{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:48:56Z","timestamp":1792097336975,"version":"4.4.0"},"reference-count":225,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82222058"],"award-info":[{"award-number":["82222058"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173256"],"award-info":[{"award-number":["82173256"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82573226"],"award-info":[{"award-number":["82573226"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015401","name":"Shaanxi Province Key Research and Development Projects","doi-asserted-by":"publisher","award":["2024SF-GJHX-04"],"award-info":[{"award-number":["2024SF-GJHX-04"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.canlet.2025.218222","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T17:03:47Z","timestamp":1765818227000},"page":"218222","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Roles and therapeutic targeting of SLC transporters in gastrointestinal malignancies"],"prefix":"10.1016","volume":"639","author":[{"given":"Junshu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanci","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuya","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1817-803X","authenticated-orcid":false,"given":"Xiaodi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2025.218222_bib1","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/his.13975","article-title":"The 2019 WHO classification of tumours of the digestive system","volume":"76","author":"Nagtegaal","year":"2020","journal-title":"Histopathology"},{"key":"10.1016\/j.canlet.2025.218222_bib2","first-page":"10","article-title":"Cancer statistics","volume":"75","author":"Siegel","year":"2025","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.canlet.2025.218222_bib3","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2025.218222_bib4","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nrd4626","article-title":"SLC transporters as therapeutic targets: emerging opportunities","volume":"14","author":"Lin","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.canlet.2025.218222_bib5","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.drup.2015.05.003","article-title":"Pharmacogenomics of intrinsic and acquired pharmacoresistance in colorectal cancer: toward targeted personalized therapy","volume":"20","author":"De Mattia","year":"2015","journal-title":"Drug Resist. Updates: Rev. Comment. Antimicrob. Anticancer Chemother."},{"key":"10.1016\/j.canlet.2025.218222_bib6","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/j.drudis.2021.03.004","article-title":"Solute carriers as potential oncodrivers or suppressors: their key functions in malignant tumor formation","volume":"26","author":"Rashid","year":"2021","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.canlet.2025.218222_bib7","article-title":"The SLC-ome of membrane transport: from molecular discovery to physiology and clinical applications","volume":"105","author":"Gyimesi","year":"2025","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.canlet.2025.218222_bib8","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.mam.2012.05.008","article-title":"The SLC30 family of zinc transporters - a review of current understanding of their biological and pathophysiological roles","volume":"34","author":"Huang","year":"2013","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.canlet.2025.218222_bib9","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.mam.2012.10.007","article-title":"The SLC3 and SLC7 families of amino acid transporters","volume":"34","author":"Fotiadis","year":"2013","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.canlet.2025.218222_bib10","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cmet.2019.11.020","article-title":"A variant of SLC1A5 is a mitochondrial glutamine transporter for metabolic reprogramming in cancer cells","volume":"31","author":"Yoo","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.canlet.2025.218222_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2023.216179","article-title":"Glucose transporter 4: insulin response mastermind, glycolysis catalyst and treatment direction for cancer progression","volume":"563","author":"Chang","year":"2023","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2025.218222_bib12","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.mam.2013.01.001","article-title":"The SLC1 high-affinity glutamate and neutral amino acid transporter family","volume":"34","author":"Kanai","year":"2013","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.canlet.2025.218222_bib13","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13796","article-title":"Role of SLC4 and SLC26 solute carriers during oxidative stress","volume":"235","author":"Remigante","year":"2022","journal-title":"Acta physiologica (Oxford, England)"},{"key":"10.1016\/j.canlet.2025.218222_bib14","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.cell.2025.01.015","article-title":"Solute carriers: the gatekeepers of metabolism","volume":"188","author":"Khan","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2025.218222_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.117376","article-title":"Cancer-associated transporters: molecular drivers and drug delivery gateways","volume":"242","author":"Khan","year":"2025","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.canlet.2025.218222_bib16","doi-asserted-by":"crossref","first-page":"5910","DOI":"10.7150\/ijbs.102460","article-title":"Research progress on the molecular structure, function, and application in tumor therapy of zinc transporter ZIP4","volume":"20","author":"Guo","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.canlet.2025.218222_bib17","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1053\/j.gastro.2022.06.058","article-title":"Acetyl-Coenzyme A synthetase 2 potentiates macropinocytosis and muscle wasting through metabolic reprogramming in pancreatic cancer","volume":"163","author":"Zhou","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.canlet.2025.218222_bib18","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1053\/j.gastro.2022.02.017","article-title":"Circular RNA ANAPC7 inhibits tumor growth and muscle wasting via PHLPP2-AKT-TGF-I3 signaling axis in pancreatic cancer","volume":"162","author":"Shi","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.canlet.2025.218222_bib19","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s43440-021-00281-9","article-title":"Blockade of fructose transporter protein GLUT5 inhibits proliferation of colon cancer cells: proof of concept for a new class of anti-tumor therapeutics","volume":"73","author":"W\u0142odarczyk","year":"2021","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.canlet.2025.218222_bib20","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1111\/cas.13995","article-title":"Glucose transporter 1 regulates the proliferation and cisplatin sensitivity of esophageal cancer","volume":"110","author":"Sawayama","year":"2019","journal-title":"Cancer Sci."},{"key":"10.1016\/j.canlet.2025.218222_bib21","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.freeradbiomed.2022.03.026","article-title":"Functional role of the SLC7A11-AS1\/xCT axis in the development of gastric cancer cisplatin-resistance by a GSH-dependent mechanism","volume":"184","author":"Luo","year":"2022","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.canlet.2025.218222_bib22","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41588-020-00753-3","article-title":"The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer","volume":"53","author":"Najumudeen","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.canlet.2025.218222_bib23","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1101\/gad.327056.119","article-title":"MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancer","volume":"33","author":"Venkateswaran","year":"2019","journal-title":"Genes Dev."},{"key":"10.1016\/j.canlet.2025.218222_bib24","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s43556-024-00172-4","article-title":"Fat mass and obesity-associated protein (FTO) mediated m(6)a modification of circFAM192A promoted gastric cancer proliferation by suppressing SLC7A5 decay","volume":"5","author":"Wu","year":"2024","journal-title":"Mol. Biomed."},{"key":"10.1016\/j.canlet.2025.218222_bib25","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1186\/s13046-022-02466-3","article-title":"CircARID1A binds to IGF2BP3 in gastric cancer and promotes cancer proliferation by forming a circARID1A-IGF2BP3-SLC7A5 RNA-protein ternary complex","volume":"41","author":"Ma","year":"2022","journal-title":"J. Exp. Clin. Cancer Res. : CR"},{"key":"10.1016\/j.canlet.2025.218222_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23772","article-title":"CircCOL5A1 is involved in proliferation, invasion, and inhibition of ferroptosis of colorectal cancer cells via miR-1287-5p\/SLC7A11","volume":"38","author":"Wang","year":"2024","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.canlet.2025.218222_bib27","article-title":"Suppression of colorectal cancer growth: interplay between curcumin and metformin through DMT1 downregulation and ROS\u2010mediated pathways","volume":"51","author":"Chuang","year":"2025","journal-title":"Biofactors (Oxf. Engl.)"