{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:32:22Z","timestamp":1790353942057,"version":"4.1.0"},"reference-count":199,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271513"],"award-info":[{"award-number":["82271513"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2019YFA0508603"],"award-info":[{"award-number":["2019YFA0508603"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009076","name":"University of Science and Technology of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["L222080"],"award-info":[{"award-number":["L222080"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["Z240011"],"award-info":[{"award-number":["Z240011"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["7192103"],"award-info":[{"award-number":["7192103"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["F251031"],"award-info":[{"award-number":["F251031"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2026ZD0552701"],"award-info":[{"award-number":["2026ZD0552701"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.canlet.2026.218460","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T16:52:14Z","timestamp":1774630334000},"page":"218460","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Cancer neuroscience: Dissecting autonomic and sensory neural regulation of tumor progression and therapeutic resistance"],"prefix":"10.1016","volume":"648","author":[{"given":"Jiaxin","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinmiao","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2026.218460_bib1","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.trecan.2020.07.005","article-title":"Tumor innervation: cancer has some nerve","volume":"6","author":"Reavis","year":"2020","journal-title":"Trends Cancer"},{"key":"10.1016\/j.canlet.2026.218460_bib2","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/s41568-023-00556-8","article-title":"The neural addiction of cancer","volume":"23","author":"Magnon","year":"2023","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.canlet.2026.218460_bib3","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1002\/cncr.20198","article-title":"Greco-Roman thought about cancer","volume":"100","author":"Hajdu","year":"2004","journal-title":"Cancer"},{"key":"10.1016\/j.canlet.2026.218460_bib4","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1002\/ijc.29134","article-title":"A brief history of cancer: age-old milestones underlying our current knowledge database","volume":"136","author":"Faguet","year":"2015","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.canlet.2026.218460_bib5","first-page":"98","article-title":"The distribution of secondary growths in cancer of the breast. 1889","volume":"8","author":"Paget","year":"1989","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.canlet.2026.218460_bib6","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/nrc3131","article-title":"Perineural invasion and associated pain in pancreatic cancer","volume":"11","author":"Bapat","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.canlet.2026.218460_bib7","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1158\/0008-5472.CAN-14-3180","article-title":"Nerve-cancer cell cross-talk: a novel promoter of tumor progression","volume":"75","author":"Jobling","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2026.218460_bib8","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s12943-025-02336-4","article-title":"Cancer-nervous system crosstalk: from biological mechanism to therapeutic opportunities","volume":"24","author":"Huang","year":"2025","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.canlet.2026.218460_bib9","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ccell.2017.11.007","article-title":"\u03b22 adrenergic-neurotrophin feedforward loop promotes pancreatic cancer","volume":"33","author":"Renz","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2026.218460_bib10","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/s41422-025-01098-4","article-title":"Nociceptor neurons promote PDAC progression and cancer pain by interaction with cancer-associated fibroblasts and suppression of natural killer cells","volume":"35","author":"Wang","year":"2025","journal-title":"Cell Res."},{"key":"10.1016\/j.canlet.2026.218460_bib11","doi-asserted-by":"crossref","DOI":"10.1126\/science.1236361","article-title":"Autonomic nerve development contributes to prostate cancer progression","volume":"341","author":"Magnon","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.canlet.2026.218460_bib12","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1126\/science.aah5072","article-title":"Adrenergic nerves activate an angio-metabolic switch in prostate cancer","volume":"358","author":"Zahalka","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.canlet.2026.218460_bib13","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/s41586-024-07767-5","article-title":"Neuronal substance P drives metastasis through an extracellular RNA-TLR7 axis","volume":"633","author":"Padmanaban","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2026.218460_bib14","first-page":"254","article-title":"Sensory nerve release of CGRP increases tumor growth in HNSCC by suppressing TILs","volume":"5","author":"Darragh","year":"2024","journal-title":"Nineteenth-Century Contexts-An Interdisciplinary Journal"},{"key":"10.1016\/j.canlet.2026.218460_bib15","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/s41586-020-1996-3","article-title":"Loss of p53 drives neuron reprogramming in head and neck cancer","volume":"578","author":"Amit","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2026.218460_bib16","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3009569","article-title":"Denervation suppresses gastric tumorigenesis","volume":"6","author":"Zhao","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.canlet.2026.218460_bib17","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/s41586-025-08591-1","article-title":"Nociceptive neurons promote gastric tumour progression via a CGRP-RAMP1 axis","volume":"640","author":"Zhi","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2026.218460_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12102335","article-title":"Remarks on selected morphological aspects of cancer neuroscience: a microscopic photo review","volume":"12","author":"I\u017cycka-\u015awieszewska","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.canlet.2026.218460_bib19","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1096\/fba.2021-00046","article-title":"Nerve density in cancer: less is better","volume":"3","author":"Schmitd","year":"2021","journal-title":"FASEB Bioadv."},{"key":"10.1016\/j.canlet.2026.218460_bib20","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.cell.2022.02.017","article-title":"Large-scale two-photon calcium imaging in freely moving mice","volume":"185","author":"Zong","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2026.218460_bib21","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s12929-025-01194-y","article-title":"Human liver and pancreas innervation: resolving 3D neurohistological challenges and advancing insights","volume":"32","author":"Lee","year":"2025","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.canlet.2026.218460_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneumeth.2025.110436","article-title":"Three-dimensional imaging and computational quantitation as a novel approach to assess nerve fibers, enteric glial cells, mast cells, and the proximity of mast cells to the nerve fibers in human sigmoid mucosal biopsies from healthy subjects","volume":"418","author":"Yuan","year":"2025","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.canlet.2026.218460_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2018.e00669","article-title":"Automated analysis of images for molecular quantification in immunohistochemistry","volume":"4","author":"Guirado","year":"2018","journal-title":"Heliyon"},{"key":"10.1016\/j.canlet.2026.218460_bib24","article-title":"Intrinsic cholinergic innervation in the human sigmoid colon revealed using CLARITY, three-dimensional (3D) imaging, and a novel anti-human peripheral choline acetyltransferase (hpChAT) antiserum","volume":"33","author":"Yuan","year":"2021","journal-title":"Neuro Gastroenterol. Motil."