{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:49:22Z","timestamp":1792097362733,"version":"4.4.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172628"],"award-info":[{"award-number":["82172628"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974371"],"award-info":[{"award-number":["81974371"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173048"],"award-info":[{"award-number":["82173048"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373370"],"award-info":[{"award-number":["82373370"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8227262 0"],"award-info":[{"award-number":["8227262 0"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32130036"],"award-info":[{"award-number":["32130036"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["2022XD010"],"award-info":[{"award-number":["2022XD010"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["2025-71"],"award-info":[{"award-number":["2025-71"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["20JC1419100"],"award-info":[{"award-number":["20JC1419100"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017633","name":"Shanghai Anti-Cancer Association","doi-asserted-by":"publisher","award":["SACA-CY21C01"],"award-info":[{"award-number":["SACA-CY21C01"]}],"id":[{"id":"10.13039\/100017633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.canlet.2025.218208","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T16:03:21Z","timestamp":1765209801000},"page":"218208","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Loss of branched-chain amino acid (BCAA) metabolism mediated by IGF2BP1-LPAL2-YBX1 interaction promotes malignancy in gallbladder cancer"],"prefix":"10.1016","volume":"639","author":[{"given":"Xuechuan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liguo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajun","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingbin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangsong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2025.218208_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2023.216184","article-title":"YKL-40 derived from infiltrating macrophages cooperates with GDF15 to establish an immune suppressive microenvironment in gallbladder cancer","volume":"563","author":"Wang","year":"2023","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2025.218208_bib2","article-title":"DNMT3A cooperates with YAP\/TAZ to drive gallbladder cancer metastasis","volume":"16","author":"Xu","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.canlet.2025.218208_bib3","article-title":"Super-Enhancer reprograming driven by SOX9 and TCF7L2 represents transcription-targeted therapeutic vulnerability for treating gallbladder cancer","volume":"11","author":"Yan","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.canlet.2025.218208_bib4","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adv6723","article-title":"HLF transactivates TFEB to promote gallbladder cancer stem cells' self-renewal and determines tumor response to distinct therapies","volume":"11","author":"Xiang","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.canlet.2025.218208_bib5","doi-asserted-by":"crossref","DOI":"10.5306\/wjco.v16.i10.111028","article-title":"Global gene expression landscape of gallbladder cancer and advances in targeted therapeutic strategies","volume":"16","author":"Choudhury","year":"2025","journal-title":"World J. Clin. Oncol."},{"key":"10.1016\/j.canlet.2025.218208_bib6","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1136\/gutjnl-2018-316039","article-title":"Genomic ERBB2\/ERBB3 mutations promote PD-L1-mediated immune escape in gallbladder cancer: a whole-exome sequencing analysis","volume":"68","author":"Li","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.canlet.2025.218208_bib7","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.jhep.2021.06.023","article-title":"Single-cell RNA-sequencing atlas reveals an MDK-dependent immunosuppressive environment in ErbB pathway-mutated gallbladder cancer","volume":"75","author":"Zhang","year":"2021","journal-title":"J. Hepatol."},{"key":"10.1016\/j.canlet.2025.218208_bib8","article-title":"Branched chain amino acids and their aberrant metabolism in cancer","author":"Brown","year":"2025","journal-title":"Trends Cancer"},{"key":"10.1016\/j.canlet.2025.218208_bib9","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1126\/science.aaf5171","article-title":"Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers","volume":"353","author":"Mayers","year":"2016","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.canlet.2025.218208_bib10","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/s41556-019-0455-6","article-title":"BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma","volume":"22","author":"Li","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.canlet.2025.218208_bib11","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/nm.3217","article-title":"BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1","volume":"19","author":"T\u00f6njes","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.canlet.2025.218208_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.117445","article-title":"PTGFRN promotes non-small cell lung cancer malignant progression and reprograms BCAA metabolism by activating STAT3\/BCAT1 pathway","volume":"242","author":"Liu","year":"2025","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.canlet.2025.218208_bib13","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.cmet.2018.12.020","article-title":"Loss of BCAA catabolism during carcinogenesis enhances mTORC1 activity and promotes tumor development and progression","volume":"29","author":"Ericksen","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.canlet.2025.218208_bib14","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ccell.2019.12.011","article-title":"Emerging roles for branched-chain amino acid metabolism in cancer","volume":"37","author":"Sivanand","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2025.218208_bib15","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41392-020-0168-0","article-title":"Acetylation promotes BCAT2 degradation to suppress BCAA catabolism and pancreatic cancer growth","volume":"5","author":"Lei","year":"2020","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.canlet.2025.218208_bib16","article-title":"The critical role of the branched chain amino acids (BCAAs) catabolism-regulating enzymes, branched-chain aminotransferase (BCAT) and Branched-Chain \u03b1-Keto Acid Dehydrogenase (BCKD)","volume":"23","author":"Dimou","year":"2022","journal-title":"Human Pathophysiol., Int.J.Mol. Sci."