},{"key":"10.1016\/j.canlet.2025.218222_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2021.153706","article-title":"SLC34A2 promotes cancer proliferation and cell cycle progression by targeting TMPRSS3 in colorectal cancer","volume":"229","author":"Yang","year":"2022","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.canlet.2025.218222_bib29","doi-asserted-by":"crossref","first-page":"22164","DOI":"10.18632\/aging.203502","article-title":"SLCO1B3 promotes colorectal cancer tumorigenesis and metastasis through STAT3","volume":"13","author":"Zhi","year":"2021","journal-title":"Aging (Milano)"},{"key":"10.1016\/j.canlet.2025.218222_bib30","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/cas.16351","article-title":"Analysis of SLC genes alternative splicing identifies the SLC7A6 RI isoform as a therapeutic target for colorectal cancer","volume":"116","author":"Sun","year":"2024","journal-title":"Cancer Sci."},{"key":"10.1016\/j.canlet.2025.218222_bib31","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s12013-023-01183-8","article-title":"Circular RNA circ-SLC7A5 functions as a competing endogenous RNA to impact cell biological behaviors in esophageal squamous cell carcinoma (ESCC)","volume":"82","author":"Wang","year":"2024","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.canlet.2025.218222_bib32","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s11596-024-2871-5","article-title":"Identification and validation of SLC9A2 as a potential tumor suppressor in colorectal cancer: integrating bioinformatics analysis with experimental confirmation","volume":"44","author":"Liu","year":"2024","journal-title":"Curr. Med. Sci."},{"key":"10.1016\/j.canlet.2025.218222_bib33","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/s41392-022-01046-3","article-title":"Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy","volume":"7","author":"Gao","year":"2022","journal-title":"Signal Transduct. Tar."},{"key":"10.1016\/j.canlet.2025.218222_bib34","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/s41568-022-00459-0","article-title":"Targeting ferroptosis as a vulnerability in cancer","volume":"22","author":"Lei","year":"2022","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.canlet.2025.218222_bib35","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/4772134","article-title":"Vitamin D promotes ferroptosis in colorectal cancer stem cells via SLC7A11 downregulation","volume":"2023","author":"Guo","year":"2023","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.canlet.2025.218222_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113436","article-title":"ANP32E promotes esophageal cancer progression and paclitaxel resistance via P53\/SLC7A11 axis-regulated ferroptosis","volume":"144","author":"Sun","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.canlet.2025.218222_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2023.113697","article-title":"E3 ubiquitin ligase HECTD3 is a tumor suppressor and mediates the polyubiquitination of SLC7A11 to promote ferroptosis in colon cancer","volume":"430","author":"Huang","year":"2023","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.canlet.2025.218222_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217726","article-title":"SIK1 promotes ferroptosis resistance in pancreatic cancer via HDAC5-STAT6-SLC7A11 axis","volume":"623","author":"Zhang","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2025.218222_bib39","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/s41419-025-07621-0","article-title":"TMEM160 inhibits KEAP1 to suppress ferroptosis and induce chemoresistance in gastric cancer","volume":"16","author":"Huang","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.canlet.2025.218222_bib40","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10565-024-09843-y","article-title":"POU6F1 promotes ferroptosis by increasing lncRNA-CASC2 transcription to regulate SOCS2\/SLC7A11 signaling in gastric cancer","volume":"40","author":"Wang","year":"2024","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.canlet.2025.218222_bib41","unstructured":"Y. Yin, Z. Jiang, J. Fu, Y. Li, C. Fang, X. Yin, Y. Chen, N. Chen, J. Li, Y. Ji, X. Su, M. Qiu, W. Huang, B. Zhang, H. Deng, L. Dai, Choline-Induced SLC5A7 Impairs Colorectal Cancer Growth by Stabilizing p53 Protein."},{"key":"10.1016\/j.canlet.2025.218222_bib42","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.neo.2021.11.002","article-title":"ABCC5 facilitates the acquired resistance of sorafenib through the inhibition of SLC7A11-induced ferroptosis in hepatocellular carcinoma","volume":"23","author":"Huang","year":"2021","journal-title":"Neoplasia (N. Y. N.Y.)"},{"key":"10.1016\/j.canlet.2025.218222_bib43","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1038\/s41388-025-03457-2","article-title":"PRMT5 K240lac confers ferroptosis resistance via ALKBH5\/SLC7A11 axis in colorectal cancer","volume":"44","author":"Qu","year":"2025","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2025.218222_bib44","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/jgh.16402","article-title":"CircTMEM87A promotes the tumorigenesis of gastric cancer by regulating the miR-1276\/SLC7A11 axis","volume":"39","author":"Dong","year":"2024","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.canlet.2025.218222_bib45","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/tox.23668","article-title":"CircRPPH1 promotes the stemness of gastric cancer cells by targeting miR-375\/SLC7A11 axis","volume":"38","author":"Liu","year":"2023","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.canlet.2025.218222_bib46","doi-asserted-by":"crossref","first-page":"675","DOI":"10.21037\/atm-21-997","article-title":"Ferroptosis is involved in the progression of hepatocellular carcinoma through the circ0097009\/miR-1261\/SLC7A11 axis","volume":"9","author":"Lyu","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.canlet.2025.218222_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2023.154557","article-title":"miR-509-5p promotes colorectal cancer cell ferroptosis by targeting SLC7A11","volume":"247","author":"Elrebehy","year":"2023","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.canlet.2025.218222_bib48","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1111\/cas.16181","article-title":"SNHG15-mediated feedback loop interplays with HNRNPA1\/SLC7A11\/GPX4 pathway to promote gastric cancer progression","volume":"115","author":"Duan","year":"2024","journal-title":"Cancer Sci."},{"key":"10.1016\/j.canlet.2025.218222_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103362","article-title":"LncRNA-HMG incites colorectal cancer cells to chemoresistance via repressing p53-mediated ferroptosis","volume":"77","author":"Xin","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.canlet.2025.218222_bib50","article-title":"Downregulation of lncRNA SLC7A11-AS1 decreased the NRF2\/SLC7A11 expression and inhibited the progression of colorectal cancer cells","volume":"11","author":"Wang","year":"2023","journal-title":"Peerj"},{"key":"10.1016\/j.canlet.2025.218222_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217523","article-title":"Tumor-derived miR-203a-3p potentiates muscle wasting by inducing muscle ferroptosis in pancreatic cancer","volume":"614","author":"Hu","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2025.218222_bib52","doi-asserted-by":"crossref","first-page":"15327","DOI":"10.1074\/jbc.M114.633560","article-title":"The endoplasmic reticulum stress sensor IRE1\u03b1 in intestinal epithelial cells is essential for protecting against colitis","volume":"290","author":"Zhang","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2025.218222_bib53","article-title":"IRE1\u03b1 determines ferroptosis sensitivity through regulation of glutathione synthesis","volume":"15","author":"Jiang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2025.218222_bib54","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1186\/s12967-021-03042-7","article-title":"SLC7A11 regulated by NRF2 modulates esophageal squamous cell carcinoma radiosensitivity by inhibiting ferroptosis","volume":"19","author":"Feng","year":"2021","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.canlet.2025.218222_bib55","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s12032-024-02483-6","article-title":"ML385 promotes ferroptosis and radiotherapy sensitivity by inhibiting the NRF2-SLC7A11 pathway in esophageal squamous cell carcinoma","volume":"41","author":"Yan","year":"2024","journal-title":"Med. oncol. (Northwood Lond. Engl.)"