},{"key":"10.1016\/j.canlet.2026.218460_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.carpath.2023.107603","article-title":"Detailed study of collagen, vasculature, and innervation in the human cardiac conduction system","volume":"69","author":"Depes","year":"2024","journal-title":"Cardiovasc. Pathol."},{"key":"10.1016\/j.canlet.2026.218460_bib26","first-page":"55","article-title":"Cell-spreading assays","volume":"294","author":"Berrier","year":"2005","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.canlet.2026.218460_bib27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40708-018-0081-2","article-title":"DeepNeuron: an open deep learning toolbox for neuron tracing","volume":"5","author":"Zhou","year":"2018","journal-title":"Brain Informatics"},{"key":"10.1016\/j.canlet.2026.218460_bib28","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nmeth.3662","article-title":"NeuroGPS-Tree: automatic reconstruction of large-scale neuronal populations with dense neurites","volume":"13","author":"Quan","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.canlet.2026.218460_bib29","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.1002\/cncr.24396","article-title":"Perineural invasion in cancer: a review of the literature","volume":"115","author":"Liebig","year":"2009","journal-title":"Cancer"},{"key":"10.1016\/j.canlet.2026.218460_bib30","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.ijrobp.2018.12.009","article-title":"Perineural invasion and perineural tumor spread in head and neck cancer","volume":"103","author":"Bakst","year":"2019","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.canlet.2026.218460_bib31","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/cac2.12188","article-title":"Cellular and molecular mechanisms of perineural invasion of pancreatic ductal adenocarcinoma","volume":"41","author":"Li","year":"2021","journal-title":"Cancer Commun."},{"key":"10.1016\/j.canlet.2026.218460_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.710899","article-title":"Investigation of neural microenvironment in prostate cancer in context of neural density, perineural invasion, and neuroendocrine profile of tumors","volume":"11","author":"Sigorski","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.canlet.2026.218460_bib33","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.3390\/cancers15092623","article-title":"CD51 intracellular domain promotes cancer cell neurotropism through interacting with transcription factor NR4A3 in colorectal cancer","volume":"15","author":"Huang","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.canlet.2026.218460_bib34","first-page":"1","article-title":"Perineural invasion of cancer: a complex crosstalk between cells and molecules in the perineural niche","volume":"9","author":"Chen","year":"2019","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.canlet.2026.218460_bib35","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.pan.2016.09.005","article-title":"Nerve growth factor regulates CD133 function to promote tumor cell migration and invasion via activating ERK1\/2 signaling in pancreatic cancer","volume":"16","author":"Xin","year":"2016","journal-title":"Pancreatology"},{"key":"10.1016\/j.canlet.2026.218460_bib36","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/8445093","article-title":"Nerve growth factor (NGF) encourages the neuroinvasive potential of pancreatic cancer cells by activating the warburg effect and promoting tumor derived exosomal miRNA-21 expression","volume":"2022","author":"Peng","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.canlet.2026.218460_bib37","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41585-019-0274-3","article-title":"Tumour innervation and neurosignalling in prostate cancer","volume":"17","author":"March","year":"2020","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.canlet.2026.218460_bib38","first-page":"34","volume":"vol. 24","author":"Lei","year":"2022"},{"key":"10.1016\/j.canlet.2026.218460_bib39","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1159\/000326564","article-title":"BDNF\/TrkB content and interaction with gastrin-releasing peptide receptor blockade in colorectal cancer","volume":"79","author":"Brunetto de Farias","year":"2010","journal-title":"Oncology"},{"key":"10.1016\/j.canlet.2026.218460_bib40","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1530\/ERC-15-0007","article-title":"Brain-derived neurotrophic factor regulates cell motility in human colon cancer","volume":"22","author":"Huang","year":"2015","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.canlet.2026.218460_bib41","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.joms.2005.12.011","article-title":"Nerve growth factor and tyrosine kinase A in human salivary adenoid cystic carcinoma: expression patterns and effects on in vitro invasive behavior","volume":"64","author":"Wang","year":"2006","journal-title":"J. Oral Maxillofac. Surg. : official journal of the American."},{"key":"10.1016\/j.canlet.2026.218460_bib42","doi-asserted-by":"crossref","first-page":"427","DOI":"10.3892\/or.2015.4366","article-title":"Schwann cells promote EMT and the Schwann-like differentiation of salivary adenoid cystic carcinoma cells via the BDNF\/TrkB axis","volume":"35","author":"Shan","year":"2016","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.canlet.2026.218460_bib43","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.4103\/0366-6999.241808","article-title":"Effects of nerve growth factor expression on perineural invasion and worse prognosis in early-stage cervical cancer","volume":"131","author":"Long","year":"2018","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.canlet.2026.218460_bib44","article-title":"NGF signaling interacts with the Hippo\/YAP pathway to regulate cervical cancer progression","volume":"11","author":"Wang","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.canlet.2026.218460_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2024.167484","article-title":"CCL2\/CCR2 axis promotes perineural invasion of salivary adenoid cystic carcinoma via ITG\u03b25-mediated nerve-tumor interaction","volume":"1871","author":"Yang","year":"2025","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.canlet.2026.218460_bib46","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1158\/1541-7786.MCR-14-0303","article-title":"The chemokine (CCL2-CCR2) signaling axis mediates perineural invasion","volume":"13","author":"He","year":"2015","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.canlet.2026.218460_bib47","doi-asserted-by":"crossref","first-page":"6400","DOI":"10.1158\/0008-5472.CAN-17-1612","article-title":"Inflammatory monocytes promote perineural invasion via CCL2-Mediated recruitment and cathepsin B expression","volume":"77","author":"Bakst","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2026.218460_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111944","article-title":"The nanobody targeting PD-L1 and CXCR4 counteracts pancreatic stellate cell-mediated tumour progression by disrupting tumour microenvironment","volume":"132","author":"Li","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.canlet.2026.218460_bib49","doi-asserted-by":"crossref","first-page":"7901","DOI":"10.1111\/jcmm.16713","article-title":"CXCL12\/CXCR4 facilitates perineural invasion via induction of the Twist\/S100A4 axis in salivary adenoid cystic carcinoma","volume":"25","author":"Zhang","year":"2021","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.canlet.2026.218460_bib50","first-page":"1143","article-title":"Induction