{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:04:54Z","timestamp":1793070294369,"version":"4.5.0"},"reference-count":146,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32371524"],"award-info":[{"award-number":["32371524"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.canlet.2025.218174","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T16:40:27Z","timestamp":1764088827000},"page":"218174","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Peptide-drug conjugates in tumor therapy: Current advances and future perspectives"],"prefix":"10.1016","volume":"638","author":[{"given":"Huiyuan","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peizhen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7271-4355","authenticated-orcid":false,"given":"Yingqiu","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2025.218174_bib1","doi-asserted-by":"crossref","DOI":"10.1002\/psc.70040","article-title":"Peptide-drug conjugates: a new hope for cancer","volume":"31","author":"Armstrong","year":"2025","journal-title":"J. Pept. Sci."},{"key":"10.1016\/j.canlet.2025.218174_bib2","article-title":"Peptide-drug conjugates as next-generation therapeutics: exploring the potential and clinical progress","volume":"12","author":"Jadhav","year":"2025","journal-title":"Bioengineering (Basel)"},{"key":"10.1016\/j.canlet.2025.218174_bib3","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1186\/s12951-025-03277-2","article-title":"Current progress and remaining challenges of peptide-drug conjugates (PDCs): next generation of antibody-drug conjugates (ADCs)?","volume":"23","author":"Wang","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.canlet.2025.218174_bib4","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.apsb.2022.07.020","article-title":"Peptide-drug conjugates (PDCs): a novel trend of research and development on targeted therapy, hype or hope?","volume":"13","author":"Fu","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.canlet.2025.218174_bib5","doi-asserted-by":"crossref","first-page":"3659","DOI":"10.1016\/j.apsb.2023.02.013","article-title":"Research advances in peptide\u2012drug conjugates","volume":"13","author":"Gong","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.canlet.2025.218174_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejca.2025.115673","article-title":"Availability and characteristics of clinical trials for neuroendocrine tumors: is there an unmet need?","volume":"227","author":"Melhorn","year":"2025","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.canlet.2025.218174_bib7","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1158\/1078-0432.CCR-12-3752","article-title":"In vitro and in vivo antitumor activity of a novel alkylating agent, melphalan-flufenamide, against multiple myeloma cells","volume":"19","author":"Chauhan","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2025.218174_bib8","doi-asserted-by":"crossref","first-page":"D1102","DOI":"10.1093\/nar\/gkaa950","article-title":"ConjuPepDB: a database of peptide-drug conjugates","volume":"49","author":"Balogh","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.canlet.2025.218174_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14010212","article-title":"Molecular engineering of peptide-drug conjugates for therapeutics","volume":"14","author":"Fang","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.canlet.2025.218174_bib10","article-title":"Trends in the research and development of peptide drug conjugates: artificial intelligence aided design","volume":"16","author":"Zhang","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.canlet.2025.218174_bib11","article-title":"Interfacial self-assembly nanostructures: constructions and applications","volume":"20","author":"Li","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.canlet.2025.218174_bib12","doi-asserted-by":"crossref","first-page":"6084","DOI":"10.1021\/acs.joc.5c00247","article-title":"Optimized monomer-based synthesis of Poly-N-amino peptides","volume":"90","author":"Anwar","year":"2025","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.canlet.2025.218174_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.semcancer.2019.06.001","article-title":"Antibody therapeutics and immunoregulation in cancer and autoimmune disease","volume":"64","author":"Yasunaga","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.canlet.2025.218174_bib14","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3892\/or.2025.8956","article-title":"Breaking therapeutic barriers in solid tumors: clinical progress of antibody-drug conjugate\/immune checkpoint inhibitor combinations (Review)","volume":"54","author":"Zheng","year":"2025","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.canlet.2025.218174_bib15","first-page":"290","article-title":"Revolutionizing breast cancer treatment: the promise of antibody-drug conjugates","volume":"23","author":"Alkassis","year":"2025","journal-title":"Clin. Adv. Hematol. Oncol."},{"key":"10.1016\/j.canlet.2025.218174_bib16","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1007\/s002590100574","article-title":"[177Lu-DOTAOTyr3]octreotate: comparison with [111In-DTPAo]octreotide in patients","volume":"28","author":"Kwekkeboom","year":"2001","journal-title":"Eur. J. Nucl. Med."},{"key":"10.1016\/j.canlet.2025.218174_bib17","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s00259-002-1050-8","article-title":"Treatment of patients with gastro-entero-pancreatic (GEP) tumours with the novel radiolabelled somatostatin analogue [177Lu-DOTA(0),Tyr3]octreotate","volume":"30","author":"Kwekkeboom","year":"2003","journal-title":"Eur. J. Nucl. Med. Mol. Imag."