},{"key":"10.1016\/j.canlet.2025.218222_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2020.112453","article-title":"RNA binding protein DAZAP1 promotes HCC progression and regulates ferroptosis by interacting with SLC7A11 mRNA","volume":"399","author":"Wang","year":"2021","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.canlet.2025.218222_bib57","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1016\/j.apsb.2025.02.013","article-title":"p52-ZER6\/DAZAP1 axis promotes ferroptosis resistance and colorectal cancer progression via regulating SLC7A11 mRNA stabilization","volume":"15","author":"Qiu","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.canlet.2025.218222_bib58","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.7150\/ijms.91446","article-title":"Construction and validation of novel ferroptosis-related risk score signature and prognostic prediction nomogram for patients with colorectal cancer","volume":"21","author":"Liu","year":"2024","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.canlet.2025.218222_bib59","article-title":"Impact of oncogenic changes in p53 and KRAS on macropinocytosis and ferroptosis in colon cancer cells and anticancer efficacy of niclosamide with differential effects on these two processes","volume":"13","author":"Nguyen","year":"2024","journal-title":"Cells-Basel"},{"key":"10.1016\/j.canlet.2025.218222_bib60","article-title":"SLC25A42 promotes gastric cancer growth by conferring ferroptosis resistance through enhancing CPT2-mediated fatty acid oxidation","volume":"16","author":"Wang","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.canlet.2025.218222_bib61","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.freeradbiomed.2025.04.029","article-title":"Exosomal SLC1A5 from senescent endothelial cells promotes gastric cancer progression by dampening ferroptosis via the EGFR\/SRC\/YAP1\/GPX4 signaling","volume":"235","author":"Zhang","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.canlet.2025.218222_bib62","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1111\/1759-7714.15314","article-title":"SLC34A2 promotes cell proliferation by activating STX17-mediated autophagy in esophageal squamous cell carcinoma","volume":"15","author":"Xu","year":"2024","journal-title":"Thorac. Cancer"},{"key":"10.1016\/j.canlet.2025.218222_bib63","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.70362","article-title":"Coordination of SLC39A1 and DRP1 facilitates HCC recurrence by impairing mitochondrial quality control","volume":"15","author":"Li","year":"2025","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.canlet.2025.218222_bib64","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.cell.2017.09.046","article-title":"mTORC1 activator SLC38A9 is required to efflux essential amino acids from lysosomes and use protein as a nutrient","volume":"171","author":"Wyant","year":"2017","journal-title":"CELL"},{"key":"10.1016\/j.canlet.2025.218222_bib65","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-025-07476-5","article-title":"SLC5A3 depletion promotes apoptosis by inducing mitochondrial dysfunction and mitophagy in gemcitabine-resistant pancreatic cancer cells","volume":"16","author":"Kim","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.canlet.2025.218222_bib66","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12964-025-02109-y","article-title":"SLC25A35 enhances fatty acid oxidation and mitochondrial biogenesis to promote the carcinogenesis and progression of hepatocellular carcinoma by upregulating PGC-1\u03b1","volume":"23","author":"Yu","year":"2025","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.canlet.2025.218222_bib67","article-title":"Gatekeepers of mitochondrial metabolism: the emerging role of the SLC25 family in leukemia","volume":"110","author":"Haran","year":"2025","journal-title":"Haematologica"},{"key":"10.1016\/j.canlet.2025.218222_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.107233","article-title":"SLC25A3 negatively regulates NLRP3 inflammasome activation by restricting the function of NLRP3","volume":"300","author":"Xiao","year":"2024","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2025.218222_bib69","doi-asserted-by":"crossref","first-page":"G703","DOI":"10.1152\/ajpgi.00118.2020","article-title":"hsa_circRNA_001587 upregulates SLC4A4 expression to inhibit migration, invasion, and angiogenesis of pancreatic cancer cells via binding to microRNA-223","volume":"319","author":"Zhang","year":"2020","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.canlet.2025.218222_bib70","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/s13046-023-02765-3","article-title":"Fructose promotes angiogenesis by improving vascular endothelial cell function and upregulating VEGF expression in cancer cells","volume":"42","author":"Cui","year":"2023","journal-title":"J. Exp. Clin. Cancer Res. : CR"},{"key":"10.1016\/j.canlet.2025.218222_bib71","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/s41419-023-06274-1","article-title":"SOX2 promotes vasculogenic mimicry by accelerating glycolysis via the lncRNA AC005392.2-GLUT1 axis in colorectal cancer","volume":"14","author":"Huang","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.canlet.2025.218222_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112086","article-title":"Ginsenoside Rg3 inhibits angiogenesis in gastric precancerous lesions through downregulation of Glut1 and Glut4","volume":"145","author":"Zeng","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.canlet.2025.218222_bib73","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1053\/j.gastro.2020.12.077","article-title":"Zinc-Dependent regulation of ZEB1 and YAP1 coactivation promotes epithelial-mesenchymal transition plasticity and metastasis in pancreatic cancer","volume":"160","author":"Liu","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.canlet.2025.218222_bib74","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1042\/BCJ20200099","article-title":"SLC6A14, a Na+\/Cl--coupled amino acid transporter, functions as a tumor promoter in colon and is a target for Wnt signaling","volume":"477","author":"Sikder","year":"2020","journal-title":"Biochem. J."},{"key":"10.1016\/j.canlet.2025.218222_bib75","doi-asserted-by":"crossref","first-page":"379","DOI":"10.2147\/OTT.S288709","article-title":"Aberrant SLC6A14 expression promotes proliferation and metastasis of colorectal cancer via enhancing the JAK2\/STAT3 pathway","volume":"14","author":"Mao","year":"2021","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.canlet.2025.218222_bib76","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1186\/s12885-022-09935-0","article-title":"Blockade of the amino acid transporter SLC6A14 suppresses tumor growth in colorectal cancer","volume":"22","author":"Lu","year":"2022","journal-title":"BMC Cancer"},{"key":"10.1016\/j.canlet.2025.218222_bib77","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1042\/BCJ20210855","article-title":"Deletion of Slc6a14 reduces cancer growth and metastatic spread and improves survival in KPC mouse model of spontaneous pancreatic cancer","volume":"479","author":"Schniers","year":"2022","journal-title":"Biochem. J."},{"key":"10.1016\/j.canlet.2025.218222_bib78","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/s41419-022-04827-4","article-title":"xCT contributes to colorectal cancer tumorigenesis through upregulation of the MELK oncogene and activation of the AKT\/mTOR cascade","volume":"13","author":"Tang","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.canlet.2025.218222_bib79","article-title":"N7-methyladenosine-induced SLC7A7 serves as a prognostic biomarker in pan-cancer and promotes CRC progression in colorectal cancer","volume":"14","author":"Wang","year":"2024","journal-title":"Sci. Rep.-Uk"},{"key":"10.1016\/j.canlet.2025.218222_bib80","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.cmet.2021.03.009","article-title":"Creatine promotes cancer metastasis through activation of Smad2\/3","volume":"33","author":"Zhang","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.canlet.2025.218222_bib81","first-page":"53","article-title":"Circ_0067717 promotes colorectal cancer cell growth, invasion and glutamine metabolism by serving as a miR-497-5p sponge to upregulate SLC7A5","volume":"38","author":"Song","year":"2023","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.canlet.2025.218222_bib82","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1038\/s41388-022-02230-z","article-title":"LncRNA GAL promotes colorectal cancer liver metastasis through stabilizing GLUT1","volume":"41","author":"Li","year":"2022","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2025.218222_bib83","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/s41416-021-01306-z","article-title":"S100P contributes to promoter demethylation and transcriptional activation of SLC2A5 to promote metastasis in colorectal cancer","volume":"125","author":"Lin","year":"2021","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.canlet.2025.218222_bib84","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.cell.2014.12.018","article-title":"Extracellular metabolic energetics can promote cancer progression","volume":"160","author":"Loo","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2025.218222_bib85","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abi7511","article-title":"Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels","volume":"7","author":"Kurth","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.canlet.2025.218222_bib86","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/s41540-024-00463-0","article-title":"Endosomal pH is an evolutionarily conserved driver of phenotypic plasticity in colorectal cancer","volume":"10","author":"Prasad","year":"2024","journal-title":"Npj Syst. Biol. Appl."