of apoptosis in human salivary gland tumor cells by anti-NCAM antibody","volume":"14","author":"Fukuda","year":"2005","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.canlet.2026.218460_bib51","doi-asserted-by":"crossref","first-page":"280","DOI":"10.3390\/cells11020280","article-title":"Tumoral neuroligin 1 promotes cancer-nerve interactions and synergizes with the glial cell line-derived neurotrophic factor","volume":"11","author":"Bizzozero","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.canlet.2026.218460_bib52","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1101\/gad.227502","article-title":"Nr-CAM is a target gene of the beta-catenin\/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis","volume":"16","author":"Conacci-Sorrell","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.canlet.2026.218460_bib53","doi-asserted-by":"crossref","first-page":"5686","DOI":"10.7150\/thno.54027","article-title":"Nodal-induced L1CAM\/CXCR4 subpopulation sustains tumor growth and metastasis in colorectal cancer derived organoids","volume":"11","author":"Cave","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.canlet.2026.218460_bib54","first-page":"473","volume":"6","year":"2016","journal-title":"Cancer Discov."},{"key":"10.1016\/j.canlet.2026.218460_bib55","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/jcb.25300","article-title":"Schwann cells increase prostate and pancreatic tumor cell invasion using laminin binding A6 integrin","volume":"117","author":"Sroka","year":"2016","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.canlet.2026.218460_bib56","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3389\/fonc.2020.00019","article-title":"Schwann cell-derived CCL2 promotes the perineural invasion of cervical cancer","volume":"10","author":"Huang","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.canlet.2026.218460_bib57","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.3748\/wjg.v23.i7.1250","article-title":"B2 adrenergic receptors and morphological changes of the enteric nervous system in colorectal adenocarcinoma","volume":"23","author":"Ciurea","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.canlet.2026.218460_bib58","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bbi.2017.02.008","article-title":"Epinephrine promotes COX-2-dependent immune suppression in myeloid cells and cancer tissues","volume":"62","author":"Muthuswamy","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.canlet.2026.218460_bib59","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.2147\/OTT.S190847","article-title":"Sympathetic innervation contributes to perineural invasion of salivary adenoid cystic carcinoma via the \u03b22-adrenergic receptor","volume":"12","author":"Ma","year":"2019","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.canlet.2026.218460_bib60","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20242250","article-title":"Sympathetic axonogenesis promotes adenoid cystic carcinoma progression","volume":"222","author":"Chen","year":"2025","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.canlet.2026.218460_bib61","doi-asserted-by":"crossref","first-page":"4676","DOI":"10.1158\/1078-0432.CCR-14-3163","article-title":"Autocrine activation of CHRM3 promotes prostate cancer growth and castration resistance via CaM\/CaMKK-mediated phosphorylation of Akt","volume":"21","author":"Wang","year":"2015","journal-title":"Clin. Cancer Res. : an official journal of the American Association for."},{"key":"10.1016\/j.canlet.2026.218460_bib62","doi-asserted-by":"crossref","first-page":"596","DOI":"10.3390\/ijms24010596","article-title":"Blocking muscarinic receptor 3 attenuates tumor growth and decreases immunosuppressive and cholinergic markers in an orthotopic mouse model of colorectal cancer","volume":"24","author":"Kuol","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.canlet.2026.218460_bib63","doi-asserted-by":"crossref","first-page":"5803","DOI":"10.1007\/s00432-022-04540-x","article-title":"Neuropeptide Y and its receptors in prostate cancer: associations with cancer invasiveness and perineural spread","volume":"149","author":"Sigorski","year":"2023","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.canlet.2026.218460_bib64","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.565306","article-title":"Cancer-associated fibroblast density, prognostic characteristics, and recurrence in head and neck squamous cell carcinoma: a meta-analysis","volume":"10","author":"Knops","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.canlet.2026.218460_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2022.166540","article-title":"YAP1-TEAD1 mediates the perineural invasion of prostate cancer cells induced by cancer-associated fibroblasts","volume":"1868","author":"Shen","year":"2022","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.canlet.2026.218460_bib66","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1158\/0008-5472.CAN-24-3173","article-title":"Cancer-associated fibroblasts foster a high-lactate microenvironment to drive perineural invasion in pancreatic cancer","volume":"85","author":"Li","year":"2025","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2026.218460_bib67","first-page":"3152","volume":"vol. 25","author":"Su","year":"2023"},{"key":"10.1016\/j.canlet.2026.218460_bib68","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1186\/s13046-023-02894-9","article-title":"Hedgehog-Gli1-derived exosomal circ-0011536 mediates peripheral neural remodeling in pancreatic cancer by modulating the miR-451a\/VGF axis","volume":"42","author":"Dai","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2026.218460_bib69","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1097\/CM9.0000000000003262","article-title":"Cancer cell-derived exosomal miRNA induces and reprograms Schwann cells to augment the perineural invasion of salivary adenoid cystic carcinoma","volume":"137","author":"Li","year":"2024","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.canlet.2026.218460_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2022.153897","article-title":"Distinct expression signatures of miR-130a, miR-301a, miR-454 in formalin fixed paraffin embedded tissue samples of prostate cancer patients","volume":"234","author":"Bozgeyik","year":"2022","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.canlet.2026.218460_bib71","first-page":"1669","article-title":"The \u03b2-adrenoceptor antagonist, propranolol, induces human gastric cancer cell apoptosis and cell cycle arrest via inhibiting nuclear factor \u03baB signaling","volume":"24","author":"Liao","year":"2010","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.canlet.2026.218460_bib72","doi-asserted-by":"crossref","first-page":"95","DOI":"10.18632\/oncoscience.357","article-title":"Beta-adrenergic receptors are expressed across diverse cancers","volume":"4","author":"Rains","year":"2017","journal-title":"Oncoscience"},{"key":"10.1016\/j.canlet.2026.218460_bib73","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1158\/2159-8290.CD-24-0718","article-title":"Sympathetic neurons promote small cell lung cancer through the \u03b22-Adrenergic receptor","volume":"15","author":"Fnu","year":"2025","journal-title":"Cancer Discov."