{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T14:51:16Z","timestamp":1792248676882,"version":"4.4.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2021YFA0909300"],"award-info":[{"award-number":["2021YFA0909300"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2023B1212060013"],"award-info":[{"award-number":["2023B1212060013"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2020B1212030004"],"award-info":[{"award-number":["2020B1212030004"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017696","name":"Guangzhou Women and Childrens Medical Center","doi-asserted-by":"publisher","award":["2024BS024"],"award-info":[{"award-number":["2024BS024"]}],"id":[{"id":"10.13039\/100017696","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013111","name":"Tip-top Scientific and Technical Innovative Youth Talents of Guangdong Special Support Program","doi-asserted-by":"publisher","award":["0720240105"],"award-info":[{"award-number":["0720240105"]}],"id":[{"id":"10.13039\/501100013111","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013111","name":"Tip-top Scientific and Technical Innovative Youth Talents of Guangdong Special Support Program","doi-asserted-by":"publisher","award":["2021TQ06Y125"],"award-info":[{"award-number":["2021TQ06Y125"]}],"id":[{"id":"10.13039\/501100013111","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515111211"],"award-info":[{"award-number":["2021A1515111211"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515111023"],"award-info":[{"award-number":["2023A1515111023"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82573408"],"award-info":[{"award-number":["82573408"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373023"],"award-info":[{"award-number":["82373023"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373150"],"award-info":[{"award-number":["82373150"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82503623"],"award-info":[{"award-number":["82503623"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172636"],"award-info":[{"award-number":["82172636"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32570638"],"award-info":[{"award-number":["32570638"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.canlet.2025.218213","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T23:53:27Z","timestamp":1765238007000},"page":"218213","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["HP1 enhances radio- and chemotherapy resistance in osteosarcoma via PARP1-dependent transcriptional repression and HR repair"],"prefix":"10.1016","volume":"639","author":[{"given":"Yuanxin","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5653-7956","authenticated-orcid":false,"given":"Yuntan","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihuai","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengxing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daning","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2157-6239","authenticated-orcid":false,"given":"Kaishun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongsheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.canlet.2025.218213_bib1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/ijc.24320","article-title":"International osteosarcoma incidence patterns in children and adolescents, middle ages and elderly persons","volume":"125","author":"Mirabello","year":"2009","journal-title":"Int. J. Cancer"},{"issue":"27","key":"10.1016\/j.canlet.2025.218213_bib2","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1200\/JCO.2014.59.4895","article-title":"Osteosarcoma: current treatment and a collaborative pathway to success","volume":"33","author":"Isakoff","year":"2015","journal-title":"J. Clin. Oncol."},{"issue":"10","key":"10.1016\/j.canlet.2025.218213_bib3","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/s41571-021-00519-8","article-title":"Advancing therapy for osteosarcoma","volume":"18","author":"Gill","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"2","key":"10.1016\/j.canlet.2025.218213_bib4","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41568-022-00535-5","article-title":"Targeting DNA damage response pathways in cancer","volume":"23","author":"Groelly","year":"2023","journal-title":"Nat. Rev. Cancer"},{"issue":"4","key":"10.1016\/j.canlet.2025.218213_bib5","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/nsmb.2796","article-title":"Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks","volume":"21","author":"Aymard","year":"2014","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"5","key":"10.1016\/j.canlet.2025.218213_bib6","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.molcel.2014.06.028","article-title":"Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin","volume":"55","author":"Kakarougkas","year":"2014","journal-title":"Mol. Cell"},{"issue":"6","key":"10.1016\/j.canlet.2025.218213_bib7","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.cell.2010.04.038","article-title":"ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks","volume":"141","author":"Shanbhag","year":"2010","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.canlet.2025.218213_bib8","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.cell.2007.12.013","article-title":"Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression","volume":"132","author":"Shimada","year":"2008","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.canlet.2025.218213_bib9","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/nsmb.2224","article-title":"DNAPKcs-dependent