},{"key":"10.1016\/j.canlet.2025.218222_bib87","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jcmgh.2018.08.005","article-title":"NHE8 deficiency promotes colitis-associated cancer in mice via expansion of Lgr5-expressing cells","volume":"7","author":"Xu","year":"2019","journal-title":"Cellular Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.canlet.2025.218222_bib88","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22041664","article-title":"Target score-a proteomics data selection tool applied to esophageal cancer identifies GLUT1-sialyl tn glycoforms as biomarkers of cancer aggressiveness","volume":"22","author":"Cotton","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.canlet.2025.218222_bib89","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1007\/s10620-021-07145-5","article-title":"LINC00667 promotes progression of esophageal cancer cells by regulating miR-200b-3p\/SLC2A3 axis","volume":"67","author":"Pan","year":"2022","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.canlet.2025.218222_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217186","article-title":"YTHDF1 regulates GID8-mediated glutamine metabolism to promote colorectal cancer progression in m6A-dependent manner","volume":"601","author":"Han","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2025.218222_bib91","article-title":"SLC1A1, SLC16A9, and CNTN3 are potential biomarkers for the occurrence of colorectal cancer","volume":"2020","author":"Zhou","year":"2020","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.canlet.2025.218222_bib92","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/ijc.32079","article-title":"Genetic variants in SLC22A3 contribute to the susceptibility to colorectal cancer","volume":"145","author":"Ren","year":"2019","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.canlet.2025.218222_bib93","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1007\/s10495-023-01875-9","article-title":"The regulation of amino acid metabolism in tumor cell death: from the perspective of physiological functions","volume":"28","author":"Wang","year":"2023","journal-title":"Apoptosis"},{"key":"10.1016\/j.canlet.2025.218222_bib94","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.canlet.2020.12.021","article-title":"The oncogenic and clinical implications of lactate induced immunosuppression in the tumour microenvironment","volume":"500","author":"Hayes","year":"2021","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2025.218222_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2023.154480","article-title":"SNHG15 promotes chemoresistance and glycolysis in colorectal cancer","volume":"246","author":"Li","year":"2023","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.canlet.2025.218222_bib96","article-title":"TRIM32 promotes the growth of gastric cancer cells through enhancing AKT activity and glucose transportation","volume":"2020","author":"Wang","year":"2020","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.canlet.2025.218222_bib97","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1248\/bpb.b21-00443","article-title":"Salidroside induces apoptosis in human gastric cancer cells via the downregulation of ENO1\/PKM2\/GLUT1 expression","volume":"44","author":"Dai","year":"2021","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.canlet.2025.218222_bib98","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1093\/carcin\/bgaa074","article-title":"GLUT5 regulation by AKT1\/3-miR-125b-5p downregulation induces migratory activity and drug resistance in TLR-modified colorectal cancer cells","volume":"41","author":"Park","year":"2020","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.canlet.2025.218222_bib99","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2022.215617","article-title":"GLUT5-KHK axis-mediated fructose metabolism drives proliferation and chemotherapy resistance of colorectal cancer","volume":"534","author":"Shen","year":"2022","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2025.218222_bib100","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s12943-020-01190-w","article-title":"m6A-dependent glycolysis enhances colorectal cancer progression","volume":"19","author":"Shen","year":"2020","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.canlet.2025.218222_bib101","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1002\/iub.2545","article-title":"m(6) a transferase KIAA1429-stabilized LINC00958 accelerates gastric cancer aerobic glycolysis through targeting GLUT1","volume":"73","author":"Yang","year":"2021","journal-title":"IUBMB Life"},{"key":"10.1016\/j.canlet.2025.218222_bib102","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.devcel.2021.12.006","article-title":"YAP1 and PRDM14 converge to promote cell survival and tumorigenesis","volume":"57","author":"Kim","year":"2022","journal-title":"Dev. Cell"},{"key":"10.1016\/j.canlet.2025.218222_bib103","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s11596-022-2606-4","article-title":"Arginine ADP-ribosyltransferase 1 regulates glycolysis in colorectal cancer via the PI3K\/AKT\/HIF1\u03b1 pathway","volume":"42","author":"Long","year":"2022","journal-title":"Curr. Med. Sci."},{"key":"10.1016\/j.canlet.2025.218222_bib104","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22115547","article-title":"Mutant p53 mediates sensitivity to cancer treatment agents in oesophageal adenocarcinoma associated with MicroRNA and SLC7A11 expression","volume":"22","author":"Eichelmann","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.canlet.2025.218222_bib105","article-title":"Amino acid transporter SLC38A5 is a tumor promoter and a novel therapeutic target for pancreatic cancer","volume":"13","author":"Sniegowski","year":"2023","journal-title":"Sci. Rep.-Uk"},{"key":"10.1016\/j.canlet.2025.218222_bib106","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1016\/j.celrep.2019.07.097","article-title":"UCP2 deficiency increases colon tumorigenesis by promoting lipid synthesis and depleting NADPH for antioxidant defenses","volume":"28","author":"Aguilar","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.canlet.2025.218222_bib107","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.150408","article-title":"Myeloid-derived suppressor cells in the tumor microenvironment reduce uncoupling protein 1 expression to boost immunosuppressive activity","volume":"732","author":"Zhao","year":"2024","journal-title":"Biochem. Biophys. Res. Co."},{"key":"10.1016\/j.canlet.2025.218222_bib108","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s12033-023-00696-0","article-title":"CircSCUBE3 reduces the anti-gastric cancer activity of anti-PD-L1","volume":"66","author":"Shan","year":"2024","journal-title":"Mol. Biotechnol."},{"key":"10.1016\/j.canlet.2025.218222_bib109","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0245075","article-title":"High SLC2A1 expression associated with suppressing CD8 T cells and B cells promoted cancer survival in gastric cancer","volume":"16","author":"Min","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.canlet.2025.218222_bib110","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1084\/jem.20182044","article-title":"Creatine uptake regulates CD8 T cell antitumor immunity","volume":"216","author":"Di Biase","year":"2019","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.canlet.2025.218222_bib111","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2021.108838","article-title":"Yes associated protein 1 promotes resistance to 5-fluorouracil in gastric cancer by regulating GLUT3-dependent glycometabolism reprogramming of tumor-associated macrophages","volume":"702","author":"He","year":"2021","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.canlet.2025.218222_bib112","doi-asserted-by":"crossref","DOI":"10.1002\/pmic.201800148","article-title":"Exosomes derived from human primary and metastatic colorectal cancer cells contribute to functional heterogeneity of activated fibroblasts by reprogramming their proteome","volume":"19","author":"Rai","year":"2019","journal-title":"Proteomics"},{"key":"10.1016\/j.canlet.2025.218222_bib113","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3390\/cells9020397","article-title":"BGN\/TLR4\/NF-\u03baB mediates epigenetic silencing of immunosuppressive siglec ligands in colon cancer cells","volume":"9","author":"Huang","year":"2020","journal-title":"Cells-Basel"},{"key":"10.1016\/j.canlet.2025.218222_bib114","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217150","article-title":"Serotonylation in tumor-associated fibroblasts contributes to the tumor-promoting roles of serotonin in colorectal cancer","volume":"600","author":"Ling","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2025.218222_bib115","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2217\/bmm-2018-0256","article-title":"Elevated SLC6A6 expression drives tumorigenesis and affects clinical outcomes in gastric cancer","volume":"13","author":"Dazhi","year":"2019","journal-title":"Biomarkers Med."