{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:59:18Z","timestamp":1791993558331,"version":"4.4.0"},"reference-count":101,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002809","name":"Government of Catalonia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012099","name":"Indian Institute of Technology Guwahati","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["IFA24-LSBM 295"],"award-info":[{"award-number":["IFA24-LSBM 295"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020571","name":"Berhampur University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020571","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.canlet.2026.218428","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T17:25:27Z","timestamp":1773249927000},"page":"218428","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["The mitochondrial enigma: Deciphering mechanisms and identifying drug targets in polyploid giant cancer cells"],"prefix":"10.1016","volume":"646","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0166-0903","authenticated-orcid":false,"given":"Srimanta","family":"Patra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakash Priyadarshi","family":"Praharaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mrutyunjay","family":"Jena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Zorzano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2026.218428_bib1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.semcancer.2020.11.003","article-title":"Genome chaos: creating new genomic information essential for cancer macroevolution","volume":"81","author":"Heng","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.canlet.2026.218428_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.567116","article-title":"Polyploid giant cancer cells, a hallmark of oncoviruses and a new therapeutic challenge","volume":"10","author":"Herbein","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.canlet.2026.218428_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.216843","article-title":"Recent advancement of autophagy in polyploid giant cancer cells and its interconnection with senescence and stemness for therapeutic opportunities","volume":"590","author":"Patra","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2026.218428_bib4","article-title":"Polyploid giant cancer cells: origin, possible pathways of formation, characteristics, and mechanisms of regulation","volume":"12","author":"Liu","year":"2024"},{"key":"10.1016\/j.canlet.2026.218428_bib5","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.semcancer.2021.10.005","article-title":"The life cycle of polyploid giant cancer cells and dormancy in cancer: opportunities for novel therapeutic interventions","volume":"81","author":"Liu","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.canlet.2026.218428_bib6","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/onc.2013.96","article-title":"Generation of cancer stem-like cells through the formation of polyploid giant cancer cells","volume":"33","author":"Zhang","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2026.218428_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.semcancer.2021.10.006","article-title":"Polyploid giant cancer cells: an emerging new field of cancer biology","volume":"81","author":"Liu","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.canlet.2026.218428_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.767221","article-title":"The multifaceted regulation of mitochondrial dynamics during mitosis","volume":"9","author":"Pangou","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.canlet.2026.218428_bib9","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.semcancer.2019.07.015","article-title":"The emerging, multifaceted role of mitophagy in cancer and cancer therapeutics","volume":"66","author":"Panigrahi","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.canlet.2026.218428_bib10","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.canlet.2020.10.036","article-title":"Mitochondrial rewiring through mitophagy and mitochondrial biogenesis in cancer stem cells: a potential target for anti-CSC cancer therapy","volume":"498","author":"Praharaj","year":"2021","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2026.218428_bib11","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/s41419-023-06232-x","article-title":"SIRT1 inhibits mitochondrial hyperfusion associated mito-bulb formation to sensitize oral cancer cells for apoptosis in a mtROS-dependent signalling pathway","volume":"14","author":"Patra","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.canlet.2026.218428_bib12","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1158\/0008-5472.CAN-21-2342","article-title":"AMPK\u2013mTOR\u2013Mediated activation of autophagy promotes Formation of dormant polyploid giant cancer cells","volume":"82","author":"You","year":"2022","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2026.218428_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217818","article-title":"Evolutionary adaptation and asymmetric inheritance of polyploid giant cancer cells in esophageal squamous cell carcinoma","author":"Song","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2026.218428_bib14","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201487826","article-title":"Genome-wide siRNA screen reveals coupling between mitotic apoptosis and adaptation","volume":"33","author":"D\u00edaz-Mart\u00ednez","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.canlet.2026.218428_bib15","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1038\/emboj.2009.89","article-title":"SLP-2 is required for stress-induced mitochondrial hyperfusion","volume":"28","author":"Tondera","year":"2009","journal-title":"EMBO J."