},{"key":"10.1016\/j.canlet.2025.218208_bib17","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/nm.3686","article-title":"Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development","volume":"20","author":"Mayers","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.canlet.2025.218208_bib18","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1016\/j.clnu.2023.10.019","article-title":"Association of plasma branched-chain amino acid with multiple cancers: a mendelian randomization analysis","volume":"42","author":"Xu","year":"2023","journal-title":"Clin. Nutr. (Edinburgh, Scotland)"},{"key":"10.1016\/j.canlet.2025.218208_bib19","doi-asserted-by":"crossref","first-page":"8711","DOI":"10.1096\/fj.201802842RR","article-title":"Role of branched-chain amino acid-catabolizing enzymes in intertissue signaling, metabolic remodeling, and energy homeostasis","volume":"33","author":"Biswas","year":"2019","journal-title":"FASEB J. Off. Pub. Federation American Soc. Experimental Biol."},{"key":"10.1016\/j.canlet.2025.218208_bib20","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0969-2126(00)00105-2","article-title":"Crystal structure of human branched-chain alpha-ketoacid dehydrogenase and the molecular basis of multienzyme complex deficiency in maple syrup urine disease","volume":"8","author":"A","year":"2000","journal-title":"Structure (London, England : 1993)"},{"key":"10.1016\/j.canlet.2025.218208_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101198","article-title":"Branched chain amino acids, aging and age-related health","volume":"64","author":"Le Couteur","year":"2020","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.canlet.2025.218208_bib22","doi-asserted-by":"crossref","first-page":"604","DOI":"10.21037\/hbsn.2019.04.11","article-title":"Somatic genetic aberrations in gallbladder cancer: comparison between Chinese and US patients","volume":"8","author":"Yang","year":"2019","journal-title":"Hepatobiliary Surg. Nutr."},{"key":"10.1016\/j.canlet.2025.218208_bib23","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1186\/s13023-025-03740-1","article-title":"mTOR pathway diseases: challenges and opportunities from bench to bedside and the mTOR node","volume":"20","author":"Mantoan Ritter","year":"2025","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.canlet.2025.218208_bib24","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/path.6144","article-title":"ELF3 suppresses gallbladder cancer development through downregulation of the EREG\/EGFR\/mTOR complex 1 signalling pathway","volume":"261","author":"Nakamura","year":"2023","journal-title":"J. Pathol."},{"key":"10.1016\/j.canlet.2025.218208_bib25","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41392-023-01608-z","article-title":"Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease","volume":"8","author":"Panwar","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.canlet.2025.218208_bib26","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.cell.2010.02.024","article-title":"Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids","volume":"141","author":"Sancak","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2025.218208_bib27","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1158\/0008-5472.CAN-18-1432","article-title":"Long noncoding RNA MALAT1 regulates cancer glucose metabolism by enhancing mTOR-Mediated translation of TCF7L2","volume":"79","author":"Malakar","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2025.218208_bib28","first-page":"575","article-title":"Gene co-expression analysis for functional classification and gene-disease predictions","volume":"19","author":"van Dam","year":"2018","journal-title":"Briefings Bioinf."},{"key":"10.1016\/j.canlet.2025.218208_bib29","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/gb4152","article-title":"Methods for comprehensive experimental identification of RNA-protein interactions","volume":"15","author":"McHugh","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.canlet.2025.218208_bib30","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.cell.2018.11.004","article-title":"The human RNA-Binding proteome and its dynamics during translational arrest","volume":"176","author":"Trendel","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2025.218208_bib31","article-title":"Hypoxia induced Lnc191 upregulation dictates the progression of esophageal squamous cell carcinoma by activating GRP78\/ERK pathway","volume":"12","author":"Wei","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.canlet.2025.218208_bib32","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/s41419-024-07250-z","article-title":"SP-1-activated LINC01016 overexpression promotes gastric cancer invasion and metastasis through inhibiting EIF4A3-mediated MMP9 mRNA decay","volume":"16","author":"Sun","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.canlet.2025.218208_bib33","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/s41419-025-07374-w","article-title":"Long noncoding RNA GDIL acts as a scaffold for CHAC1 and XRN2 to promote platinum resistance of colorectal cancer through inhibition of glutathione degradation","volume":"16","author":"Deng","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.canlet.2025.218208_bib34","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1038\/s41467-020-15403-9","article-title":"An oncopeptide regulates m(6)A recognition by the m(6)A reader IGF2BP1 and tumorigenesis","volume":"11","author":"Zhu","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2025.218208_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.136094","article-title":"METTL3-regulated m6A modification of lncRNA E230001N04Rik is involved in myofibroblast differentiation in arsenic-induced pulmonary fibrosis through promoting senescence of lung epithelial cells","volume":"480","author":"Xiao","year":"2024","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.canlet.2025.218208_bib36","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s41392-020-00375-5","article-title":"CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1","volume":"5","author":"Xu","year":"2020","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.canlet.2025.218208_bib37","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.7150\/thno.111180","article-title":"The TMBIM1-YBX1 axis orchestrates MDSC recruitment and immunosuppressive microenvironment in pancreatic cancer","volume":"15","author":"Tong","year":"2025","journal-title":"Theranostics"},{"key":"10.1016\/j.canlet.2025.218208_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217494","article-title":"CircKIAA0182-YBX1 axis: a key driver of lung cancer progression and chemoresistance","volume":"612","author":"Huang","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2025.218208_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217957","article-title":"O-GlcNAcylation of YBX1 drives a glycolysis-histone lactylation feedback loop in hepatocellular carcinoma","volume":"631","author":"Ji","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2025.218208_bib40","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/nm0497-447","article-title":"Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression","volume":"3","author":"Bargou","year":"1997","journal-title":"Nat. Med."