arrest of RNA polymerase II transcription in the presence of DNA breaks","volume":"19","author":"Pankotai","year":"2012","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"5","key":"10.1016\/j.canlet.2025.218213_bib10","doi-asserted-by":"crossref","first-page":"745","DOI":"10.15252\/embr.201643191","article-title":"NELF-E is recruited to DNA double-strand break sites to promote transcriptional repression and repair","volume":"18","author":"Awwad","year":"2017","journal-title":"EMBO Rep."},{"issue":"10","key":"10.1016\/j.canlet.2025.218213_bib11","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/nrm.2017.53","article-title":"The multifaceted roles of PARP1 in DNA repair and chromatin remodelling","volume":"18","author":"Ray Chaudhuri","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"9","key":"10.1016\/j.canlet.2025.218213_bib12","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.tibs.2021.01.014","article-title":"Rapid detection and signaling of DNA damage by PARP-1","volume":"46","author":"Pandey","year":"2021","journal-title":"Trends Biochem. Sci."},{"issue":"3","key":"10.1016\/j.canlet.2025.218213_bib13","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.celrep.2015.09.017","article-title":"TIMELESS forms a complex with PARP1 distinct from its complex with TIPIN and plays a role in the DNA damage response","volume":"13","author":"Young","year":"2015","journal-title":"Cell Rep."},{"issue":"6","key":"10.1016\/j.canlet.2025.218213_bib14","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.molcel.2015.01.034","article-title":"Biology of Poly(ADP-Ribose) polymerases: the factotums of cell maintenance","volume":"58","author":"Bai","year":"2015","journal-title":"Mol. Cell"},{"issue":"12","key":"10.1016\/j.canlet.2025.218213_bib15","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1038\/s41418-022-01024-w","article-title":"BAP1 promotes the repair of UV-induced DNA damage via PARP1-mediated recruitment to damage sites and control of activity and stability","volume":"29","author":"Lee","year":"2022","journal-title":"Cell Death Differ."},{"issue":"1","key":"10.1016\/j.canlet.2025.218213_bib16","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.molcel.2015.07.031","article-title":"Timeless interacts with PARP-1 to promote homologous recombination repair","volume":"60","author":"Xie","year":"2015","journal-title":"Mol. Cell"},{"issue":"4","key":"10.1016\/j.canlet.2025.218213_bib17","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/s41556-022-00872-5","article-title":"Poly(ADP-ribosylation) of P-TEFb by PARP1 disrupts phase separation to inhibit global transcription after DNA damage","volume":"24","author":"Fu","year":"2022","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.canlet.2025.218213_bib18","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.38771","article-title":"PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loading","volume":"7","author":"Rona","year":"2018","journal-title":"eLife"},{"issue":"7445","key":"10.1016\/j.canlet.2025.218213_bib19","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/nature12032","article-title":"A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly","volume":"496","author":"Canzio","year":"2013","journal-title":"Nature"},{"issue":"7782","key":"10.1016\/j.canlet.2025.218213_bib20","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/s41586-019-1669-2","article-title":"HP1 reshapes nucleosome core to promote phase separation of heterochromatin","volume":"575","author":"Sanulli","year":"2019","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.canlet.2025.218213_bib21","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1083\/jcb.200810035","article-title":"Heterochromatin protein 1 is recruited to various types of DNA damage","volume":"185","author":"Luijsterburg","year":"2009","journal-title":"J. Cell Biol."},{"issue":"7","key":"10.1016\/j.canlet.2025.218213_bib22","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1158\/0008-5472.CAN-14-2796","article-title":"Interaction of BARD1 and HP1 is required for BRCA1 retention at sites of DNA damage","volume":"75","author":"Wu","year":"2015","journal-title":"Cancer Res."},{"issue":"11","key":"10.1016\/j.canlet.2025.218213_bib23","doi-asserted-by":"crossref","first-page":"5784","DOI":"10.1093\/nar\/gkt231","article-title":"HP1 promotes tumor suppressor BRCA1 functions during the DNA damage response","volume":"41","author":"Lee","year":"2013","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.canlet.2025.218213_bib24","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202051041","article-title":"POGZ promotes homology-directed DNA repair in an HP1-dependent manner","volume":"23","author":"Heath","year":"2022","journal-title":"EMBO Rep."