},{"key":"10.1016\/j.canlet.2026.218460_bib74","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21217958","article-title":"Neurobiology of cancer: the role of \u03b2-Adrenergic receptor signaling in various tumor environments","volume":"21","author":"Mravec","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.canlet.2026.218460_bib75","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1002\/eji.201646395","article-title":"Sympathetic neural signaling via the \u03b22-adrenergic receptor suppresses T-cell receptor-mediated human and mouse CD8(+) T-cell effector function","volume":"46","author":"Estrada","year":"2016","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.canlet.2026.218460_bib76","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/s41586-023-06568-6","article-title":"The \u03b2(1)-adrenergic receptor links sympathetic nerves to T cell exhaustion","volume":"622","author":"Globig","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2026.218460_bib77","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00262-018-2243-8","article-title":"\u03b2-Adrenergic signaling blocks murine CD8(+) T-cell metabolic reprogramming during activation: a mechanism for immunosuppression by adrenergic stress","volume":"68","author":"Qiao","year":"2019","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.canlet.2026.218460_bib78","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1002\/eji.201243005","article-title":"Beta2-adrenergic receptor signaling in CD4+ Foxp3+ regulatory T cells enhances their suppressive function in a PKA-dependent manner","volume":"43","author":"Guereschi","year":"2013","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.canlet.2026.218460_bib79","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1158\/0008-5472.CAN-16-2143","article-title":"Enriching the housing environment for mice enhances their NK cell antitumor immunity via sympathetic nerve-dependent regulation of NKG2D and CCR5","volume":"77","author":"Song","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2026.218460_bib80","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1038\/s41467-022-29659-w","article-title":"Sympathetic axonal sprouting induces changes in macrophage populations and protects against pancreatic cancer","volume":"13","author":"Guillot","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2026.218460_bib81","doi-asserted-by":"crossref","first-page":"7042","DOI":"10.1158\/0008-5472.CAN-10-0522","article-title":"The sympathetic nervous system induces a metastatic switch in primary breast cancer","volume":"70","author":"Sloan","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2026.218460_bib82","doi-asserted-by":"crossref","first-page":"295","DOI":"10.5483\/BMBRep.2015.48.5.008","article-title":"Adrenergic receptor \u03b22 activation by stress promotes breast cancer progression through macrophages M2 polarization in tumor microenvironment","volume":"48","author":"Qin","year":"2015","journal-title":"BMB Rep."},{"key":"10.1016\/j.canlet.2026.218460_bib83","doi-asserted-by":"crossref","first-page":"5537","DOI":"10.1172\/JCI129502","article-title":"\u03b22 adrenergic receptor-mediated signaling regulates the immunosuppressive potential of myeloid-derived suppressor cells","volume":"129","author":"Mohammadpour","year":"2019","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.canlet.2026.218460_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109883","article-title":"\u03b22-adrenergic receptor signaling regulates metabolic pathways critical to myeloid-derived suppressor cell function within the TME","volume":"37","author":"Mohammadpour","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.canlet.2026.218460_bib85","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aay9368","article-title":"Sympathetic nervous tone limits the development of myeloid-derived suppressor cells","volume":"5","author":"Nevin","year":"2020","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.canlet.2026.218460_bib86","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.4049\/jimmunol.1201391","article-title":"\u03b22-Adrenoreceptor agonist inhibits antigen cross-presentation by dendritic cells","volume":"190","author":"Herv\u00e9","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.canlet.2026.218460_bib87","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0085086","article-title":"Adrenergic \u03b22 receptor activation stimulates anti-inflammatory properties of dendritic cells in vitro","volume":"9","author":"Nijhuis","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.canlet.2026.218460_bib88","article-title":"\u03b22-adrenoceptor signaling reduction in dendritic cells is involved in the inflammatory response in adjuvant-induced arthritic rats","volume":"6","author":"Wu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.canlet.2026.218460_bib89","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1096\/fba.2021-00097","article-title":"\u03b2-Adrenergic signaling in skin cancer","volume":"4","author":"Batalla-Covello","year":"2022","journal-title":"FASEB Bioadv"},{"key":"10.1016\/j.canlet.2026.218460_bib90","doi-asserted-by":"crossref","first-page":"3824","DOI":"10.1038\/s41598-025-87492-9","article-title":"Sympathetic innervation induced by nerve growth factor promotes malignant transformation in gastric cancer","volume":"15","author":"Itami","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.canlet.2026.218460_bib91","doi-asserted-by":"crossref","first-page":"5725","DOI":"10.1038\/s41467-021-25967-9","article-title":"Environmental eustress modulates \u03b2-ARs\/CCL2 axis to induce anti-tumor immunity and sensitize immunotherapy against liver cancer in mice","volume":"12","author":"Liu","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2026.218460_bib92","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.4049\/jimmunol.2100719","article-title":"The sympathetic nervous system modulates cancer vaccine activity through monocyte-derived cells","volume":"207","author":"Hinkle","year":"2021","journal-title":"J. Immunol."},{"key":"10.1016\/j.canlet.2026.218460_bib93","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adf1147","article-title":"Beta-blockade enhances anthracycline control of metastasis in triple-negative breast cancer","volume":"15","author":"Chang","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.canlet.2026.218460_bib94","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aao4307","article-title":"Stress hormones promote EGFR inhibitor resistance in NSCLC: implications for combinations with \u03b2-blockers","volume":"9","author":"Nilsson","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.canlet.2026.218460_bib95","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/s41586-025-08735-3","article-title":"Characterization of single neurons reprogrammed by pancreatic cancer","volume":"640","author":"Thiel","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2026.218460_bib96","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41389-018-0099-6","article-title":"Muscarinic acetylcholine receptor 3 mediates vagus nerve-induced gastric cancer","volume":"7","author":"Wang","year":"2018","journal-title":"Oncogenesis"},{"key":"10.1016\/j.canlet.2026.218460_bib97","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ccell.2016.11.005","article-title":"Nerve growth factor promotes gastric tumorigenesis through aberrant cholinergic signaling","volume":"31","author":"Hayakawa","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2026.218460_bib98","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174626","article-title":"Parasympathetic, but not sympathetic denervation, suppressed colorectal cancer progression","volume":"913","author":"Sadighparvar","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.canlet.2026.218460_bib99","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1158\/2159-8290.CD-18-0046","article-title":"Cholinergic signaling via muscarinic receptors directly and indirectly suppresses pancreatic tumorigenesis and cancer stemness","volume":"8","author":"Renz","year":"2018","journal-title":"Cancer Discov."