},{"key":"10.1016\/j.canlet.2026.218428_bib16","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.freeradbiomed.2022.08.019","article-title":"MTP18 inhibition triggers mitochondrial hyperfusion to induce apoptosis through ROS-mediated lysosomal membrane permeabilization-dependent pathway in oral cancer","volume":"190","author":"Panigrahi","year":"2022","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.canlet.2026.218428_bib17","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.semcancer.2021.03.021","article-title":"Biological functions of therapy-induced senescence in cancer","volume":"81","author":"Fitsiou","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.canlet.2026.218428_bib18","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.neo.2015.11.008","article-title":"Polyploidy Formation in doxorubicin-treated cancer cells can favor escape from senescence","volume":"17","author":"Mosieniak","year":"2015","journal-title":"Neoplasia"},{"key":"10.1016\/j.canlet.2026.218428_bib19","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.1038\/s41388-018-0272-6","article-title":"Multi-nucleated cells use ROS to induce breast cancer chemo-resistance in vitro and in vivo","volume":"37","author":"Parekh","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2026.218428_bib20","series-title":"Mitosis, Cold Spring Harbor Perspectives in Biology","first-page":"8","author":"McIntosh","year":"2016"},{"key":"10.1016\/j.canlet.2026.218428_bib21","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.semcdb.2021.06.009","article-title":"Spindle assembly checkpoint activation and silencing at kinetochores","volume":"117","author":"Lara-Gonzalez","year":"2021","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.canlet.2026.218428_bib22","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/s41586-020-03114-6","article-title":"Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition","volume":"590","author":"Cohen-Sharir","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2026.218428_bib23","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cytogfr.2019.11.002","article-title":"Senescence in polyploid giant cancer cells: a road that leads to chemoresistance","volume":"52","author":"Bharadwaj","year":"2020","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.canlet.2026.218428_bib24","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.devcel.2021.02.009","article-title":"Quality control of the mitochondrion","volume":"56","author":"Ng","year":"2021","journal-title":"Dev. Cell"},{"key":"10.1016\/j.canlet.2026.218428_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22062935","article-title":"Cyclin-Dependent kinases (CDK) and their role in diseases development-review","volume":"22","author":"\u0141ukasik","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.canlet.2026.218428_bib26","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.devcel.2014.03.012","article-title":"Cyclin B1\/Cdk1 coordinates mitochondrial respiration for cell-cycle G2\/M progression","volume":"29","author":"Wang","year":"2014","journal-title":"Dev. Cell"},{"key":"10.1016\/j.canlet.2026.218428_bib27","doi-asserted-by":"crossref","first-page":"11521","DOI":"10.1074\/jbc.M607279200","article-title":"Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission","volume":"282","author":"Taguchi","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2026.218428_bib28","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1038\/ncb2310","article-title":"RALA and RALBP1 regulate mitochondrial fission at mitosis","volume":"13","author":"Kashatus","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.canlet.2026.218428_bib29","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.38111","article-title":"Aurora kinase A localises to mitochondria to control organelle dynamics and energy production","volume":"7","author":"Bertolin","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.canlet.2026.218428_bib30","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.193","article-title":"Mps1 kinase regulates tumor cell viability via its novel role in mitochondria","volume":"7","author":"Zhang","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.canlet.2026.218428_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0099143","article-title":"CoCl2, a mimic of hypoxia, induces formation of polyploid giant cells with stem characteristics in colon cancer","volume":"9","author":"Lopez-S\u00e1nchez","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.canlet.2026.218428_bib32","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1091\/mbc.e10-07-0567","article-title":"Regulation of mitochondrial morphology by APC\/CCdh1-mediated control of Drp1 stability","volume":"22","author":"Horn","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.canlet.2026.218428_bib33","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1747-1028-7-25","article-title":"Mitofusin 1 is degraded at G2\/M phase through ubiquitylation by MARCH5","volume":"7","author":"Park","year":"2012","journal-title":"Cell Div."