{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T02:53:57Z","timestamp":1786503237543,"version":"build-2736575974"},"reference-count":100,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008746","name":"National Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008746","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R 37CA227865-01A1"],"award-info":[{"award-number":["R 37CA227865-01A1"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R 01 CA281219"],"award-info":[{"award-number":["R 01 CA281219"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["5P50CA150964-08"],"award-info":[{"award-number":["5P50CA150964-08"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA043703"],"award-info":[{"award-number":["P30CA043703"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008533","name":"Case Comprehensive Cancer Center, Case Western Reserve University","doi-asserted-by":"publisher","award":["GI SPORE 5P50CA150964-08"],"award-info":[{"award-number":["GI SPORE 5P50CA150964-08"]}],"id":[{"id":"10.13039\/100008533","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008533","name":"Case Comprehensive Cancer Center, Case Western Reserve University","doi-asserted-by":"publisher","award":["P 30CA043703"],"award-info":[{"award-number":["P 30CA043703"]}],"id":[{"id":"10.13039\/100008533","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["G-22-1100"],"award-info":[{"award-number":["G-22-1100"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["134170-MBG-19-174-01- MBG"],"award-info":[{"award-number":["134170-MBG-19-174-01- MBG"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["MRSG -14-019-01- CDD"],"award-info":[{"award-number":["MRSG -14-019-01- CDD"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012324","name":"University Hospitals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012324","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.canlet.2026.218334","type":"journal-article","created":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:21:26Z","timestamp":1771633286000},"page":"218334","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Vitamin B3 derivatives support pancreatic cancer cell survival and chemotherapy resistance"],"prefix":"10.1016","volume":"645","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4855-7302","authenticated-orcid":false,"given":"Faith","family":"Nakazzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrdad","family":"Zarei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4370-8688","authenticated-orcid":false,"given":"Hallie J.","family":"Graor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"Beegan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6213-7998","authenticated-orcid":false,"given":"Eric","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7999-3246","authenticated-orcid":false,"given":"Sakineh","family":"Rezaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2146-8724","authenticated-orcid":false,"given":"Peder J.","family":"Lund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan M.","family":"Winter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2026.218334_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.149590","article-title":"The therapeutic perspective of NAD+ precursors in age-related diseases","volume":"702","author":"Iqbal","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.canlet.2026.218334_bib2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/s41392-020-00311-7","article-title":"NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential","volume":"5","author":"Xie","year":"2020","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.canlet.2026.218334_bib3","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jare.2021.08.003","article-title":"Nicotinamide mononucleotide (NMN) as an anti-aging health product \u2013 promises and safety concerns","volume":"37","author":"Nadeeshani","year":"2022","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.canlet.2026.218334_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.868640","article-title":"Oral administration of nicotinamide mononucleotide is safe and efficiently increases blood nicotinamide adenine dinucleotide levels in healthy subjects","volume":"9","author":"Okabe","year":"2022","journal-title":"Front. Nutr."