},{"key":"10.1016\/j.canlet.2025.218174_bib18","first-page":"44","article-title":"New developments in the treatment of neuroendocrine tumours - RADIANT-4, NETTER-1 and Telotristat etiprate","volume":"12","author":"Sbardella","year":"2016","journal-title":"Eur. Endocrinol."},{"key":"10.1016\/j.canlet.2025.218174_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.111006","article-title":"Redox- and MMP-2-sensitive drug delivery nanoparticles based on gelatin and albumin for tumor targeted delivery of paclitaxel","volume":"114","author":"Zhou","year":"2020","journal-title":"Mater. Sci. Eng., C"},{"key":"10.1016\/j.canlet.2025.218174_bib20","first-page":"3743","article-title":"Remodeling of collagen matrix by human tumor cells requires activation and cell surface association of matrix metalloproteinase-2","volume":"58","author":"Deryugina","year":"1998","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2025.218174_bib21","doi-asserted-by":"crossref","first-page":"8324","DOI":"10.1021\/acs.jmedchem.3c00382","article-title":"Identification of a pH-Responsive peptide-paclitaxel conjugate as a novel drug with improved therapeutic potential","volume":"66","author":"Rizvi","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.canlet.2025.218174_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15041110","article-title":"Lutathera(\u00ae) orphans: state of the art and future application of radioligand therapy with (177)Lu-DOTATATE","volume":"15","author":"Urso","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.canlet.2025.218174_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/ph12030114","article-title":"Lutathera(\u00ae): the first FDA- and EMA-approved radiopharmaceutical for peptide receptor radionuclide therapy","volume":"12","author":"Hennrich","year":"2019","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.canlet.2025.218174_bib24","doi-asserted-by":"crossref","first-page":"14014","DOI":"10.1039\/D2NR02200A","article-title":"PSMA-specific degradable dextran for multiplexed immunotargeted siRNA therapeutics against prostate cancer","volume":"14","author":"Chen","year":"2022","journal-title":"Nanoscale"},{"key":"10.1016\/j.canlet.2025.218174_bib25","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.clgc.2022.07.009","article-title":"Antibody-drug conjugates in prostate cancer: where are we?","volume":"21","author":"Mjaess","year":"2023","journal-title":"Clin. Genitourin. Cancer"},{"key":"10.1016\/j.canlet.2025.218174_bib26","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1007\/s40265-021-01522-0","article-title":"Melphalan flufenamide (Melflufen): first approval","volume":"81","author":"Dhillon","year":"2021","journal-title":"Drugs"},{"key":"10.1016\/j.canlet.2025.218174_bib27","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.2147\/DDDT.S295215","article-title":"Spotlight on Melphalan flufenamide: an up-and-coming therapy for the treatment of myeloma","volume":"15","author":"Morabito","year":"2021","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.canlet.2025.218174_bib28","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.immuni.2018.11.003","article-title":"Age-Related loss of innate immune antimicrobial function of dermal fat is mediated by transforming growth factor beta","volume":"50","author":"Zhang","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.canlet.2025.218174_bib29","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.actbio.2022.07.066","article-title":"A carrier-free, dual-functional hydrogel constructed of antimicrobial peptide Jelleine-1 and 8Br-cAMP for MRSA infected diabetic wound healing","volume":"151","author":"Zhou","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.canlet.2025.218174_bib30","doi-asserted-by":"crossref","first-page":"61751","DOI":"10.1021\/acsami.4c15649","article-title":"Multifunctional SEBS\/AgNWs nanocomposite films with antimicrobial, antioxidant, and anti-inflammatory properties promote infected wound healing","volume":"16","author":"Chen","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.canlet.2025.218174_bib31","doi-asserted-by":"crossref","first-page":"10967","DOI":"10.1021\/acs.jmedchem.4c00511","article-title":"Development of peptide paratope mimics derived from the Anti-ROR1 antibody and long-acting peptide-drug conjugates for targeted cancer therapy","volume":"67","author":"Zhang","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.canlet.2025.218174_bib32","doi-asserted-by":"crossref","first-page":"79401","DOI":"10.18632\/oncotarget.12708","article-title":"Delivery of a peptide-drug conjugate targeting the blood brain barrier improved the efficacy of paclitaxel against glioma","volume":"7","author":"Li","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.canlet.2025.218174_bib33","doi-asserted-by":"crossref","first-page":"4888","DOI":"10.7150\/ijbs.98846","article-title":"Antioxidant genes in cancer and metabolic diseases: focusing on Nrf2, Sestrin, and heme oxygenase 1","volume":"20","author":"Shrestha","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.canlet.2025.218174_bib34","doi-asserted-by":"crossref","first-page":"334","DOI":"10.4143\/crt.2021.1022","article-title":"Phase 1 Study of No-Carrier added 177Lu-DOTATATE (SNU-KB-01) in patients with somatostatin receptor-positive neuroendocrine tumors: the first clinical trial of peptide receptor radionuclide therapy in Korea","volume":"55","author":"Ryoo","year":"2023","journal-title":"Cancer Res. Treat."