},{"key":"10.1016\/j.canlet.2026.218428_bib34","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.4161\/cc.29061","article-title":"Mitochondrial genome regulates mitotic fidelity by maintaining centrosomal homeostasis","volume":"13","author":"Donthamsetty","year":"2014","journal-title":"Cell Cycle"},{"key":"10.1016\/j.canlet.2026.218428_bib35","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3389\/fcell.2020.00041","article-title":"Molecular mechanisms of radiation-induced cancer cell death: a primer","volume":"8","author":"Sia","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.canlet.2026.218428_bib36","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.bbrc.2019.11.027","article-title":"Mitochondrial fission promotes radiation-induced increase in intracellular Ca(2+) level leading to mitotic catastrophe in mouse breast cancer EMT6 cells","volume":"522","author":"Bo","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.canlet.2026.218428_bib37","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1038\/s41418-020-0527-y","article-title":"Drp1 modulates mitochondrial stress responses to mitotic arrest","volume":"27","author":"Pe\u00f1a-Blanco","year":"2020","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.canlet.2026.218428_bib38","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1242\/jcs.185165","article-title":"Cooperative and independent roles of the Drp1 adaptors Mff, MiD49 and MiD51 in mitochondrial fission","volume":"129","author":"Osellame","year":"2016","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.canlet.2026.218428_bib39","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/j.bbamcr.2010.12.018","article-title":"Phosphorylation of dynamin II at serine-764 is associated with cytokinesis","volume":"1813","author":"Chircop","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.canlet.2026.218428_bib40","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1042\/BST20150274","article-title":"Dynamics of the mitochondrial network during mitosis","volume":"44","author":"Kanfer","year":"2016","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.canlet.2026.218428_bib41","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.226084","article-title":"Motor proteins at the mitochondria-cytoskeleton interface","volume":"134","author":"Kruppa","year":"2021","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.canlet.2026.218428_bib42","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13008-016-0015-4","article-title":"Mitochondria-cytoskeleton associations in mammalian cytokinesis","volume":"11","author":"Lawrence","year":"2016","journal-title":"Cell Div."},{"key":"10.1016\/j.canlet.2026.218428_bib43","doi-asserted-by":"crossref","first-page":"321","DOI":"10.15252\/embj.201696380","article-title":"Miro proteins coordinate microtubule- and actin-dependent mitochondrial transport and distribution","volume":"37","author":"L\u00f3pez-Dom\u00e9nech","year":"2018","journal-title":"EMBO J."},{"key":"10.1016\/j.canlet.2026.218428_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1008050","article-title":"Miro-dependent mitochondrial pool of CENP-F and its farnesylated C-terminal domain are dispensable for normal development in mice","volume":"15","author":"Peterka","year":"2019","journal-title":"PLoS Genet."},{"key":"10.1016\/j.canlet.2026.218428_bib45","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.255844","article-title":"Coordination of mitochondrial and cellular dynamics by the actin-based motor Myo19","volume":"134","author":"Majstrowicz","year":"2021","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.canlet.2026.218428_bib46","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.bbadis.2011.12.007","article-title":"The C-terminus of PARK2 is required for its self-interaction, solubility and role in the spindle assembly checkpoint","volume":"1822","author":"Chen","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.canlet.2026.218428_bib47","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.celrep.2019.08.085","article-title":"PINK1\/Parkin influences cell cycle by sequestering TBK1 at damaged Mitochondria, inhibiting mitosis","volume":"29","author":"Sarraf","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.canlet.2026.218428_bib48","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/s41556-019-0296-3","article-title":"AMPK-mediated activation of MCU stimulates mitochondrial Ca(2+) entry to promote mitotic progression","volume":"21","author":"Zhao","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.canlet.2026.218428_bib49","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s41388-022-02588-0","article-title":"Spatiotemporal view of malignant histogenesis and macroevolution via formation of polyploid giant cancer cells","volume":"42","author":"Li","year":"2023","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2026.218428_bib50","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.tcb.2005.03.004","article-title":"Aurora kinases, aneuploidy and cancer, a coincidence or a real