":"9","author":"Kaur","year":"2019","journal-title":"Cancer Discov."},{"key":"10.1016\/j.canlet.2025.218076_bib132","doi-asserted-by":"crossref","first-page":"11619","DOI":"10.1093\/nar\/gkac1027","article-title":"METTL3-mediated m6A modification stabilizes TERRA and maintains telomere stability","volume":"50","author":"Chen","year":"2022","journal-title":"Nucleic acids research"},{"key":"10.1016\/j.canlet.2025.218076_bib133","doi-asserted-by":"crossref","first-page":"3936","DOI":"10.1158\/0008-5472.CAN-24-0857","article-title":"Single-Cell transcriptomic analysis identifies senescent osteocytes that trigger bone destruction in breast cancer metastasis","volume":"84","author":"Kaur","year":"2024","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2025.218076_bib134","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.ccell.2025.02.013","article-title":"Sex hormones, the anticancer immune response, and therapeutic opportunities","volume":"43","author":"Conforti","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2025.218076_bib135","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.tem.2020.07.002","article-title":"The sex bias of cancer","volume":"31","author":"Costa","year":"2020","journal-title":"Trends in endocrinology and metabolism: TEM (Trends Endocrinol. Metab.)"},{"key":"10.1016\/j.canlet.2025.218076_bib136","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s00268-004-7817-2","article-title":"Roles of thymosins in cancers and other organ systems","volume":"29","author":"Chen","year":"2005","journal-title":"World J. Surg."},{"key":"10.1016\/j.canlet.2025.218076_bib137","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.annonc.2024.10.824","article-title":"Estrogens and breast cancer","volume":"36","author":"Kim","year":"2025","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.canlet.2025.218076_bib138","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1001\/jama.2025.0228","article-title":"Prostate cancer: a review","volume":"333","author":"Raychaudhuri","year":"2025","journal-title":"JAMA"},{"key":"10.1016\/j.canlet.2025.218076_bib139","first-page":"480","article-title":"Systemic therapy for hormone receptor-positive\/human epidermal growth factor receptor 2-negative early stage and metastatic breast cancer","volume":"73","author":"Huppert","year":"2023","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.canlet.2025.218076_bib140","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.annonc.2020.06.011","article-title":"Prostate cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"31","author":"Parker","year":"2020","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.canlet.2025.218076_bib141","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1016\/j.immuni.2023.10.008","article-title":"Sex hormone signaling and regulation of immune function","volume":"56","author":"Hoffmann","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.canlet.2025.218076_bib142","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/s41574-024-01052-1","article-title":"Growth hormone-releasing hormone and its analogues in health and disease","volume":"21","author":"Granata","year":"2025","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.canlet.2025.218076_bib143","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/s41568-024-00772-w","article-title":"Androgen receptor signalling in non-prostatic malignancies: challenges and opportunities","volume":"25","author":"Dotto","year":"2025","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.canlet.2025.218076_bib144","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-004779","article-title":"Gut microbiota and metabolites associate with outcomes of immune checkpoint inhibitor-treated unresectable hepatocellular carcinoma","volume":"10","author":"Lee","year":"2022","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.canlet.2025.218076_bib145","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41423-023-00987-1","article-title":"Complex regulatory effects of gut microbial short-chain fatty acids on immune tolerance and autoimmunity","volume":"20","author":"Kim","year":"2023","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.canlet.2025.218076_bib146","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2274124","article-title":"Gut microbiota regulates postprandial GLP-1 response via ileal bile acid-TGR5 signaling","volume":"15","author":"Wang","year":"2023","journal-title":"Gut Microbes"},{"key":"10.1016\/j.canlet.2025.218076_bib147","article-title":"Gut Microbiota-Butyrate-PPAR\u03b3 axis modulates adipose regulatory T cell population","volume":"12","author":"Chen","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.canlet.2025.218076_bib148","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2022.102470","article-title":"The conundrum of breast cancer and microbiome - a comprehensive review of the current evidence","volume":"111","author":"Papakonstantinou","year":"2022","journal-title":"Cancer Treat Rev."},{"key":"10.1016\/j.canlet.2025.218076_bib149","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.tem.2021.04.014","article-title":"Gut and vaginal microbiomes on steroids: implications for women's health","volume":"32","author":"Graham","year":"2021","journal-title":"Trends in endocrinology and metabolism: TEM (Trends Endocrinol. Metab.)"