},{"issue":"5","key":"10.1016\/j.canlet.2025.218213_bib25","first-page":"4205","article-title":"CBX3 predicts an unfavorable prognosis and promotes tumorigenesis in osteosarcoma","volume":"19","author":"Ma","year":"2019","journal-title":"Mol. Med. Rep."},{"issue":"20","key":"10.1016\/j.canlet.2025.218213_bib26","article-title":"ATM-Dependent recruitment of BRD7 is required for transcriptional repression and DNA repair at DNA breaks flanking transcriptional active regions","volume":"7","author":"Hu","year":"2020","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.canlet.2025.218213_bib27","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13100-018-0139-y","article-title":"High-performance gene expression and knockout tools using sleeping beauty transposon system","volume":"9","author":"Hu","year":"2018","journal-title":"Mob DNA"},{"issue":"6","key":"10.1016\/j.canlet.2025.218213_bib28","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1158\/2159-8290.CD-18-1218","article-title":"PARP inhibitor efficacy depends on CD8(+) T-cell recruitment via intratumoral STING pathway activation in BRCA-Deficient models of triple-negative breast cancer","volume":"9","author":"Pantelidou","year":"2019","journal-title":"Cancer Discov."},{"issue":"1","key":"10.1016\/j.canlet.2025.218213_bib29","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12943-020-01167-9","article-title":"PARP inhibitors in pancreatic cancer: molecular mechanisms and clinical applications","volume":"19","author":"Zhu","year":"2020","journal-title":"Mol. Cancer"},{"issue":"2","key":"10.1016\/j.canlet.2025.218213_bib30","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ccell.2019.12.015","article-title":"EZH2 inhibition sensitizes CARM1-High, homologous recombination proficient ovarian cancers to PARP inhibition","volume":"37","author":"Karakashev","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2025.218213_bib31","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.ejca.2020.06.014","article-title":"A phase I trial of talazoparib and irinotecan with and without temozolomide in children and young adults with recurrent or refractory solid malignancies","volume":"137","author":"Federico","year":"2020","journal-title":"Eur. J. Cancer"},{"issue":"8","key":"10.1016\/j.canlet.2025.218213_bib32","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1002\/cncr.33349","article-title":"SARC025 arms 1 and 2: a phase 1 study of the poly(ADP-ribose) polymerase inhibitor niraparib with temozolomide or irinotecan in patients with advanced Ewing sarcoma","volume":"127","author":"Chugh","year":"2021","journal-title":"Cancer"},{"issue":"10","key":"10.1016\/j.canlet.2025.218213_bib33","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/S1470-2045(18)30438-8","article-title":"Trabectedin and olaparib in patients with advanced and non-resectable bone and soft-tissue sarcomas (TOMAS): an open-label, phase 1b study from the Italian sarcoma group","volume":"19","author":"Grignani","year":"2018","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.canlet.2025.218213_bib34","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1186\/1471-2407-14-813","article-title":"Phase II study of olaparib in patients with refractory ewing sarcoma following failure of standard chemotherapy","volume":"14","author":"Choy","year":"2014","journal-title":"BMC Cancer"},{"issue":"5","key":"10.1016\/j.canlet.2025.218213_bib35","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201846166","article-title":"Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents","volume":"20","author":"Hu","year":"2019","journal-title":"EMBO Rep."},{"issue":"3","key":"10.1016\/j.canlet.2025.218213_bib36","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nsmb.2499","article-title":"Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination","volume":"20","author":"Tang","year":"2013","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"10","key":"10.1016\/j.canlet.2025.218213_bib37","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/s41594-021-00661-y","article-title":"PRC1 drives Polycomb-mediated gene repression by controlling transcription initiation and burst frequency","volume":"28","author":"Dobrinic","year":"2021","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"4","key":"10.1016\/j.canlet.2025.218213_bib38","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.molcel.2019.11.021","article-title":"Histone H2AK119 mono-Ubiquitination is essential for polycomb-mediated transcriptional repression","volume":"77","author":"Tamburri","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.canlet.2025.218213_bib39","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.22767","article-title":"A high-resolution map of transcriptional repression","volume":"6","author":"Liang","year":"2017","journal-title":"eLife"},{"issue":"13","key":"10.1016\/j.canlet.2025.218213_bib40","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1007\/s00018-015-1880-8","article-title":"Structure and function insights into the NuRD chromatin remodeling