{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T08:08:59Z","timestamp":1778746139448,"version":"3.51.4"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Letters"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.canlet.2026.218536","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T15:46:16Z","timestamp":1777045576000},"page":"218536","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Integrative analysis of lactylation patterns reveals prognostic biomarkers and therapeutic targets in pancreatic cancer"],"prefix":"10.1016","volume":"651","author":[{"given":"Wenbo","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Congjia","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xintong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingxiao","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongpu","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengyuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoshen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiqi","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyu","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1328-8192","authenticated-orcid":false,"given":"Fanyang","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.canlet.2026.218536_bib1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41575-023-00840-w","article-title":"Therapeutic developments in pancreatic cancer","volume":"21","author":"Hu","year":"2024","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.canlet.2026.218536_bib2","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.canlet.2026.218536_bib3","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2016.22","article-title":"Pancreatic cancer","volume":"2","author":"Kleeff","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.canlet.2026.218536_bib4","doi-asserted-by":"crossref","first-page":"eaaw5473","DOI":"10.1126\/science.aaw5473","article-title":"Metabolic reprogramming and cancer progression","volume":"368","author":"Faubert","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.canlet.2026.218536_bib5","doi-asserted-by":"crossref","first-page":"15824","DOI":"10.1016\/S0021-9258(18)71551-2","article-title":"Involvement of the carboxyl-terminal propeptide of beta-glucuronidase in its compartmentalization within the endoplasmic reticulum as determined by a synthetic peptide approach","volume":"264","author":"Medda","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.canlet.2026.218536_bib6","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1158\/2326-6066.CIR-20-0111","article-title":"Lactate-modulated immunosuppression of myeloid-derived suppressor cells contributes to the radioresistance of pancreatic cancer","volume":"8","author":"Yang","year":"2020","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.canlet.2026.218536_bib7","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41586-019-1678-1","article-title":"Metabolic regulation of gene expression by histone lactylation","volume":"574","author":"Zhang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.canlet.2026.218536_bib8","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1128\/iai.51.3.884-890.1986","article-title":"Use of a two-sited monoclonal antibody assay to detect a heat-stable malarial antigen in the sera of mice infected with plasmodium yoelii","volume":"51","author":"Taylor","year":"1986","journal-title":"Infect. Immun."},{"key":"10.1016\/j.canlet.2026.218536_bib9","first-page":"11331","article-title":"Exosome and lipid metabolism-related genes in pancreatic adenocarcinoma: a prognosis analysis","volume":"15","author":"Wu","year":"2023","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.canlet.2026.218536_bib10","article-title":"Prognostic fifteen-gene signature for early stage pancreatic ductal adenocarcinoma","volume":"10","author":"Chen","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.canlet.2026.218536_bib11","doi-asserted-by":"crossref","first-page":"644","DOI":"10.3390\/ph16050644","article-title":"Lactylation-related gene signature effectively predicts prognosis and treatment responsiveness in hepatocellular carcinoma","volume":"16","author":"Cheng","year":"2023","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.canlet.2026.218536_bib12","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.canlet.2026.218536_bib13","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1021\/acs.accounts.0c00857","article-title":"The genesis of molecular volcano plots","volume":"54","author":"Wodrich","year":"2021","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.canlet.2026.218536_bib14","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA-seq data","volume":"14","author":"H\u00e4nzelmann","year":"2013","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.canlet.2026.218536_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.scog.2017.10.001","article-title":"Model selection and prediction of outcomes in recent onset schizophrenia patients who undergo cognitive training","volume":"11","author":"Ramsay","year":"2018","journal-title":"Schizophr Res Cogn"},{"key":"10.1016\/j.canlet.2026.218536_bib16","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.canlet.2026.218536_bib17","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1471-2105-12-35","article-title":"VennDiagram: a package for the generation of highly-customizable venn and euler diagrams in R","volume":"12","author":"Chen","year":"2011","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.canlet.2026.218536_bib18","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"10.1016\/j.canlet.2026.218536_bib19","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/3023127","article-title":"Potential molecular mechanisms of plantain in the treatment of gout and hyperuricemia based on network pharmacology","volume":"2020","author":"Liu","year":"2020","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.canlet.2026.218536_bib20","article-title":"Applying logistic LASSO regression for the diagnosis of atypical Crohn's disease","volume":"12","author":"Li","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.canlet.2026.218536_bib21","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1002\/jso.27358","article-title":"Clinicopathological characteristics of pheochromocytoma\/paraganglioma and screening of prognostic markers","volume":"128","author":"Lei","year":"2023","journal-title":"J. Surg. Oncol."},{"key":"10.1016\/j.canlet.2026.218536_bib22","doi-asserted-by":"crossref","first-page":"5381","DOI":"10.1002\/sim.5958","article-title":"Estimating and comparing time-dependent areas under receiver operating characteristic curves for censored event times with competing risks","volume":"32","author":"Blanche","year":"2013","journal-title":"Stat. Med."