},{"key":"10.1016\/j.canlet.2025.218208_bib41","doi-asserted-by":"crossref","first-page":"7322","DOI":"10.1073\/pnas.85.19.7322","article-title":"Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box","volume":"85","author":"Didier","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.canlet.2025.218208_bib42","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/cdd.2013.13","article-title":"Targeting the Y\/CCAAT box in cancer: YB-1 (YBX1) or NF-Y?","volume":"20","author":"Dolfini","year":"2013","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.canlet.2025.218208_bib43","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1134\/S0006297911130049","article-title":"Y-box-binding protein 1 (YB-1) and its functions","volume":"76","author":"Eliseeva","year":"2011","journal-title":"Biochemistry. Biokhimiia"},{"key":"10.1016\/j.canlet.2025.218208_bib44","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1038\/s41467-020-17007-9","article-title":"The lncRNA lincNMR regulates nucleotide metabolism via a YBX1 - RRM2 axis in cancer","volume":"11","author":"Gandhi","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2025.218208_bib45","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/wrna.1200","article-title":"YB-1 protein: functions and regulation","volume":"5","author":"Lyabin","year":"2014","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"10.1016\/j.canlet.2025.218208_bib46","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/nature22314","article-title":"Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia","volume":"545","author":"Hattori","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2025.218208_bib47","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41387-022-00213-3","article-title":"Role of branched-chain amino acid metabolism in the pathogenesis of obesity and type 2 diabetes-related metabolic disturbances BCAA metabolism in type 2 diabetes","volume":"12","author":"Vanweert","year":"2022","journal-title":"Nutr. Diabetes"},{"key":"10.1016\/j.canlet.2025.218208_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/nu15071580","article-title":"Association of circulating branched-chain amino acids with cardiovascular diseases: a mendelian randomization Study","volume":"15","author":"Xu","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.canlet.2025.218208_bib49","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41569-022-00760-3","article-title":"Branched-chain amino acids in cardiovascular disease","volume":"20","author":"McGarrah","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.canlet.2025.218208_bib50","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.scib.2022.01.011","article-title":"Long-term exposure to genistein inhibits the proliferation of gallbladder cancer by downregulating the MCM complex","volume":"67","author":"Geng","year":"2022","journal-title":"Sci Bull (Beijing)"},{"key":"10.1016\/j.canlet.2025.218208_bib51","article-title":"Branched-chain amino acids for people with hepatic encephalopathy","volume":"5","author":"Gluud","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.canlet.2025.218208_bib52","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1161\/CIRCULATIONAHA.119.043581","article-title":"Branched-Chain amino acid catabolism promotes thrombosis risk by enhancing Tropomodulin-3 propionylation in platelets","volume":"142","author":"Xu","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.canlet.2025.218208_bib53","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/j.cmet.2022.09.008","article-title":"Extra-cardiac BCAA catabolism lowers blood pressure and protects from heart failure","volume":"34","author":"Murashige","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.canlet.2025.218208_bib54","doi-asserted-by":"crossref","DOI":"10.1093\/nsr\/nwab212","article-title":"Diet high in branched-chain amino acid promotes PDAC development by USP1-mediated BCAT2 stabilization","volume":"9","author":"Li","year":"2022","journal-title":"Natl. Sci. Rev."},{"key":"10.1016\/j.canlet.2025.218208_bib55","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1007\/s12282-022-01379-5","article-title":"Dietary intake of branched-chain amino acids in relation to the risk of breast cancer","volume":"29","author":"Nouri-Majd","year":"2022","journal-title":"Breast cancer (Tokyo, Japan)"},{"key":"10.1016\/j.canlet.2025.218208_bib56","article-title":"Establishment and characterization of an immortalized epithelial cell line from human gallbladder","volume":"12","author":"Wang","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.canlet.2025.218208_bib57","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1038\/s41467-019-11447-8","article-title":"LncRNA GLCC1 promotes colorectal carcinogenesis and glucose metabolism by stabilizing c-Myc","volume":"10","author":"Tang","year":"2019","journal-title":"Nat. Commun."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383525007803?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383525007803?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:40:24Z","timestamp":1792096824000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383525007803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":57,"alternative-id":["S0304383525007803"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2025.218208","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss of branched-chain amino acid (BCAA) metabolism mediated by IGF2BP1-LPAL2-YBX1 interaction promotes malignancy in gallbladder cancer","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2025.218208","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"218208"}}