{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:53:38Z","timestamp":1786985618113,"version":"build-2736575974"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372881"],"award-info":[{"award-number":["82372881"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82303655"],"award-info":[{"award-number":["82303655"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025MD774159"],"award-info":[{"award-number":["2025MD774159"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004374","name":"Chongqing Medical University","doi-asserted-by":"publisher","award":["CYYY-BSYJSCXXM-202224"],"award-info":[{"award-number":["CYYY-BSYJSCXXM-202224"]}],"id":[{"id":"10.13039\/501100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.canlet.2026.218337","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:23:23Z","timestamp":1771287803000},"page":"218337","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Nutrient deprivation promotes bladder cancer metastasis through Beclin-1 deacetylation-mediated autophagy activation"],"prefix":"10.1016","volume":"645","author":[{"given":"Yan","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guozhi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linfeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tinghao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junlong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunyao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubin","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2026.218337_bib1","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.canlet.2026.218337_bib2","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1001\/jama.2020.17598","article-title":"Bladder cancer: a review","volume":"324","author":"Lenis","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.canlet.2026.218337_bib3","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1016\/S0140-6736(22)01188-6","article-title":"Current best practice for bladder cancer: a narrative review of diagnostics and treatments","volume":"400","author":"Comp\u00e9rat","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.canlet.2026.218337_bib4","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/s41572-023-00468-9","article-title":"Bladder cancer","volume":"9","author":"Dyrskj\u00f8t","year":"2023","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.canlet.2026.218337_bib5","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.canlet.2016.04.009","article-title":"Targeting tumor microenvironment in cancer therapy","volume":"380","author":"Singh","year":"2016","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2026.218337_bib6","first-page":"139","article-title":"Nutrient deprivation modulates the metastatic potential of breast cancer cells","volume":"8","author":"Ahmadiankia","year":"2019","journal-title":"Rep. Biochem. Mol. Biol."},{"key":"10.1016\/j.canlet.2026.218337_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.216823","article-title":"Hypoxia-associated autophagy flux dysregulation in human cancers","volume":"590","author":"Fu","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2026.218337_bib8","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adg4993","article-title":"ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation","volume":"9","author":"Jia","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.canlet.2026.218337_bib9","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/nature07976","article-title":"Autophagy regulates lipid metabolism","volume":"458","author":"Singh","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2026.218337_bib10","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s41580-023-00585-z","article-title":"Autophagy and autophagy-related pathways in cancer","volume":"24","author":"Debnath","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.canlet.2026.218337_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217285","article-title":"Autophagy and cancer therapy","volume":"605","author":"Pimentel","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2026.218337_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.216867","article-title":"Autophagy flux in bladder cancer: cell death crosstalk, drug and nanotherapeutics","volume":"591","author":"Liu","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2026.218337_bib13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1158\/0008-5472.CAN-12-2464","article-title":"Chloroquine in cancer therapy: a double-edged sword of autophagy","volume":"73","author":"Kimura","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2026.218337_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105582","article-title":"Chloroquine and hydroxychloroquine in antitumor therapies based on autophagy-related mechanisms","volume":"168","author":"Ferreira","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.canlet.2026.218337_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1506426","article-title":"Beclin-1: a therapeutic target at the intersection of autophagy, immunotherapy, and cancer treatment","volume":"15","author":"Cao","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.canlet.2026.218337_bib16","doi-asserted-by":"crossref","first-page":"4688","DOI":"10.1016\/j.apsb.2023.08.008","article-title":"Targeting autophagy and beyond: deconvoluting the complexity of Beclin-1 from biological function to cancer therapy","volume":"13","author":"Ye","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.canlet.2026.218337_bib17","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/s41419-021-03733-5","article-title":"SOX2 promotes chemoresistance, cancer stem cells properties, and epithelial-mesenchymal transition by \u03b2-catenin and Beclin1\/autophagy signaling in colorectal cancer","volume":"12","author":"Zhu","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.canlet.2026.218337_bib18","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/cdd.2010.191","article-title":"The beclin 1 network regulates autophagy and apoptosis","volume":"18","author":"Kang","year":"2011","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.canlet.2026.218337_bib19","doi-asserted-by":"crossref","first-page":"5118","DOI":"10.1002\/jcb.27788","article-title":"Starvation-induced autophagy promotes the invasion and migration of human bladder cancer cells via TGF-\u03b21\/Smad3-mediated epithelial-mesenchymal transition activation","volume":"120","author":"Tong","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.canlet.2026.218337_bib20","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1186\/s12935-021-02303-1","article-title":"Starvation induced autophagy promotes the progression of bladder cancer by LDHA mediated metabolic reprogramming","volume":"21","author":"Li","year":"2021","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.canlet.2026.218337_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.216758","article-title":"Unleashing the power of immune checkpoints: post-translational modification of novel molecules and clinical applications","volume":"588","author":"Wang","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2026.218337_bib22","first-page":"1061","volume":"8","author":"Huang","year":"2025"},{"key":"10.1016\/j.canlet.2026.218337_bib23","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s41392-020-0196-9","article-title":"Regulating