},{"key":"10.1016\/j.canlet.2025.218076_bib150","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217077","article-title":"Pan-cancer atlas of tumor-resident microbiome, immunity and prognosis","volume":"598","author":"Sheng","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2025.218076_bib151","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2022.2108655","article-title":"The double-edged sword of probiotic supplementation on gut microbiota structure in Helicobacter pylori management","volume":"14","author":"Nabavi-Rad","year":"2022","journal-title":"Gut Microbes"},{"key":"10.1016\/j.canlet.2025.218076_bib152","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2024.2412376","article-title":"Gut microbiome therapy: fecal microbiota transplantation vs live biotherapeutic products","volume":"16","author":"Kim","year":"2024","journal-title":"Gut Microbes"},{"key":"10.1016\/j.canlet.2025.218076_bib153","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/s41568-024-00786-4","article-title":"Metabolic interplays between the tumour and the host shape the tumour macroenvironment","volume":"25","author":"Altea-Manzano","year":"2025","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.canlet.2025.218076_bib154","doi-asserted-by":"crossref","DOI":"10.1210\/endrev\/bnz014","article-title":"Review: diabetes, obesity, and cancer-pathophysiology and clinical implications","volume":"41","author":"Lega","year":"2020","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.canlet.2025.218076_bib155","doi-asserted-by":"crossref","DOI":"10.1172\/JCI187202","article-title":"Inhibiting inflammation in adipocytes accelerates mammary tumor development in mice","volume":"135","author":"Kim","year":"2025","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.canlet.2025.218076_bib156","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217162","article-title":"Enhanced cytokine signaling and ferroptosis defense interplay initiates obesity-associated pancreatic ductal adenocarcinoma","volume":"601","author":"Ruze","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2025.218076_bib157","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.ajpath.2021.02.006","article-title":"The Tumor promotional role of adipocytes in the breast cancer microenvironment and macroenvironment","volume":"191","author":"Bernard","year":"2021","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.canlet.2025.218076_bib158","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1038\/s41467-022-29846-9","article-title":"USP22 regulates lipidome accumulation by stabilizing PPAR\u03b3 in hepatocellular carcinoma","volume":"13","author":"Ning","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2025.218076_bib159","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s42255-023-00945-1","article-title":"Depletion of JunB increases adipocyte thermogenic capacity and ameliorates diet-induced insulin resistance","volume":"6","author":"Zhang","year":"2024","journal-title":"Nat. Metab."},{"key":"10.1016\/j.canlet.2025.218076_bib160","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1093\/neuonc\/noad117","article-title":"Insulin feedback is a targetable resistance mechanism of PI3K inhibition in glioblastoma","volume":"25","author":"Noch","year":"2023","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.canlet.2025.218076_bib161","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1016\/j.cmet.2024.04.018","article-title":"Oncogenic fatty acid oxidation senses circadian disruption in sleep-deficiency-enhanced tumorigenesis","volume":"36","author":"Peng","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.canlet.2025.218076_bib162","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1016\/j.cell.2024.04.015","article-title":"Circadian tumor infiltration and function of CD8(+) T cells dictate immunotherapy efficacy","volume":"187","author":"Wang","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2025.218076_bib163","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.trecan.2023.08.007","article-title":"Lifestyle and host determinants of antitumor immunity and cancer health disparities","volume":"9","author":"Swaby","year":"2023","journal-title":"Trends Cancer"},{"key":"10.1016\/j.canlet.2025.218076_bib164","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41392-024-01771-x","article-title":"Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential","volume":"9","author":"Xiao","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.canlet.2025.218076_bib165","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1200\/JCO.1984.2.6.702","article-title":"Macrobiotic diets for cancer treatment and prevention","volume":"2","author":"Bowman","year":"1984","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.canlet.2025.218076_bib166","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/j.cmet.2024.06.014","article-title":"Cyclic fasting-mimicking diet in cancer treatment: preclinical and clinical evidence","volume":"36","author":"Vernieri","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.canlet.2025.218076_bib167","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/s42255-020-00277-4","article-title":"Exercise and immunometabolic regulation in cancer","volume":"2","author":"Koelwyn","year":"2020","journal-title":"Nat. Metab."