},{"key":"10.1016\/j.canlet.2025.218174_bib35","doi-asserted-by":"crossref","first-page":"40","DOI":"10.2967\/jnumed.122.263856","article-title":"Long-Term outcomes of submaximal activities of peptide receptor radionuclide therapy with (177)Lu-DOTATATE in neuroendocrine tumor patients","volume":"64","author":"Minczeles","year":"2023","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.canlet.2025.218174_bib36","doi-asserted-by":"crossref","first-page":"e314","DOI":"10.1016\/S2352-3026(23)00056-X","article-title":"Melflufen: post-hoc subgroup analyses and the US FDA Oncologic drugs advisory committee","volume":"10","author":"Cliff","year":"2023","journal-title":"Lancet Haematol"},{"key":"10.1016\/j.canlet.2025.218174_bib37","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.coph.2019.01.008","article-title":"The future of peptides in cancer treatment","volume":"47","author":"Kurrikoff","year":"2019","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.canlet.2025.218174_bib38","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12929-019-0498-9","article-title":"H. pylori isolates with amino acid sequence polymorphisms as presence of both HtrA-L171 & CagL-Y58\/E59 increase the risk of gastric cancer","volume":"26","author":"Yeh","year":"2019","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.canlet.2025.218174_bib39","doi-asserted-by":"crossref","first-page":"792","DOI":"10.2967\/jnumed.119.234971","article-title":"Imaging the distribution of gastrin-releasing peptide receptors in cancer","volume":"61","author":"Baratto","year":"2020","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.canlet.2025.218174_bib40","doi-asserted-by":"crossref","first-page":"13126","DOI":"10.1021\/jacs.3c01829","article-title":"Photoswitchable calixarene activators for controlled peptide transport across lipid membranes","volume":"145","author":"Martins","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.canlet.2025.218174_bib41","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202206456","article-title":"Polymer nanoparticles with uniform monomer sequences for sequence-specific peptide recognition","volume":"61","author":"Saito","year":"2022","journal-title":"Angew Chem. Int. Ed. Engl."},{"key":"10.1016\/j.canlet.2025.218174_bib42","doi-asserted-by":"crossref","first-page":"27697","DOI":"10.1021\/acsami.5c04775","article-title":"Peptide coacervates: formation, mechanism, and biological applications","volume":"17","author":"Yuan","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.canlet.2025.218174_bib43","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s12013-021-01019-3","article-title":"Advances in research on bladder cancer targeting peptides: a review","volume":"79","author":"Zheng","year":"2021","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.canlet.2025.218174_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.114044","article-title":"Cell-penetrating peptides in protein mimicry and cancer therapeutics","volume":"180","author":"Zorko","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.canlet.2025.218174_bib45","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abm1232","article-title":"Receptor-specific recognition of NPY peptides revealed by structures of NPY receptors","volume":"8","author":"Tang","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.canlet.2025.218174_bib46","doi-asserted-by":"crossref","first-page":"4076","DOI":"10.1021\/acssensors.1c01574","article-title":"Subcellular dynamic immunopatterning of cytosolic protein complexes on microstructured polymer substrates","volume":"6","author":"Hager","year":"2021","journal-title":"ACS Sens."},{"key":"10.1016\/j.canlet.2025.218174_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.118318","article-title":"Peptide-drug conjugates with linker-dependent payload release coordinate dual antitumor efficacy: intrinsic RGDS-mediated metastasis suppression synergizes with camptothecin cytotoxicity","volume":"189","author":"Cao","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.canlet.2025.218174_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27217232","article-title":"Peptide-drug conjugates: a new hope for cancer management","volume":"27","author":"Chavda","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.canlet.2025.218174_bib49","doi-asserted-by":"crossref","DOI":"10.26599\/NR.2025.94907427","article-title":"Tumor-triggered morphology switch of a peptide-drug conjugate enhances antitumor immunity and inhibits metastasis","volume":"18","author":"Peng","year":"2025","journal-title":"Nano Res."},{"key":"10.1016\/j.canlet.2025.218174_bib50","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.coph.2019.01.006","article-title":"Tumor targeting peptides: novel therapeutic strategies in glioblastoma","volume":"47","author":"Raucher","year":"2019","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.canlet.2025.218174_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24043400","article-title":"Targeting the gastrin-releasing peptide receptor (GRP-R) in cancer therapy: development of bombesin-based peptide-drug conjugates","volume":"24","author":"Gomena","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.canlet.2025.218174_bib52","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202306676","article-title":"Inhibiting endothelial cell-mediated T lymphocyte apoptosis with integrin-targeting peptide-drug conjugate filaments for chemoimmunotherapy of triple-negative breast cancer","volume":"36","author":"Cai","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.canlet.2025.218174_bib53","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13050661","article-title":"Evaluation of a keratin 1 targeting peptide-doxorubicin conjugate in a mouse model of triple-negative breast cancer","volume":"13","author":"Saghaeidehkordi","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.canlet.2025.218174_bib54","article-title":"A dual-targeting peptide\u2013drug conjugate based on CXCR4 and FOLR1 inhibits triple-negative breast cancer","author":"Wang","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.canlet.2025.218174_bib55","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.biomaterials.2017.08.001","article-title":"Traceable