},{"issue":"1","key":"10.1016\/j.canlet.2026.218334_bib5","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1038\/s41467-018-03421-7","article-title":"Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults","volume":"9","author":"Martens","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2026.218334_bib6","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.tma.2021.09.001","article-title":"A single oral supplementation of nicotinamide within the daily tolerable upper level increases blood NAD+ levels in healthy subjects","volume":"5","author":"Ito","year":"2021","journal-title":"Transl Med Aging"},{"issue":"7","key":"10.1016\/j.canlet.2026.218334_bib7","doi-asserted-by":"crossref","first-page":"630","DOI":"10.3390\/metabo12070630","article-title":"NAD+ precursors: a questionable redundancy","volume":"12","author":"Canto","year":"2022","journal-title":"Metabolites"},{"issue":"2","key":"10.1016\/j.canlet.2026.218334_bib8","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3390\/life14020175","article-title":"Evolution at the origins of life?","volume":"14","author":"Schoenmakers","year":"2024","journal-title":"Life"},{"key":"10.1016\/j.canlet.2026.218334_bib9","series-title":"Planetary Biology and Chemical Evolution","first-page":"1","article-title":"Search for life's origins: progress and future directions","author":"Staff","year":"1990"},{"issue":"1","key":"10.1016\/j.canlet.2026.218334_bib10","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1038\/s41467-023-36904-3","article-title":"Uracil in the carbonaceous asteroid (162173) ryugu","volume":"14","author":"Oba","year":"2023","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.canlet.2026.218334_bib11","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1079\/BJN19820094","article-title":"Probable mechanisms of regulation of the utilization of dietary tryptophan, nicotinamide and nicotinic acid as precursors of nicotinamide nucleotides in the rat","volume":"48","author":"Bender","year":"1982","journal-title":"Br. J. Nutr."},{"issue":"2","key":"10.1016\/j.canlet.2026.218334_bib12","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1079\/BJN19880035","article-title":"Utilization of tryptophan, nicotinamide and nicotinic acid as precursors for nicotinamide nucleotide synthesis in isolated rat liver cells","volume":"59","author":"Bender","year":"1988","journal-title":"Br. J. Nutr."},{"issue":"3","key":"10.1016\/j.canlet.2026.218334_bib13","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s13668-023-00475-y","article-title":"NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR): potential dietary contribution to health","volume":"12","author":"Alegre","year":"2023","journal-title":"Curr Nutr Rep"},{"issue":"4","key":"10.1016\/j.canlet.2026.218334_bib14","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0092-8674(04)00416-7","article-title":"Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a preiss-handler independent route to NAD+ in fungi and humans","volume":"117","author":"Bieganowski","year":"2004","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.canlet.2026.218334_bib15","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.cmet.2021.04.003","article-title":"Evolving concepts in NAD+ metabolism","volume":"33","author":"Chini","year":"2021","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.canlet.2026.218334_bib16","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s42255-018-0009-4","article-title":"Slc12a8 is a nicotinamide mononucleotide transporter","volume":"1","author":"Grozio","year":"2019","journal-title":"Nat. Metab."},{"issue":"2","key":"10.1016\/j.canlet.2026.218334_bib17","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1210\/er.2009-0026","article-title":"The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways","volume":"31","author":"Houtkooper","year":"2010","journal-title":"Endocr. Rev."},{"issue":"6","key":"10.1016\/j.canlet.2026.218334_bib18","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1080\/15384101.2017.1285631","article-title":"NAD + in DNA repair and mitochondrial maintenance","volume":"16","author":"Croteau","year":"2017","journal-title":"Cell Cycle"},{"key":"10.1016\/j.canlet.2026.218334_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2020.110888","article-title":"Age-related NAD+ decline","volume":"134","author":"McReynolds","year":"2020","journal-title":"Exp. Gerontol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218334_bib20","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1186\/s12889-019-7762-5","article-title":"Consequences of chronic diseases and other limitations associated with old age \u2013 a scoping review","volume":"19","author":"Maresova","year":"2019","journal-title":"BMC Public Health"},{"issue":"2","key":"10.1016\/j.canlet.2026.218334_bib21","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.122.026850","article-title":"High prevalence of geriatric conditions among older adults with cardiovascular disease","volume":"12","author":"A\u00efdoud","year":"2023","journal-title":"J. Am. Heart Assoc."