},{"key":"10.1016\/j.canlet.2025.218076_bib168","doi-asserted-by":"crossref","first-page":"e261","DOI":"10.1016\/S2468-2667(24)00018-5","article-title":"Life course epidemiology and public health","volume":"9","author":"Wagner","year":"2024","journal-title":"Lancet Public Health"},{"key":"10.1016\/j.canlet.2025.218076_bib169","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1136\/bjsports-2024-109392","article-title":"Impact of exercise on health outcomes in people with cancer: an umbrella review of systematic reviews and meta-analyses of randomised controlled trials","volume":"59","author":"Bai","year":"2025","journal-title":"Br. J. Sports Med."},{"key":"10.1016\/j.canlet.2025.218076_bib170","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/s41571-023-00734-5","article-title":"Cancer-associated cachexia - understanding the tumour macroenvironment and microenvironment to improve management","volume":"20","author":"Argil\u00e9s","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.canlet.2025.218076_bib171","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13045-023-01429-1","article-title":"LCN2 secreted by tissue-infiltrating neutrophils induces the ferroptosis and wasting of adipose and muscle tissues in lung cancer cachexia","volume":"16","author":"Wang","year":"2023","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.canlet.2025.218076_bib172","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1016\/j.cell.2023.03.028","article-title":"Cachexia: a systemic consequence of progressive, unresolved disease","volume":"186","author":"Ferrer","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2025.218076_bib173","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1080\/15548627.2024.2360340","article-title":"PGAM5 interacts with and maintains BNIP3 to license cancer-associated muscle wasting","volume":"20","author":"Zhang","year":"2024","journal-title":"Autophagy"},{"key":"10.1016\/j.canlet.2025.218076_bib174","first-page":"119","article-title":"An immune-sympathetic neuron communication axis guides adipose tissue browning in cancer-associated cachexia","author":"Xie","year":"2022","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.canlet.2025.218076_bib175","doi-asserted-by":"crossref","first-page":"e1157","DOI":"10.1016\/j.cgh.2021.09.022","article-title":"Cachexia is prevalent in patients with hepatocellular carcinoma and associated with worse prognosis","volume":"20","author":"Rich","year":"2022","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.canlet.2025.218076_bib176","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107476","article-title":"Gut microbiota-driven metabolic alterations reveal the distinct pathogenicity of chemotherapy-induced cachexia in gastric cancer","volume":"209","author":"Wu","year":"2024","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.canlet.2025.218076_bib177","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.ccell.2024.03.009","article-title":"The crosstalk between macrophages and cancer cells potentiates pancreatic cancer cachexia","volume":"42","author":"Liu","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2025.218076_bib178","article-title":"Complement pathway activation mediates pancreatic cancer-induced muscle wasting and pathological remodeling","volume":"135","author":"D'Lugos","year":"2025","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.canlet.2025.218076_bib179","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/j.jtho.2023.05.024","article-title":"Air pollution and lung cancer: a review by International Association for the Study of lung cancer Early Detection and Screening Committee","volume":"18","author":"Berg","year":"2023","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.canlet.2025.218076_bib180","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.jhep.2023.02.034","article-title":"The exposome and liver disease - how environmental factors affect liver health","volume":"79","author":"Barouki","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.canlet.2025.218076_bib181","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105126","article-title":"Impact of ambient air pollution on colorectal cancer risk and survival: insights from a prospective cohort and epigenetic Mendelian randomization study","volume":"103","author":"Jiang","year":"2024","journal-title":"EBioMedicine"},{"key":"10.1016\/j.canlet.2025.218076_bib182","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1053\/j.seminoncol.2024.10.005","article-title":"Screening adherence for second primary malignancies in breast cancer survivors: behaviors, facilitators, and barriers to enhance quality care","volume":"51","author":"Mesa-Chavez","year":"2024","journal-title":"Semin. Oncol."