PEO-poly(ester) micelles for breast cancer targeting: the effect of core structure and targeting peptide on micellar tumor accumulation","volume":"144","author":"Garg","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.canlet.2025.218174_bib56","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s12943-025-02395-7","article-title":"Promising therapeutic efficacy and safety of a novel integrin \u03b16-targeting peptide-drug conjugate in lung adenocarcinoma","volume":"24","author":"Gao","year":"2025","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.canlet.2025.218174_bib57","doi-asserted-by":"crossref","first-page":"3570","DOI":"10.1021\/acs.molpharmaceut.3c00189","article-title":"Peptide-drug conjugate targeting keratin 1 inhibits triple-negative breast cancer in mice","volume":"20","author":"Ziaei","year":"2023","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.canlet.2025.218174_bib58","doi-asserted-by":"crossref","DOI":"10.1038\/s41401-025-01584-w","article-title":"Somatostatin receptor 2 targeting peptide modifications for peptide-drug conjugate treatment of small cell lung cancer","author":"Bo","year":"2025","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.canlet.2025.218174_bib59","article-title":"Fibulin-4 is highly expressed in metastatic breast cancer and can serve as a target of peptide-based imaging probes and experimental therapeutics","author":"Daquinag","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.canlet.2025.218174_bib60","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1021\/acsomega.3c07486","article-title":"Development of a targeted SN-38-Conjugate for the treatment of glioblastoma","volume":"9","author":"Bataille Backer","year":"2024","journal-title":"ACS Omega"},{"key":"10.1016\/j.canlet.2025.218174_bib61","first-page":"658","article-title":"Biochemical uniformity and heterogeneity in cancer tissue (further discussion)","volume":"16","author":"Potter","year":"1956","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2025.218174_bib62","doi-asserted-by":"crossref","first-page":"10840","DOI":"10.1039\/D2RA07758B","article-title":"LWJ-M30, a conjugate of DM1 and B6, for the targeted therapy of colorectal cancer with improved therapeutic effects","volume":"13","author":"Zhang","year":"2023","journal-title":"RSC Adv."},{"key":"10.1016\/j.canlet.2025.218174_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116701","article-title":"A peptide-salinomycin conjugate with a bystander effect reduces the stemness characteristics of ovarian cancer cells and enhances drug sensitivity","volume":"276","author":"Hao","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.canlet.2025.218174_bib64","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1126\/science.67.1737.396.b","article-title":"A note on ovarian secretion and cancer","volume":"67","author":"Murray","year":"1928","journal-title":"Science"},{"key":"10.1016\/j.canlet.2025.218174_bib65","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.semcancer.2019.07.005","article-title":"Horizons of nanotechnology applications in female specific cancers","volume":"69","author":"Rajitha","year":"2021","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.canlet.2025.218174_bib66","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1021\/acs.nanolett.4c05354","article-title":"LRG1-Targeted camptothecin nanomicelles with simultaneous delivery of olaparib for enhanced colorectal cancer chemotherapy","volume":"25","author":"Du","year":"2025","journal-title":"Nano Lett."},{"key":"10.1016\/j.canlet.2025.218174_bib67","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.jconrel.2020.10.063","article-title":"pH-Activatable cell penetrating peptide dimers for potent delivery of anticancer drug to triple-negative breast cancer","volume":"330","author":"Nam","year":"2021","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.canlet.2025.218174_bib68","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.jcis.2020.10.103","article-title":"pH-dependent reversibly activatable cell-penetrating peptides improve the antitumor effect of artemisinin-loaded liposomes","volume":"586","author":"Yu","year":"2021","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.canlet.2025.218174_bib69","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1096\/fsb2fasebj.12.1.67","article-title":"Cell penetration by transportan","volume":"12","author":"Pooga","year":"1998","journal-title":"FASEB J."},{"key":"10.1016\/j.canlet.2025.218174_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.lungcan.2024.107957","article-title":"Blood-brain barrier and blood-brain tumor barrier penetrating peptide-drug conjugate as targeted therapy for the treatment of lung cancer brain metastasis","volume":"196","author":"Zheng","year":"2024","journal-title":"Lung Cancer"},{"key":"10.1016\/j.canlet.2025.218174_bib71","doi-asserted-by":"crossref","DOI":"10.1111\/cbdd.70051","article-title":"Synthesis and investigation of peptide-drug conjugates comprising camptothecin and a human protein-derived cell-penetrating peptide","volume":"105","author":"Palombi","year":"2025","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.canlet.2025.218174_bib72","doi-asserted-by":"crossref","DOI":"10.1002\/cnma.202100532","article-title":"Reactive oxygen species-responsive peptide-drug conjugate for mitochondria-specific chemotherapy","volume":"8","author":"Ji","year":"2022","journal-title":"ChemNanoMat"},{"key":"10.1016\/j.canlet.2025.218174_bib73","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1042\/BCJ20200006","article-title":"Cell-penetrating peptides: two faces of the same coin","volume":"477","author":"Pierantoni","year":"2020","journal-title":"Biochem. J."