},{"key":"10.1016\/j.canlet.2026.218460_bib100","doi-asserted-by":"crossref","first-page":"22501","DOI":"10.18632\/oncotarget.15019","article-title":"Subdiaphragmatic vagotomy promotes tumor growth and reduces survival via TNF\u03b1 in a murine pancreatic cancer model","volume":"8","author":"Partecke","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.canlet.2026.218460_bib101","doi-asserted-by":"crossref","first-page":"E378","DOI":"10.1152\/ajpendo.2001.280.2.E378","article-title":"Parasympathetic inhibition of sympathetic neural activity to the pancreas","volume":"280","author":"Benthem","year":"2001","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.canlet.2026.218460_bib102","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1046\/j.1460-9568.2003.02503.x","article-title":"Vagal modulation of nociception is mediated by adrenomedullary epinephrine in the rat","volume":"17","author":"Khasar","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.canlet.2026.218460_bib103","first-page":"20","volume":"vol. 190","author":"Mravec","year":"2015"},{"key":"10.1016\/j.canlet.2026.218460_bib104","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1158\/0008-5472.CAN-19-2689","article-title":"Perineural invasion reprograms the immune microenvironment through cholinergic signaling in pancreatic ductal adenocarcinoma","volume":"80","author":"Yang","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2026.218460_bib105","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1365-2249.2006.03169.x","article-title":"Nicotine inhibits the production of proinflammatory mediators in human monocytes by suppression of I-kappaB phosphorylation and nuclear factor-kappaB transcriptional activity through nicotinic acetylcholine receptor alpha7","volume":"146","author":"Yoshikawa","year":"2006","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.canlet.2026.218460_bib106","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1159\/000362240","article-title":"Vagotomy induces deregulation of the inflammatory response during the development of amoebic liver abscess in hamsters","volume":"22","author":"S\u00e1nchez-Alem\u00e1n","year":"2015","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.canlet.2026.218460_bib107","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10517","article-title":"Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer","volume":"7","author":"Dubeykovskaya","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2026.218460_bib108","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119259","article-title":"Electroacupuncture regulates inflammatory cytokines by activating the vagus nerve to enhance antitumor immunity in mice with breast tumors","volume":"272","author":"Zhang","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.canlet.2026.218460_bib109","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s41577-019-0147-2","article-title":"Pain and immunity: implications for host defence","volume":"19","author":"Baral","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.canlet.2026.218460_bib110","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s12967-025-06104-2","article-title":"Increased nerve density adversely affects outcome in colorectal cancer and denervation suppresses tumor growth","volume":"23","author":"Wang","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.canlet.2026.218460_bib111","doi-asserted-by":"crossref","first-page":"13550","DOI":"10.1073\/pnas.0800767105","article-title":"Neuronal system-dependent facilitation of tumor angiogenesis and tumor growth by calcitonin gene-related peptide","volume":"105","author":"Toda","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.canlet.2026.218460_bib112","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2024.1497735","article-title":"Sensory innervation in the prostate and a role for calcitonin gene-related peptide in prostatic epithelial proliferation","volume":"17","author":"Xia","year":"2024","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.canlet.2026.218460_bib113","doi-asserted-by":"crossref","first-page":"9574","DOI":"10.1111\/jcmm.15381","article-title":"Ablation of sensory nerves favours melanoma progression","volume":"24","author":"Prazeres","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.canlet.2026.218460_bib114","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.bbi.2015.02.024","article-title":"Activation of neuroimmune pathways increases therapeutic effects of radiotherapy on poorly differentiated breast carcinoma","volume":"48","author":"Erin","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.canlet.2026.218460_bib115","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2025.101212","article-title":"Sciatic nerve stimulation enhances NK cell cytotoxicity through dopamine signaling and synergizes immunotherapy in triple-negative breast cancer","volume":"79","author":"Li","year":"2025","journal-title":"Drug Resist. Updates : reviews and commentaries in antimicrobial and"},{"key":"10.1016\/j.canlet.2026.218460_bib116","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1016\/j.cmet.2022.10.012","article-title":"Cancer cells co-opt nociceptive nerves to thrive in nutrient-poor environments and upon nutrient-starvation therapies","volume":"34","author":"Zhang","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.canlet.2026.218460_bib117","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202302041","article-title":"Crosstalk between bone metastatic cancer cells and sensory nerves in bone metastatic progression","volume":"7","author":"Park","year":"2024","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.canlet.2026.218460_bib118","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/s41523-022-00485-z","article-title":"Sensory nerves enhance triple-negative breast cancer invasion and metastasis via the axon guidance molecule PlexinB3","volume":"8","author":"Le","year":"2022","journal-title":"npj Breast Cancer"},{"key":"10.1016\/j.canlet.2026.218460_bib119","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1053\/j.gastro.2019.05.065","article-title":"Axon guidance molecules promote perineural invasion and metastasis of orthotopic pancreatic tumors in mice","volume":"157","author":"Jurcak","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.canlet.2026.218460_bib120","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120305","article-title":"Olvanil activates sensory nerve fibers, increases T cell response and decreases metastasis of breast carcinoma","volume":"291","author":"Erin","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.canlet.2026.218460_bib121","first-page":"1003","article-title":"Capsaicin-mediated denervation of sensory neurons promotes mammary tumor metastasis to lung and heart","volume":"24","author":"Erin","year":"2004","journal-title":"Anticancer Res."},{"key":"10.1016\/j.canlet.2026.218460_bib122","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.3389\/fimmu.2017.01463","article-title":"Sense and immunity: context-dependent neuro-immune interplay","volume":"8","author":"Foster","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.canlet.2026.218460_bib123","doi-asserted-by":"crossref","DOI":"10.1002\/adbi.202200019","article-title":"Sensory neurotransmitter calcitonin gene-related peptide modulates tumor growth and lymphocyte infiltration in oral squamous cell carcinoma","volume":"6","author":"McIlvried","year":"2022","journal-title":"Advanced Biology"},{"key":"10.1016\/j.canlet.2026.218460_bib124","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/s41586-022-05374-w","article-title":"Nociceptor neurons affect cancer immunosurveillance","volume":"611","author":"Balood","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2026.218460_bib125","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1158\/2326-6066.CIR-22-0110","article-title":"Sensory nerves impede the formation of tertiary lymphoid structures and development of protective Antimelanoma immune responses","volume":"10","author":"Vats","year":"2022","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.canlet.2026.218460_bib126","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0156095","article-title":"Impact of the sensory neurons on melanoma growth in vivo","volume":"11","author":"Keskinov","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.canlet.2026.218460_bib127","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1016\/j.cell.2024.04.027","article-title":"Innervation of nociceptor neurons in the spleen promotes germinal center responses and humoral immunity","volume":"187","author":"Wu","year":"2024","journal-title":"Cell."