},{"key":"10.1016\/j.canlet.2025.218076_bib183","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s41576-022-00569-3","article-title":"Molecular mechanisms of environmental exposures and human disease","volume":"24","author":"Wu","year":"2023","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.canlet.2025.218076_bib184","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/imr.13315","article-title":"Maternal-driven immune education in offspring","volume":"323","author":"Fernandes","year":"2024","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.canlet.2025.218076_bib185","doi-asserted-by":"crossref","first-page":"4381","DOI":"10.1200\/JCO.23.00428","article-title":"Polygenic risk and chemotherapy-related subsequent malignancies in childhood cancer survivors: a childhood cancer survivor Study and St Jude lifetime cohort Study report","volume":"41","author":"Im","year":"2023","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.canlet.2025.218076_bib186","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1016\/j.ccell.2023.11.003","article-title":"Genomic alterations driving precancerous to cancerous lesions in esophageal cancer development","volume":"41","author":"Chang","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2025.218076_bib187","doi-asserted-by":"crossref","first-page":"4516","DOI":"10.1038\/s41467-020-18207-z","article-title":"Single-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells' heterogeneity","volume":"11","author":"Schlesinger","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2025.218076_bib188","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1053\/j.gastro.2021.09.073","article-title":"Clinical management of pancreatic premalignant lesions","volume":"162","author":"S\u00f8reide","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.canlet.2025.218076_bib189","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/s13046-024-03117-5","article-title":"The cross-talk between the macro and micro-environment in precursor lesions of pancreatic cancer leads to new and promising circulating biomarkers","volume":"43","author":"Mottini","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2025.218076_bib190","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.semcancer.2019.12.021","article-title":"The tumor organismal environment: role in tumor development and cancer immunotherapy","volume":"65","author":"Dieterich","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.canlet.2025.218076_bib191","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2024.108750","article-title":"Neurobiology of cancer: adrenergic signaling and drug repurposing","volume":"264","author":"Dong","year":"2024","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.canlet.2025.218076_bib192","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2024.155666","article-title":"Exosomal microRNAs in cancer metastasis: a bridge between tumor micro and macroenvironment","volume":"263","author":"Saadh","year":"2024","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.canlet.2025.218076_bib193","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1053\/j.seminoncol.2024.04.001","article-title":"Isolated lung metastases from pancreatic ductal adenocarcinoma (PDAC): diagnostic and therapeutic challenges of a different disease","volume":"51","author":"Giulia","year":"2024","journal-title":"Semin. Oncol."},{"key":"10.1016\/j.canlet.2025.218076_bib194","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature22341","article-title":"Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer","volume":"546","author":"Kamerkar","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2025.218076_bib195","doi-asserted-by":"crossref","first-page":"5395","DOI":"10.1038\/s41467-018-07810-w","article-title":"Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis","volume":"9","author":"Zeng","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2025.218076_bib196","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2025.101275","article-title":"Hypoxia-induced upregulation of HIF1A-AS3 promotes MSC transition to cancer-associated fibroblasts and confers drug resistance in gastric cancer","volume":"82","author":"Xu","year":"2025","journal-title":"Drug Resist Updat"},{"key":"10.1016\/j.canlet.2025.218076_bib197","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217596","article-title":"Tumor-derived exosomal LINC01812 induces M2 macrophage polarization to promote perineural invasion in cholangiocarcinoma","volume":"617","author":"Wang","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2025.218076_bib198","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41586-023-06114-4","article-title":"Tumour extracellular vesicles and particles induce liver metabolic dysfunction","volume":"618","author":"Wang","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2025.218076_bib199","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.cell.2019.02.016","article-title":"Suppression of exosomal PD-L1 induces systemic anti-tumor immunity and memory","volume":"177","author":"Poggio","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2025.218076_bib200","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2022.215841","article-title":"Melanoma-derived small extracellular vesicles remodel the systemic onco-immunity via disrupting hematopoietic stem cell proliferation and differentiation","volume":"545","author":"Du","year":"2022","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2025.218076_bib201","article-title":"Locoregional immune checkpoint blockade and remodeling of lymph nodes by engineered dendritic cell-derived exosomes for suppressing tumor progression and metastasis","volume":"12","author":"Wang","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.canlet.2025.218076_bib202","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1002\/cac2.12574","article-title":"Exposure of benzo[a]pyrene induces HCC exosome-circular RNA to activate lung fibroblasts and trigger organotropic metastasis","volume":"44","author":"Mu","year":"2024","journal-title":"Cancer Commun."