},{"key":"10.1016\/j.canlet.2025.218174_bib74","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/BF00249295","article-title":"Pharmacology of melittin","volume":"222","author":"Habermann","year":"1954","journal-title":"Naunyn-Schmiedebergs Arch. Exp. Pathol. Pharmakol."},{"key":"10.1016\/j.canlet.2025.218174_bib75","article-title":"Design of pH-responsive antimicrobial peptide melittin analog-camptothecin conjugates for tumor therapy","volume":"19","author":"Huang","year":"2024","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.canlet.2025.218174_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2022.112650","article-title":"\"Dual-functional\" strontium titanate nanotubes designed based on fusion peptides simultaneously enhancing anti-infection and osseointegration","volume":"133","author":"Wang","year":"2022","journal-title":"Biomater. Adv."},{"key":"10.1016\/j.canlet.2025.218174_bib77","doi-asserted-by":"crossref","first-page":"3658","DOI":"10.1080\/10408398.2020.1867958","article-title":"The colorful world of carotenoids: a profound insight on therapeutics and recent trends in nano delivery systems","volume":"62","author":"Maghsoudi","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.canlet.2025.218174_bib78","doi-asserted-by":"crossref","first-page":"15384","DOI":"10.1039\/D2NR02118H","article-title":"An assembly-inducing PDC enabling the efficient nuclear delivery of nucleic acid for cancer stem-like cell suppression","volume":"14","author":"Wang","year":"2022","journal-title":"Nanoscale"},{"key":"10.1016\/j.canlet.2025.218174_bib79","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.addr.2020.10.009","article-title":"Multifunctional peptides for tumor therapy","volume":"160","author":"Li","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.canlet.2025.218174_bib80","article-title":"Designed multifunctional peptides for intracellular targets","volume":"11","author":"Jureti\u0107","year":"2022","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.canlet.2025.218174_bib81","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41467-020-20279-w","article-title":"Site-specific incorporation of citrulline into proteins in mammalian cells","volume":"12","author":"Mondal","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2025.218174_bib82","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1007\/s13238-019-0639-7","article-title":"Phage display screening of therapeutic peptide for cancer targeting and therapy","volume":"10","author":"Saw","year":"2019","journal-title":"Protein Cell"},{"key":"10.1016\/j.canlet.2025.218174_bib83","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.bioorg.2017.11.020","article-title":"Development of optimized conditions for Glaser-Hay bioconjugations","volume":"76","author":"Nimmo","year":"2018","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.canlet.2025.218174_bib84","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.cbpa.2018.03.019","article-title":"Peptide modification and cyclization via transition-metal catalysis","volume":"46","author":"Malins","year":"2018","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.canlet.2025.218174_bib85","article-title":"Transcytosable peptide-paclitaxel prodrug nanoparticle for targeted treatment of triple-negative breast cancer","volume":"24","author":"Wang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.canlet.2025.218174_bib86","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.1021\/acs.biomac.6b00997","article-title":"Modular design and facile synthesis of enzyme-responsive peptide-linked block copolymers for efficient delivery of Doxorubicin","volume":"17","author":"Ke","year":"2016","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.canlet.2025.218174_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.113050","article-title":"Discovery of novel cell-penetrating and tumor-targeting peptide-drug conjugate (PDC) for programmable delivery of paclitaxel and cancer treatment","volume":"213","author":"Deng","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.canlet.2025.218174_bib88","doi-asserted-by":"crossref","first-page":"33288","DOI":"10.1021\/acsami.3c03471","article-title":"Dual-targeting biomimetic nanomaterials for Photo-\/Chemo-\/Antiangiogenic synergistic therapy","volume":"15","author":"Zhang","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.canlet.2025.218174_bib89","doi-asserted-by":"crossref","first-page":"7347","DOI":"10.1007\/s12274-023-5396-5","article-title":"Modularly designed peptide-based nanomedicine inhibits angiogenesis to enhance chemotherapy for post-surgical recurrence of esophageal squamous cell carcinomas","volume":"16","author":"Qi","year":"2023","journal-title":"Nano Res."},{"key":"10.1016\/j.canlet.2025.218174_bib90","doi-asserted-by":"crossref","first-page":"25110","DOI":"10.1021\/acsami.2c05469","article-title":"Stimuli-responsive self-assembly disassembly in peptide amphiphiles to endow block-co-fibers and tunable piezoelectric response","volume":"15","author":"Gupta","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.canlet.2025.218174_bib91","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jcis.2022.08.104","article-title":"Exploiting terminal charged residue shift for wide bilayer nanotube assembly","volume":"629","author":"Zhao","year":"2023","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.canlet.2025.218174_bib92","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1021\/acsami.2c14413","article-title":"Enhancing photothermal therapy efficacy by in situ self-assembly in Glioma","volume":"15","author":"Song","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.canlet.2025.218174_bib93","first-page":"47","article-title":"An enzyme-responsive and transformable