},{"key":"10.1016\/j.canlet.2026.218460_bib128","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/s41586-025-09370-8","article-title":"Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy","volume":"646","author":"Baruch Erez","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2026.218460_bib129","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/s12943-024-02067-y","article-title":"Targeting DKK1 enhances the antitumor activity of paclitaxel and alleviates chemotherapy-induced peripheral neuropathy in breast cancer","volume":"23","author":"Shi","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.canlet.2026.218460_bib130","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s41586-023-06537-z","article-title":"The power and potential of mitochondria transfer","volume":"623","author":"Borcherding","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2026.218460_bib131","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/s41586-025-09176-8","article-title":"Nerve-to-cancer transfer of mitochondria during cancer metastasis","volume":"644","author":"Hoover","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2026.218460_bib132","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/s43018-023-00556-5","article-title":"GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity","volume":"4","author":"Watson","year":"2023","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.canlet.2026.218460_bib133","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-030-65768-0_1","article-title":"Glucose metabolism in cancer: the warburg effect and beyond","volume":"1311","author":"Bose","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.canlet.2026.218460_bib134","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.cell.2020.10.016","article-title":"Neurons release serine to support mRNA translation in pancreatic cancer","volume":"183","author":"Banh","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2026.218460_bib135","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/BF00536990","article-title":"Chemical sympathectomy by selective destruction of adrenergic nerve endings with 6-Hydroxydopamine","volume":"261","author":"Thoenen","year":"1968","journal-title":"Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie"},{"key":"10.1016\/j.canlet.2026.218460_bib136","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/s41556-025-01667-0","article-title":"Psychological stress-induced ALKBH5 deficiency promotes tumour innervation and pancreatic cancer via extracellular vesicle transfer of RNA","volume":"27","author":"Chen","year":"2025","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.canlet.2026.218460_bib137","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/pros.23454","article-title":"Influence of the neural microenvironment on prostate cancer","volume":"78","author":"Coarfa","year":"2018","journal-title":"Prostate"},{"key":"10.1016\/j.canlet.2026.218460_bib138","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.humpath.2016.02.001","article-title":"Biologic effect of neurogenesis in pancreatic cancer","volume":"52","author":"He","year":"2016","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.canlet.2026.218460_bib139","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1158\/1078-0432.CCR-05-1222","article-title":"Botulinum toxin potentiates cancer radiotherapy and chemotherapy","volume":"12","author":"Ansiaux","year":"2006","journal-title":"Clin. Cancer Res. : an official journal of the American Association for."},{"key":"10.1016\/j.canlet.2026.218460_bib140","doi-asserted-by":"crossref","first-page":"3078","DOI":"10.1073\/pnas.1512603113","article-title":"Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer","volume":"113","author":"Saloman","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.canlet.2026.218460_bib141","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1158\/0008-5472.CAN-16-0899","article-title":"PanIN neuroendocrine cells promote tumorigenesis via neuronal cross-talk","volume":"77","author":"Sinha","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2026.218460_bib142","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/s40478-021-01273-9","article-title":"Chemogenetic modulation of sensory neurons reveals their regulating role in melanoma progression","volume":"9","author":"Costa","year":"2021","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.canlet.2026.218460_bib143","doi-asserted-by":"crossref","first-page":"5639","DOI":"10.1158\/0008-5472.CAN-17-0546","article-title":"\u03b2-Adrenergic signaling in mice housed at standard temperatures suppresses an effector phenotype in CD8(+) T cells and undermines checkpoint inhibitor therapy","volume":"77","author":"Bucsek","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2026.218460_bib144","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/s41419-019-2030-2","article-title":"Chronic stress promotes gastric cancer progression and metastasis: an essential role for ADRB2","volume":"10","author":"Zhang","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.canlet.2026.218460_bib145","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1158\/2159-8290.CD-24-0287","article-title":"Neuro-mesenchymal interaction mediated by a \u03b22-Adrenergic nerve growth factor feedforward loop promotes colorectal cancer progression","volume":"15","author":"Kobayashi","year":"2025","journal-title":"Cancer Discov."},{"key":"10.1016\/j.canlet.2026.218460_bib146","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1158\/1078-0432.CCR-19-2641","article-title":"Preoperative \u03b2-Blockade with propranolol reduces biomarkers of metastasis in breast cancer: a phase II randomized trial","volume":"26","author":"Hiller","year":"2020","journal-title":"Clin. Cancer Res. : an official journal of the American Association for."},{"key":"10.1016\/j.canlet.2026.218460_bib147","first-page":"1836","article-title":"Beta blockers and improved progression-free survival in patients with advanced HER2 negative breast cancer: a retrospective analysis of the ROSE\/TRIO-012 study, annals of oncology","volume":"28","author":"Spera","year":"2017","journal-title":"official journal of the European Society for Medical"},{"key":"10.1016\/j.canlet.2026.218460_bib148","doi-asserted-by":"crossref","first-page":"4651","DOI":"10.1158\/1078-0432.CCR-17-0152","article-title":"Perioperative COX-2 and \u03b2-Adrenergic blockade improves metastatic biomarkers in breast cancer patients in a Phase-II randomized trial","volume":"23","author":"Shaashua","year":"2017","journal-title":"Clin. Cancer Res. : an official journal of the American Association for."},{"key":"10.1016\/j.canlet.2026.218460_bib149","article-title":"Acetylcholine acts through M3 muscarinic receptor to activate the EGFR signaling and promotes gastric cancer cell proliferation","volume":"7","author":"Yu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.canlet.2026.218460_bib150","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41392-024-01761-z","article-title":"Alpha5 nicotine acetylcholine receptor subunit promotes intrahepatic cholangiocarcinoma metastasis","volume":"9","author":"Fu","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.canlet.2026.218460_bib151","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s00018-023-04742-7","article-title":"Acetylcholine promotes chronic stress-induced lung adenocarcinoma progression via \u03b15-nAChR\/FHIT pathway","volume":"80","author":"Jiao","year":"2023","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.canlet.2026.218460_bib152","doi-asserted-by":"crossref","first-page":"4640","DOI":"10.1016\/j.cell.2025.05.031","article-title":"Cholinergic neuronal activity promotes diffuse midline glioma growth through muscarinic signaling","volume":"188","author":"Drexler","year":"2025","journal-title":"Cell."