},{"key":"10.1016\/j.canlet.2025.218076_bib203","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/s43018-020-00121-4","article-title":"Multimodal mapping of the tumor and peripheral blood immune landscape in human pancreatic cancer","volume":"1","author":"Steele","year":"2020","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.canlet.2025.218076_bib204","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1186\/s12916-021-02138-7","article-title":"Telomerase-positive circulating tumor cells are associated with poor prognosis via a neutrophil-mediated inflammatory immune environment in glioma","volume":"19","author":"Zhang","year":"2021","journal-title":"BMC Med."},{"key":"10.1016\/j.canlet.2025.218076_bib205","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1038\/s41556-024-01508-6","article-title":"Solid tumour-induced systemic immunosuppression involves dichotomous myeloid-B cell interactions","volume":"26","author":"Hao","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.canlet.2025.218076_bib206","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.stem.2023.04.005","article-title":"Osteoprogenitor-GMP crosstalk underpins solid tumor-induced systemic immunosuppression and persists after tumor removal","volume":"30","author":"Hao","year":"2023","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.canlet.2025.218076_bib207","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abg3551","article-title":"Tumor-draining lymph nodes: at the crossroads of metastasis and immunity","volume":"6","author":"du Bois","year":"2021","journal-title":"Sci Immunol"},{"key":"10.1016\/j.canlet.2025.218076_bib208","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/s12943-024-02119-3","article-title":"Altered metabolism in cancer: insights into energy pathways and therapeutic targets","volume":"23","author":"Tufail","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.canlet.2025.218076_bib209","first-page":"240","article-title":"Glycolytic activity in vivo of the mouse Ehrlich ascites tumor","volume":"17","author":"Hiatt","year":"1957","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2025.218076_bib210","article-title":"A novel zebrafish intestinal tumor model reveals a role for cyp7a1-dependent tumor-liver crosstalk in causing adverse effects on the host","volume":"11","author":"Enya","year":"2018","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.canlet.2025.218076_bib211","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.cmet.2021.04.014","article-title":"Isotope tracing in adult zebrafish reveals alanine cycling between melanoma and liver","volume":"33","author":"Naser","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.canlet.2025.218076_bib212","doi-asserted-by":"crossref","DOI":"10.1126\/science.adm8857","article-title":"A neuroimmune circuit mediates cancer cachexia-associated apathy","volume":"388","author":"Zhu","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.canlet.2025.218076_bib213","first-page":"135","article-title":"Cancer therapy and cachexia","author":"Thakir","year":"2025","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.canlet.2025.218076_bib214","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s41577-021-00624-w","article-title":"The interplay of immunology and cachexia in infection and cancer","volume":"22","author":"Baazim","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.canlet.2025.218076_bib215","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1186\/s12885-018-5080-4","article-title":"Pharmacological management of cachexia in adult cancer patients: a systematic review of clinical trials","volume":"18","author":"Advani","year":"2018","journal-title":"BMC Cancer"},{"key":"10.1016\/j.canlet.2025.218076_bib216","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1002\/jcsm.12441","article-title":"Tumour-derived transforming growth factor-\u03b2 signalling contributes to fibrosis in patients with cancer cachexia","volume":"10","author":"Lima","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.canlet.2025.218076_bib217","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/s41591-023-02232-8","article-title":"Body composition and lung cancer-associated cachexia in TRACERx","volume":"29","author":"Al-Sawaf","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.canlet.2025.218076_bib218","doi-asserted-by":"crossref","first-page":"6966","DOI":"10.1158\/1078-0432.CCR-05-0910","article-title":"Vascular endothelial growth factor trap combined with paclitaxel strikingly inhibits tumor and ascites, prolonging survival in a human ovarian cancer model","volume":"11","author":"Hu","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2025.218076_bib219","doi-asserted-by":"crossref","first-page":"E758","DOI":"10.1152\/ajpendo.00172.2018","article-title":"Adipose tissue-derived free fatty acids initiate myeloid cell accumulation in mouse liver in states of lipid oversupply","volume":"315","author":"Harmon","year":"2018","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.canlet.2025.218076_bib220","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1172\/JCI28898","article-title":"TLR4 links innate immunity and fatty acid-induced insulin resistance","volume":"116","author":"Shi","year":"2006","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.canlet.2025.218076_bib221","doi-asserted-by":"crossref","first-page":"181","DOI":"10.20892\/j.issn.2095-3941.2019.0348","article-title":"A systematic review of metabolomic profiling of gastric cancer and esophageal cancer","volume":"17","author":"Huang","year":"2020","journal-title":"Cancer Biol Med"},{"key":"10.1016\/j.canlet.2025.218076_bib222","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1158\/2159-8290.CD-21-0010","article-title":"Metastasis-Initiating cells and ecosystems","volume":"11","author":"Massagu\u00e9","year":"2021","journal-title":"Cancer Discov."