},{"key":"10.1016\/j.canlet.2025.218222_bib116","doi-asserted-by":"crossref","first-page":"4852","DOI":"10.1038\/srep04852","article-title":"Role of SLC6A6 in promoting the survival and multidrug resistance of colorectal cancer","volume":"4","author":"Yasunaga","year":"2014","journal-title":"Sci. Rep.-Uk"},{"key":"10.1016\/j.canlet.2025.218222_bib117","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1007\/s00262-022-03308-z","article-title":"Taurine enhances the antitumor efficacy of PD-1 antibody by boosting CD8+ T cell function","volume":"72","author":"Ping","year":"2022","journal-title":"Cancer Immunol. Immunother. : Cii"},{"key":"10.1016\/j.canlet.2025.218222_bib118","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1016\/j.cell.2024.03.011","article-title":"Cancer SLC6A6-mediated taurine uptake transactivates immune checkpoint genes and induces exhaustion in CD8+T cells","volume":"187","author":"Cao","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2025.218222_bib119","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1042\/BST20160038","article-title":"The SLC28 (CNT) and SLC29 (ENT) nucleoside transporter families: a 30-year collaborative odyssey","volume":"44","author":"Young","year":"2016","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.canlet.2025.218222_bib120","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s00424-003-1103-2","article-title":"The equilibrative nucleoside transporter family, SLC29","volume":"447","author":"Baldwin","year":"2004","journal-title":"Pfl\u00fcgers Archiv"},{"key":"10.1016\/j.canlet.2025.218222_bib121","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1007\/s00424-003-1107-y","article-title":"The concentrative nucleoside transporter family, SLC28","volume":"447","author":"Gray","year":"2004","journal-title":"Pfl\u00fcgers Archiv"},{"key":"10.1016\/j.canlet.2025.218222_bib122","doi-asserted-by":"crossref","unstructured":"H. Suleiman, A. Emerson, P.M. Wilson, K.A. Mulligan, R.D. Ladner, M.J. LaBonte, Harnessing nucleotide metabolism and immunity in cancer: a tumour microenvironment perspective, FEBS J. 292(2025)2155\u20132172.","DOI":"10.1111\/febs.17278"},{"key":"10.1016\/j.canlet.2025.218222_bib123","doi-asserted-by":"crossref","first-page":"7505","DOI":"10.1007\/s00018-021-03959-8","article-title":"OncomiRs miR-106a and miR-17 negatively regulate the nucleoside-derived drug transporter hCNT1","volume":"78","author":"Boces-Pascual","year":"2021","journal-title":"Cell. Mol. Life Sci.: Cmls"},{"key":"10.1016\/j.canlet.2025.218222_bib124","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.canlet.2021.08.029","article-title":"Tumor microenvironment and metabolic remodeling in gemcitabine-based chemoresistance of pancreatic cancer","volume":"521","author":"Gu","year":"2021","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2025.218222_bib125","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s00280-013-2246-2","article-title":"The association between the expression of solute carrier transporters and the prognosis of pancreatic cancer","volume":"72","author":"Mohelnikova-Duchonova","year":"2013","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.canlet.2025.218222_bib126","unstructured":"K. Chen, T. Li, H. Diao, Q. Wang, X. Zhou, Z. Huang, M. Wang, Z. Mao, Y. Yang, W. Yu, SIRT7 Knockdown Promotes Gemcitabine Sensitivity of Pancreatic Cancer Cell via Upregulation of GLUT3 Expression."},{"key":"10.1016\/j.canlet.2025.218222_bib127","unstructured":"Y. Xi, P. Yuan, T. Li, M. Zhang, M.F. Liu, B. Li, hENT1 Reverses Chemoresistance by Regulating Glycolysis in Pancreatic Cancer."},{"key":"10.1016\/j.canlet.2025.218222_bib128","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2023.113892","article-title":"Equilibrative nucleotide transporter ENT3 (SLC29A3): a unique transporter for inherited disorders and cancers","volume":"434","author":"Ma","year":"2024","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.canlet.2025.218222_bib129","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.173","article-title":"Concentrative nucleoside transporter 1 (hCNT1) promotes phenotypic changes relevant to tumor biology in a translocation-independent manner","volume":"4","author":"P\u00e9rez-Torras","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.canlet.2025.218222_bib130","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1053\/j.gastro.2019.10.038","article-title":"ZIP4 increases expression of transcription factor ZEB1 to promote integrin \u03b13\u03b21 signaling and inhibit expression of the gemcitabine transporter ENT1 in pancreatic cancer cells","volume":"158","author":"Liu","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.canlet.2025.218222_bib131","unstructured":"J. Yang, Z. Zhang, Y. Zhang, X. Ni, G. Zhang, X. Cui, M. Liu, C. Xu, Q. Zhang, H. Zhu, J. Yan, V.F. Zhu, Y. Luo, J.P. Hagan, Z. Li, J. Fang, A. Jatoi, M.E. Fernandez-Zapico, L. Zheng, B.H. Edil, M.S. Bronze, C.W. Houchen, Y.P. Li, M. Li, ZIP4 Promotes Muscle Wasting and Cachexia in Mice with Orthotopic Pancreatic Tumors by Stimulating RAB27B-Regulated Release of Extracellular Vesicles from Cancer Cells."},{"key":"10.1016\/j.canlet.2025.218222_bib132","unstructured":"M. Liu, Y. Ren, Z. Zhou, J. Yang, X. Shi, Y. Cai, A.X. Arreola, W. Luo, K.M. Fung, C. Xu, R.D. Nipp, M.S. Bronze, L. Zheng, Y.P. Li, C.W. Houchen, Y. Zhang, M. Li, The Crosstalk Between Macrophages and Cancer Cells Potentiates Pancreatic Cancer Cachexia."},{"key":"10.1016\/j.canlet.2025.218222_bib133","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1053\/j.gastro.2019.10.038","article-title":"ZIP4 increases expression of transcription factor ZEB1 to promote Integrin \u03b13\u03b21 signaling and inhibit expression of the gemcitabine transporter ENT1 in pancreatic cancer cells","volume":"158","author":"Liu","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.canlet.2025.218222_bib134","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2023.101626","article-title":"Copper transporter Ctr1 contributes to enhancement of the sensitivity of cisplatin in esophageal squamous cell carcinoma","volume":"29","author":"Wang","year":"2023","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.canlet.2025.218222_bib135","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1002\/ijc.32590","article-title":"Hypotonic stress enhances colon cancer cell death induced by platinum derivatives and immunologically improves antitumor efficacy of intraperitoneal chemotherapy","volume":"145","author":"Demontoux","year":"2019","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.canlet.2025.218222_bib136","doi-asserted-by":"crossref","first-page":"jcs249201","DOI":"10.1242\/jcs.249201","article-title":"Mammalian copper homeostasis requires retromer-dependent recycling of the high-affinity copper transporter 1","volume":"133","author":"Curnock","year":"2020","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.canlet.2025.218222_bib137","first-page":"549","article-title":"Targeting the copper transport system to improve treatment efficacies of platinum-containing drugs in cancer chemotherapy","volume":"14","author":"Kuo","year":"2021","journal-title":"Pharm. Times"},{"key":"10.1016\/j.canlet.2025.218222_bib138","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41421-022-00508-w","article-title":"Molecular mechanism of substrate recognition by folate transporter SLC19A1","volume":"8","author":"Dang","year":"2022","journal-title":"Cell Discov."},{"key":"10.1016\/j.canlet.2025.218222_bib139","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1038\/s41586-022-05168-0","article-title":"Methotrexate recognition by the human reduced folate carrier SLC19A1","volume":"609","author":"Wright","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2025.218222_bib140","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/d41586-022-03767-5","article-title":"Folate transporter offers clues for anticancer drugs","volume":"612","author":"Matherly","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2025.218222_bib141","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202101704R","article-title":"The evolving biology of the proton-coupled folate transporter: new insights into regulation, structure, and mechanism","volume":"36","author":"Hou","year":"2022","journal-title":"FASEB J.: Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"10.1016\/j.canlet.2025.218222_bib142","doi-asserted-by":"crossref","first-page":"6389","DOI":"10.1038\/s41598-021-85818-x","article-title":"Folate transporter dynamics and therapy with classic and tumor-targeted antifolates","volume":"11","author":"O'Connor","year":"2021","journal-title":"Sci. Rep.