tumor suppressor genes: post-translational modifications","volume":"5","author":"Chen","year":"2020","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.canlet.2026.218337_bib24","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/s41418-018-0254-9","article-title":"Post-translational modifications of Beclin 1 provide multiple strategies for autophagy regulation","volume":"26","author":"Hill","year":"2019","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.canlet.2026.218337_bib25","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1080\/15548627.2022.2062112","article-title":"Acetylation in the regulation of autophagy","volume":"19","author":"Xu","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.canlet.2026.218337_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106957","article-title":"SIRT1 is a regulator of autophagy: implications for the progression and treatment of myocardial ischemia-reperfusion","volume":"199","author":"Ding","year":"2024","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.canlet.2026.218337_bib27","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S0955-0674(03)00003-6","article-title":"Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation","volume":"15","author":"Brooks","year":"2003","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.canlet.2026.218337_bib28","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1080\/15548627.2018.1466013","article-title":"Role of the MAPK\/cJun NH2-terminal kinase signaling pathway in starvation-induced autophagy","volume":"14","author":"Barutcu","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.canlet.2026.218337_bib29","doi-asserted-by":"crossref","first-page":"7215","DOI":"10.1038\/ncomms8215","article-title":"Acetylation of Beclin 1 inhibits autophagosome maturation and promotes tumour growth","volume":"6","author":"Sun","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2026.218337_bib30","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.cmet.2018.11.018","article-title":"Starvation and pseudo-starvation as drivers of cancer metastasis through translation reprogramming","volume":"29","author":"Garc\u00eda-Jim\u00e9nez","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.canlet.2026.218337_bib31","first-page":"170","article-title":"The XAF1 tumor suppressor induces autophagic cell death via upregulation of Beclin-1 and inhibition of Akt pathway","volume":"310","author":"Sun","year":"2011","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2026.218337_bib32","doi-asserted-by":"crossref","first-page":"720","DOI":"10.4161\/auto.5.5.8625","article-title":"Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XL","volume":"5","author":"Zalckvar","year":"2009","journal-title":"Autophagy"},{"key":"10.1016\/j.canlet.2026.218337_bib33","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1038\/s41418-021-00907-8","article-title":"USP11 regulates autophagy-dependent ferroptosis after spinal cord ischemia-reperfusion injury by deubiquitinating Beclin 1","volume":"29","author":"Rong","year":"2022","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.canlet.2026.218337_bib34","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1016\/j.cub.2018.05.094","article-title":"AMPK-mediated BECN1 phosphorylation promotes ferroptosis by directly blocking system Xc- activity","volume":"28","author":"Song","year":"2018","journal-title":"Curr. Biol."},{"key":"10.1016\/j.canlet.2026.218337_bib35","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.semcancer.2013.05.007","article-title":"Autophagosome formation--the role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage","volume":"23","author":"Wirth","year":"2013","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.canlet.2026.218337_bib36","unstructured":"USP14 regulates autophagy by suppressing K63 ubiquitination of Beclin 1 - PubMed, (n.d.). https:\/\/pubmed.ncbi.nlm.nih.gov\/27542828\/(accessed April 4, 2024)."},{"key":"10.1016\/j.canlet.2026.218337_bib37","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1080\/15548627.2024.2429380","article-title":"RNF144A inhibits autophagy by targeting BECN1 for degradation during L. monocytogenes infection","volume":"21","author":"Yang","year":"2025","journal-title":"Autophagy"},{"key":"10.1016\/j.canlet.2026.218337_bib38","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1126\/science.aax3769","article-title":"Cellular quality control by the ubiquitin-proteasome system and autophagy","volume":"366","author":"Pohl","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.canlet.2026.218337_bib39","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1080\/15548627.2023.2299514","article-title":"UBE3C tunes autophagy via ATG4B ubiquitination","volume":"20","author":"Sun","year":"2024","journal-title":"Autophagy"},{"key":"10.1016\/j.canlet.2026.218337_bib40","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1080\/15548627.2017.1376160","article-title":"The E3 ubiquitin ligase NEDD4 enhances killing of membrane-perturbing intracellular bacteria by promoting autophagy","volume":"13","author":"Pei","year":"2017","journal-title":"Autophagy"},{"key":"10.1016\/j.canlet.2026.218337_bib41","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.4161\/15548627.2014.981792","article-title":"Regulation of autophagy by E3 ubiquitin ligase RNF216 through BECN1 ubiquitination","volume":"10","author":"Xu","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.canlet.2026.218337_bib42","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1615\/CritRevEukaryotGeneExpr.2015012975","article-title":"mTOR, AMPK, and Sirt1: key players in metabolic stress management","volume":"25","author":"Cetrullo","year":"2015","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"10.1016\/j.canlet.2026.218337_bib43","doi-asserted-by":"crossref","first-page":"46","DOI":"10.4161\/15548627.2014.984271","article-title":"Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway","volume":"11","author":"Song","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.canlet.2026.218337_bib44","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ymeth.2003.11.023","article-title":"Advanced transfection with lipofectamine 2000 reagent: primary neurons, siRNA, and high-throughput applications","volume":"33","author":"Dalby","year":"2004","journal-title":"Methods"}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030438352600100X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030438352600100X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:08:32Z","timestamp":1777550912000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030438352600100X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":44,"alternative-id":["S030438352600100X"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218337","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nutrient deprivation promotes bladder cancer metastasis through Beclin-1 deacetylation-mediated autophagy activation","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218337","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"218337"}}