},{"key":"10.1016\/j.canlet.2025.218076_bib223","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/S0140-6736(23)02268-7","article-title":"Individualised neoantigen therapy mRNA-4157 (V940) plus pembrolizumab versus pembrolizumab monotherapy in resected melanoma (KEYNOTE-942): a randomised, phase 2b study","volume":"403","author":"Weber","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.canlet.2025.218076_bib224","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s43018-021-00291-9","article-title":"A tumor-derived type III collagen-rich ECM niche regulates tumor cell dormancy","volume":"3","author":"Di Martino","year":"2022","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.canlet.2025.218076_bib225","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.tips.2015.04.006","article-title":"New therapeutic targets for cancer bone metastasis","volume":"36","author":"Krzeszinski","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.canlet.2025.218076_bib226","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1158\/1078-0432.CCR-20-1319","article-title":"IL8, neutrophils, and NETs in a collusion against cancer immunity and immunotherapy","volume":"27","author":"Teijeira","year":"2021","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2025.218076_bib227","doi-asserted-by":"crossref","DOI":"10.4172\/2155-9899.1000230","article-title":"An inflammatory cytokine milieu is prominent in premalignant oral lesions, but subsides when lesions progress to squamous cell carcinoma","volume":"5","author":"Woodford","year":"2014","journal-title":"J. Clin. Cell. Immunol."},{"key":"10.1016\/j.canlet.2025.218076_bib228","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.semcancer.2021.03.023","article-title":"Multifaceted functions of chronic inflammation in regulating tumor dormancy and relapse","volume":"78","author":"Manjili","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.canlet.2025.218076_bib229","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1186\/s13046-022-02520-0","article-title":"Osteoblasts and osteoclasts: an important switch of tumour cell dormancy during bone metastasis","volume":"41","author":"Dai","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2025.218076_bib230","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.trecan.2024.10.005","article-title":"Metabolic landscape of disseminated cancer dormancy","volume":"11","author":"Drapela","year":"2025","journal-title":"Trends Cancer"},{"key":"10.1016\/j.canlet.2025.218076_bib231","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20242250","article-title":"Sympathetic axonogenesis promotes adenoid cystic carcinoma progression","volume":"222","author":"Chen","year":"2025","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.canlet.2025.218076_bib232","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.cytogfr.2025.04.001","article-title":"Decoding the neuroimmune axis in colorectal cancer: from neural circuitry to therapeutic innovation","volume":"83","author":"Li","year":"2025","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.canlet.2025.218076_bib233","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41579-024-01103-4","article-title":"Bacterial small molecule metabolites implicated in gastrointestinal cancer development","volume":"23","author":"Turocy","year":"2025","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.canlet.2025.218076_bib234","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3350\/cmh.2024.0857","article-title":"Gut microbiota-mediated gut-liver axis: a breakthrough point for understanding and treating liver cancer","volume":"31","author":"Li","year":"2025","journal-title":"Clin. Mol. Hepatol."},{"key":"10.1016\/j.canlet.2025.218076_bib235","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/cncr.31078","article-title":"Biobehavioral modulation of the exosome transcriptome in ovarian carcinoma","volume":"124","author":"Lutgendorf","year":"2018","journal-title":"Cancer"},{"key":"10.1016\/j.canlet.2025.218076_bib236","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/s41556-025-01667-0","article-title":"Psychological stress-induced ALKBH5 deficiency promotes tumour innervation and pancreatic cancer via extracellular vesicle transfer of RNA","volume":"27","author":"Chen","year":"2025","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.canlet.2025.218076_bib237","doi-asserted-by":"crossref","first-page":"5725","DOI":"10.1038\/s41467-021-25967-9","article-title":"Environmental eustress modulates \u03b2-ARs\/CCL2 axis to induce anti-tumor immunity and sensitize immunotherapy against liver cancer in mice","volume":"12","author":"Liu","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2025.218076_bib238","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-003609","article-title":"Peripherally-driven myeloid NFkB and IFN\/ISG responses predict malignancy risk, survival, and immunotherapy regime in ovarian cancer","volume":"9","author":"Sprooten","year":"2021","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.canlet.2025.218076_bib239","first-page":"910","article-title":"2D and 3D cell cultures - a comparison of different types of cancer cell cultures","volume":"14","author":"Kapa\u0142czy\u0144ska","year":"2018","journal-title":"Arch. Med. Sci."