link?","volume":"15","author":"Giet","year":"2005","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.canlet.2026.218428_bib51","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/biolre\/ioab102","article-title":"Polyploid giant cancer cells and ovarian cancer: new insights into mitotic regulators and polyploidy","volume":"105","author":"Richards","year":"2021","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.canlet.2026.218428_bib52","doi-asserted-by":"crossref","first-page":"6083","DOI":"10.1038\/s41388-019-0859-6","article-title":"Fusion-mediated chromosomal instability promotes aneuploidy patterns that resemble human tumors","volume":"38","author":"Delespaul","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2026.218428_bib53","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1615\/CritRevOncog.v18.i1-2.60","article-title":"Cell fusion is a potent inducer of aneuploidy and drug resistance in tumor cell\/normal cell hybrids","volume":"18","author":"Berndt","year":"2013","journal-title":"Crit. Rev. Oncog."},{"key":"10.1016\/j.canlet.2026.218428_bib54","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1186\/s12885-022-09648-4","article-title":"Linking unfolded protein response to ovarian cancer cell fusion","volume":"22","author":"Yart","year":"2022","journal-title":"BMC Cancer"},{"key":"10.1016\/j.canlet.2026.218428_bib55","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/s41598-022-27090-1","article-title":"Zoledronic acid targets chemo-resistant polyploid giant cancer cells","volume":"13","author":"Adibi","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.canlet.2026.218428_bib56","article-title":"Mitochondrial nucleoid trafficking regulated by the inner-membrane AAA-ATPase ATAD3A modulates respiratory complex formation","volume":"119","author":"Ishihara","year":"2022","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.canlet.2026.218428_bib57","first-page":"11863","volume":"110","author":"Ban-Ishihara","year":"2013"},{"key":"10.1016\/j.canlet.2026.218428_bib58","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.freeradbiomed.2023.11.008","article-title":"Mitochondrial hyperfusion induces metabolic remodeling in lung endothelial cells by modifying the activities of electron transport chain complexes I and III","volume":"210","author":"Yegambaram","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.canlet.2026.218428_bib59","doi-asserted-by":"crossref","first-page":"296","DOI":"10.18632\/aging.100654","article-title":"Mitochondria hyperfusion and elevated autophagic activity are key mechanisms for cellular bioenergetic preservation in centenarians","volume":"6","author":"Sgarbi","year":"2014","journal-title":"Aging"},{"key":"10.1016\/j.canlet.2026.218428_bib60","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.placenta.2020.07.008","article-title":"Stomatin-like protein 2 (SLP2) regulates the proliferation and invasion of trophoblast cells by modulating mitochondrial functions","volume":"100","author":"Zhang","year":"2020","journal-title":"Placenta"},{"key":"10.1016\/j.canlet.2026.218428_bib61","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1567","article-title":"Dormant cancer cells and polyploid giant cancer cells: the roots of cancer recurrence and metastasis","volume":"14","author":"Jiao","year":"2024","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.canlet.2026.218428_bib62","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41392-023-01547-9","article-title":"Mitochondrial dynamics in health and disease: mechanisms and potential targets","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.canlet.2026.218428_bib63","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.cophys.2018.02.006","article-title":"Mitochondrial dynamics and metabolic homeostasis","volume":"3","author":"Sebasti\u00e1n","year":"2018","journal-title":"Curr. Opin. Physiol."},{"key":"10.1016\/j.canlet.2026.218428_bib64","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/s41586-021-03510-6","article-title":"Distinct fission signatures predict mitochondrial degradation or biogenesis","volume":"593","author":"Kleele","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2026.218428_bib65","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0092-8674(00)80611-X","article-title":"Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1","volume":"98","author":"Wu","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2026.218428_bib66","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrm.2017.95","article-title":"AMPK: guardian of metabolism and mitochondrial homeostasis","volume":"19","author":"Herzig","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.canlet.2026.218428_bib67","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.cellsig.2015.02.008","article-title":"Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: identification of mitochondrial fission factor as a new AMPK substrate","volume":"27","author":"Ducommun","year":"2015","journal-title":"Cell. Signal."},{"key":"10.1016\/j.canlet.2026.218428_bib68","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.celrep.2015.03.057","article-title":"Compartmentalized AMPK signaling illuminated by genetically encoded molecular sensors and actuators","volume":"11","author":"Miyamoto","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.canlet.2026.218428_bib69","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/s41422-019-0163-6","article-title":"Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress","volume":"29","author":"Zong","year":"2019","journal-title":"Cell Res."