PD-L1 blocking peptide-photosensitizer conjugate enables efficient photothermal immunotherapy for breast cancer","volume":"22","author":"Sun","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.canlet.2025.218174_bib94","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.actbio.2022.11.013","article-title":"A simple self-assembly nanomicelle based on brain tumor-targeting peptide-mediated siRNA delivery for glioma immunotherapy via intranasal administration","volume":"155","author":"Tang","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.canlet.2025.218174_bib95","doi-asserted-by":"crossref","first-page":"16188","DOI":"10.1021\/acs.jmedchem.5c01098","article-title":"Self-assembling peptides alter cell death pathway for pyroptosis-enhanced immune activation","volume":"68","author":"Zhang","year":"2025","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.canlet.2025.218174_bib96","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1021\/acs.molpharmaceut.0c00118","article-title":"Drug-bearing peptide-based nanospheres for the inhibition of metastasis and growth of cancer","volume":"17","author":"Zhang","year":"2020","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.canlet.2025.218174_bib97","doi-asserted-by":"crossref","first-page":"50191","DOI":"10.1021\/acsami.5c05264","article-title":"Self-assembling cyclic peptide nanotubes for the delivery of Doxorubicin into drug-resistant cancer cells","volume":"17","author":"Vilela-Picos","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.canlet.2025.218174_bib98","doi-asserted-by":"crossref","first-page":"D1476","DOI":"10.1093\/nar\/gkae859","article-title":"PDCdb: the biological activity and pharmaceutical information of peptide-drug conjugate (PDC)","volume":"53","author":"Sun","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.canlet.2025.218174_bib99","doi-asserted-by":"crossref","first-page":"11469","DOI":"10.1021\/acs.jmedchem.4c00106","article-title":"Recent advances in targeted cancer therapy: are PDCs the next generation of ADCs?","volume":"67","author":"Zhang","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.canlet.2025.218174_bib100","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1021\/acs.jmedchem.0c01530","article-title":"Peptide-drug conjugates with different linkers for cancer therapy","volume":"64","author":"Alas","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.canlet.2025.218174_bib101","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14020396","article-title":"Linkers: an assurance for controlled delivery of antibody-drug conjugate","volume":"14","author":"Sheyi","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.canlet.2025.218174_bib102","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.117204","article-title":"Recent progress in the development of peptide-drug conjugates (PDCs) for cancer therapy","volume":"284","author":"He","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.canlet.2025.218174_bib103","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2025.216641","article-title":"Application of smart responsive nanomaterials in the theranostics of gastrointestinal malignancies: current status and future perspectives","volume":"535","author":"Huang","year":"2025","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.canlet.2025.218174_bib104","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.2174\/1568026618666180118153502","article-title":"ADME and safety aspects of non-cleavable linkers in drug discovery and development","volume":"17","author":"Walles","year":"2017","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.canlet.2025.218174_bib105","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s10555-024-10231-5","article-title":"Influence of antibody-drug conjugate cleavability, drug-to-antibody ratio, and free payload concentration on systemic toxicities: a systematic review and meta-analysis","volume":"44","author":"Tang","year":"2024","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.canlet.2025.218174_bib106","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.bmcl.2019.01.009","article-title":"Novel PIKK inhibitor antibody-drug conjugates: synthesis and anti-tumor activity","volume":"29","author":"Zhou","year":"2019","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.canlet.2025.218174_bib107","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41420-022-01198-9","article-title":"A VEGFR targeting peptide-drug conjugate (PDC) suppresses tumor angiogenesis in a TACE model for hepatocellular carcinoma therapy","volume":"8","author":"Wang","year":"2022","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.canlet.2025.218174_bib108","article-title":"A novel homodimer peptide-drug conjugate improves the efficacy of HER2-Positive breast cancer therapy","volume":"24","author":"Liu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.canlet.2025.218174_bib109","doi-asserted-by":"crossref","first-page":"5977","DOI":"10.1021\/acsbiomaterials.4c00897","article-title":"Nanomedicines with versatile GSH-responsive linkers for cancer theranostics","volume":"10","author":"Ding","year":"2024","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.canlet.2025.218174_bib110","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2024.117663","article-title":"Development of an oxazole-based cleavable linker for peptides","volume":"102","author":"Taggart","year":"2024","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.canlet.2025.218174_bib111","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1039\/D0MO00181C","article-title":"Cleavable linkers and their application in MS-based target identification","volume":"17","author":"Beard","year":"2021","journal-title":"Mol