},{"key":"10.1016\/j.canlet.2025.218076_bib240","article-title":"Patient-derived xenograft model in cancer: establishment and applications","volume":"6","author":"Gu","year":"2020","journal-title":"MedComm"},{"key":"10.1016\/j.canlet.2025.218076_bib241","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2025.101381","article-title":"Type 2 diabetes Mellitus and bladder cancer: a narrative review on associated signaling pathways","volume":"104","author":"da Cunha Agostini","year":"2025","journal-title":"Mol Aspects Med"},{"key":"10.1016\/j.canlet.2025.218076_bib242","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.it.2025.02.014","article-title":"Diabetes can impact cellular immunity in solid tumors","volume":"46","author":"Garstka","year":"2025","journal-title":"Trends Immunol."},{"key":"10.1016\/j.canlet.2025.218076_bib243","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107367","article-title":"Metformin: from diabetes to cancer to prolongation of life","volume":"208","author":"Sirtori","year":"2024","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.canlet.2025.218076_bib244","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/s43018-020-0087-6","article-title":"Pan-cancer image-based detection of clinically actionable genetic alterations","volume":"1","author":"Kather","year":"2020","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.canlet.2025.218076_bib245","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1016\/j.ccell.2024.08.005","article-title":"Cancer cell states: lessons from ten years of single-cell RNA-sequencing of human tumors","volume":"42","author":"Tirosh","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2025.218076_bib246","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/s41576-022-00553-x","article-title":"Spatial biology of cancer evolution","volume":"24","author":"Seferbekova","year":"2023","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.canlet.2025.218076_bib247","article-title":"A zinc transporter drives glioblastoma progression via extracellular vesicles-reprogrammed microglial plasticity","volume":"122","author":"Zhang","year":"2025","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.canlet.2025.218076_bib248","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1053\/j.gastro.2018.10.026","article-title":"ZIP4 promotes muscle wasting and Cachexia in mice with orthotopic pancreatic tumors by stimulating RAB27B-Regulated release of extracellular vesicles from cancer cells","volume":"156","author":"Yang","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.canlet.2025.218076_bib249","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1053\/j.gastro.2020.12.077","article-title":"Zinc-Dependent regulation of ZEB1 and YAP1 coactivation promotes epithelial-mesenchymal transition plasticity and metastasis in pancreatic cancer","volume":"160","author":"Liu","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.canlet.2025.218076_bib250","doi-asserted-by":"crossref","first-page":"5993","DOI":"10.1158\/1078-0432.CCR-09-0557","article-title":"Down-regulation of ZIP4 by RNA interference inhibits pancreatic cancer growth and increases the survival of nude mice with pancreatic cancer xenografts","volume":"15","author":"Li","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2025.218076_bib251","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1053\/j.gastro.2022.06.058","article-title":"Acetyl-Coenzyme A synthetase 2 potentiates macropinocytosis and muscle wasting through metabolic reprogramming in pancreatic cancer","volume":"163","author":"Zhou","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.canlet.2025.218076_bib252","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2024.103281","article-title":"Protocol for establishing and evaluating a cancer cachexia mouse model","volume":"5","author":"Zhou","year":"2024","journal-title":"STAR Protoc"},{"key":"10.1016\/j.canlet.2025.218076_bib253","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2015.04.009","article-title":"Genomic profiling guides the choice of molecular targeted therapy of pancreatic cancer","volume":"363","author":"Frank","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2025.218076_bib254","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.4161\/cc.28111","article-title":"ZIP4 confers resistance to zinc deficiency-induced apoptosis in pancreatic cancer","volume":"13","author":"Cui","year":"2014","journal-title":"Cell Cycle"},{"key":"10.1016\/j.canlet.2025.218076_bib255","doi-asserted-by":"crossref","first-page":"309","DOI":"10.2174\/1566524013666131217112921","article-title":"ZIP4 is a novel diagnostic and prognostic marker in human pancreatic cancer: a systemic comparison between EUS-FNA and surgical specimens","volume":"14","author":"Xu","year":"2014","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.canlet.2025.218076_bib256","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1200\/JCO.24.00287","article-title":"Development and validation of a cell-free DNA Fragmentomics-Based model for early detection of