},{"issue":"8","key":"10.1016\/j.canlet.2026.218334_bib22","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.3390\/nu10081114","article-title":"Dietary supplement use differs by socioeconomic and health-related characteristics among U.S. adults, NHANES 2011\u20132014","volume":"10","author":"Cowan","year":"2018","journal-title":"Nutrients"},{"issue":"13","key":"10.1016\/j.canlet.2026.218334_bib23","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1158\/0008-5472.CAN-20-3290","article-title":"Nicotinamide mononucleotide prevents cisplatin-induced cognitive impairments","volume":"81","author":"Yoo","year":"2021","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2026.218334_bib24","first-page":"1","article-title":"Nicotinic acid riboside regulates Nrf-2\/P62-Related oxidative stress and autophagy to attenuate doxorubicin-induced cardiomyocyte injury","author":"Zou","year":"2022","journal-title":"BioMed Res. Int."},{"issue":"6","key":"10.1016\/j.canlet.2026.218334_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.105","article-title":"ROS homeostasis and metabolism: a dangerous liaison in cancer cells","volume":"7","author":"Panieri","year":"2016","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.canlet.2026.218334_bib26","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1200\/JCO.2007.13.5905","article-title":"Vitamin and mineral supplement use among US adults after cancer diagnosis: a systematic review","volume":"26","author":"Velicer","year":"2008","journal-title":"J. Clin. Oncol."},{"issue":"5","key":"10.1016\/j.canlet.2026.218334_bib27","first-page":"319","article-title":"Use of antioxidants during chemotherapy and radiotherapy should be avoided","volume":"55","author":"D'Andrea","year":"2005","journal-title":"CA Cancer J. Clin."},{"issue":"3","key":"10.1016\/j.canlet.2026.218334_bib28","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1158\/0008-5472.CAN-14-2211","article-title":"Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein","volume":"75","author":"Kamphorst","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2026.218334_bib29","doi-asserted-by":"crossref","first-page":"617","DOI":"10.3389\/fonc.2018.00617","article-title":"Winter JM. Metabolic dependencies in pancreatic cancer","volume":"8","author":"Vaziri-Gohar","year":"2018","journal-title":"Front. Oncol."},{"issue":"9","key":"10.1016\/j.canlet.2026.218334_bib30","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1002\/1878-0261.13209","article-title":"Nicotinamide (Niacin) supplement increases lipid metabolism and ROS\u2010induced energy disruption in triple\u2010negative breast cancer: potential for drug repositioning as an anti\u2010tumor agent","volume":"16","author":"Jung","year":"2022","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.canlet.2026.218334_bib31","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.lfs.2017.06.003","article-title":"Nicotinamide induces mitochondrial-mediated apoptosis through oxidative stress in human cervical cancer HeLa cells","volume":"181","author":"Feng","year":"2017","journal-title":"Life Sci."},{"issue":"6","key":"10.1016\/j.canlet.2026.218334_bib32","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.3390\/nu15061447","article-title":"Nicotinamide adenine dinucleotide precursor suppresses hepatocellular cancer progression in mice","volume":"15","author":"Pang","year":"2023","journal-title":"Nutrients"},{"issue":"9","key":"10.1016\/j.canlet.2026.218334_bib33","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.3390\/cancers15092427","article-title":"High-dosage NMN promotes ferroptosis to suppress lung adenocarcinoma growth through the NAM-mediated SIRT1\u2013AMPK\u2013ACC pathway","volume":"15","author":"Zhang","year":"2023","journal-title":"Cancers"},{"key":"10.1016\/j.canlet.2026.218334_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2022.114826","article-title":"A bioluminescent-based probe for in vivo non-invasive monitoring of nicotinamide riboside uptake reveals a link between metastasis and NAD+ metabolism","volume":"220","author":"Maric","year":"2023","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.canlet.2026.218334_bib35","article-title":"Comparison of protective effects of nicotinamide mononucleotide and nicotinamide riboside on DNA damage induced by cisplatin in HeLa cells","volume":"37","author":"Qiu","year":"2024","journal-title":"Biochem. Biophys. Rep."},{"issue":"1","key":"10.1016\/j.canlet.2026.218334_bib36","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1158\/1078-0432.CCR-13-0150","article-title":"Targeting of NAD metabolism in pancreatic cancer cells: potential novel therapy for pancreatic tumors","volume":"20","author":"Chini","year":"2014","journal-title":"Clin. Cancer Res."},{"issue":"23","key":"10.1016\/j.canlet.2026.218334_bib37","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.1039\/C7AN01378G","article-title":"Stable isotope labeling by essential nutrients in cell culture (SILEC) for accurate measurement of nicotinamide adenine dinucleotide metabolism","volume":"142","author":"Frederick","year":"2017","journal-title":"The Analyst"},{"issue":"2","key":"10.1016\/j.canlet.2026.218334_bib38","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1158\/2767-9764.CRC-21-0073","article-title":"Nuclear receptor 4A2 (NR4A2\/NURR1) regulates autophagy and chemoresistance in pancreatic ductal adenocarcinoma","volume":"1","author":"Zarei","year":"2021","journal-title":"Cancer Res. Commun."