},{"key":"10.1016\/j.canlet.2026.218428_bib70","doi-asserted-by":"crossref","first-page":"3677","DOI":"10.1016\/j.molcel.2021.08.015","article-title":"AMPK: restoring metabolic homeostasis over space and time","volume":"81","author":"Trefts","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.canlet.2026.218428_bib71","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/4830418","article-title":"The Nrf2\/PGC1\u03b1 pathway regulates antioxidant and proteasomal activity to alter cisplatin sensitivity in ovarian cancer","volume":"2020","author":"Deng","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.canlet.2026.218428_bib72","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1186\/s13046-024-03194-6","article-title":"Targeting DNM1L\/DRP1-FIS1 axis inhibits high-grade glioma progression by impeding mitochondrial respiratory cristae remodeling","volume":"43","author":"Li","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2026.218428_bib73","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.105","article-title":"ROS homeostasis and metabolism: a dangerous liaison in cancer cells","volume":"7","author":"Panieri","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.canlet.2026.218428_bib74","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.canlet.2020.10.036","article-title":"Mitochondrial rewiring through mitophagy and mitochondrial biogenesis in cancer stem cells: a potential target for anti-CSC cancer therapy","volume":"498","author":"Praharaj","year":"2021","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2026.218428_bib75","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.canlet.2017.05.034","article-title":"Mitochondrial fission forms a positive feedback loop with cytosolic calcium signaling pathway to promote autophagy in hepatocellular carcinoma cells","volume":"403","author":"Huang","year":"2017","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2026.218428_bib76","doi-asserted-by":"crossref","first-page":"360","DOI":"10.2174\/1568009618666180703154233","article-title":"Polyploid giant cancer cells (PGCCs): the evil roots of cancer","volume":"19","author":"Chen","year":"2019","journal-title":"Curr. Cancer Drug Targets"},{"key":"10.1016\/j.canlet.2026.218428_bib77","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1158\/2159-8290.CD-14-0250","article-title":"Serine catabolism regulates mitochondrial redox control during hypoxia","volume":"4","author":"Ye","year":"2014","journal-title":"Cancer Discov."},{"key":"10.1016\/j.canlet.2026.218428_bib78","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.tcb.2017.10.006","article-title":"Cell-Autonomous metabolic reprogramming in hypoxia","volume":"28","author":"Schito","year":"2018","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.canlet.2026.218428_bib79","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/s41419-021-03505-1","article-title":"The crosstalk between HIFs and mitochondrial dysfunctions in cancer development","volume":"12","author":"Bao","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.canlet.2026.218428_bib80","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/ncb1691","article-title":"Direct regulation of TWIST by HIF-1alpha promotes metastasis","volume":"10","author":"Yang","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.canlet.2026.218428_bib81","article-title":"Number of polyploid giant cancer cells and expression of EZH2 are associated with VM formation and tumor grade in human ovarian tumor","volume":"2014","author":"Zhang","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.canlet.2026.218428_bib82","doi-asserted-by":"crossref","DOI":"10.3390\/biom13010050","article-title":"Hypoxia-inducible factor 1 and mitochondria: an intimate connection","volume":"13","author":"Huang","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.canlet.2026.218428_bib83","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.tcb.2018.11.004","article-title":"The cellular mitochondrial genome landscape in disease","volume":"29","author":"Hahn","year":"2019","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.canlet.2026.218428_bib84","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.bbabio.2004.03.013","article-title":"Bioenergetics of mitochondrial diseases associated with mtDNA mutations","volume":"1658","author":"Lenaz","year":"2004","journal-title":"Biochim. Biophys. Acta Bioenerg."