Omics"},{"key":"10.1016\/j.canlet.2025.218174_bib112","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9080849","article-title":"Development and characterization of a novel peptide-drug conjugate with DM1 for treatment of FGFR2-Positive tumors","volume":"9","author":"Wang","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.canlet.2025.218174_bib113","doi-asserted-by":"crossref","DOI":"10.1002\/cbic.202400426","article-title":"A dual bispecific hydrolysis peptide-drug conjugate responsive to micro-acidic and reduction circumstance promotes antitumor efficacy in triple-negative breast cancer","volume":"25","author":"Tang","year":"2024","journal-title":"Chembiochem"},{"key":"10.1016\/j.canlet.2025.218174_bib114","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ejps.2016.05.024","article-title":"Enzyme-responsive destabilization of stabilized plasmid-lipid nanoparticles as an efficient gene delivery","volume":"91","author":"Song","year":"2016","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.canlet.2025.218174_bib115","doi-asserted-by":"crossref","first-page":"647","DOI":"10.3389\/fchem.2020.00647","article-title":"Enzyme-responsive nanoparticles for anti-tumor drug delivery","volume":"8","author":"Li","year":"2020","journal-title":"Front. Chem."},{"key":"10.1016\/j.canlet.2025.218174_bib116","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114617","article-title":"An auristatin-based peptide-drug conjugate targeting Kita-Kyushu lung cancer antigen 1 for precision chemoradiotherapy in gastric cancer","volume":"241","author":"Chen","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.canlet.2025.218174_bib117","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.stemcr.2017.12.007","article-title":"Real-Time monitoring of glutathione in living cells reveals that high glutathione levels are required to maintain stem cell function","volume":"10","author":"Jeong","year":"2018","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.canlet.2025.218174_bib118","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113430","article-title":"Tumor vasculature-targeting PEGylated peptide-drug conjugate prodrug nanoparticles improve chemotherapy and prevent tumor metastasis","volume":"219","author":"Hao","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.canlet.2025.218174_bib119","doi-asserted-by":"crossref","first-page":"8159","DOI":"10.2147\/IJN.S338272","article-title":"Innovative approaches of engineering tumor-targeting bacteria with different therapeutic payloads to fight cancer: a smart strategy of disease management","volume":"16","author":"Allemailem","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.canlet.2025.218174_bib120","article-title":"New transferrin receptor-targeted peptide-doxorubicin conjugates: synthesis and in vitro antitumor activity","volume":"29","author":"Yu","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.canlet.2025.218174_bib121","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1021\/acs.bioconjchem.4c00485","article-title":"Antitumor effect of peptide-camptothecin conjugate targeting CD133 protein","volume":"35","author":"Tao","year":"2024","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.canlet.2025.218174_bib122","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107371","article-title":"Discovery of novel HER2 targeting peptide-camptothecin conjugates with effective suppression for selective cancer treatment","volume":"147","author":"Wu","year":"2024","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.canlet.2025.218174_bib123","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121139","article-title":"Targeted in situ self-assembly augments peptide drug conjugate cell-entry efficiency","volume":"278","author":"Wang","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.canlet.2025.218174_bib124","doi-asserted-by":"crossref","first-page":"12950","DOI":"10.1021\/acs.jmedchem.5c00847","article-title":"MMAE-Based peptide-drug conjugates targeting GPC3 for precision chemoradiotherapy in hepatocellular carcinoma","volume":"68","author":"Pan","year":"2025","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.canlet.2025.218174_bib125","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.116032","article-title":"Design, synthesis and bioactivity evaluation of novel fusion peptides and their CPT conjugates inducing effective anti-tumor responses on HER2 positive tumors","volume":"264","author":"Zhou","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.canlet.2025.218174_bib126","doi-asserted-by":"crossref","first-page":"17051","DOI":"10.1021\/acs.jmedchem.1c00705","article-title":"Bradykinin-Potentiating peptide-paclitaxel conjugate directed at ectopically expressed angiotensin-converting enzyme in triple-negative breast cancer","volume":"64","author":"Guo","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.canlet.2025.218174_bib127","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.117276","article-title":"Design and synthesis of isatin derivative payloaded peptide-drug conjugate as tubulin inhibitor against colorectal cancer","volume":"285","author":"Sun","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.canlet.2025.218174_bib128","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1016\/j.apsb.2023.02.009","article-title":"Sequential delivery of PD-1\/PD-L1 blockade peptide and IDO inhibitor for immunosuppressive microenvironment remodeling via an MMP-2 responsive dual-targeting liposome","volume":"13","author":"Hu","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.canlet.2025.218174_bib129","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics16121613","article-title":"Novel cyclic peptide-drug conjugate P6-SN38 toward targeted treatment of EGFR overexpressed non-small cell lung