},{"issue":"2","key":"10.1016\/j.canlet.2026.218334_bib39","doi-asserted-by":"crossref","first-page":"300","DOI":"10.3390\/nu14020300","article-title":"Oral administration of nicotinamide mononucleotide increases nicotinamide adenine dinucleotide level in an animal brain","volume":"14","author":"Ramanathan","year":"2022","journal-title":"Nutrients"},{"issue":"6","key":"10.1016\/j.canlet.2026.218334_bib40","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/j.advnut.2023.08.008","article-title":"The safety and antiaging effects of nicotinamide mononucleotide in human clinical trials: an update","volume":"14","author":"Song","year":"2023","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.canlet.2026.218334_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2023.1201317","article-title":"Nicotinamide enhances myelin production after demyelination through reduction of astrogliosis and microgliosis","volume":"17","author":"Kaplanis","year":"2023","journal-title":"Front. Cell. Neurosci."},{"issue":"4","key":"10.1016\/j.canlet.2026.218334_bib42","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.intimp.2012.09.013","article-title":"Protective effects of nicotinamide against acetaminophen-induced acute liver injury","volume":"14","author":"Shi","year":"2012","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.canlet.2026.218334_bib43","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/1096-9098(200102)76:2<106::AID-JSO1020>3.0.CO;2-E","article-title":"Pharmacokinetics of intraperitoneal oxaliplatin: experimental studies","volume":"76","author":"Pestieau","year":"2001","journal-title":"J. Surg. Oncol."},{"issue":"3","key":"10.1016\/j.canlet.2026.218334_bib44","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1136\/gut.2010.211722","article-title":"Oxaliplatin in combination with liver-specific expression of interleukin 12 reduces the immunosuppressive microenvironment of tumours and eradicates metastatic colorectal cancer in mice","volume":"60","author":"Gonzalez-Aparicio","year":"2011","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.canlet.2026.218334_bib45","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.cell.2012.01.058","article-title":"Oncogenic kras maintains pancreatic tumors through regulation of anabolic glucose metabolism","volume":"149","author":"Ying","year":"2012","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.canlet.2026.218334_bib46","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.chembiol.2017.08.028","article-title":"Targeting metabolism for cancer therapy","volume":"24","author":"Luengo","year":"2017","journal-title":"Cell Chem. Biol."},{"issue":"2","key":"10.1016\/j.canlet.2026.218334_bib47","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41580-020-00313-x","article-title":"NAD+ metabolism and its roles in cellular processes during ageing","volume":"22","author":"Covarrubias","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.canlet.2026.218334_bib48","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.dnarep.2014.09.004","article-title":"ARTD1 (PARP1) activation and NAD+ in DNA repair and cell death","volume":"23","author":"Fouquerel","year":"2014","journal-title":"DNA Repair"},{"issue":"7","key":"10.1016\/j.canlet.2026.218334_bib49","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/j.cell.2013.11.037","article-title":"Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging","volume":"155","author":"Gomes","year":"2013","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.canlet.2026.218334_bib50","doi-asserted-by":"crossref","first-page":"4254","DOI":"10.1074\/jbc.M411662200","article-title":"Mitochondrial O 2 \u22c5 \u203e and H2O2 mediate glucose Deprivation-induced stress in human cancer cells","volume":"280","author":"Ahmad","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.canlet.2026.218334_bib51","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1158\/0008-5472.CAN-03-1101","article-title":"Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells","volume":"64","author":"Rossignol","year":"2004","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.canlet.2026.218334_bib52","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/s41598-020-57506-9","article-title":"Extracellular NAD+ enhances PARP-Dependent DNA repair capacity independently of CD73 activity","volume":"10","author":"Wilk","year":"2020","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.canlet.2026.218334_bib53","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.3390\/nu12061616","article-title":"Nicotinamide riboside\u2014the current state of research and therapeutic uses","volume":"12","author":"Mehmel","year":"2020","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.canlet.2026.218334_bib54","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.cmet.2015.05.023","article-title":"NAD+ metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus","volume":"22","author":"Cant\u00f3","year":"2015","journal-title":"Cell Metab."