-Uk"},{"key":"10.1016\/j.canlet.2025.218222_bib143","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.cmet.2020.12.002","article-title":"Tumor reliance on cytosolic versus mitochondrial one-carbon flux depends on folate availability","volume":"33","author":"Lee","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.canlet.2025.218222_bib144","article-title":"The SLC34A2-ROS-HIF-1-induced up-regulation of EZH2 expression promotes proliferation and chemo-resistance to apoptosis in colorectal cancer","volume":"39","author":"Li","year":"2019","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.canlet.2025.218222_bib145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0222074","article-title":"Nitric oxide regulates the expression of heme carrier protein-1 via hypoxia inducible factor-1\u03b1 stabilization","volume":"14","author":"Kurokawa","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.canlet.2025.218222_bib146","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13062-024-00478-x","article-title":"CircHIF1A induces cetuximab resistance in colorectal cancer by promoting HIF1\u03b1-mediated glycometabolism alteration","volume":"19","author":"Geng","year":"2024","journal-title":"Biol. Direct"},{"key":"10.1016\/j.canlet.2025.218222_bib147","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.abn5881","article-title":"Osmotic stress activates RIPK3\/MLKL-mediated necroptosis by increasing cytosolic pH through a plasma membrane Na+\/H+ exchanger","volume":"15","author":"Zhang","year":"2022","journal-title":"Sci. Signal."},{"key":"10.1016\/j.canlet.2025.218222_bib148","article-title":"Genetic disruption of the pHi-regulating proteins Na+\/H+ exchanger 1 (SLC9A1) and carbonic anhydrase 9 severely reduces growth of colon cancer cells","volume":"8","author":"Parks","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.canlet.2025.218222_bib149","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221910581","article-title":"Inhibition of NHE-1 increases smoke-induced proliferative activity of barrett's esophageal cell line","volume":"22","author":"Becskeh\u00e1zi","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.canlet.2025.218222_bib150","unstructured":"Z. He, Y. Zhong, T. Lv, J. Wang, Y. Jin, F. Li, H. Hu, PP4R1 Promotes Glycolysis and Gallbladder Cancer Progression Through Facilitating ERK1\/2 Mediated PKM2 Nuclear Translocation."},{"key":"10.1016\/j.canlet.2025.218222_bib151","unstructured":"J. Ren, B. Ren, X. Liu, M. Cui, Y. Fang, X. Wang, F. Zhou, M. Gu, R. Xiao, J. Bai, L. You, Y. Zhao, Crosstalk Between Metabolic Remodeling and Epigenetic Reprogramming: a New Perspective on Pancreatic Cancer."},{"key":"10.1016\/j.canlet.2025.218222_bib152","unstructured":"L. Chen, M. Hu, L. Chen, Y. Peng, C. Zhang, X. Wang, X. Li, Y. Yao, Q. Song, J. Li, H. Pei, Targeting O-GlcNAcylation in Cancer Therapeutic Resistance: the Sugar Saga Continues."},{"key":"10.1016\/j.canlet.2025.218222_bib153","unstructured":"S. Chen, Y. Xu, W. Zhuo, L. Zhang, The Emerging Role of Lactate in Tumor Microenvironment and its Clinical Relevance."},{"key":"10.1016\/j.canlet.2025.218222_bib154","unstructured":"X. Gao, C. Pang, Z. Fan, Y. Wang, Y. Duan, H. Zhan, Regulation of Newly Identified Lysine Lactylation in Cancer."},{"key":"10.1016\/j.canlet.2025.218222_bib155","unstructured":"H. Huang, S. Wang, H. Xia, X. Zhao, K. Chen, G. Jin, S. Zhou, Z. Lu, T. Chen, H. Yu, X. Zheng, H. Huang, L. Lan, Lactate Enhances NMNAT1 Lactylation to Sustain Nuclear NAD(+) Salvage Pathway and Promote Survival of Pancreatic Adenocarcinoma Cells Under glucose-deprived Conditions."},{"key":"10.1016\/j.canlet.2025.218222_bib156","unstructured":"J. Lin, W. Zhong, Z. Lyu, J. Peng, Y. Rong, K. Zeng, J. Lai, D. Wu, J. Wang, Y. Li, J. Zheng, J. Zhang, Z. Pan, CIrcular RNA circTATDN3 Promotes the Warburg Effect and Proliferation in Colorectal Cancer."},{"key":"10.1016\/j.canlet.2025.218222_bib157","unstructured":"Y. Lu, Y. Wang, L. Zhang, Z. Ma, K. Yu, Y. Shu, X. Zou, J. Yang, X. Liu, C. Wang, Y. Du, Q. Li, KAT7 Enhances the Proliferation and Metastasis of Head and Neck Squamous Carcinoma by Promoting the Acetylation Level of LDHA."},{"key":"10.1016\/j.canlet.2025.218222_bib158","unstructured":"K. Yang, Z. Zhong, J. Zou, J.Y. Liao, S. Chen, S. Zhou, Y. Zhao, J. Li, D. Yin, K. Huang, Y. Li, Glycolysis and Tumor Progression Promoted by the m(6)A Writer VIRMA via m(6)A-dependent Upregulation of STRA6 in Pancreatic Ductal Adenocarcinoma."},{"key":"10.1016\/j.canlet.2025.218222_bib159","unstructured":"T. Yu, Z. Liu, Q. Tao, X. Xu, X. Li, Y. Li, M. Chen, R. Liu, D. Chen, M. Wu, J. Yu, Targeting tumor-intrinsic SLC16A3 to Enhance anti-PD-1 Efficacy via Tumor Immune Microenvironment Reprogramming."},{"key":"10.1016\/j.canlet.2025.218222_bib160","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/cpt.2633","article-title":"Quantitative proteomics of hepatic drug-metabolizing enzymes and transporters in patients with colorectal cancer metastasis","volume":"112","author":"Vasilogianni","year":"2022","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.canlet.2025.218222_bib161","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113470","article-title":"Colorectal cancer cells establish metabolic reprogramming with cancer-associated fibroblasts (CAFs) through lactate shuttle to enhance invasion, migration, and angiogenesis","volume":"143","author":"Wang","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.canlet.2025.218222_bib162","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.semcancer.2023.01.007","article-title":"Targeting monocarboxylate transporters (MCTs) in cancer: how close are we to the clinics?","volume":"90","author":"Singh","year":"2023","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.canlet.2025.218222_bib163","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217091","article-title":"MCT1-dependent lactate recycling is a metabolic vulnerability in colorectal cancer cells upon acquired resistance to anti-EGFR targeted therapy","volume":"598","author":"Richiardone","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2025.218222_bib164","unstructured":"H. Zhao, C. Yan, Y. Hu, L. Mu, S. Liu, K. Huang, Q. Li, X. Li, D. Tao, J. Qin, Differentiated Cancer cell-originated Lactate Promotes the self-renewal of Cancer Stem Cells in patient-derived Colorectal Cancer Organoids."},{"key":"10.1016\/j.canlet.2025.218222_bib165","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.canlet.2005.07.032","article-title":"Membrane transporters and channels in chemoresistance and -sensitivity of tumor cells","volume":"239","author":"Huang","year":"2006","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2025.218222_bib166","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.ijpharm.2019.05.033","article-title":"Nonionic surfactants modulate the transport activity of ATP-binding cassette (ABC) transporters and solute carriers (SLC): relevance to oral drug absorption","volume":"566","author":"Al-Ali","year":"2019","journal-title":"Int. J. Pharm. (Amst.)"},{"key":"10.1016\/j.canlet.2025.218222_bib167","doi-asserted-by":"crossref","first-page":"3868","DOI":"10.1111\/bph.12748","article-title":"Nucleoside transporters and human organic cation transporter 1 determine the cellular handling of DNA-methyltransferase inhibitors","volume":"171","author":"Arimany-Nardi","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.canlet.2025.218222_bib168","article-title":"Protein abundance of drug transporters and drug-metabolizing enzymes in paired healthy and tumor tissue from colorectal cancer patients","volume":"671","author":"Steigert","year":"2025","journal-title":"Int. J. Pharm. (Amst.)"},{"key":"10.1016\/j.canlet.2025.218222_bib169","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.canlet.2019.01.044","article-title":"Oncogenic PITX2 facilitates tumor cell drug resistance by inverse regulation of hOCT3\/SLC22A3 and ABC drug transporters in colon and kidney cancers","volume":"449","author":"Lee","year":"2019","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2025.218222_bib170","doi-asserted-by":"crossref","first-page":"7835","DOI":"10.1039\/D5FO03078A","article-title":"Arabinoxylan and glycolysis inhibitors alleviate trimethylamine accumulation and gut barrier impairment by inhibiting the PERK pathway","volume":"16","author":"Zhang","year":"2025","journal-title":"Food Funct."},{"key":"10.1016\/j.canlet.2025.218222_bib171","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/s41577-024-01014-8","article-title":"Short-chain fatty acids: linking diet, the microbiome and immunity","volume":"24","author":"Mann","year":"2024","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.canlet.2025.218222_bib172","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1136\/gutjnl-2024-333020","article-title":"Fasting-mimicking diet-enriched bifidobacterium pseudolongum suppresses colorectal cancer by inducing memory CD8+ T cells","volume":"74","author":"Nan","year":"2025","journal-title":"Gut."