},{"key":"10.1016\/j.canlet.2026.218536_bib23","doi-asserted-by":"crossref","first-page":"2","DOI":"10.18637\/jss.v079.c02","article-title":"plotROC: a tool for plotting ROC curves","volume":"79","author":"Sachs","year":"2017","journal-title":"J. Stat. Software"},{"key":"10.1016\/j.canlet.2026.218536_bib24","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.0006-341X.2000.00337.x","article-title":"Time-dependent ROC curves for censored survival data and a diagnostic marker","volume":"56","author":"Heagerty","year":"2000","journal-title":"Biometrics"},{"key":"10.1016\/j.canlet.2026.218536_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.687975","article-title":"IOBR: multi-omics immuno-oncology biological research to decode tumor microenvironment and signatures","volume":"12","author":"Zeng","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.canlet.2026.218536_bib26","doi-asserted-by":"crossref","first-page":"3844","DOI":"10.1093\/bioinformatics\/btac409","article-title":"Ggtranscript: an R package for the visualization and interpretation of transcript isoforms using ggplot2","volume":"38","author":"Gustavsson","year":"2022","journal-title":"Bioinformatics"},{"key":"10.1016\/j.canlet.2026.218536_bib27","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.3390\/cells11213432","article-title":"Construction and evaluation of a risk score model for lymph node metastasis-associated circadian clock genes in esophageal squamous carcinoma","volume":"11","author":"Cheng","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.canlet.2026.218536_bib28","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1093\/bioinformatics\/btab806","article-title":"Make interactive complex heatmaps in R","volume":"38","author":"Gu","year":"2022","journal-title":"Bioinformatics"},{"key":"10.1016\/j.canlet.2026.218536_bib29","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1101\/gr.239244.118","article-title":"Maftools: efficient and comprehensive analysis of somatic variants in cancer","volume":"28","author":"Mayakonda","year":"2018","journal-title":"Genome Res."},{"key":"10.1016\/j.canlet.2026.218536_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0107468","article-title":"pRRophetic: an R package for prediction of clinical chemotherapeutic response from tumor gene expression levels","volume":"9","author":"Geeleher","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.canlet.2026.218536_bib31","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.3748\/wjg.v30.i19.2575","article-title":"Novel lactylation-related signature to predict prognosis for pancreatic adenocarcinoma","volume":"30","author":"Peng","year":"2024","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.canlet.2026.218536_bib32","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/s41592-022-01523-1","article-title":"Cyclic immonium ion of lactyllysine reveals widespread lactylation in the human proteome","volume":"19","author":"Wan","year":"2022","journal-title":"Nat. Methods"},{"key":"10.1016\/j.canlet.2026.218536_bib33","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1093\/annonc\/mdt419","article-title":"Genomic aberrations in the FGFR pathway: opportunities for targeted therapies in solid tumors","volume":"25","author":"Dienstmann","year":"2014","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.canlet.2026.218536_bib34","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1038\/sj.onc.1210422","article-title":"Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer","volume":"26","author":"Roberts","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.canlet.2026.218536_bib35","doi-asserted-by":"crossref","first-page":"880","DOI":"10.4161\/cbt.20840","article-title":"C1B domain peptide of protein kinase C\u03b3 significantly suppresses growth of human colon cancer cells in vitro and in an in vivo mouse xenograft model through induction of cell cycle arrest and apoptosis","volume":"13","author":"Kawabata","year":"2012","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.canlet.2026.218536_bib36","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/s41392-022-01151-3","article-title":"Lactate metabolism in human health and disease","volume":"7","author":"Li","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.canlet.2026.218536_bib37","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1113\/JP278810","article-title":"Revisiting the warburg effect: historical dogma versus current understanding","volume":"599","author":"Vaupel","year":"2021","journal-title":"J. Physiol."},{"key":"10.1016\/j.canlet.2026.218536_bib38","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.cell.2015.03.011","article-title":"A lactate-induced response to hypoxia","volume":"161","author":"Lee","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.canlet.2026.218536_bib39","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12943-024-02008-9","article-title":"Positive feedback regulation between glycolysis and histone lactylation drives oncogenesis in pancreatic ductal adenocarcinoma","volume":"23","author":"Li","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.canlet.2026.218536_bib40","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.imlet.2015.07.003","article-title":"Effects of extracellular pH and hypoxia on the function and development of antigen-specific cytotoxic T lymphocytes","volume":"167","author":"Nakagawa","year":"2015","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.canlet.2026.218536_bib41","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ccell.2022.01.003","article-title":"Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer","volume":"40","author":"Alam","year":"2022","journal-title":"Cancer Cell"},{"key":"10.1016\/j.canlet.2026.218536_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112471","article-title":"The glycolysis\/HIF-1\u03b1 axis defines the inflammatory role of IL-4-primed macrophages","volume":"42","author":"Dang","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.canlet.2026.218536_bib43","doi-asserted-by":"crossref","first-page":"9169","DOI":"10.3390\/ijms23169169","article-title":"The emerging key role of the mGluR1-PKC\u03b3 signaling pathway in the pathogenesis of spinocerebellar ataxias: a neurodevelopmental viewpoint","volume":"23","author":"Wu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.canlet.2026.218536_bib44","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s13058-024-01870-1","article-title":"Downregulation of tRF-Cys-GCA-029 by hyperglycemia promotes tumorigenesis and glycolysis of diabetic breast cancer through upregulating PRKCG translation","volume":"26","author":"Huang","year":"2024","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.canlet.2026.218536_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.modpat.2023.100286","article-title":"Histologic and genetic features of 51 melanocytic neoplasms with protein kinase C fusion genes","volume":"36","author":"de la Fouchardi\u00e8re","year":"2023","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.canlet.2026.218536_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.105501","article-title":"Downregulation of protein kinase C gamma reduces epithelial property and enhances malignant phenotypes in colorectal cancer cells","volume":"25","author":"Satow","year":"2022","journal-title":"iScience"}],"container-title":["Cancer Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383526002995?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304383526002995?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:22:24Z","timestamp":1778743344000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304383526002995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":46,"alternative-id":["S0304383526002995"],"URL":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218536","relation":{},"ISSN":["0304-3835"],"issn-type":[{"value":"0304-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrative analysis of lactylation patterns reveals prognostic biomarkers and therapeutic targets in pancreatic cancer","name":"articletitle","label":"Article Title"},{"value":"Cancer Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.canlet.2026.218536","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"218536"}}