cancer","volume":"16","author":"Bazylevich","year":"2024","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.canlet.2025.218174_bib130","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jconrel.2024.06.028","article-title":"Stimulating macropinocytosis of peptide-drug conjugates through DNA-dependent protein kinase inhibition for treating KRAS-mutant cancer","volume":"372","author":"Kim","year":"2024","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.canlet.2025.218174_bib131","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15041131","article-title":"Development of a peptide-based nano-sized cathepsin B inhibitor for anticancer therapy","volume":"15","author":"Park","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.canlet.2025.218174_bib132","doi-asserted-by":"crossref","first-page":"414","DOI":"10.2174\/1386207320666170113123132","article-title":"Recent advances in developing photosensitizers for photodynamic cancer therapy","volume":"20","author":"Chen","year":"2017","journal-title":"Comb. Chem. High Throughput Screen."},{"key":"10.1016\/j.canlet.2025.218174_bib133","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.jcis.2023.05.131","article-title":"A serum-stable supramolecular drug carrier for chemotherapeutics fabricated by a peptide-photosensitizer conjugate","volume":"646","author":"Chen","year":"2023","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.canlet.2025.218174_bib134","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines5040069","article-title":"Photodynamic therapy for eye cancer","volume":"5","author":"Rundle","year":"2017","journal-title":"Biomedicines"},{"key":"10.1016\/j.canlet.2025.218174_bib135","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s40820-020-00561-8","article-title":"Photosensitizer nanoparticles boost photodynamic therapy for pancreatic cancer treatment","volume":"13","author":"Yang","year":"2021","journal-title":"Nano-Micro Lett."},{"key":"10.1016\/j.canlet.2025.218174_bib136","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.116047","article-title":"Smart glypican-3-targeting peptide-chlorin e6 conjugates for targeted photodynamic therapy of hepatocellular carcinoma","volume":"264","author":"Fang","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.canlet.2025.218174_bib137","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines4020011","article-title":"Recent innovations in peptide based targeted drug delivery to cancer cells","volume":"4","author":"Gilad","year":"2016","journal-title":"Biomedicines"},{"key":"10.1016\/j.canlet.2025.218174_bib138","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2022.215969","article-title":"Drug conjugate-based anticancer therapy - current status and perspectives","volume":"552","author":"Yang","year":"2023","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2025.218174_bib139","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.218016","article-title":"Polyamines in pancreatic cancer: reshaping the immunosuppressive tumor microenvironment","volume":"633","author":"Jiang","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2025.218174_bib140","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.218076","article-title":"Tumor microenvironment and macroenvironment: a new perspective on holistic oncology","volume":"634","author":"Chen","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2025.218174_bib141","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/bph.15861","article-title":"Mesenchymal stem cells and cancer-associated fibroblasts as a therapeutic strategy for breast cancer","volume":"181","author":"Borzone","year":"2024","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.canlet.2025.218174_bib142","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.218002","article-title":"Protective role of epithelial deoxyhypusine synthase in colorectal carcinogenesis caused by deletion of the adenomatous polyposis coli gene","volume":"633","author":"Gobert","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2025.218174_bib143","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2025.115181","article-title":"Hybrid nanoparticle-immune cell conjugates for augmented anticancer efficacy","volume":"257","author":"Jangid","year":"2026","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.canlet.2025.218174_bib144","article-title":"Recent advances in peptide linkers for antibody-drug conjugates","author":"Li","year":"2025","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.canlet.2025.218174_bib145","doi-asserted-by":"crossref","first-page":"5474","DOI":"10.1016\/j.apsb.2025.07.029","article-title":"mRNA display-enabled discovery of proximity-triggered covalent peptide\u2013drug conjugates","volume":"15","author":"Wang","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.canlet.2025.218174_bib146","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.216979","article-title":"The new era of pancreatic cancer treatment: application of nanotechnology breaking through bottlenecks","volume":"594","author":"Luo","year":"2024","journal-title":"Cancer Lett."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383525007463?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383525007463?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T15:45:20Z","timestamp":1783093520000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383525007463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":146,"alternative-id":["S0304383525007463"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2025.218174","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Peptide-drug conjugates in tumor therapy: Current advances and future perspectives","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2025.218174","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"218174"}}