complex","volume":"72","author":"Torchy","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"issue":"18","key":"10.1016\/j.canlet.2025.218213_bib41","doi-asserted-by":"crossref","first-page":"10534","DOI":"10.1093\/nar\/gkx711","article-title":"CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality","volume":"45","author":"Hoffmeister","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"10.1016\/j.canlet.2025.218213_bib42","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.stem.2014.05.006","article-title":"Chromatin repressive complexes in stem cells, development, and cancer","volume":"14","author":"Laugesen","year":"2014","journal-title":"Cell Stem Cell"},{"issue":"Suppl 7","key":"10.1016\/j.canlet.2025.218213_bib43","doi-asserted-by":"crossref","first-page":"vii320","DOI":"10.1093\/annonc\/mdq276","article-title":"Osteosarcoma","volume":"21","author":"Ritter","year":"2010","journal-title":"Ann. Oncol."},{"issue":"2","key":"10.1016\/j.canlet.2025.218213_bib44","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1200\/JCO.2017.75.1743","article-title":"Osteosarcoma, chondrosarcoma, and chordoma","volume":"36","author":"Whelan","year":"2018","journal-title":"J. Clin. Oncol."},{"issue":"17","key":"10.1016\/j.canlet.2025.218213_bib45","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1200\/JCO.2011.38.4420","article-title":"Neoadjuvant chemotherapy with methotrexate, cisplatin, and doxorubicin with or without ifosfamide in nonmetastatic osteosarcoma of the extremity: an Italian sarcoma group trial ISG\/OS-1","volume":"30","author":"Ferrari","year":"2012","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.canlet.2025.218213_bib46","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ejca.2018.11.027","article-title":"Survival and prognosis with osteosarcoma: outcomes in more than 2000 patients in the EURAMOS-1 (European and American osteosarcoma study) cohort","volume":"109","author":"Smeland","year":"2019","journal-title":"Eur. J. Cancer"},{"issue":"1","key":"10.1016\/j.canlet.2025.218213_bib47","doi-asserted-by":"crossref","first-page":"7207","DOI":"10.1038\/s41467-022-34689-5","article-title":"Multi-omics analysis identifies osteosarcoma subtypes with distinct prognosis indicating stratified treatment","volume":"13","author":"Jiang","year":"2022","journal-title":"Nat. Commun."},{"issue":"7195","key":"10.1016\/j.canlet.2025.218213_bib48","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nature06875","article-title":"HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response","volume":"453","author":"Ayoub","year":"2008","journal-title":"Nature"},{"issue":"6294","key":"10.1016\/j.canlet.2025.218213_bib49","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1126\/science.aaf7865","article-title":"Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation","volume":"353","author":"Gibson","year":"2016","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.canlet.2025.218213_bib50","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/nmeth.2603","article-title":"Site-specific characterization of the Asp- and Glu-ADP-ribosylated proteome","volume":"10","author":"Zhang","year":"2013","journal-title":"Nat. Methods"},{"issue":"3","key":"10.1016\/j.canlet.2025.218213_bib51","doi-asserted-by":"crossref","first-page":"422","DOI":"10.4161\/cc.23215","article-title":"Differential contribution of HP1 proteins to DNA end resection and homology-directed repair","volume":"12","author":"Soria","year":"2013","journal-title":"Cell Cycle"},{"issue":"6","key":"10.1016\/j.canlet.2025.218213_bib52","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1093\/nar\/gkaa006","article-title":"SIRT6 coordinates with CHD4 to promote chromatin relaxation and DNA repair","volume":"48","author":"Hou","year":"2020","journal-title":"Nucleic Acids Res."},{"issue":"7872","key":"10.1016\/j.canlet.2025.218213_bib53","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/s41586-021-03716-8","article-title":"Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation","volume":"596","author":"Hu","year":"2021","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.canlet.2025.218213_bib54","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/s41467-023-37013-x","article-title":"Deacetylation induced nuclear condensation of HP1gamma promotes multiple myeloma drug resistance","volume":"14","author":"Li","year":"2023","journal-title":"Nat. Commun."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383525007852?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383525007852?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:39:46Z","timestamp":1792096786000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383525007852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":54,"alternative-id":["S0304383525007852"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2025.218213","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HP1 enhances radio- and chemotherapy resistance in osteosarcoma via PARP1-dependent transcriptional repression and HR repair","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2025.218213","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"218213"}}