},{"key":"10.1016\/j.canlet.2026.218428_bib85","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/s41556-017-0017-8","article-title":"Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos","volume":"20","author":"Floros","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.canlet.2026.218428_bib86","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.mito.2021.01.002","article-title":"Intricate role of mitochondrial calcium signalling in mitochondrial quality control for regulation of cancer cell fate","volume":"57","author":"Patra","year":"2021","journal-title":"Mitochondrion"},{"key":"10.1016\/j.canlet.2026.218428_bib87","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41392-020-0155-5","article-title":"MCU-induced mitochondrial calcium uptake promotes mitochondrial biogenesis and colorectal cancer growth","volume":"5","author":"Liu","year":"2020","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.canlet.2026.218428_bib88","doi-asserted-by":"crossref","first-page":"6407","DOI":"10.1038\/onc.2008.308","article-title":"Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis","volume":"27","author":"Pinton","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2026.218428_bib89","article-title":"Drp1 and the cytoskeleton: mechanistic nexus in mitochondrial division","volume":"29","author":"Mears","year":"2022","journal-title":"Curr. Opin. Physiol."},{"key":"10.1016\/j.canlet.2026.218428_bib90","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1038\/s12276-024-01211-4","article-title":"Socialized mitochondria: mitonuclear crosstalk in stress","volume":"56","author":"Kim","year":"2024","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.canlet.2026.218428_bib91","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.3389\/fimmu.2018.01605","article-title":"Diverse roles of Mitochondria in immune responses: novel insights into immuno-metabolism","volume":"9","author":"Angajala","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.canlet.2026.218428_bib92","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41586-024-08439-0","article-title":"Immune evasion through mitochondrial transfer in the tumour microenvironment","volume":"638","author":"Ikeda","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2026.218428_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.118289","article-title":"Discovery of a fluorinated squaramide as a potential CXCR2- autophagy signalling modulator in chemo-resistant oral squamous cell carcinoma and polyploid giant cancer cells","volume":"302","author":"Jadhav","year":"2026","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.canlet.2026.218428_bib94","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.tcb.2023.03.009","article-title":"Mitochondria in cancer stem cells: achilles heel or hard armor","volume":"33","author":"Zheng","year":"2023","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.canlet.2026.218428_bib95","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1186\/s12967-024-05234-3","article-title":"The microtubule targeting agent ST-401 triggers cell death in interphase and prevents the formation of polyploid giant cancer cells","volume":"22","author":"Vicente","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.canlet.2026.218428_bib96","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1073\/pnas.1318440111","article-title":"Resveratrol and aspirin eliminate tetraploid cells for anticancer chemoprevention","volume":"111","author":"Lissa","year":"2014","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.canlet.2026.218428_bib97","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/s41598-022-27090-1","article-title":"Zoledronic acid targets chemo-resistant polyploid giant cancer cells","volume":"13","author":"Adibi","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.canlet.2026.218428_bib98","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/s41419-023-06232-x","article-title":"SIRT1 inhibits mitochondrial hyperfusion associated mito-bulb formation to sensitize oral cancer cells for apoptosis in a mtROS-dependent signalling pathway","volume":"14","author":"Patra","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.canlet.2026.218428_bib99","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1038\/s42003-023-05674-5","article-title":"Single-cell morphological and transcriptome analysis unveil inhibitors of polyploid giant breast cancer cells in vitro","volume":"6","author":"Zhou","year":"2023","journal-title":"Commun. Biol."},{"key":"10.1016\/j.canlet.2026.218428_bib100","doi-asserted-by":"crossref","first-page":"8971","DOI":"10.1038\/s41598-022-12705-4","article-title":"Polyploid giant cancer cells are dependent on cholesterol for progeny formation through amitotic division","volume":"12","author":"White-Gilbertson","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.canlet.2026.218428_bib101","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.118289","article-title":"Discovery of a fluorinated squaramide as a potential CXCR2- autophagy signalling modulator in chemo-resistant oral squamous cell carcinoma and polyploid giant cancer cells","volume":"302","author":"Jadhav","year":"2026","journal-title":"Eur. J. Med. Chem."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383526001916?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383526001916?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T11:41:48Z","timestamp":1776858108000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383526001916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":101,"alternative-id":["S0304383526001916"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218428","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The mitochondrial enigma: Deciphering mechanisms and identifying drug targets in polyploid giant cancer cells","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218428","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"218428"}}