},{"issue":"18","key":"10.1016\/j.canlet.2026.218334_bib55","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1158\/0008-5472.CAN-23-1895","article-title":"IDH1 inhibition potentiates chemotherapy efficacy in pancreatic cancer","volume":"84","author":"Zarei","year":"2024","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2026.218334_bib56","series-title":"Limited Nutrient Availability in the Tumor Microenvironment Renders Pancreatic Tumors Sensitive to Allosteric IDH1 Inhibitors","volume":"vol. 3","author":"Vaziri-Gohar","year":"2022"},{"issue":"8","key":"10.1016\/j.canlet.2026.218334_bib57","doi-asserted-by":"crossref","first-page":"270","DOI":"10.3390\/biomedicines8080270","article-title":"Mitochondrial metabolism in PDAC: from better knowledge to new targeting strategies","volume":"8","author":"Reyes-Castellanos","year":"2020","journal-title":"Biomedicines"},{"key":"10.1016\/j.canlet.2026.218334_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2024.102089","article-title":"Metabolic plasticity in pancreatic cancer: the mitochondrial connection","volume":"92","author":"Ghiglione","year":"2025","journal-title":"Mol. Metabol."},{"issue":"14","key":"10.1016\/j.canlet.2026.218334_bib59","doi-asserted-by":"crossref","first-page":"5505","DOI":"10.1007\/s00018-021-03866-y","article-title":"Overcoming chemoresistance by targeting reprogrammed metabolism: the achilles' heel of pancreatic ductal adenocarcinoma","volume":"78","author":"Tuerhong","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.canlet.2026.218334_bib60","first-page":"1","article-title":"Understanding of ROS-inducing strategy in anticancer therapy","volume":"2019","author":"Kim","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"4","key":"10.1016\/j.canlet.2026.218334_bib61","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.3390\/ijms22041534","article-title":"Targeting redox metabolism in pancreatic cancer","volume":"22","author":"Abdel Hadi","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.canlet.2026.218334_bib62","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/s41392-020-00326-0","article-title":"NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications","volume":"5","author":"Ju","year":"2020","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.canlet.2026.218334_bib63","unstructured":"Eustermann S. Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1."},{"issue":"12","key":"10.1016\/j.canlet.2026.218334_bib64","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1038\/s42255-024-01174-w","article-title":"Subcellular NAD+ pools are interconnected and buffered by mitochondrial NAD+","volume":"6","author":"H\u00f8yland","year":"2024","journal-title":"Nat. Metab."},{"issue":"2","key":"10.1016\/j.canlet.2026.218334_bib65","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jsps.2017.12.013","article-title":"Antioxidants as precision weapons in war against cancer chemotherapy induced toxicity \u2013 exploring the armoury of obscurity","volume":"26","author":"Singh","year":"2018","journal-title":"Saudi Pharm. J."},{"issue":"221","key":"10.1016\/j.canlet.2026.218334_bib66","article-title":"Antioxidants accelerate lung cancer progression in mice","volume":"6","author":"Sayin","year":"2014","journal-title":"Sci Transl Med [Internet]"},{"issue":"308","key":"10.1016\/j.canlet.2026.218334_bib67","article-title":"Antioxidants can increase melanoma metastasis in mice","volume":"7","author":"Le Gal","year":"2015","journal-title":"Sci Transl Med [Internet]"},{"issue":"9","key":"10.1016\/j.canlet.2026.218334_bib68","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1002\/ijc.22042","article-title":"Antioxidant vitamins supplementation and mortality: a randomized trial in head and neck cancer patients","volume":"119","author":"Bairati","year":"2006","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.canlet.2026.218334_bib69","series-title":"Vitamin E and the Risk of Prostate Cancer","author":"Klein","year":"2011"},{"issue":"7","key":"10.1016\/j.canlet.2026.218334_bib70","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/s43018-022-00393-y","article-title":"Limited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors","volume":"3","author":"Vaziri-Gohar","year":"2022","journal-title":"Nat. Cancer"},{"issue":"3","key":"10.1016\/j.canlet.2026.218334_bib71","article-title":"NRF2\u2010mediated SIRT3 induction protects hepatocytes from ER stress\u2010induced liver injury","volume":"36","author":"Kim","year":"2022","journal-title":"FASEB J [Internet]"},{"issue":"5","key":"10.1016\/j.canlet.2026.218334_bib72","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.molcel.2011.05.008","article-title":"The SirT3 divining rod points to oxidative stress","volume":"42","author":"Bell","year":"2011","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.canlet.2026.218334_bib73","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1038\/s41467-019-10741-9","article-title":"Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks","volume":"10","author":"Caron","year":"2019","journal-title":"Nat. Commun."