},{"key":"10.1016\/j.canlet.2025.218222_bib173","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpha.2024.101068","article-title":"Ursodeoxycholic acid inhibits the uptake of cystine through SLC7A11 and impairs de novo synthesis of glutathione","volume":"15","author":"Xie","year":"2025","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.canlet.2025.218222_bib174","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms13061292","article-title":"Early inoculation of a multi-species probiotic in piglets-impacts on the gut microbiome and immune responses","volume":"13","author":"Hansen","year":"2025","journal-title":"Microorganisms"},{"key":"10.1016\/j.canlet.2025.218222_bib175","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109560","article-title":"Hemocompatible L-type amino acid transporter 1 (LAT1)-utilizing prodrugs of perforin inhibitors can accumulate into the pancreas and alleviate inflammation-induced apoptosis","volume":"345","author":"Tampio","year":"2021","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.canlet.2025.218222_bib176","unstructured":"N.J. Mullen, R. Thakur, S.K. Shukla, N.V. Chaika, S.S. Kollala, D. Wang, C. He, Y. Fujii, S. Sharma, S.E. Mulder, D.B. Sykes, P.K. Singh, ENT1 Blockade by CNX-774 Overcomes Resistance to DHODH Inhibition in Pancreatic Cancer."},{"key":"10.1016\/j.canlet.2025.218222_bib177","unstructured":"K. Nagaoka, X. Bai, D. Liu, K. Cao, J. Mulla, C. Ji, H. Chen, M.A. Nisar, A. Bay, W. Mueller, G. Hildebrand, J.S. Gao, S. Lu, H. Setoyama, Y. Tanaka, J.R. Wands, C.K. Huang, Elevated 2-oxoglutarate Antagonizes DNA Damage Responses in Cholangiocarcinoma Chemotherapy Through Regulating Aspartate beta-hydroxylase."},{"key":"10.1016\/j.canlet.2025.218222_bib178","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.1002\/cncr.35343","article-title":"Pharmacogenomic study of gemcitabine efficacy in patients with metastatic pancreatic cancer: a multicenter, prospective, observational cohort study (GENESECT study)","volume":"130","author":"Hatori","year":"2024","journal-title":"Cancer"},{"key":"10.1016\/j.canlet.2025.218222_bib179","doi-asserted-by":"crossref","first-page":"796","DOI":"10.21037\/hbsn-20-383","article-title":"Molecular characterization of circulating tumor cells in pancreatic ductal adenocarcinoma: potential diagnostic and prognostic significance in clinical practice","volume":"10","author":"Zhao","year":"2021","journal-title":"Hepatobiliary Surg. Nutr."},{"key":"10.1016\/j.canlet.2025.218222_bib180","unstructured":"H.J. Chen, M.M. Yu, J.C. Huang, F.Y. Lan, H.H. Liao, Z.H. Xu, Y.J. Yu, Y.C. Huang, F. Chen, SLC4A4 is a Novel Driver of Enzalutamide Resistance in Prostate Cancer."},{"key":"10.1016\/j.canlet.2025.218222_bib181","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/s41401-024-01387-5","article-title":"G3BP2 promotes tumor progression and gemcitabine resistance in PDAC via regulating PDIA3-DKC1-hENT in a stress granules-dependent manner","volume":"46","author":"Xing","year":"2025","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.canlet.2025.218222_bib182","unstructured":"G. Riegel, C. Orvain, S. Recberlik, M.E. Spaety, G. Poschet, A. Venkatasamy, M. Yamamoto, S. Nomura, T. Tsukamoto, M. Masson, I. Gross, R. Le Lagadec, G. Mellitzer, C. Gaiddon, The Unfolded Protein response-glutathione Metabolism Axis: a Novel Target of a Cycloruthenated Complexes Bypassing Tumor Resistance Mechanisms."},{"key":"10.1016\/j.canlet.2025.218222_bib183","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1038\/s41598-025-87522-6","article-title":"Pharmacological and structural insights into nanvuranlat, a selective LAT1 (SLC7A5) inhibitor, and its N-acetyl metabolite with implications for cancer therapy","volume":"15","author":"Jin","year":"2025","journal-title":"Sci. Rep.-Uk"},{"key":"10.1016\/j.canlet.2025.218222_bib184","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s12935-023-02957-z","article-title":"Combination effects of amino acid transporter LAT1 inhibitor nanvuranlat and cytotoxic anticancer drug gemcitabine on pancreatic and biliary tract cancer cells","volume":"23","author":"Nishikubo","year":"2023","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.canlet.2025.218222_bib185","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40170-022-00295-8","article-title":"Phosphoproteomics revealed cellular signals immediately responding to disruption of cancer amino acid homeostasis induced by inhibition of l-type amino acid transporter 1","volume":"10","author":"Okanishi","year":"2022","journal-title":"Cancer Metabol."},{"key":"10.1016\/j.canlet.2025.218222_bib186","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1111\/cas.14756","article-title":"Proteomics and phosphoproteomics reveal key regulators associated with cytostatic effect of amino acid transporter LAT1 inhibitor","volume":"112","author":"Okanishi","year":"2021","journal-title":"Cancer Sci."},{"key":"10.1016\/j.canlet.2025.218222_bib187","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1038\/s41467-025-56903-w","article-title":"Structural basis of anticancer drug recognition and amino acid transport by LAT1","volume":"16","author":"Lee","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2025.218222_bib188","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/s12967-025-06276-x","article-title":"IDO1 inhibition enhances CLDN18.2-CAR-T cell therapy in gastrointestinal cancers by overcoming kynurenine-mediated metabolic suppression in the tumor microenvironment","volume":"23","author":"Wu","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.canlet.2025.218222_bib189","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.104827","article-title":"IL4i1 and IDO1: oxidases that control a tryptophan metabolic nexus in cancer","volume":"299","author":"Zeitler","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2025.218222_bib190","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/s41392-020-00220-9","article-title":"GLUT3 induced by AMPK\/CREB1 axis is key for withstanding energy stress and augments the efficacy of current colorectal cancer therapies","volume":"5","author":"Dai","year":"2020","journal-title":"Signal Transduct. Tar."},{"key":"10.1016\/j.canlet.2025.218222_bib191","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1158\/1535-7163.MCT-21-0925","article-title":"Diaminobutoxy-substituted isoflavonoid (DBI-1) enhances the therapeutic efficacy of GLUT1 inhibitor BAY-876 by modulating metabolic pathways in colon cancer cells","volume":"21","author":"Guo","year":"2022","journal-title":"Mol. Cancer Therapeut."},{"key":"10.1016\/j.canlet.2025.218222_bib192","first-page":"15","article-title":"Resetting amino acid metabolism of cancer cells by ATB0,+-targeted nanoparticles for enhanced anticancer therapy","volume":"9","author":"Kou","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.canlet.2025.218222_bib193","article-title":"ATB0,+-targeted nanoparticles initiate autophagy suppression to overcome chemoresistance for enhanced colorectal cancer therapy","volume":"641","author":"Chen","year":"2023","journal-title":"Int. J. Pharm. (Amst.)"},{"key":"10.1016\/j.canlet.2025.218222_bib194","unstructured":"Q. Zhao, W.L. Chen, G. Melino, W. Jia, Targeting Fructose Metabolism for Cancer Therapy."},{"key":"10.1016\/j.canlet.2025.218222_bib195","unstructured":"Z. Xiang, Z.A.-O. Zhou, S. Song, J. Li, J. Ji, R. Yan, J. Wang, W. Cai, W. Hu, L. Zang, Z. Zhu, Z.A.-O. Zhang, M.A.-O. Li, Y.A.-O. Yu, Dexamethasone Suppresses Immune Evasion by Inducing GR\/STAT3 Mediated Downregulation of PD-L1 and IDO1 Pathways."},{"key":"10.1016\/j.canlet.2025.218222_bib196","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/s41419-025-07781-z","article-title":"SLC44A2 negatively regulates mitochondrial fatty acid oxidation to suppress colorectal progression by blocking the MUL1-CPT2 interaction","volume":"16","author":"Yang","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.canlet.2025.218222_bib197","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.107843","article-title":"N(6)-methyladenosine modification of SLC38A7 promotes cell migration, invasion, oxidative phosphorylation, and mitochondrial function in gastric cancer","volume":"300","author":"Hua","year":"2024","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2025.218222_bib198","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.7150\/ijms.109767","article-title":"Solute carrier family 35 A2 (SLC35A2) promotes tumor progression through MYC-Mediated pathways in colorectal cancer","volume":"22","author":"Tsai","year":"2025","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.canlet.2025.218222_bib199","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113831","article-title":"SLC39A14 promotes the development of esophageal squamous cell carcinoma through PI3K\/Akt\/mTOR signaling pathway","volume":"146","author":"Qu","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.canlet.2025.218222_bib200","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2025.110754","article-title":"SLC39A5 promotes the malignant progression of gastric cancer by activating BATF phosphorylation","volume":"301","author":"Wang","year":"2025","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2025.218222_bib201","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-17143-6","article-title":"Long chain fatty acid transport via SLC27A1 enhances DAG-3-P synthesis and accelerates colorectal cancer metastasis","volume":"15","author":"Tong","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.canlet.2025.218222_bib202","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13008-025-00148-y","article-title":"YAP1 activates SLC2A1 transcription and augments the malignant behavior of colorectal cancer cells by activating the Wnt\/\u03b2-catenin signaling pathway","volume":"20","author":"Li","year":"2025","journal-title":"Cell Div."