pancreatic cancer","author":"Yin","year":"2025","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.canlet.2025.218076_bib257","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1016\/j.molp.2022.09.001","article-title":"Smart breeding driven by big data, artificial intelligence, and integrated genomic-enviromic prediction","volume":"15","author":"Xu","year":"2022","journal-title":"Mol. Plant"},{"key":"10.1016\/j.canlet.2025.218076_bib258","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13045-022-01278-4","article-title":"Tumor organoids: applications in cancer modeling and potentials in precision medicine","volume":"15","author":"Xu","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.canlet.2025.218076_bib259","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ctrv.2018.12.003","article-title":"New clinical trial designs in the era of precision medicine: an overview of definitions, strengths, weaknesses, and current use in oncology","volume":"73","author":"Janiaud","year":"2019","journal-title":"Cancer Treat Rev."},{"key":"10.1016\/j.canlet.2025.218076_bib260","first-page":"110","article-title":"Study human pancreatic cancer in mice: how close are they?","volume":"1835","author":"Zhang","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.canlet.2025.218076_bib261","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0022-4804(03)00276-2","article-title":"Somatostatin receptor gene transfer inhibits established pancreatic cancer xenografts","volume":"115","author":"Celinski","year":"2003","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.canlet.2025.218076_bib262","doi-asserted-by":"crossref","DOI":"10.1016\/j.lungcan.2025.108726","article-title":"Integrating tumor macroenvironment, microenvironment and mechanobiology with organoid and organ-on-a-chip models for lung cancer immunotherapy","volume":"207","author":"Park","year":"2025","journal-title":"Lung Cancer"},{"key":"10.1016\/j.canlet.2025.218076_bib263","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2174\/1566524020666200521075252","article-title":"Metabolic ink lactate modulates epigenomic landscape: a concerted role of pro-tumor microenvironment and macroenvironment during carcinogenesis","volume":"21","author":"Sharma","year":"2021","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.canlet.2025.218076_bib264","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/s41568-020-0258-x","article-title":"Executable cancer models: successes and challenges","volume":"20","author":"Clarke","year":"2020","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.canlet.2025.218076_bib265","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1001\/jamaoncol.2024.3456","article-title":"Neoadjuvant immune checkpoint inhibitors plus chemotherapy in early breast cancer: a systematic review and meta-analysis","volume":"10","author":"Villacampa","year":"2024","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.canlet.2025.218076_bib266","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41573-019-0016-5","article-title":"Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond","volume":"18","author":"Platten","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.canlet.2025.218076_bib267","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1126\/science.aaz7015","article-title":"Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response","volume":"374","author":"Spencer","year":"2021","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.canlet.2025.218076_bib268","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1053\/j.seminoncol.2024.10.001","article-title":"Efficacy of metformin drug in preventing metabolic syndrome associated with androgen deprivation therapy (ADT) in prostate cancer patients: a systematic review and meta-analysis","volume":"51","author":"Yakout","year":"2024","journal-title":"Semin. Oncol."},{"key":"10.1016\/j.canlet.2025.218076_bib269","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S1470-2045(23)00063-3","article-title":"Testosterone suppression plus enzalutamide versus testosterone suppression plus standard antiandrogen therapy for metastatic hormone-sensitive prostate cancer (ENZAMET): an international, open-label, randomised, phase 3 trial","volume":"24","author":"Sweeney","year":"2023","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.canlet.2025.218076_bib270","doi-asserted-by":"crossref","DOI":"10.1016\/j.cpr.2022.102237","article-title":"The efficacy of psychosocial interventions for cancer caregiver burden: a systematic review and meta-analysis of randomized controlled trials","volume":"99","author":"Secinti","year":"2023","journal-title":"Clin. Psychol. Rev."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383525006482?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383525006482?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T21:21:21Z","timestamp":1785273681000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383525006482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":270,"alternative-id":["S0304383525006482"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2025.218076","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tumor microenvironment and macroenvironment: A new perspective on holistic oncology","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2025.218076","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"218076"}}