},{"issue":"13","key":"10.1016\/j.canlet.2026.218334_bib74","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.3390\/ijms20133153","article-title":"The role of SIRT1 on DNA damage response and epigenetic alterations in cancer","volume":"20","author":"Alves-Fernandes","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.canlet.2026.218334_bib75","doi-asserted-by":"crossref","first-page":"13538","DOI":"10.18632\/oncotarget.6455","article-title":"SIRT1 inhibition impairs non-homologous end joining DNA damage repair by increasing Ku70 acetylation in chronic myeloid leukemia cells","volume":"7","author":"Zhang","year":"2016","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.canlet.2026.218334_bib76","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.molcel.2007.05.029","article-title":"SIRT1 regulates the function of the nijmegen breakage syndrome protein","volume":"27","author":"Yuan","year":"2007","journal-title":"Mol. Cell"},{"issue":"3","key":"10.1016\/j.canlet.2026.218334_bib77","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1093\/nar\/gkp1039","article-title":"SIRT1 deacetylates APE1 and regulates cellular base excision repair","volume":"38","author":"Yamamori","year":"2010","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.canlet.2026.218334_bib78","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/emm.2007.2","article-title":"SIRT1 promotes DNA repair activity and deacetylation of Ku70","volume":"39","author":"Jeong","year":"2007","journal-title":"Exp. Mol. Med."},{"issue":"44","key":"10.1016\/j.canlet.2026.218334_bib79","doi-asserted-by":"crossref","first-page":"41310","DOI":"10.1021\/acsomega.3c04859","article-title":"Activation of SIRT6 deacetylation by DNA strand breaks","volume":"8","author":"Kang","year":"2023","journal-title":"ACS Omega"},{"issue":"16","key":"10.1016\/j.canlet.2026.218334_bib80","doi-asserted-by":"crossref","first-page":"9181","DOI":"10.1093\/nar\/gkaa661","article-title":"The deacetylase SIRT6 promotes the repair of UV-induced DNA damage by targeting DDB2","volume":"48","author":"Geng","year":"2020","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.canlet.2026.218334_bib81","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.pbi.2004.03.007","article-title":"Respiratory metabolism: glycolysis, the TCA cycle and mitochondrial electron transport","volume":"7","author":"Fernie","year":"2004","journal-title":"Curr. Opin. Plant Biol."},{"issue":"1","key":"10.1016\/j.canlet.2026.218334_bib82","doi-asserted-by":"crossref","first-page":"521","DOI":"10.3892\/mmr.2014.2724","article-title":"Sirtuin 1 activation enhances the PGC-1\u03b1\/mitochondrial antioxidant system pathway in status epilepticus","volume":"11","author":"Wang","year":"2015","journal-title":"Mol. Med. Rep."},{"issue":"9","key":"10.1016\/j.canlet.2026.218334_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.102286","article-title":"Vitamin B3, nicotinamide, enhances mitochondrial metabolism to promote differentiation of the retinal pigment epithelium","volume":"298","author":"Hazim","year":"2022","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.canlet.2026.218334_bib84","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.molcel.2007.08.030","article-title":"Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity","volume":"28","author":"Kim","year":"2007","journal-title":"Mol. Cell"},{"issue":"2","key":"10.1016\/j.canlet.2026.218334_bib85","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/s41418-019-0369-7","article-title":"SIRT1 modulates cell cycle progression by regulating CHK2 acetylation\u2212phosphorylation","volume":"27","author":"Zhang","year":"2020","journal-title":"Cell Death Differ."},{"issue":"11","key":"10.1016\/j.canlet.2026.218334_bib86","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/s41388-023-02592-y","article-title":"NAD+ supplementation limits triple-negative breast cancer metastasis via SIRT1-P66Shc signaling","volume":"42","author":"Jiang","year":"2023","journal-title":"Oncogene"},{"issue":"10","key":"10.1016\/j.canlet.2026.218334_bib87","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1038\/s44321-024-00119-w","article-title":"Fertility protection during chemotherapy treatment by boosting the NAD(P)+ metabolome","volume":"16","author":"Ho","year":"2024","journal-title":"EMBO Mol. Med."