},{"key":"10.1016\/j.canlet.2025.218222_bib203","doi-asserted-by":"crossref","first-page":"6135","DOI":"10.7150\/jca.100147","article-title":"LINC01134 directly binds and regulates SLC1A5 stability to promotes colorectal cancer progression","volume":"15","author":"Yao","year":"2024","journal-title":"J. Cancer"},{"key":"10.1016\/j.canlet.2025.218222_bib204","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2025.156033","article-title":"ETV4 promotes the growth, metastasis, glycolysis, and oxaliplatin resistance of colorectal cancer by transcription activation-mediated SLC38A5 upregulation","volume":"271","author":"Huang","year":"2025","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.canlet.2025.218222_bib205","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s12672-025-01948-y","article-title":"Downregulation of solute carrier family 4 members 4 as a biomarker for colorectal cancer","volume":"16","author":"Pawar","year":"2025","journal-title":"Discov. Oncol."},{"key":"10.1016\/j.canlet.2025.218222_bib206","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217512","article-title":"Acidosis overrides molecular heterogeneity to shape therapeutically targetable metabolic phenotypes in colon cancers","volume":"613","author":"Richiardone","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2025.218222_bib207","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/j.cell.2023.02.014","article-title":"Pancreatic cancer: advances and challenges","volume":"186","author":"Halbrook","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2025.218222_bib208","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.jare.2024.10.012","article-title":"Single-cell transcriptomic profiling uncovers cellular complexity and microenvironment in gastric tumorigenesis associated with Helicobacter pylori","volume":"74","author":"Li","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.canlet.2025.218222_bib209","doi-asserted-by":"crossref","first-page":"946","DOI":"10.20892\/j.issn.2095-3941.2025.0077","article-title":"Proteomic profiling and scRNA sequencing identify signatures associated with Helicobacter pylori infection and risk of developing gastric cancer","volume":"22","author":"Jin","year":"2025","journal-title":"Cancer Biol. Med."},{"key":"10.1016\/j.canlet.2025.218222_bib210","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1007\/s00535-025-02305-0","article-title":"Inhibition of integrin \u03b13 suppresses gastric cancer progression via STAT3-mediated regulation of SLC1A5-dependent glutamine uptake","volume":"60","author":"Zhu","year":"2025","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.canlet.2025.218222_bib211","article-title":"Extracellular vesicle-packaged Linc-ZNF25-1 from pancreatic cancer cell promotes pancreatic stellate cell uptake of asparagine to advance chemoresistance","volume":"12","author":"Yu","year":"2025","journal-title":"Adv. Sci. (Weinheim, Baden-Wurttemberg, Germany)"},{"key":"10.1016\/j.canlet.2025.218222_bib212","doi-asserted-by":"crossref","unstructured":"Z. Tian, M. Su, M. Yu, E. Huang, B. Hu, Y. Chen, KRAS\/ACTN4\/p65-NR2A axis mediates glutamine-glutamate metabolic coupling between schwann cells and pancreatic cancer promoting perineural invasion, J. Adv. Res. (2025)[in press].","DOI":"10.1016\/j.jare.2025.10.030"},{"key":"10.1016\/j.canlet.2025.218222_bib213","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2319686121","article-title":"Orphan lysosomal solute carrier MFSD1 facilitates highly selective dipeptide transport","volume":"121","author":"Boytsov","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.canlet.2025.218222_bib214","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s44320-025-00106-4","article-title":"Metabolic mapping of the human solute carrier superfamily","volume":"21","author":"Wiedmer","year":"2025","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.canlet.2025.218222_bib215","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1016\/j.ccell.2024.10.010","article-title":"Itaconate transporter SLC13A3 impairs tumor immunity via endowing ferroptosis resistance","volume":"42","author":"Lin","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2025.218222_bib216","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1158\/0008-5472.CAN-24-3180","article-title":"SLC3A2-Mediated lysine uptake by cancer cells restricts T-cell activity in hepatocellular carcinoma","volume":"85","author":"Chang","year":"2025","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2025.218222_bib217","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1158\/1535-7163.MCT-24-0319","article-title":"Development and characterization of a lysosome-targeting SLC3A2\/PD-L1 bispecific antibody-drug conjugate for enhanced Antitumor efficacy in solid tumors","volume":"24","author":"Wang","year":"2025","journal-title":"Mol. Cancer Therapeut."},{"key":"10.1016\/j.canlet.2025.218222_bib218","article-title":"SSRP1\/SLC3A2 axis in arginine transport: a new target for overcoming immune evasion and tumor progression in peripheral T-Cell lymphoma","volume":"12","author":"Ren","year":"2025","journal-title":"Adv. Sci. (Weinheim, Baden-Wurttemberg, Germany)"},{"key":"10.1016\/j.canlet.2025.218222_bib219","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1016\/j.cmet.2025.06.011","article-title":"Xylulose 5-phosphate fosters sustained antitumor activity of progenitor-like exhausted SLC35E2(+) CD8(+) T effector cells","volume":"37","author":"Shi","year":"2025","journal-title":"Cell Metab."},{"key":"10.1016\/j.canlet.2025.218222_bib220","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s00018-025-05742-5","article-title":"Sulfasalazine combined with anti-IL-1\u03b2 mAb induces ferroptosis and immune modulation in oral squamous cell carcinoma","volume":"82","author":"Zhou","year":"2025","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.canlet.2025.218222_bib221","doi-asserted-by":"crossref","first-page":"4769","DOI":"10.1158\/0008-5472.CAN-25-1693","article-title":"Long-Chain fatty acid redistribution induced by SLC27A2 deficiency facilitates hypoxic adaptation and immunosuppression in hepatocellular carcinoma","volume":"85","author":"Fu","year":"2025","journal-title":"Cancer Res"},{"key":"10.1016\/j.canlet.2025.218222_bib222","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.115130","article-title":"SLC7A5 is required for cancer cell growth under arginine-limited conditions","volume":"44","author":"Dunlap","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.canlet.2025.218222_bib223","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/s44320-025-00108-2","article-title":"Data- and knowledge-derived functional landscape of human solute carriers","volume":"21","author":"Goldmann","year":"2025","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.canlet.2025.218222_bib224","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/s44320-025-00109-1","article-title":"The solute carrier superfamily interactome","volume":"21","author":"Frommelt","year":"2025","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.canlet.2025.218222_bib225","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12864-025-11330-5","article-title":"Predicting substrates for orphan solute carrier proteins using multi-omics datasets","volume":"26","author":"Zhang","year":"2025","journal-title":"BMC Genom."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383525007943?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383525007943?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:37:03Z","timestamp":1792096623000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383525007943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":225,"alternative-id":["S0304383525007943"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2025.218222","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Roles and therapeutic targeting of SLC transporters in gastrointestinal malignancies","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2025.218222","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"218222"}}