},{"key":"10.1016\/j.canlet.2026.218460_bib153","doi-asserted-by":"crossref","first-page":"5555","DOI":"10.1038\/s41467-024-49824-7","article-title":"The neurotransmitter calcitonin gene-related peptide shapes an immunosuppressive microenvironment in medullary thyroid cancer","volume":"15","author":"Hou","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.canlet.2026.218460_bib154","first-page":"131","article-title":"Aprepitant inhibits the progression of esophageal squamous cancer by blocking the truncated neurokinin-1 receptor, oncol","volume":"50","author":"Zheng","year":"2023","journal-title":"Rep."},{"key":"10.1016\/j.canlet.2026.218460_bib155","doi-asserted-by":"crossref","first-page":"3868","DOI":"10.1158\/0008-5472.CAN-23-1012","article-title":"Neurotransmitter receptor HTR2B regulates lipid metabolism to inhibit ferroptosis in gastric cancer","volume":"83","author":"Tu","year":"2023","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2026.218460_bib156","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1158\/1541-7786.MCR-23-0513","article-title":"Serotonin receptor HTR2B facilitates colorectal cancer metastasis via CREB1-ZEB1 axis-mediated epithelial-mesenchymal transition","volume":"22","author":"Li","year":"2024","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.canlet.2026.218460_bib157","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.molonc.2015.09.008","article-title":"5-Hydroxytryptamine promotes hepatocellular carcinoma proliferation by influencing \u03b2-catenin","volume":"10","author":"Fatima","year":"2016","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.canlet.2026.218460_bib158","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s13046-024-03060-5","article-title":"Blockade of histamine receptor H1 augments immune checkpoint therapy by enhancing MHC-I expression in pancreatic cancer cells","volume":"43","author":"Zhong","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2026.218460_bib159","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/s41590-023-01723-7","article-title":"Breaking NGF-TrkA immunosuppression in melanoma sensitizes immunotherapy for durable memory T cell protection","volume":"25","author":"Yin","year":"2024","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.canlet.2026.218460_bib160","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s13046-021-02198-w","article-title":"Autophagic schwann cells promote perineural invasion mediated by the NGF\/ATG7 paracrine pathway in pancreatic cancer","volume":"41","author":"Zhang","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2026.218460_bib161","doi-asserted-by":"crossref","first-page":"10015","DOI":"10.1021\/acsami.1c21997","article-title":"Nanoemulsion-assisted siRNA delivery to modulate the nervous tumor microenvironment in the treatment of pancreatic cancer","volume":"14","author":"Ding","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.canlet.2026.218460_bib162","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s13046-022-02314-4","article-title":"Direct interaction of TrkA\/CD44v3 is essential for NGF-Promoted aggressiveness of breast cancer cells","volume":"41","author":"Trouvilliez","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2026.218460_bib163","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/1476-4598-9-157","article-title":"Nerve growth factor promotes breast cancer angiogenesis by activating multiple pathways","volume":"9","author":"Romon","year":"2010","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.canlet.2026.218460_bib164","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1172\/JCI96060","article-title":"TRAF4-mediated ubiquitination of NGF receptor TrkA regulates prostate cancer metastasis","volume":"128","author":"Singh","year":"2018","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.canlet.2026.218460_bib165","doi-asserted-by":"crossref","first-page":"9426","DOI":"10.1158\/0008-5472.CAN-05-0826","article-title":"A blocking antibody to nerve growth factor attenuates skeletal pain induced by prostate tumor cells growing in bone","volume":"65","author":"Halvorson","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2026.218460_bib166","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.canlet.2019.12.015","article-title":"Nerve growth factor (NGF)-TrkA axis in head and neck squamous cell carcinoma triggers EMT and confers resistance to the EGFR inhibitor erlotinib","volume":"472","author":"Lin","year":"2020","journal-title":"Cancer Lett."},{"key":"10.1016\/j.canlet.2026.218460_bib167","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1186\/s13046-024-03202-9","article-title":"Mechanisms of neural infiltration-mediated tumor metabolic reprogramming impacting immunotherapy efficacy in non-small cell lung cancer","volume":"43","author":"Zheng","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.canlet.2026.218460_bib168","doi-asserted-by":"crossref","first-page":"7014","DOI":"10.1158\/0008-5472.CAN-14-1220","article-title":"NGF blockade at early times during bone cancer development attenuates bone destruction and increases limb use","volume":"74","author":"McCaffrey","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.canlet.2026.218460_bib169","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2024-009910","article-title":"CAR T cells secreting NGF-neutralizing scFv enhance efficacy in clear cell renal cell carcinoma by relieving immunosuppression through immunosympathectomy","volume":"12","author":"Yang","year":"2024","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.canlet.2026.218460_bib170","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1023\/B:DRUG.0000047103.64335.b0","article-title":"Phase I trial of orally administered CEP-701, a novel neurotrophin receptor-linked tyrosine kinase inhibitor","volume":"23","author":"Marshall","year":"2005","journal-title":"Invest. N. Drugs"},{"key":"10.1016\/j.canlet.2026.218460_bib171","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1007\/s10637-011-9774-6","article-title":"Phase I study of the safety, tolerability and pharmacokinetics of PHA-848125AC, a dual tropomyosin receptor kinase A and cyclin-dependent kinase inhibitor, in patients with advanced solid malignancies","volume":"30","author":"Weiss","year":"2012","journal-title":"Invest. N. Drugs"},{"key":"10.1016\/j.canlet.2026.218460_bib172","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1158\/2159-8290.CD-15-0443","article-title":"An oncogenic NTRK fusion in a patient with soft-tissue sarcoma with response to the tropomyosin-related kinase inhibitor LOXO-101","volume":"5","author":"Doebele","year":"2015","journal-title":"Cancer Discov."},{"key":"10.1016\/j.canlet.2026.218460_bib173","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S1470-2045(18)30119-0","article-title":"Larotrectinib for paediatric solid tumours harbouring NTRK gene fusions: phase 1 results from a multicentre, open-label, phase 1\/2 study","volume":"19","author":"Laetsch","year":"2018","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.canlet.2026.218460_bib174","doi-asserted-by":"crossref","first-page":"4241","DOI":"10.1002\/cncr.31701","article-title":"The use of neoadjuvant larotrectinib in the management of children with locally advanced TRK fusion sarcomas","volume":"124","author":"DuBois","year":"2018","journal-title":"Cancer"},{"key":"10.1016\/j.canlet.2026.218460_bib175","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1158\/2159-8290.CD-16-1237","article-title":"Safety and antitumor activity of the multitargeted Pan-TRK, ROS1, and ALK inhibitor entrectinib: combined results from two phase I trials (ALKA-372-001 and STARTRK-1)","volume":"7","author":"Drilon","year":"2017","journal-title":"Cancer Discov."