},{"issue":"10","key":"10.1016\/j.canlet.2026.218334_bib88","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1097\/j.pain.0000000000001924","article-title":"Nicotinamide riboside relieves paclitaxel-induced peripheral neuropathy and enhances suppression of tumor growth in tumor-bearing rats","volume":"161","author":"Hamity","year":"2020","journal-title":"Pain"},{"key":"10.1016\/j.canlet.2026.218334_bib89","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115607","article-title":"Recent advances of targeting nicotinamide phosphoribosyltransferase (NAMPT) for cancer drug discovery","volume":"258","author":"Tang","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.canlet.2026.218334_bib90","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.biochi.2015.07.012","article-title":"Combinative effects of \u03b2-Lapachone and APO866 on pancreatic cancer cell death through reactive oxygen species production and PARP-1 activation","volume":"116","author":"Breton","year":"2015","journal-title":"Biochimie"},{"issue":"33","key":"10.1016\/j.canlet.2026.218334_bib91","doi-asserted-by":"crossref","first-page":"53783","DOI":"10.18632\/oncotarget.10776","article-title":"A pancreatic ductal adenocarcinoma subpopulation is sensitive to FK866, an inhibitor of NAMPT","volume":"7","author":"Barraud","year":"2016","journal-title":"Oncotarget"},{"issue":"6","key":"10.1016\/j.canlet.2026.218334_bib92","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1158\/1535-7163.MCT-09-1130","article-title":"A preclinical study on the rescue of normal tissue by nicotinic acid in high-dose treatment with APO866, a specific nicotinamide phosphoribosyltransferase inhibitor","volume":"9","author":"Olesen","year":"2010","journal-title":"Mol. Cancer Therapeut."},{"issue":"3","key":"10.1016\/j.canlet.2026.218334_bib93","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3109\/15376516.2015.1014080","article-title":"Preclinical models of nicotinamide phosphoribosyltransferase inhibitor-mediated hematotoxicity and mitigation by co-treatment with nicotinic acid","volume":"25","author":"Tarrant","year":"2015","journal-title":"Toxicol. Mech. Methods"},{"issue":"1","key":"10.1016\/j.canlet.2026.218334_bib94","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s10637-007-9083-2","article-title":"The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor","volume":"26","author":"Holen","year":"2008","journal-title":"Invest. N. Drugs"},{"issue":"14","key":"10.1016\/j.canlet.2026.218334_bib95","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.1158\/0008-5472.CAN-16-3079","article-title":"Nicotinic acid phosphoribosyltransferase regulates cancer cell metabolism, susceptibility to NAMPT inhibitors, and DNA repair","volume":"77","author":"Piacente","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2026.218334_bib96","doi-asserted-by":"crossref","DOI":"10.20517\/cdr.2024.216","article-title":"Mechanisms of resistance to NAMPT inhibitors in cancer","author":"Redler","year":"2025","journal-title":"Cancer Drug Resist [Internet]"},{"issue":"3","key":"10.1016\/j.canlet.2026.218334_bib97","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.bbrc.2017.07.143","article-title":"Identification of novel resistance mechanisms to NAMPT inhibition via the de novo NAD+ biosynthesis pathway and NAMPT mutation","volume":"491","author":"Guo","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"12","key":"10.1016\/j.canlet.2026.218334_bib98","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1016\/j.cmet.2022.11.004","article-title":"NAD precursors cycle between host tissues and the gut microbiome","volume":"34","author":"Chellappa","year":"2022","journal-title":"Cell Metab."},{"issue":"12","key":"10.1016\/j.canlet.2026.218334_bib99","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adr1538","article-title":"Nicotinamide riboside and nicotinamide mononucleotide facilitate NAD+ synthesis via enterohepatic circulation","volume":"11","author":"Yaku","year":"2025","journal-title":"Sci. Adv."},{"issue":"17","key":"10.1016\/j.canlet.2026.218334_bib100","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1002\/1873-3468.14698","article-title":"Host\u2013microbiome interactions in nicotinamide mononucleotide (NMN) deamidation","volume":"597","author":"Kim","year":"2023","journal-title":"FEBS Lett."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383526000972?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383526000972?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:12:44Z","timestamp":1777551164000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383526000972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":100,"alternative-id":["S0304383526000972"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218334","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitamin B3 derivatives support pancreatic cancer cell survival and chemotherapy resistance","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218334","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"218334"}}