},{"key":"10.1016\/j.canlet.2026.218460_bib176","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1093\/neuonc\/noac087","article-title":"Entrectinib in children and young adults with solid or primary CNS tumors harboring NTRK, ROS1, or ALK aberrations (STARTRK-NG)","volume":"24","author":"Desai","year":"2022","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.canlet.2026.218460_bib177","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejca.2025.115308","article-title":"Efficacy and safety of entrectinib in children with extracranial solid or central nervous system (CNS) tumours harbouring NTRK or ROS1 fusions","volume":"220","author":"Desai","year":"2025","journal-title":"European journal of cancer (Oxford, England : 1990)"},{"key":"10.1016\/j.canlet.2026.218460_bib178","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1158\/2159-8290.CD-17-0507","article-title":"A next-generation TRK kinase inhibitor overcomes acquired resistance to prior TRK kinase inhibition in patients with TRK fusion-positive solid tumors","volume":"7","author":"Drilon","year":"2017","journal-title":"Cancer Discov."},{"key":"10.1016\/j.canlet.2026.218460_bib179","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1001\/jamadermatol.2018.1610","article-title":"Targeting tropomyosin receptor kinase in cutaneous CYLD defective tumors with pegcantratinib: the TRAC randomized clinical trial","volume":"154","author":"Danilenko","year":"2018","journal-title":"JAMA Dermatol."},{"key":"10.1016\/j.canlet.2026.218460_bib180","first-page":"981","article-title":"The potential long-term comparative effectiveness of larotrectinib and entrectinib for second-line treatment of TRK fusion-positive metastatic lung cancer","volume":"26","author":"Roth","year":"2020","journal-title":"J Manag Care Spec Pharm"},{"key":"10.1016\/j.canlet.2026.218460_bib181","doi-asserted-by":"crossref","first-page":"oyae339","DOI":"10.1093\/oncolo\/oyae339","article-title":"A phase II trial of larotrectinib in tumors with NTRK fusions or extremes of NTRK mRNA overexpression identified by comprehensive genomic profiling","volume":"30","author":"Thavaneswaran","year":"2025","journal-title":"Oncologist"},{"key":"10.1016\/j.canlet.2026.218460_bib182","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.cell.2014.07.017","article-title":"Single-cell phenotyping within transparent intact tissue through whole-body clearing","volume":"158","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2026.218460_bib183","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nbt.4281","article-title":"Protection of tissue physicochemical properties using polyfunctional crosslinkers","volume":"37","author":"Park","year":"2019","journal-title":"Nat. Biotechnol"},{"key":"10.1016\/j.canlet.2026.218460_bib184","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-38891-3","article-title":"Expandable ELAST for super-resolution imaging of thick tissue slices using a hydrogel containing charged monomers","volume":"13","author":"La","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.canlet.2026.218460_bib185","article-title":"MACS: rapid aqueous clearing system for 3D mapping of intact organs","volume":"7","author":"Zhu","year":"2020","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.canlet.2026.218460_bib186","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1038\/nn.3447","article-title":"SeeDB: a simple and morphology-preserving optical clearing agent for neuronal circuit reconstruction","volume":"16","author":"Ke","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.canlet.2026.218460_bib187","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1038\/nn.2928","article-title":"Scale: a chemical approach for fluorescence imaging and reconstruction of transparent mouse brain","volume":"14","author":"Hama","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.canlet.2026.218460_bib188","article-title":"Local sympathetic innervations modulate the lung innate immune responses","volume":"6","author":"Liu","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.canlet.2026.218460_bib189","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.cell.2015.04.012","article-title":"Neuronal activity promotes glioma growth through Neuroligin-3 secretion","volume":"161","author":"Venkatesh","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2026.218460_bib190","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.cell.2019.05.045","article-title":"Controlling visually guided behavior by holographic recalling of cortical ensembles","volume":"178","author":"Carrillo-Reid","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2026.218460_bib191","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/s41593-018-0318-7","article-title":"Temporal evolution of cortical ensembles promoting remote memory retrieval","volume":"22","author":"DeNardo","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.canlet.2026.218460_bib192","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/s41592-018-0115-y","article-title":"Three-photon imaging of mouse brain structure and function through the intact skull","volume":"15","author":"Wang","year":"2018","journal-title":"Nat. Methods"},{"key":"10.1016\/j.canlet.2026.218460_bib193","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.cell.2016.04.019","article-title":"Mass cytometry: single cells, many features","volume":"165","author":"Spitzer","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2026.218460_bib194","doi-asserted-by":"crossref","first-page":"6754","DOI":"10.1016\/j.cell.2025.09.029","article-title":"Cancer cells co-opt an inter-organ neuroimmune circuit to escape immune surveillance","volume":"188","author":"Yu","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2026.218460_bib195","doi-asserted-by":"crossref","first-page":"852","DOI":"10.3390\/cancers17050852","article-title":"Spatial transcriptomics reveals novel mechanisms involved in perineural invasion in pancreatic ductal adenocarcinomas","volume":"17","author":"Lakis","year":"2025","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.canlet.2026.218460_bib196","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/j.stem.2025.08.006","article-title":"A combined enteric neuron-gastric tumor organoid reveals metabolic vulnerabilities in gastric cancer","volume":"32","author":"Chan","year":"2025","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.canlet.2026.218460_bib197","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aat5847","article-title":"Microphysiological 3D model of amyotrophic lateral sclerosis (ALS) from human iPS-derived muscle cells and optogenetic motor neurons","volume":"4","author":"Osaki","year":"2018","journal-title":"Sci. Adv."},{"key":"10.1016\/j.canlet.2026.218460_bib198","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1039\/C6LC00638H","article-title":"A 3D neurovascular microfluidic model consisting of neurons, astrocytes and cerebral endothelial cells as a blood-brain barrier","volume":"17","author":"Adriani","year":"2017","journal-title":"Lab Chip"},{"key":"10.1016\/j.canlet.2026.218460_bib199","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aax6040","article-title":"Sight and switch off: nerve density visualization for interventions targeting nerves in prostate cancer","volume":"6","author":"You","year":"2020","journal-title":"Sci. Adv."}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383526002235?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383526002235?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T14:30:09Z","timestamp":1776349809000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383526002235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":199,"alternative-id":["S0304383526002235"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218460","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cancer neuroscience: Dissecting autonomic and sensory neural regulation of tumor progression and therapeutic resistance","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218460","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"218460"}}